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Human bestrophin-1 (hBest1) is a transmembrane Ca2+- dependent anion channel, associated with the transport of Cl−, HCO3- ions, γ-aminobutiric acid (GABA), glutamate (Glu), and regulation of retinal homeostasis. Its mutant forms cause retinal degenerative diseases, defined as Bestrophinopathies. Using both physicochemical - surface pressure/mean molecular area (π/A) isotherms, hysteresis, compressibility moduli of hBest1/sphingomyelin (SM) monolayers, Brewster angle microscopy (BAM) studies, and biological approaches - detergent membrane fractionation, Laurdan (6-dodecanoyl-N,N-dimethyl-2-naphthylamine) and immunofluorescence staining of stably transfected MDCK-hBest1 and MDCK II cells, we report:
1) Ca2+, Glu and GABA interact with binary hBest1/SM monolayers at 35 °C, resulting in changes in hBest1 surface conformation, structure, self-organization and surface dynamics. The process of mixing in hBest1/SM monolayers is spontaneous and the effect of protein on binary films was defined as “fluidizing”, hindering the phase-transition of monolayer from liquid-expanded to intermediate (LE-M) state;
2) in stably transfected MDCK-hBest1 cells, bestrophin-1 was distributed between detergent resistant (DRM) and detergent-soluble membranes (DSM) - up to 30 % and 70 %, respectively; in alive cells, hBest1 was visualized in both liquid-ordered (Lo) and liquid-disordered (Ld) fractions, quantifying protein association up to 35 % and 65 % with Lo and Ld. Our results indicate that the spontaneous miscibility of hBest1 and SM is a prerequisite to diverse protein interactions with membrane domains, different structural conformations and biological functions.
Motto der Herbstkonferenz Informatics Inside 2020 ist KInside. Wieder einmal blicken Studierende inside und schauen sich Methoden, Anwendungen und Zusammenhänge genauer an. Die Beiträge sind vielfältig und entsprechend dem Studiengang human-centered. Es ist der Anspruch, dass sich die Themen um die Bedürfnisse der Menschen drehen und eingesetzte Methoden kein Selbstzweck sind, sondern am Nutzen für den Menschen gemessen werden.
The Twelfth International Conference on Advances in Databases, Knowledge, and Data Applications (DBKDA 2020) continued a series of events covering a large spectrum of topics related to advances in fundamentals on databases, evolution of relation between databases and other domains, data base technologies and content processing, as well as specifics in applications domains databases. Advances in different technologies and domains related to databases triggered substantial improvements for content processing, information indexing, and data, process and knowledge mining. The push came from Web services, artificial intelligence, and agent technologies, as well as from the generalization of the XML adoption. High-speed communications and computations, large storage capacities, and load-balancing for distributed databases access allow new approaches for content processing with incomplete patterns, advanced ranking algorithms and advanced indexing methods. Evolution on e-business, ehealth and telemedicine, bioinformatics, finance and marketing, geographical positioning systems put pressure on database communities to push the ‘de facto’ methods to support new requirements in terms of scalability, privacy, performance, indexing, and heterogeneity of both content and technology.
Steady state efficiency optimization techniques for induction motors are state of the art and various methods have already been developed. This paper provides new insights in the efficiency optimized operation in dynamic regime. The paper proposes an anticipative flux modification in order to decrease losses during torque and speed transients. These trajectories are analyzed based on a numerical study for different motors. Measurement results for one motor are given as well.
The shift of populations to cities is creating challenges in many respects, thus leading to increasing demand for smart solutions of urbanization problems. Smart city applications range from technical and social to economic and ecological. The main focus of this work is to provide a systematic literature review of smart city research to answer two main questions: (1) How is current research on smart cities structured? and (2) What directions are relevant for future research on smart cities? To answer these research questions, a text-mining approach is applied to a large number of publications. This provides an overview and gives insights into relevant dimensions of smart city research. Although the main dimensions of research are already described in the literature, an evaluation of the relevance of such dimensions is missing. Findings suggest that the dimensions of environment and governance are popular, while the dimension of economy has received only limited attention.
Purpose: Despite growing interest in the intersection of supply chain management (SCM) and management accounting (MA) in the academic debate, there is a lack of understanding regarding both the content and the delimitation of this topic. As of today, no common conceptualization of supply chain management accounting (SCMA) exists. The purpose of this study is to provide an overview of the research foci of SCMA in the scholarly debate of the past two decades. Additionally, it analyzes whether and to what extent the academic discourse of MA in SCs has already found its way into both SCM and MA higher education, respectively.
Design/methodology/approach: A content analysis is conducted including 114 higher education textbooks written in English or in German language.
Findings: The study finds that SC-specific concepts of MA are seldom covered in current textbooks of both disciplines. The authors conclude that although there is an extensive body of scholarly research about SCMA concepts, there is a significant discrepancy with what is taught in higher education textbooks.
Practical implications: There is a large discrepancy between the extensive knowledge available in scholarly research and what we teach in both disciplines. This implies that graduates of both disciplines lack important knowledge and skills in controlling and accounting for SCs. To bring about the necessary change, MA and SCM in higher education must be more integrative.
Originality/value: To the best of the authors knowledge, this study is first of its kind comprising a large textbook sample in both English and German languages. It is the first substantiated assessment of the current state of integration between SCM and MA in higher education.
