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Product-Service Systems (PSS) in the fashion industry : an analysis of intra-organizational factors
(2018)
The fashion industry is a vast industry that has grown tremendously over the last decades. This growth causes significant environmental impact since the production of clothes involves high input of energy, water, chemicals and generates great volumes of waste. Even though fashion firms have started to address this challenge by adopting environmental standards, it has turned out that the sole use of eco-friendly material and new manufacturing techniques is insufficient. Instead, sustainable business models are increasingly gaining attention to solve the environmental problems. Offers to rent, swap, repair or redesign clothes are among the most prominent and promising examples. For analytical purposes, these concepts can be assigned to the growing research stream of Product-Service Systems (PSS) that shift the focus from the pure sale of a product toward complementary or substitutional service offers. This decouples customer satisfaction from material consumption, prolongs the garments' lifetime and thus diminishes both material input and appertaining waste. Besides environmental sustainability, PSS imply potential economic benefits for organizations. Particularly in highly competitive industries like the fashion industry, PSS allow firms to differentiate, better compete with cost pressure and mitigate the risk of being imitated by rivels since service is more difficult to replicate. However, fashion PSS are still mainly operated in a niche market by small firms and have yet to be anchored in the mainstream fashion industry.
The Tenth International Conference on Advances in Databases, Knowledge, and Data Applications (DBKDA 2018), held between May 20 - 24, 2018 - Nice, France, continued a series of international events covering a large spectrum of topics related to advances in fundamentals on databases, evolution of relation between databases and other domains, data base technologies and content processing, as well as specifics in applications domains databases.
Advances in different technologies and domains related to databases triggered substantial improvements for content processing, information indexing, and data, process and knowledge mining. The push came from Web services, artificial intelligence, and agent technologies, as well as from the generalization of the XML adoption.
High-speed communications and computations, large storage capacities, and loadbalancing for distributed databases access allow new approaches for content processing with incomplete patterns, advanced ranking algorithms and advanced indexing methods.
Evolution on e-business, ehealth and telemedicine, bioinformatics, finance and marketing, geographical positioning systems put pressure on database communities to push the ‘de facto’ methods to support new requirements in terms of scalability, privacy, performance, indexing, and heterogeneity of both content and technology.
Im Rahmen dieser Arbeit wurde eine Software-Architektur entwickelt, mit der sich Interaktionen zwischen autonomen Fahrzeugen und Passanten im Straßenverkehr in einer simulierten Umgebung untersuchen lassen. Hierbei wird das autonome Fahrzeug durch einen externen Fahrsimulator gesteuert. Der Einsatz eines Motion-Capture-Systems ermöglicht dabei die Aufzeichnung und Übertragungen der Bewegungsdaten von Passant und Fahrer in die virtuelle Umgebung. Durch den Einsatz von head-mounted Displays sollen Akteure die virtuelle Umgebung möglichst als real empfinden. Auf Basis der entwickelten Software-Architektur wurde eine Simulationsumgebung realisiert, in der Interaktionen zwischen einem Passant und einem autonomem Fahrzeug untersucht werden können. Das Projekt soll das Potential von Motion-Capture gestützten Simulationsumgebungen für die Konzeption und Entwicklung von autonomen Fahrsystemen aufzeigen.
Über die letzten Jahre nehmen die Verkehrsunfälle zwischen Fahrzeugen und Fahrrädern und Motorrädern immer weiter zu. Die Ursache ist meistens eine unachtsam geöffnete Fahrzeugtür, mit der ein anfahrender Zweiradfahrer kollidiert. Diese Unfälle können verheerende Folgen für alle Beteiligten haben. Aus diesem Grund soll der technologische Fortschritt, welcher sich durch die gesamte Automobilbranche zieht, um eine zusätzliche Komponente erweitert werden. Hierbei handelt es sich um ein System für Zweiradfahrer, welches eine sich öffnende Fahrzeugtür frühzeitig erkennen soll, den Fahrer somit frühzeitig warnen kann und gegebenenfalls Strategien zu Unfallvermeidung einleiten kann. Dieses Konzept soll die Entwicklung des Systems vorgeben und grundlegend erläutern.
