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Purpose
Supporting the surgeon during surgery is one of the main goals of intelligent ORs. The OR-Pad project aims to optimize the information flow within the perioperative area. A shared information space should enable appropriate preparation and provision of relevant information at any time before, during, and after surgery.
Methods
Based on previous work on an interaction concept and system architecture for the sterile OR-Pad system, we designed a user interface for mobile and intraoperative (stationary) use, focusing on the most important functionalities like clear information provision to reduce information overload. The concepts were transferred into a high-fidelity prototype for demonstration purposes. The prototype was evaluated from different perspectives, including a usability study.
Results
The prototype’s central element is a timeline displaying all available case information chronologically, like radiological images, labor findings, or notes. This information space can be adapted for individual purposes (e.g., highlighting a tumor, filtering for own material). With the mobile and intraoperative mode of the system, relevant information can be added, preselected, viewed, and extended during the perioperative process. Overall, the evaluation showed good results and confirmed the vision of the information system.
Conclusion
The high-fidelity prototype of the information system OR-Pad focuses on supporting the surgeon via a timeline making all available case information accessible before, during, and after surgery. The information space can be personalized to enable targeted support. Further development is reasonable to optimize the approach and address missing or insufficient aspects, like the holding arm and sterility concept or new desired features.
Glioblastoma WHO IV belongs to a group of brain tumors that are still incurable. A promising treatment approach applies photodynamic therapy (PDT) with hypericin as a photosensitizer. To generate a comprehensive understanding of the photosensitizer-tumor interactions, the first part of our study is focused on investigating the distribution and penetration behavior of hypericin in glioma cell spheroids by fluorescence microscopy. In the second part, fluorescence lifetime imaging microscopy (FLIM) was used to correlate fluorescence lifetime (FLT) changes of hypericin to environmental effects inside the spheroids. In this context, 3D tumor spheroids are an excellent model system since they consider 3D cell–cell interactions and the extracellular matrix is similar to tumors in vivo. Our analytical approach considers hypericin as probe molecule for FLIM and as photosensitizer for PDT at the same time, making it possible to directly draw conclusions of the state and location of the drug in a biological system. The knowledge of both state and location of hypericin makes a fundamental understanding of the impact of hypericin PDT in brain tumors possible. Following different incubation conditions, the hypericin distribution in peripheral and central cryosections of the spheroids were analyzed. Both fluorescence microscopy and FLIM revealed a hypericin gradient towards the spheroid core for short incubation periods or small concentrations. On the other hand, a homogeneous hypericin distribution is observed for long incubation times and high concentrations. Especially, the observed FLT change is crucial for the PDT efficiency, since the triplet yield, and hence the O2 activation, is directly proportional to the FLT. Based on the FLT increase inside spheroids, an incubation time 30 min is required to achieve most suitable conditions for an effective PDT.
Data analysis is becoming increasingly important to pursue organizational goals, especially in the context of Industry 4.0, where a wide variety of data is available. Here numerous challenges arise, especially when using unstructured data. However, this subject has not been focused by research so far. This research paper addresses this gap, which is interesting for science and practice as well. In a study three major challenges of using unstructured data has been identified: analytical know-how, data issues, variety. Additionally, measures how to improve the analysis of unstructured data in the industry 4.0 context are described. Therefore, the paper provides empirical insights about challenges and potential measures when analyzing unstructured data. The findings are presented in a framework, too. Hence, next steps of the research project and future research points become apparent.
Characterization of low density polyethylene greenhouse films during the composting of rose residues
(2022)
This study presents an evaluation of a potential alternative to plastic degradation in the form of organic composting. It stems from the urgent need of finding solutions to the plastic residues and focuses on the compost-based degradation of greenhouse film covers in an important rose exporter company in Ecuador. Thus, this study analyzes the physical, chemical, and biological changes of rose wastes composting, and also evaluates the stability of new and aged agricultural plastic under these conditions. Interestingly, results of compost characterization show a slow degradation rate of organic matter and total organic carbon, along with a significant increase in pH and rise of bacterial populations. However, the results demonstrate that despite these findings, composting conditions had no significant influence on plastic degradation, and while deterioration of aged plastic samples was reported in some tests, it may be the result of environmental conditions and a prolonged exposure to solar radiation. Importantly, these factors could facilitate the adhesion of microorganisms and promote plastic biodegradation. Hence, it is encouraged for future studies to analyze the ecotoxicity of plastics in the compost, as well as isolate, identify, and evaluate the possible biodegradative potential of these microorganisms as an alternative to plastic waste management.
Public transport causes in rural areas high costs per passenger and kilometer as the frequency of scheduled busses is low and therefore, many people avoid using public transport. With the trend of moving from urban regions to countryside individual traffic will further increase. To tackle issues of emissions, mobility for young and elderly people and provide economically meaningful public transport a new concept was elaborated in Germany. This consists of (partly) autonomous shuttle busses which are remote controlled. For implementation rural districts of Germany have worked together and set up a three-phase plan consisting of a project with public funding, a highly frequent used pilot region and industrial partners with the commitment and possibilities for necessary investments. The concept promises economical value with respect to installation, service and maintaining costs, it leads to lower barriers for public transport of young and elderly people and ultimately reduces emissions and congestions.