Die Ausrüstung von Textilien mit Sol-Gel-Beschichtungen wird seit einigen Jahren intensiv verfolgt. Eine Vielzahl von bekannten, aber auch neuen Ausrüstungseffekten können über diesen Ansatz realisiert werden. Besonders interessant ist die Sol-Gel-Technik wegen der Möglichkeiten, multifunktionelle Ausrüstungen zu synthetisieren. Problematisch ist eine in vielen Fällen geringe Beständigkeit solcher Ausrüstungen, insbesondere gegenüber Waschprozessen. Ziel des Projektes war es davon ausgehend, Vorbehandlungsstrategien für textile Fasermaterialien, basierend auf synthetischen Polymeren oder aus Naturfasern, zu entwickeln, die die Haltbarkeit von Sol-Gel-basierten Ausrüstungen verbessern. Im Rahmen der Arbeiten wurden, angepasst an die jeweiligen Faserpolymere - Polyethylenterephthalat, Polyamid, Polypropylen und Baumwolle - funktionelle Gruppen über geeignete Anker auf den Polymeren etabliert, die in der Lage sind, kovalente Bindungen zu Sol-Gel-basierten Beschichtungssystemen auszubilden. Als Anker wurden primär Trialkoxysilane verwendet, die zusätzlich z.B. Epoxy-, Isocyanato-, Azido- oder Amino-funktionelle Reste besitzen. Mit diesen Resten können die Anker kovalent an die Polymere angebunden werden. Die meisten Sol-Gel-basierten Systeme enthalten zumindest zu einem gewissen Anteil SiOx und/oder MexOy-Cluster. Die zur Funktionalisierung der Oberflächen eingesetzten Alkoxysilane können generell an solche Systeme/Cluster per Kondensation gebunden werden und dienen daher für die effektive Anbindung verschiedenster funktioneller Sol-Gel-Schichten. Entsprechend vorfunktionalisierte Substrate wurden in der Folge mit exemplarisch ausgewählten Sol-Gel-Ausrüstungen beschichtet. Dabei wurden für den Großteil der Untersuchungen hydrophobierende Sole appliziert. Vorteilhaft ist, dass sich der mit hydrophobierenden Solen erzielte Ausrüstungseffekt genau wie dessen Beständigkeit mit vergleichsweise überschaubarem Aufwand über die Untersuchung der Benetzbarkeit (DuPont-Noten, Kontaktwinkel, Tropfeneinsinkzeiten) charakterisieren lässt. Die Wirksamkeit der Vorbehandlungen wurde dann vor allem anhand von Untersuchungen zur Waschbeständigkeit der Ausrüstungen überprüft. Im Rahmen der Arbeiten konnte gezeigt werden, dass sich über die Etablierung geeigneter Anker die Beständigkeit von Sol-Gel-Ausrüstungen bzw. der daraus hervorgehenden Effekte verbessern lässt. Es zeigt sich gleichzeitig, dass die erzielten Verbesserungen sehr stark vom jeweiligen Sol abhängen. D.h., dass sich erzielte Verbesserungen nicht zwangsläufig auf andere Sol übertragen lassen. Analytische Charakterisierungen weisen darauf hin, dass in vielen Fällen die Beständigkeit der Beschichtungsnetzwerke selbst einen weit größeren Einfluss besitzt als die Anbindung an das Substrat. So zeigt sich bei verschiedenen Untersuchungen, dass die Auflage der Sol-Gel-Beschichtung vor allem nach einer ersten Wäsche, aber auch darüber hinaus, signifikant sinkt, oftmals aber ohne dass der durch Ausrüstung erzielte Effekt verloren geht. Dies deutet auf ein (Auf-)Lösen der Beschichtungsmatrizes hin, wovor die Anker nicht schützen können, da deren Wirkung auf die Grenzfläche zum Substrat beschränkt ist. Neben den hydrophobierenden Ausrüstungen wurden exemplarisch auch antibakterielle Ausrüstungen nach den entsprechenden Vorbehandlungen appliziert. Auch hier konnten Verbesserungen in der Beständigkeit des Effektes erzielt werden. Abschließend wurde untersucht inwieweit sich die Vorbehandlungen im Vergleich zur einfachen Ausrüstung negativ auf die textilen Produkte auswirken. Hierzu wurden relevante textile Parameter wie z.B. Höchstzugkräfte, Weißgrade, Steifigkeit oder Luftdurchlässigkeiten bestimmt. Diese Parameter wurden in der überwiegenden Zahl der Vorbehandlungen nicht oder nur geringfügig beeinflusst.
Im Rahmen des Forschungsprojektes wurden Ausrüstungsmittel und -verfahren entwickelt, die dem vorbeugenden Schutz von Textilien (insbesondere Bodenbelägen) vor Anschmutzung dienen. Das Verfahren sieht eine kombinierte Ausrüstung von Textilien mit fluorierten Polymeren mit inkorporierten Nanopartikeln (in erster Linie: SiO2) zur Erhöhung der Rauhigkeit vor. Es wurden kommerziell erhältliche Hydrophobiermittel (Fluorcarbon- oder Kohlenwasserstoff-basierte Polymere) in Kombination mit SiO2-Nanopartikeln auf Teppiche aufgebracht und hinsichtlich eines Anschmutzens - z.B. durch Kaffee, KoolAid, Rotwein, AATCC Standard Soil, schwarze Schuhcreme - untersucht. Hierzu wurden die scherempfindlichen Dispersionen der Hydrophobiermittel mit neu entwickelten angepassten Dispersionen von SiO2-Nanopartikel versetzt. Die SiO2-Nanopartikel wurden mit systematisch variierten Größen von 10-1.000 nm synthetisiert, umfassend charakterisiert und mit Hilfe von neu entwickelten Fluormethacrylat-Copolymeren mit reaktiven Gruppen (Maleinsäure-, Itaconsäure- oder Citraconsäureanhydrid) und hydrophilen Modifiern (Alkohol- oder Amingruppen) stabilisiert. Die resultierenden Polymer-Teilchen-Dispersionen konnten aus wässrigen oder ethanolisch-wässrigen Lösungen auf Textilien (PA-, PES- oder WO-Teppiche und -Gewebe) appliziert werden. Weiterhin wurden auch die neu entwickelten Fluorcarbon-Polymere hinsichtlich ihrer Anwendung getestet. In Anschmutzungsversuchen wiesen die so ausgerüsteten Teppiche ein geringeres Anschmutzen durch Standardschmutz als Referenzmaterialien auf. Die Beständigkeit der Ausrüstung bei mechanischer Belastung konnte durch Vernetzung der Polymere auf dem Textilmaterial verbessert werden. Für PA 6- und PA 6.6-Teppiche wurden die besten Ergebnisse hinsichtlich eines geringeren Anschmutzens durch wasserlösliche Verschmutzungen (Kaffee, Rotwein, KoolAid) im Vergleich zu unbehandelten Teppichen ermittelt, wenn die Ausrüstung mit Fluorpolymer-stabilisierten SiO2-Nanopartikeln oder mit einer kombinierten Dispersion aus SiO2-Partikeln und Fluorcarbonharzen vorgenommen wurde. Eine im Vergleich zu unbehandelten Teppichen weniger starke Anschmutzung durch AATCC Standard Soil (DIN EN ISO 11378-2) wurde für mit SiO2-Partikeln behandelte PA 6-Teppiche ermittelt. Hydrophobe Anschmutzungen (z.B. schwarze Schuhcreme) konnten von mit Fluorcarbon-Polymeren ausgerüsteten Teppichen am besten entfernt werden. Die Kombination von SiO2-Partikeln mit Fluorcarbon-Polymeren erwies sich meist als günstiger als die alleinige Behandlung mit Fluorcarbonharzen. Ein Zusammenhang zwischen der Größe der Nanopartikel, der Abrasionsbeständigkeit und den Reinigungseigenschaften wurde festgestellt, und es konnte gezeigt werden, dass FC-Nanopartikel-Composites diese verbessern. Die mechanische Beständigkeit der Antischmutzausrüstung mit SiO2-Nanopartikeln und Fluorcarbon-Polymeren auf Polyamidteppichen wurde z.B. durch Hexapod-Trommelbeanspruchung (nach ISO 10361) geprüft. Durch REM, IR-Spektroskopie und den Wassertropfentest wurde nach 4.000 und auch nach 12.000 Touren noch eine intakte Beschichtung nachgewiesen. Mit Vernetzern, die das Polymer selbst, das Polymer mit Partikeln und/oder der Substratoberfläche vernetzen, konnte z.T. die Abrasionsbeständigkeit verbessert werden (hier müssen ggf. optimalere Vernetzer gesucht werden).