Die Navigation mit dem E-Bike soll eine positive Nutzerfahrung sein. Deshalb wurde im Zuge dieser Arbeit im Rahmen von Bosch E-Bike Systems ein multimodales smart User Interface (MSUI) entwickelt. Das Konzept umfasst visuelle Turn-by-Turn Signale, taktile Vibrationssignale im Lenker und eine auditive Sprachausgabe. Ziel der Arbeit ist ein Prototyp, der sich für die Evaluation von Nutzerbedürfnissen in Bezug auf verschiedene multimodale Rückmeldemöglichkeiten eignet.
Die Simulation menschlichen Gruppenverhaltens kann bei der Kapazitäten-, Risiko- und Evakuierungs Planung von Gebäuden hilfreich sein, bei der Produktion von Filmen für eindrucksvolle Massen-Szenen eingesetzt werden oder virtuelle Schauplätze in Echtzeit-Anwendungen beleben. Die Herausforderungen liegen vor allem in einem realistischen Erscheinungsbild der virtuellen Crowd, glaubwürdigem Verhalten innerhalb eines sozialen Verbundes, realitätsnahen Animationen und der Wahrung der Echtzeitfähigkeit interaktiver Anwendungen. Im Rahmen dieser Arbeit wird der aktuelle Stand der Technik vorgestellt, Technologien evaluiert und ein Crowd Simulation Prototyp mit der Unity Engine implementiert.
Die Bedeutung und Stellung der Informationstechnologie erlebte in den letzten 60 Jahren einen fortlaufenden Wandel. Der anfänglich rein unterstützende Charakter entwickelte sich immer mehr zu einem wichtigen Bestandteil der Aufbau- und Ablauforganisation im Unternehmen. Ein definiertes IT-Servicemanagement im Unternehmen sieht sich mittlerweile gleichgeordnet mit den restlichen Fachabteilungen, tritt mit seinen Leistungen als Dienstleister auf und betrachtet die Fachabteilungen als „Kunde“. Neue Technologien und Innovationen und die daraus resultierenden Neudefinitionen bestehender Anforderungen sollen im Rahmen der Digitalisierung in Unternehmen positive Effekte zeigen. IT Infrastructure Library (ITIL) wird als Framework für IT-Servicemanagement in der Industrie und im öffentlichen Dienst genutzt. Der Ansatz von ITIL unterstützte den Kulturwandel und sensibilisierte das Management und die Mitarbeiter darin, serviceorientiert zu denken. Da dieser Ansatz einen vordefinierten, zyklischen Ablauf hat, könnten schnell eintreffende Kundenanforderungen nicht fristgerecht umgesetzt werden, weshalb agile Methoden wie der DevOps-Ansatz in den Vordergrund rücken. Die Herausforderung besteht darin, den Kulturwandel bei der Einführung von DevOps in bestehenden ITIL-Strukturen in Unternehmen zu fördern.
Eines der gängigsten bildgebenden Verfahren in der Medizin ist die Sonografie. Jedoch ist die Reproduzierbarkeit der Ultraschalldiagnostik bis heute noch immer ein Problem, wodurch Fehldiagnosen gestellt werden. Durch das in diesem Papier vorgestellte prototypische System zur Unterstützung für Medizinstudenten in Ultraschallseminaren sollen Anforderungen zur Reproduzierbarkeit einer Ultraschalluntersuchung definiert werden. Durch Experteninterviews wurden Einblicke in die klinischen Abläufe und den Krankenhaus-Alltag gewonnen, welche Inhalte relevant sind, um die Reproduzierbarkeit von Ultraschalluntersuchungen zu ermöglichen.
