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Characterization of pharmaceutical tablets using UV hyperspectral imaging as a rapid in-line analysis tool

  • A laboratory prototype for hyperspectral imaging in ultra-violet (UV) region from 225 to 400 nm was developed and used to rapidly characterize active pharmaceutical ingredients (API) in tablets. The APIs are ibuprofen (IBU), acetylsalicylic acid (ASA) and paracetamol (PAR). Two sample sets were used for a comparison purpose. Sample set one comprises tablets of 100% API and sample set two consists of commercially available painkiller tablets. Reference measurements were performed on the pure APIs in liquid solutions (transmission) and in solid phase (reflection) using a commercial UV spectrometer. The spectroscopic part of the prototype is based on a pushbroom imager that contains a spectrograph and charge-coupled device (CCD) camera. The tablets were scanned on a conveyor belt that is positioned inside a tunnel made of polytetrafluoroethylene (PTFE) in order to increase the homogeneity of illumination at the sample position. Principal component analysis (PCA) was used to differentiate the hyperspectral data of the drug samples. The first two PCs are sufficient to completely separate all samples. The rugged design of the prototype opens new possibilities for further development of this technique towards real large-scale application.

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Author of HS ReutlingenBrecht, Marc; Al Ktash, Mohammad; Stefanakis, Mona; Boldrini, Barbara; Ostertag, Edwin
Erschienen in:Sensors
Place of publication:Basel
Editor:Manuel GrañaORCiD
Document Type:Journal article
Publication year:2021
Tag:UV spectroscopy; active pharmaceutical ingredient API; hyperspectral imaging; principle component analysis; process analytical technology PAT; pushbroom
Page Number:13
Article Number:4436
DDC classes:620 Ingenieurwissenschaften und Maschinenbau
Open access?:Ja
Licence (German):License Logo  Creative Commons - CC BY - Namensnennung 4.0 International