Sol-Gel basierte Flammschutzmittel stellen einen vielversprechenden Ansatz für Textilien dar, gerade im Bereich des Ersatzes von derzeit etablierten halogenhaltigen Flammschutzmitteln. Letztere sind aufgrund ihrer toxikologisch Bedenklichkeit sowie ihrer mitunter bioakkumulierenden Eigenschaften in die Kritik geraten. In diesem Forschungsvorhaben wurde daher untersucht auf welche Weise ein Flammschutz per Sol-Gel-Ansatz auf Stickstoff- und/oder Phosphorbasis als halogenfreie Alternative verwirklicht werden kann. Die Sol-Gel-Schicht fungierte dabei zum einen als nicht brennbarer Binder, zum anderen konnten über das Einführen entsprechender funktioneller Seitenketten für den Flammschutz aktive Gruppen direkt mit eingebunden werden. Verschiedene Ansätze wurden dabei verfolgt. Vor allem durch die Nutzung von additivierten Systemen, d.h. durch Sol-Gel-Schichten mit Zusätzen von stickstoff- und/oder phosphorhaltigen Verbindungen konnte ein Flammschutz nach DIN EN ISO 15025 (Schutzkleidung – Schutz gegen Hitze und Flammen) erhalten werden. Anhand eines Modellsystems, bei dem in zwei aufeinanderfolgenden Schritten zuerst eine funktionalisierte Sol-Gel-Schicht und anschließend eine Phosphorverbindung in einem zweiten Schritt aufgebracht wurde, konnten die Vorteile des Flammschutzes auf Sol-Gel-Basis nachgewiesen werden. Dabei wurde unter anderem auch gezeigt, dass ein Mechanismus auf Basis der Bildung einer Schutzschicht hauptsächlich verantwortlich für den Flammschutz ist. Dieses Ergebnis ist für eine zukünftige, weitere Optimierung entsprechender Ausrüstungen nicht zu unterschätzen. Durch Ausrüstungsversuche im semi-industriellen Maßstab konnte weiterhin gezeigt werden, dass einer großtechnischen Umsetzung der angewandten Ausrüstungen prinzipiell nichts im Wege steht. Abstriche müssen bis dato lediglich bezüglich der Waschstabilität gemacht werden. Die Sol-Gel-Schichten überstanden zwar im allgemeinen typische Waschprozesse, eine Permanenz der Flammfestigkeit von additivierten Systemen ergab sich aber nur in einzelnen Fällen. Ausgehend von den Ergebnissen wurde ein neuer Ansatz vorgestellt, der über den hier zugrundeliegenden Ansatz hinausgeht. Dieser sieht vor, durch den Einsatz von neu-synthetisierten Silanen mit Stickstoff- und Phosphorgruppen Sol-Gel-Schichten herzustellen, die ein vielversprechendes Verhalten zeigen. Hier konnte auch nach ersten Waschtests eine Aufrechterhaltung der verbesserten Flammfestigkeit nachgewiesen werden. Insgesamt konnte innerhalb des Forschungsvorhabens gezeigt werden, dass ein Flammschutz auf Sol-Gel-Basis für Textilien erhalten werden kann. Darüberhinaus konnte auch erklärt werden auf welchem Mechanismus dieser Flammschutz begründet ist und wie die derzeit noch ungenügende Waschpermanenz verbessert werden kann.
Matthias Varga von Kibéd und Insa Sparrer unterscheiden zwischen drei verschiedenen Aufstellungsmethoden (Sparrer und Varga von Kibéd, o. D.): Der spezifisch (konkreten), der virtuellen und der prototypischen Aufstellung. Bei spezifischen Aufstellungen wird ein konkretes Anliegen eines Klienten betrachtet. Im Gegensatz dazu, werden bei virtuellen Aufstellungen eine Übungsumgebung geschaffen. In dieser können Aufstellungstechniken und Interventionsmethoden geübt werden. Bei prototypischen Strukturaufstellungen werden Themen zusammengefasst, die mehrere Teilnehmer im Seminar berühren bzw. in deren Alltag immer wieder auftreten können. Dieses Thema wird wie eine spezifische Aufstellung bearbeitet jedoch ohne ein konkretes vorliegendes Anliegen. Beispiele für prototypische Strukturaufstellungen kommen aus vielen Bereichen z.B. dem Führungsalltag, Teamentwicklung, Konfliktmanagement, Gesprächsführung, Zeit‐ und Selbstmanagement.
Driven by digital transformation, manufacturing systems are heading towards autonomy. The implementation of autonomous elements in manufacturing systems is still a big challenge. Especially small and medium sized enterprises (SME) often lack experience to assess the degree of Autonomous Production. Therefore, a description model for the assessment of stages for Autonomous Production has been identified as a core element to support such a transformation process. In contrast to existing models, the developed SME-tailored model comprises different levels within a manufacturing system, from single manufacturing cells to the factory level. Furthermore, the model has been validated in several case studies.
Process quality has reached a high level on mass production, utilizing well known methods like the DoE. The drawback of the unterlying statistical methods is the need for tests under real production conditions, which cause high costs due to the lost output. Research over the last decade let to methods for correcting a process by using in-situ data to correct the process parameters, but still a lot of pre-production is necessary to get this working. This paper presents a new approach in improving the product quality in process chains by using context data - which in part are gathered by using Industry 4.0 devices - to reduce the necessary pre-production.