Durch das stetige Wachstum an neuen Technologien und Möglichkeiten steht der Verschmelzung von Technologien mit dem Menschen kaum noch etwas im Wege. Die Untersuchung der Implantate und die damit verbundenen Risiken sind ein Teil dieser Arbeit. Von Bedeutung sind hier die Funktionsweise und die IT-Sicherheitsaspekte. Alle in dieser Arbeit dargestellten Implantate benötigen eine Kommunikation nach außen. Diese Kommunikationsmöglichkeit birgt Risiken, die nicht nur auf die Daten der Träger beschränkt sind, sondern auch gesundheitliche Risiken beinhalten.
Segmentierung von Polypen in Koloskopie-Bilddaten : eine Potentialanalyse von Deep-Learning-Methoden
(2018)
Kolorektale Karzinome haben eine hohe Sterblichkeitsrate, wenn sie spät entdeckt werden. Eine frühzeitige Entfernung von bösartigen Polypen im Magen-Darm-Trakt, die deren Vorstufen bilden, bietet jedoch hohe Überlebenschancen. Bei Darmspiegelungen werden gerade kleine Polypen aber recht häufig übersehen. Zuverlässige bildverarbeitende Systeme, die Polypen in einem Koloskopie-Frame nicht nur detektieren, sondern pixelgenau segmentieren, könnten Ärzten bei Darmkrebs-Screenings helfen. Diese Arbeit analysiert den aktuellen Stand der Segmentierung von Polypen im Gastrointestinaltrakt. Weiterführend wird untersucht, inwiefern die in letzter Zeit sehr erfolgreichen Methoden des Deep Learning hier Vorteile bieten.
After more than three decades of electronic design automation, most layouts for analog integrated circuits are still handcrafted in a laborious manual fashion today. Obverse to the highly automated synthesis tools in the digital domain (coping with the quantitative difficulty of packing more and more components onto a single chip – a desire well known as More Moore), analog layout automation struggles with the many diverse and heavily correlated functional requirements that turn the analog design problem into a More than Moore challenge. Facing this qualitative complexity, seasoned layout engineers rely on their comprehensive expert knowledge to consider all design constraints that uncompromisingly need to be satisfied. This usually involves both formally specified and nonformally communicated pieces of expert knowledge, which entails an explicit and implicit consideration of design constraints, respectively.
Existing automation approaches can be basically divided into optimization algorithms (where constraint consideration occurs explicitly) and procedural generators (where constraints can only be taken into account implicitly). As investigated in this thesis, these two automation strategies follow two fundamentally different paradigms denoted as top-down automation and bottom-up automation. The major trait of top-down automation is that it requires a thorough formalization of the problem to enable a self-intelligent solution finding, whereas a bottom-up automatism –controlled by parameters– merely reproduces solutions that have been preconceived by a layout expert in advance. Since the strengths of one paradigm may compensate the weaknesses of the other, it is assumed that a combination of both paradigms –called bottom-up meets top-down– has much more potential to tackle the analog design problem in its entirety than either optimization-based or generator-based approaches alone.
Against this background, the thesis at hand presents Self-organized Wiring and Arrangement of Responsive Modules (SWARM), an interdisciplinary methodology addressing the design problem with a decentralized multi-agent system. Its basic principle, similar to the roundup of a sheep herd, is to let responsive mobile layout modules (implemented as context-aware procedural generators) interact with each other inside a user-defined layout zone. Each module is allowed to autonomously move, rotate and deform itself, while a supervising control organ successively tightens the layout zone to steer the interaction towards increasingly compact (and constraint compliant) layout arrangements. Considering various principles of self-organization and incorporating ideas from existing decentralized systems, SWARM is able to evoke the phenomenon of emergence: although each module only has a limited viewpoint and selfishly pursues its personal objectives, remarkable overall solutions can emerge on the global scale.
