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Functionalization of PU-based materials for orthopedic applications

  • Knee osteoarthritis is a common complication and can lead to total loss of joint function in patients. Treatment by either partial or total knee replacement with appropriate UHMWPE based implantsis highly invasive, may cause complications and may show unsatisfying results. Alternatively, treatment may be done by insertion of an elastic interpositional knee spacer with optimized material characteristics. We report the development of high performance polyurethane-based polymers modified with bioactive molecules for fabrication of such knee spacers. In order to tailor mechanical and tribological properties and to improve resist to enzymatic degradation we propose a core-shell model for the spacer with specifically adapted properties.

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Metadaten
Name:Athanasopulu, Kiriaki; Kemkemer, Ralf; Lorenz, Günter; Kutuzova, Larysa
URN:urn:nbn:de:bsz:rt2-opus4-13332
DOI:https://doi.org/10.1515/bnm-2016-1001
ISSN:2193-066X
eISSN:2193-0651
Erschienen in:Bionanomaterials : journal of functional materials, biomechanics, and tissue engineering
Publisher:De Gruyter
Place of publication:Berlin
Document Type:Article
Language:English
Year of Publication:2016
Volume:17
Issue:S1
Pagenumber:1
First Page:158
Dewey Decimal Classification:610 Medizin, Gesundheit
Open Access:Ja
Licence (German):License Logo  Open Access