In recent years, machine learning algorithms have made a huge development in performance and applicability in industry and especially maintenance. Their application enables predictive maintenance and thus offers efficiency increases. However, a successful implementation of such solutions still requires high effort in data preparation to obtain the right information, interdisciplinarity in teams as well as a good communication to employees. Here, small and medium sized enterprises (SME) often lack in experience, competence and capacity. This paper presents a systematic and practice-oriented method for an implementation of machine learning solutions for predictive maintenance in SME, which has already been validated.
The chemical synthesis of polysiloxanes from monomeric starting materials involves a series of hydrolysis, condensation and modification reactions with complex monomeric and oligomeric reaction mixtures. Real-time monitoring and precise process control of the synthesis process is of great importance to ensure reproducible intermediates and products and can readily be performed by optical spectroscopy. In chemical reactions involving rapid and simultaneous functional group transformations and complex reaction mixtures, however, the spectroscopic signals are often ambiguous due to overlapping bands, shifting peaks and changing baselines. The univariate analysis of individual absorbance signals is hence often only of limited use. In contrast, batch modelling based on the multivariate analysis of the time course of principal components (PCs) derived from the reaction spectra provides a more efficient tool for real time monitoring. In batch modelling, not only single absorbance bands are used but information over a broad range of wavelengths is extracted from the evolving spectral fingerprints and used for analysis. Thereby, process control can be based on numerous chemical and morphological changes taking place during synthesis. “Bad” (or abnormal) batches can quickly be distinguished from “normal” ones by comparing the respective reaction trajectories in real time. In this work, FTIR spectroscopy was combined with multivariate data analysis for the in-line process characterization and batch modelling of polysiloxane formation. The synthesis was conducted under different starting conditions using various reactant concentrations. The complex spectral information was evaluated using chemometrics (principal component analysis, PCA). Specific spectral features at different stages of the reaction were assigned to the corresponding reaction steps. Reaction trajectories were derived based on batch modelling using a wide range of wavelengths. Subsequently, complexity was reduced again to the most relevant absorbance signals in order to derive a concept for a low-cost process spectroscopic set-up which could be used for real-time process monitoring and reaction control.
Der Anspruch an Energieversorger wird wachsen: in Zukunft gewinnen vor allem Aufgaben wie die Entwicklung digitalisierter Produkte/Dienstleistungen sowie ökologische Aktivitäten an Relevanz. Dies zeigt die Hochschule Reutlingen in ihrer aktuellen Untersuchung unter Aufsichtsräten, Geschäftsführern und Führungskräften. Trotz der erwarteten Veränderungen: die Aufsichtsräte sind sich zwar ihrem Druck zu mehr Professionalisierung bewusst, scheinen aktuell aber nur mäßig für die künftigen Herausforderungen des Unternehmens gerüstet. Besonders relevant dabei: die Professionalisierung der Gremienarbeit in kommunalen EVU ermöglicht einen höheren wahrgenommenen Unternehmenserfolg. So die Studie des Reutlinger Energiezentrums and der Hochschule Reutlingen im Auftrag von fünf Unternehmen der Branche.
The automation of work by means of disruptive technologies such as Artificial Intelligence (AI) and Robotic Process Automation (RPA) is currently intensely discussed in business practice and academia. Recent studies indicate that many tasks manually conducted by humans today will not in the future. In a similar vein, it is expected that new roles will emerge. The aim of this study is to analyze prospective employment opportunities in the context of RPA in order to foster our understanding of the pivotal qualifications, expertise and skills necessary to find an occupation in a completely changing world of work. This study is based on an explorative, content analysis of 119 job advertisements related to RPA in Germany. The data was collected from major German online job platforms, qualitatively coded, and subsequently analyzed quantitatively. The research indicates that there indeed are employment opportunities, especially in the consulting sector. The positions require different technological expertise such as specific programming languages and knowledge in statistics. The results of this study provide guidance for organizations and individuals on reskilling requirements for future employment. As many of the positions require profound IT expertise, the generally accepted perspective that existing employees affected by automation can be retrained to work in the emerging positions has to be seen extremely critical. This paper contributes to the body of knowledge by providing a novel perspective on the ongoing discussion of employment opportunities, and reskilling demands of the existing workforce in the context of recent technological developments and automation.
Despite strong political efforts in Europe, industrial small- and medium sized enterprises (SMEs) seem to neglect adopting practices for energy effciency. By taking a cultural perspective, this study investigated what drives the establishment of energy effciency and corresponding practices in SMEs. Based on 10 ethnographic case studies and a quantitative survey among 500 manufacturing SMEs, the results indicate the importance of everyday employee behavior in achieving energy savings. The studied enterprises value behavior related measures as similarly important as technical measures. Raising awareness for energy issues within the organization, therefore, constitutes an essential leadership task that is oftentimes perceived as challenging and frustrating. It was concluded that the embedding of energy efficiency in corporate strategy, the use of a broad spectrum of different practices, and the empowerment and involvement of employees serve as major drivers in establishing energy effciency within SMEs. Moreover, the findings reveal institutional influences on shaping the meanings of energy effciency for the SMEs by raising attention for energy effciency in the enterprises and making energy effciency decisions more likely. The main contribution of the paper is to offer an alternative perspective on energy effciency in SMEs beyond the mere adoption of energy-effcient technology.
In recent years, the development and application of decellularized extracellular matrices (ECMs) for use as biomaterials have grown rapidly. These cell-derived matrices (CDMs) represent highly bioactive and biocompatible materials consisting of a complex assembly of biomolecules. Even though CDMs mimic the natural microenvironment of cells in vivo very closely, they still lack specifically addressable functional groups, which are often required to tailor a biomaterial functionality by bioconjugation. To overcome this limitation, metabolic glycoengineering has emerged as a powerful tool to equip CDMs with chemical groups such as azides. These small chemical handles are known for their ability to undergo bioorthogonal click reactions, which represent a desirable reaction type for bioconjugation. However, ECM insolubility makes its processing very challenging. In this contribution, we isolated both the unmodified ECM and azide-modified clickECM by osmotic lysis. In a first step, these matrices were concentrated to remove excessive water from the decellularization step. Next, the hydrogel-like ECM and clickECM films were mechanically fragmentized, resulting in easy to pipette suspensions with fragment sizes ranging from 7.62 to 31.29 μm (as indicated by the mean d90 and d10 values). The biomolecular composition was not impaired as proven by immunohistochemistry. The suspensions were used for the reproducible generation of surface coatings, which proved to be homogeneous in terms of ECM fragment sizes and coating thicknesses (the mean coating thickness was found to be 33.2 ± 7.3 μm). Furthermore, they were stable against fluid-mechanical abrasion in a laminar flow cell. When primary human fibroblasts were cultured on the coated substrates, an increased bioactivity was observed. By conjugating the azides within the clickECM coatings with alkyne-coupled biotin molecules, a bioconjugation platform was obtained, where the biotin–streptavidin interaction could be used. Its applicability was demonstrated by equipping the bioactive clickECM coatings with horseradish peroxidase as a model enzyme.