Several examples exhibit this emergent behavior in SWARM, and it is particularly interesting that even optimal solutions can arise from the module interaction. Further examples demonstrate SWARM’s suitability for floorplanning purposes and its application to practical place-and-route problems. The latter illustrates how the interacting modules take care of their respective design requirements implicitly (i.e., bottom-up) while simultaneously paying respect to high level constraints (such as the layout outline imposed top-down by the supervising control organ). Experimental results show that SWARM can outperform optimization algorithms and procedural generators both in terms of layout quality and design productivity. From an academic point of view, SWARM’s grand achievement is to tap fertile virgin soil for future works on novel bottom-up meets top-down automatisms. These may one day be the key to close the automation gap in analog layout design.
Im Projekt "Heat4SmartGrid" soll untersucht werden, ob und wie mit Hilfe von Wärmepumpen der Anteil erneuerbarer Energien an der Wärmeversorgung in Baden-Württemberg (BW) gesteigert werden und gleichzeitig das Verteilnetz durch eine intelligente Steuerung der Wärmepumpensysteme entlastet werden kann. Hierzu ist im AP 1 für das Jahr 2050 ein Wärmebedarf in BW von 35 TWh errechnet worden, bei 40 TWh im Jahr 2030. Im Vergleich zum Jahr 2015 ergibt sich so ein Rückgang um 30 % zum Jahr 2030 und bis zum Jahr 2050 um 40 %. Weiterhin steigt auf Grund von energetischer Sanierung im Gebäudebestand das technische Potenzial für Wärmepumpen, ausgehend von 8 TWh im Jahr 2015, auf 20 TWh bis 2030 und auf 23 TWh bis 2040. Insgesamt könnten so 63 % aller Wohnanteile in BW durch Wärmepumpen mit thermischer Energie versorgt werden. Der Einsatz von Wärmepumpensystemen ist somit ein wichtiger Baustein für das Gelingen der Wärmewende. Zur Steuerung der Wärmepumpen sind in AP 2 Betriebsmodi in Abhängigkeit von Anwendung und Gebäudetyp entwickelt worden. Diese werden mittels Korrelationsfunktionen für die Heizleistung für Luft-Wasser- und Sole-Wasser-Wärmepumpen bestimmt. Hierauf aufbauend sind für die in AP 1 ermittelten Gebäudetypen die erreichbare Jahresarbeitszahl der beiden Wärmepumpentechnologien ermittelt worden. Zur intelligenten system- und netzdienlichen Steuerung dieser Wärmepumpensysteme werden Prognosen über die lokale Erzeugung und den lokalen Verbrauch benötigt, die in AP 5 erarbeitet werden. In Abhängigkeit der Prognose-anwendung sind sowohl univariate (elektrische Last und thermische Brauchwarmwasserlast) als auch multivariate Prognosemodelle (PV-Erzeugung und thermische Heizwarmwasserlast) implementiert worden.
In dem vorliegenden Zwischenbericht sind die Arbeiten und Ergebnisse zusammengefasst, die im Rahmen des Projektes GalvanoFlex_BW während der ersten acht Projektmonate der insgesamt 2 1/2 jährigen Laufzeit durchgeführt und erzielt wurden. Ziel des Projektes ist die Untersuchung und Verbesserung der Energieeffizienz in Industrieunternehmen mit dem speziellen Fokus auf der Einführung stromoptimiert betriebener KWK-Anlagen. Entsprechend des Arbeits- und Zeitplans sind die Literaturrecherche, die Festlegung von Prozesstypen, die Datenerfassung, die Strategieentwickung zur stromoptimierten KWK, die Optimierung der Schnittstelle zwischen KWK und Gleichrichtern, der Aufbau der Branchenplattform und die sozial-wissenschaftliche Begleitforschung beschrieben. Der aktuelle Projektstand deckt sich dabei im Wesentlichen mit den Vorgaben aus dem vorgelegten Zeitplan.