The blockchain technology represents a decentralized database that stores information securely in immutable data blocks. Regarding supply chain management, these characteristics offer potentials in increasing supply chain transparency, visibility, automation, and efficiency. In this context, first token-based mapping approaches exist to transfer certain manufacturing processes to the blockchain, such as the creation or assembly of parts as well as their transfer of ownership. However, the decentralized and immutable structure of blockchain technology also creates challenges when applying these token-based approaches to dynamic manufacturing processes. As a first step, this paper investigates existing mapping approaches and exemplifies weaknesses regarding their suitability for products with changeable configurations. Secondly, a concept is proposed to overcome these weaknesses by introducing logically coupled tokens embedded into a flexible smart contract structure. Finally, a concept for a token-based architecture is introduced to map manufacturing processes of products with changeable configurations.
Context: Nowadays the market environment is characterized by high uncertainties due to high market dynamics, confronting companies with new challenges in creating and updating product roadmaps. Most companies are still using traditional approaches which typically fail in such environments. Therefore, companies are seeking opportunities for new product roadmapping approaches.
Objective: This paper presents good practices to support companies better understand what factors are required to conduct a successful product roadmapping in a dynamic and uncertain market environment.
Method: Based on a grey literature review, essential aspects for conducting product roadmapping in a dynamic and uncertain market environment were identified. Expert workshops were then held with two researchers and three practitioners to develop best practices and the proposed approach for an outcome-driven roadmap. These results were then given to another set of practitioners and their perceptions were gathered through interviews.
Results: The study results in the development of 9 good practices that provide practitioners with insights into what aspects are crucial for product roadmapping in a dynamic and uncertain market environment. Moreover, we propose an approach to product roadmapping that includes providing a flexible structure and focusing on delivering value to the customer and the business. To ensure the latter, this approach consists of the main items outcome hypothesis, validated outcomes, and discovered outputs.
Durch die Entwicklungen der vergangenen Jahre hin zu technisch komplexeren Maschinen und Anlagen steigt die Bedeutung der Instandhaltung als wesentlichem Schlüssel zur Sicherung der Verfügbarkeit von Maschinen und Anlagen. Wesentliche Ansatzpunkte zur Verbesserung sind hier die Verfügbarkeit von Informationen, voraussagende Instandhaltungsstrategien und eine verbesserte Informationsbereitstellung. Diese können auf technischer Ebene durch spezialisierte Cyberphysische Systeme realisiert werden. In diesem Beitrag wird ein Überblick über die wesentlichen Bausteine, aus smarten Komponenten, smarten Planungssystemen und smarten Benutzerschnittstellen gegeben, die für eine erfolgreiche Umsetzung notwendig sind.
There have been substantial research efforts for algorithms to improve continuous and automated assessment of various health-related questions in recent years. This paper addresses the deployment gap between those improving algorithms and their usability in care and mobile health applications. In practice, most algorithms require significant and founded technical knowledge to be deployed at home or support healthcare professionals. Therefore, the digital participation of persons in need of health care professionals lacks a usable interface to use the current technological advances. In this paper, we propose applying algorithms taken from research as web-based microservices following the common approach of a RESTful service to bridge the gap and make algorithms accessible to caregivers and patients without technical knowledge and extended hardware capabilities. We address implementation details, interpretation and realization of guidelines, and privacy concerns using our self-implemented example. Also, we address further usability guidelines and our approach to those.
Das Buch untersucht die Umsetzung der Seidenstraßeninitiative (BRI) in Ostafrika. Die BRI gilt als das zentrale geopolitische und geoökonomische Vorhaben Chinas in der Ära von Präsident Xi Jinping. Durch die Arbeit soll ein Beitrag zur Schließung einiger Forschungslücken geleistet werden, etwa die mangelnde Tiefe von Untersuchungen einzelner BRI-Projekte und die Unterberücksichtigung von Verarbeitungsnarrativen in den teilnehmenden Ländern. Die Leitfrage ist, inwiefern die BRI ein politisches bzw. hegemoniales Projekt des von der KPCh gelenkten Staats-Zivilgesellschafts-Komplexes in Ostafrika ist. Zu deren Beantwortung werden Datenbanken internationaler Organisationen und Policy-Dokumente ausgewertet. Außerdem führt der Verfasser eine qualitative Inhaltsanalyse von Zeitungsartikeln lokaler Medienhäuser in den Ländern Äthiopien, Kenia und Tansania durch, um drei Infrastrukturprojekte zu untersuchen. Die Arbeit verdeutlicht, dass die BRI zur Steigerung der Konnektivität in Ostafrika beiträgt. Gleichzeitig führen die Verdichtung der ökonomischen Beziehungen und die Implementierung der Infrastrukturvorhaben in Ostafrika zu zahlreichen Konsequenzen und konturieren ein hegemoniales Projekt.