The extracellular matrix (ECM) naturally surrounds cells in humans, and therefore represents the ideal biomaterial for tissue engineering. ECM from different tissues exhibit different composition and physical characteristics. Thus, ECM provides not only physical support but also contains crucial biochemical signals that influence cell adhesion, morphology, proliferation and differentiation. Next to native ECM from mature tissue, ECM can also be obtained from the in vitro culture of cells. In this study, we aimed to highlight the supporting effect of cell-derived- ECM (cdECM) on adipogenic differentiation. ASCs were seeded on top of cdECM from ASCs (scdECM) or pre-adipocytes (acdECM). The impact of ECM on cellular activity was determined by LDH assay, WST I assay and BrdU assay. A supporting effect of cdECM substrates on adipogenic differentiation was determined by oil red O staining and subsequent quantification. Results revealed no effect of cdECM substrates on cellular activity. Regarding adipogenic differentiation a supporting effect of cdECM substrates was obtained compared to control. With these results, we confirm cdECM as a promising biomaterial for adipose tissue engineering.
Bone tissue is highly vascularized. The crosstalk of vascular and osteogenic cells is not only responsible for the formation of the strongly divergent tissue types but also for their physiological maintenance and repair. Extrusion-based bioprinting presents a promising fabrication method for bone replacement. It allows for the production of large-volume constructs, which can be tailored to individual tissue defect geometries. In this study, we used the all-gelatin-based toolbox of methacryl-modified gelatin (GM), non-modified gelatin (G) and acetylated GM (GMA) to tailor both the properties of the bioink towards improved printability, and the properties of the crosslinked hydrogel towards enhanced support of vascular network formation by simple blending. The vasculogenic behavior of human dermal microvascular endothelial cells (HDMECs) and human adipose-derived stem cells (ASCs) was evaluated in the different hydrogel formulations for 14 days. Co-culture constructs including a vascular component and an osteogenic component (i.e. a bone bioink based on GM, hydroxyapatite and ASCs) were fabricated via extrusion-based bioprinting. Bioprinted co-culture constructs exhibited functional tissue-specific cells whose interplay positively affected the formation and maintenance of vascular-like structures. The setup further enabled the deposition of bone matrix associated proteins like collagen type I, fibronectin and alkaline phosphatase within the 30-day culture.
Improvement of a three-layered in vitro skin model for topical application of irritating substances
(2020)
In the field of skin tissue engineering, the development of physiologically relevant in vitro skin models comprising all skin layers, namely epidermis, dermis, and subcutis, is a great challenge. Increasing regulatory requirements and the ban on animal experiments for substance testing demand the development of reliable and in vivo-like test systems, which enable high-throughput screening of substances. However, the reproducibility and applicability of in vitro testing has so far been insufficient due to fibroblast-mediated contraction. To overcome this pitfall, an advanced 3-layered skin model was developed. While the epidermis of standard skin models showed an 80% contraction, the initial epidermal area of our advanced skin models was maintained. The improved barrier function of the advanced models was quantified by an indirect barrier function test and a permeability assay. Histochemical and immunofluorescence staining of the advanced model showed well-defined epidermal layers, a dermal part with distributed human dermal fibroblasts and a subcutis with round-shaped adipocytes. The successful response of these advanced 3-layered models for skin irritation testing demonstrated the suitability as an in vitro model for these clinical tests: only the advanced model classified irritative and non-irritative substances correctly. These results indicate that the advanced set up of the 3-layered in vitro skin model maintains skin barrier function and therefore makes them more suitable for irritation testing.
Different types of raw cotton were investigated by a commercial ultraviolet-visible/near infrared (UV-Vis/NIR) spectrometer (210–2200 nm) as well as on a home-built setup for NIR hyperspectral imaging (NIR-HSI) in the range 1100–2200 nm. UV-Vis/NIR reflection spectroscopy reveals the dominant role proteins, hydrocarbons and hydroxyl groups play in the structure of cotton. NIR-HSI shows a similar result. Experimentally obtained data in combination with principal component analysis (PCA) provides a general differentiation of different cotton types. For UV-Vis/NIR spectroscopy, the first two principal components (PC) represent 82 % and 78 % of the total data variance for the UV-Vis and NIR regions, respectively. Whereas, for NIR-HSI, due to the large amount of data acquired, two methodologies for data processing were applied in low and high lateral resolution. In the first method, the average of the spectra from one sample was calculated and in the second method the spectra of each pixel were used. Both methods are able to explain ≥90 % of total variance by the first two PCs. The results show that it is possible to distinguish between different cotton types based on a few selected wavelength ranges. The combination of HSI and multivariate data analysis has a strong potential in industrial applications due to its short acquisition time and low-cost development. This study opens a novel possibility for a further development of this technique towards real large-scale processes.
Für den Unternehmer wichtig ist, binnen welcher Fristen er als Käufer seine Rechte bei Sachmängeln geltend machen muss. Ist der Unternehmer Verkäufer, kann er sich erst nach Verjährungsvollendung endgültig zurücklehnen und sicher sein, dass keine Gewährleistungsansprüche gegen ihn mehr geltend gemacht werden können. Im nationalen Rechtsverkehr hat man sich auf Verkäufer- und Käuferseite mittlerweile an die zweijährige Regelfrist im BGB gewöhnt. Welche Fristen im Auslandsgeschäft gelten, ist dagegen oft unklar, weil sich die nationalen Verjährungsfristen oft unterscheiden: Allein in Europa gibt es bei der kaufrechtlichen Gewährleistung Verjährungsfristen zwischen sechs Monaten und sechs Jahren.
This book presents an empirical investigation of the efforts that multinational pharmaceutical companies take in order to find a business model that allows for a profitable access to the Bottom of the Pyramid (BoP) markets. The Bottom of the Pyramid in Africa is frequently mentioned as an attractive market due to its sheer size. Yet most companies struggle to access it because of the low price level, difficult physical market access and challenges when it comes to payment.
More specifically, the book investigates the following business model-related questions: Do pharmaceutical companies provide products that meet the needs of the BoP? What characterizes the value generation of the company? What revenue model leads to a profitable business, and what role does a network of partners play in the business model?
Findings reveal that there is no ‘one-size-fits-all’ answer to these questions. Providing continuous availability, affordability at a good quality of goods and services, creating health awareness, as well as localizing business to achieve a level of inclusivenessare essential prerequisites for success. In the last chapter this book provides a business model prototype that accounts for these key success factors for business at the Bottom of the Pyramid and points to further research topics.
Here, we report the mechanical and water sorption properties of a green composite based on Typha latifolia fibres. The composite was prepared either completely binder-less or bonded with 10% (w/w) of a bio-based resin which was a mixture of an epoxidized linseed oil and a tall-oil based polyamide. The flexural modulus of elasticity, the flexural strength and the water absorption of hot pressed Typha panels were measured and the influence of pressing time and panel density on these properties was investigated. The cure kinetics of the biobased resin was analyzed by differential scanning calorimetry (DSC) in combination with the iso-conversional kinetic analysis method of Vyazovkin to derive the curing conditions required for achieving completely cured resin. For the binderless Typha panels the best technological properties were achieved for panels with high density. By adding 10% of the binder resin the flexural strength and especially the water absorption were improved significantly.
Here, we report the continuous peroxide-initiated grafting of vinyltrimethoxysilane (VTMS) onto a standard polyolefin by means of reactive extrusion to produce a functionalized liquid ethylene propylene copolymer (EPM). The effects of the process parameters governing the grafting reaction and their synergistic interactions are identified, quantified and used in a mathematical model of the extrusion process. As process variables the VTMS and peroxide concentrations and the extruder temperature setting were systematically studied for their influence on the grafting and the relative grafting degree using a face-centered central composite design (FCD). The grafting degree was quantified by 1H NMR spectroscopy. Response surface methodology (RSM) was used to calculate the most efficient grafting process in terms of chemical usage and graft yield. With the defined processing window, it was possible to make precise predictions about the grafting degree with at the same time highest possible relative degree of grafting.
nKV in action: accelerating KVstores on native computational storage with NearData processing
(2020)
Massive data transfers in modern data intensive systems resulting from low data-locality and data-to-code system design hurt their performance and scalability. Near-data processing (NDP) designs represent a feasible solution, which although not new, has yet to see widespread use.
In this paper we demonstrate various NDP alternatives in nKV, which is a key/value store utilizing native computational storage and near-data processing. We showcase the execution of classical operations (GET, SCAN) and complex graph-processing algorithms (Betweenness Centrality) in-situ, with 1.4x-2.7x better performance due to NDP. nKV runs on real hardware - the COSMOS+ platform.
Massive data transfers in modern key/value stores resulting from low data-locality and data-to-code system design hurt their performance and scalability. Near-data processing (NDP) designs represent a feasible solution, which although not new, have yet to see widespread use.
In this paper we introduce nKV, which is a key/value store utilizing native computational storage and near-data processing. On the one hand, nKV can directly control the data and computation placement on the underlying storage hardware. On the other hand, nKV propagates the data formats and layouts to the storage device where, software and hardware parsers and accessors are implemented. Both allow NDP operations to execute in host-intervention-free manner, directly on physical addresses and thus better utilize the underlying hardware. Our performance evaluation is based on executing traditional KV operations (GET, SCAN) and on complex graph-processing algorithms (Betweenness Centrality) in-situ, with 1.4×-2.7× better performance on real hardware – the COSMOS+ platform.
Massive data transfers in modern data intensive systems resulting from low data-locality and data-to-code system design hurt their performance and scalability. Near-data processing (NDP) and a shift to code-to-data designs may represent a viable solution as packaging combinations of storage and compute elements on the same device has become viable.
The shift towards NDP system architectures calls for revision of established principles. Abstractions such as data formats and layouts typically spread multiple layers in traditional DBMS, the way they are processed is encapsulated within these layers of abstraction. The NDP-style processing requires an explicit definition of cross-layer data formats and accessors to ensure in-situ executions optimally utilizing the properties of the underlying NDP storage and compute elements. In this paper, we make the case for such data format definitions and investigate the performance benefits under NoFTL-KV and the COSMOS hardware platform.
The tale of 1000 cores: an evaluation of concurrency control on real(ly) large multi-socket hardware
(2020)
In this paper, we set out the goal to revisit the results of “Starring into the Abyss [...] of Concurrency Control with [1000] Cores” and analyse in-memory DBMSs on today’s large hardware. Despite the original assumption of the authors, today we do not see single-socket CPUs with 1000 cores. Instead multi-socket hardware made its way into production data centres. Hence, we follow up on this prior work with an evaluation of the characteristics of concurrency control schemes on real production multi-socket hardware with 1568 cores. To our surprise, we made several interesting findings which we report on in this paper.
In this paper, we present a new approach for achieving robust performance of data structures making it easier to reuse the same design for different hardware generations but also for different workloads. To achieve robust performance, the main idea is to strictly separate the data structure design from the actual strategies to execute access operations and adjust the actual execution strategies by means of so-called configurations instead of hard-wiring the execution strategy into the data structure. In our evaluation we demonstrate the benefits of this configuration approach for individual data structures as well as complex OLTP workloads.
Modern mixed (HTAP)workloads execute fast update-transactions and long running analytical queries on the same dataset and system. In multi-version (MVCC) systems, such workloads result in many short-lived versions and long version-chains as well as in increased and frequent maintenance overhead.
Consequently, the index pressure increases significantly. Firstly, the frequent modifications cause frequent creation of new versions, yielding a surge in index maintenance overhead. Secondly and more importantly, index-scans incur extra I/O overhead to determine, which of the resulting tuple versions are visible to the executing transaction (visibility-check) as current designs only store version/timestamp information in the base table – not in the index. Such index-only visibility-check is critical for HTAP workloads on large datasets.
In this paper we propose the Multi Version Partitioned B-Tree (MV-PBT) as a version-aware index structure, supporting index-only visibility checks and flash-friendly I/O patterns. The experimental evaluation indicates a 2x improvement for analytical queries and 15% higher transactional throughput under HTAP workloads. MV-PBT offers 40% higher tx. throughput compared to WiredTiger’s LSM-Tree implementation under YCSB.
Customer orientation should be the core engine of every organisation while IT can be considered as the enabler to generate competitive advantages along customer processes in marketing, sales and service. Research shows that customer relationship management (CRM) enables organisations to perform better and experience indicates that organisations that focus on customer orientation are more successful. With marketplace organisations such as Amazon, Alibaba or Conrad shaping the future of customer centricity and information technology, German B2B organisations need to shift their value contribution from product-centric to customer-centric. While these organisations are currently attempting to implement CRM software and putting their customers more into focus, the question remains how organisations are approaching the implementation of CRM and whether these attempts are paying off in terms of business performance.
Here, we study resin cure and network formation of solid melamine formaldehyde pre-polymer over a large temperature range viadynamic temperature curing profiles. Real-time infrared spectroscopy is used to analyze the chemical changes during network formation and network hardening. By applying chemometrics (multivariate curve resolution,MCR), the essential chemical functionalities that constitute the network at a given stage of curing are mathematically extracted and tracked over time. The three spectral components identified by MCR were methylol-rich, ether linkages-rich and methylene linkages-rich resin entities. Based on dynamic changes of their characteristic spectral patterns in dependence of temperature, curing is divided into five phases: (I) stationary phase with free methylols as main chemical feature, (II) formation of flexible network cross-linked by ether linkages, (III) formation of rigid, ether-cross-linked network, (IV) further hardening via transformation of methylols and ethers into methylene-cross-linkages, and (V) network consolidation via transformation of ether into methylene bridges. The presented spectroscopic/chemometric approach can be used as methodological basis for the functionality design of MF-based surface films at the stage of laminate pressing, i.e., for tailoring the technological property profile of cured MF films using a causal understanding of the underlying chemistry based on molecular markers and spectroscopic fingerprints.
Dieser Beitrag gibt einen Überblick über die verschiedenen Möglichkeiten der Bilanzierung einens Initial Coin Offerings (ICO) beim Emittenten auf der Passivseite nach den Regelungen der IFRS. Ziel ist es, die bilanzielle Einordnung anhand verschiedenenr Arten von Token zu erörtern und den Emittenten bei der Ausgestaltung der Token sowie der anschließenden Bilanzierung zu unterstützen. Die Ergebnisse zeigen, dass die Standards für die bilanzielle Einordnung von ICO-Token zwar ausreichen, allerdings eine große Bandbreite der Bilanzierung zu berücksichtigen ist und eine detaillierte Regelung durch einen eigenen IFRS daher schwierig erscheint.
Das Value-Engineering in der Kundenkommunikation ist eine strukturierte Methode, Kommunikationsprozesse zwischen Unternehmen zu verbessern. Das Konzept greift bewährte Elemente der technischen Wertanalyse und der Gemeinkosten-Wertanalyse auf und überträgt sie auf die Kundenkommunikation. Der Ansatz bietet eine systematische Vorgehensweise, Kommunikationsprozesse zwischen Anbieter und Kunde zu durchleuchten und neu zu gestalten. Value-Engineering in der Kundenkommunikation schafft somit Wettbewerbsvorteile durch eine Optimierung der Kommunikation.
The article studies a novel approach of inflation modeling in economics. We utilize a stochastic differential equation (SDE) of the form dXt=aXtdt+bXtdBtH, where dBtH is a fractional Brownian motion in order to model inflationary dynamics. Standard economic models do not capture the stochastic nature of inflation in the Eurozone. Thus, we develop a new stochastic approach and take into consideration fractional Brownian motions as well as Lévy processes. The benefits of those stochastic processes are the modeling of interdependence and jumps, which is equally confirmed by empirical inflation data. The article defines and introduces the rules for stochastic and fractional processes and elucidates the stochastic simulation output.
Resilienz und Stabilität? Weichenstellungen im Banken- und Finanzsystem in der Corona-Pandemie
(2020)
Seit der globalen Finanzkrise 2008/2009 hat es keine vergleichbare Herausforderung wie die Corona-Krise für das Finanz- und Bankensystem mehr gegeben.
Schwache Profitabilität, ungelöste Regulierungs-herausforderungen und steigende Konkurrenz im Digitalbereich stellen die Banken vor weitere Heraus-forderungen.
Die Stabilität des Finanzsystems und der Zugang zu den Finanzmärkten war während der Pandemie nicht gefährdet. Durch gemeinsame Bemühungen und bes-sere Bankenkapitalisierung ist das Finanzsystem heute widerstandsfähiger als zu Zeiten der Finanzkrise.
Sofern die Zuschüsse und Kredite im „Next Genera-tion EU“-Fund zielgerichtet für Strukturreformen und Zukunftsinvestitionen eingesetzt werden, dürfte dies einen Vertrauens- und Wachstumsimpuls darstellen.
Weitere Verbesserungen der Finanzstabilität, wie erhöhte Eigenkapitalunterlegungen, Regulierung von Schattenbanken oder Reformen im Bereich der Finanzaufsicht, sind jedoch von Nöten.
Since the global financial crisis of 2008/2009, there has been no challenge to the financial and banking system comparable to that during the Corona crisis.
Weak profitability, unresolved regulatory challenges and increasing competition in the digital sector pose further challenges for banks.
The stability of the financial system and access to financial markets was not at risk during the pandemic. Through joint efforts and better bank capitalisation, the financial system is now more resilient than during the financial crisis.
Provided that grants and loans in the “next generation EU” fund are well targeted for structural reforms and investments in the future, this should boost confi-dence and growth.
However, further improvements in financial stability, such as increased capital requirements, regulation of shadow banks or reforms in financial supervision, are needed.
Die rasante Entwicklung der Sensortechnik im Endverbraucherbereich lässt einen klinischen Nutzen der verfügbaren dezentral erhobenen Daten aus dem Patientenalltag zur Überwachung des individuellen Gesundheitszustands vermuten. Zur Überprüfung dieser Vermutung ist die Bereitstellung einer entsprechenden Plattform in den klinischen Alltag erforderlich. Hierzu wird die bwHealthApp entwickelt, mit der sowohl die aktuelle Bandbreite als auch die Evolution der Sensortechnik auf die klinische Anwendung abbildbar ist. Mit dem flexiblen Entwurf lässt sich der klinische Nutzen für die personalisierte Medizin evaluieren. Außerdem bietet die bwHealthApp einen an Machbarkeit orientierten Diskussionsbeitrag zu offenen rechtlichen, regulatorischen und ethischen Fragestellungen der Digitalisierung in der Medizin in Deutschland.
Gibt es einen Kauf-Knopf im Gehirn des Konsumenten? Und wenn ja, wie betätigt man diesen? Die Antworten auf diese Fragen könnte das Neuromarketing liefern. Das Neuromarketing ist Bestandteil der Neuroökonomie und eine relativ junge Disziplin an der Schnittstelle von Kognitionswissenschaften, Neurowissenschaften und der Marktforschung. Durch den technologischen Fortschritt können die Neurowissenschaften wichtige Erkenntnisse für das Marketing liefern, insbesondere Einblicke zur Erklärung des Konsumentenverhaltens. Durch den Blick in das Kundengehirn können beispielsweise Handelsunternehmen ihre Kunden gezielter ansprechen und sich so einen Vorteil gegenüber Konkurrenten verschaffen.
Zielgenau aus dem Hinterhalt
(2020)
Ambush-Marketing löst meistens heftige Reaktionen aus - bei Befürwortern und Gegnern. Die Idee des Ambush-Marketings ist es, von den Erfolgen des Sponsorings zu profitieren, ohne die Pflichten eines offiziellen Sponsors einzugehen. Ambusher besitzen keine Vermarktungsrechte an einer Veranstaltung, bauen aber dennoch durch ihre Marketingmassnahmen eine Verbindung zu einem Event auf. Der Grat zwischen der Verletzung von Sponsoren-Rechten und kreativ-innovativer Kommunikationspolitik ist dabei oft sehr schmal.
Im Gegensatz etwa zur klassischen Werbung handelt es sich beim Event-Marketing um ein dynamisches Kommunikationsinstrument, das laufend Trends und Neuerungen mit sich bringt. Die vielfältigen Einsatzmöglichkeiten und Potenziale des Event-Marketing ermöglichen es, entsprechend dem momentanen Zeitgeist relevante Zielgruppen zu erreichen, markenrelevante Wirklichkeiten und Erlebniswelten zu generieren, Emotionen und Sympathiewerte zu erzeugen und auf diese Weise eine Bindung zwischen Marke bzw. Unternehmen und Rezipienten herzustellen.
The livestock sector is growing steadily and is responsible for around 18% of global greenhouse‐gas‐emissions, which is more than the global transport sec-tor (Steinfeld et al. 2006). This paper examines the potential of social marketing to reduce meat consumption. The aim is to understand consumers’ motivation in diet choices and to learn what opportunities social marketing can provide to counteract negative environmental and health trends. The authors believe that research to answer this question should start in metropolitan areas, be-cause measures should be especially effective there. Based on the Theory of Planned Behaviour (TPB, Ajzen 1991) and the Technology‐Acceptance‐Model by Huijts et al. (2012), an online‐study with participants from the metropolitan region (n = 708) was conducted in which central socio‐psychological constructs for a meat consumption reduction were examined. It was shown that attitude, personal norm and habit have a critical influence on the intention to reduce meat consumption. A segmentation of consumers based on these factors led to three consumer clusters: vegetarians/flexitarians, potential flexitarians and convinced meat eaters. Potential flexitarians are an especially relevant target group for the development of social‐marketing‐measures to reduce meat consumption. In co‐creation‐workshops with potential flexitarians from the metropolitan region, barriers and benefits of reducing meat consumption were identified. The factors of environmental protection, animal welfare and desire for variety turn out to be the most relevant motivational factors. Based on these factors, consumers proposed a variety of social marketing measures, such as applications and labels to inform about the environmental impact of meat products.
In Germany, mobility is currently in a state of flux. Since June 2019, electric kick scooters (e-scooters) have been permitted on the roads, and this market is booming. This study employs a user survey to generate new data, supplemented by expert interviews to determine whether such e-scooters are a climate-friendly means of transport. The environmental impacts are quantified using a life cycle assessment. This results in a very accurate picture of e-scooters in Germany. The global warming potential of an e-scooter calculated in this study is 165 g CO2-eq./km, mostly due to material and production (that together account for 73% of the impact). By switching to e-scooters where the battery is swapped, the global warming potential can be reduced by 12%. The lowest value of 46 g CO2-eq./km is reached if all possibilities are exploited and the life span of e-scooters is increased to 15 months. Comparing these emissions with those of the replaced modal split, e-scooters are at best 8% above the modal split value of 39 g CO2-eq./km.
Our paper investigates the response of acquiring firms’ stock returns around the announcement date in cross-border mergers and acquisitions (M&A) between listed Chinese acquirers and German targets. We apply an event study methodology to examine the shareholder value effect based on a sample of M&A deals over the most recent period of 2012-2018. We apply a market model event study based on the argumentation of Brown and Warner (1985) and use short-term observation periods according to Andrade, Mitchell, and Stafford (2001) as well as Hackbarth and Morellec (2008). The results indicate that the announcement of M&A involving German targets results in a positive cumulative abnormal return of on average 2.18% for Chinese acquirers’ shareholders in a five-day symmetric event window. Furthermore, we found slight indications of possible information leakage prior to the formal announcement. Although it shows that the size of acquiring firms is not necessarily correlated with the positive abnormal returns in the short run, this study suggests that Chinese acquirers’ shareholders gain higher abnormal returns when the German targets are non-listed companies.
Businesses need to cope with myriad challenges including increasingly competitive markets and rapid developments in digital technology. The overall aim of the research described in this paper is to generate fresh insights into the impacts of digitalisation on the design and management of global supply chains. It focuses on understanding the current adoption rate of new technologies in global supply chains, identifying perceived opportunities and challenges and clarifying the critical factors driving (and inhibiting) their deployment. The authors administered an online survey with a global sample of respondents from various supply chain functions, resulting in a sample of 142 responses. Significant differences emerged in adoption patterns between companies of different sizes. Moreover, the study pointed to a widening gap (or a ‘digital divide’) between leaders and laggards in terms of technology adoption. Perceived benefits and challenges also differ notably between companies of varying sizes. Adoption patterns are very diverse across specific technologies. The results further suggest that there is a significant correlation between adoption of digital technologies and different dimensions of company performance.