Informatics Inside : Connect(IT) : Informatik-Konferenz an der Hochschule Reutlingen, 9. Mai 2018
(2018)
Mit der Informatics Inside 2018 findet diese Veranstaltungsform bereits zum 10. Mal statt und wir freuen uns besonders auf dieses Jubiläum. Die diesjährige Konferenz steht unter dem Motto "connect(IT)" und zeigt damit einmal mehr die zentrale Bedeutung der Informatik im Zusammenhang mit Vernetzungen und dies auf allen Ebenen. Es geht nicht nur um die technische Vernetzung von Maschinen und Services, sondern auch um die Vernetzung von Menschen untereinander und die Zusammenarbeit zwischen Mensch und Maschine. Gerade die letzten beiden Punkte spiegeln einen der Schwerpunkte des Masterstudiengangs Human-Centered Computing sehr schön wieder. Sie finden in dem vorliegenden Tagungsband Fachbeiträge aus dem medizinischen Umfeld ebenso wie vielfältige Anwendungen aus dem Fahrzeugsektor. Selbstverständlich spielt das Thema Sicherheit in vernetzten Umgebungen eine wichtige Rolle und auch dazu finden Sie einen spannenden Beitrag. Der Kulturwandel im Bereich der Softwareentwicklung ist ebenso ein Thema wie Simulationen in verschiedenen Zusammenhängen.
Die Informatics Inside ist eine wissenschaftliche Konferenz des Masterstudiengangs Human-Centered Computing und wird von den Studierenden organisiert und durchgeführt. Sie erhalten während ihres Masterstudiums die Gelegenheit, sich in einem Fachgebiet ihrer Wahl zu vertiefen. Dies kann an der Hochschule, in einem Unternehmen, einem Forschungsinstitut oder im Ausland durchgeführt werden. Gerade diese flexible Ausgestaltung der Lehrveranstaltung "Wissenschaftliche Vertiefung" führt zu vielfältigen Themenfeldern, die von den Studierenden bearbeitet werden. Neben der eigentlichen fachlichen Vertiefung spielt auch die Präsentation von wissenschaftlichen Ergebnissen eine wichtige Rolle und dies nicht nur während des Studiums. Ein gewähltes Fachgebiet so allgemeinverständlich aufzubereiten und zu vermitteln, dass es auch für Nicht-Spezialisten verständlich wird, stellt immer wieder eine besondere Herausforderung dar.
Die Erfindung betrifft eine Vorrichtung und Verfahren zur Analyse eines Materialstroms (S) mit einem Einlassbereich (E), einem Messbereich (M) und einen Auslassbereich (A) sowie mit einer ersten Weiche (W1) und einer zweiten Weiche (W2) und einem Umlenkbereich (U), wobei die beiden Weichen (W1, W2) in einem ersten Schaltzustand (Z1) einen durchgängigen ersten Materialdurchströmungsraum vom Einlassbereich (E) über die erste Weiche (W1) durch den Messbereich (M) über die zweite Weiche (W2) bis zum Auslassbereich (A) ausbilden und in einem zweiten Schaltzustand einen durchgängigen zweiten Materialdurchströmungsraum vom Einlassbereich (E) über die erste Weiche (W1) durch den Umlenkbereich (U) über die zweite Weiche (W2) bis zum Auslassbereich (A) ausbilden.
Der Beitrag gibt einen Überblick über die Zusammenhänge zwischen Industrie 4.0 und Recht. Ausgangspunkt sind die vertragsrechtlichen Grundlagen mit den Fragen, ob und wie zwischen Maschinen überhaupt Verträge zustande kommen können, wie Industrie 4.0-Verträge vertragstypologisch einzuordnen sind und welche Grenzen bei der Verwendung Allgemeiner Geschäftsbedingungen bestehen können. Anschließend werden die Themen dargestellt, die derzeit die Diskussion um das Haftungsrecht der Industrie 4.0 beherrschen. Im Rahmen des Datenrechts wird geklärt, wem Daten zustehen und wie der Datenschutz geregelt ist. Zudem wird aufgezeigt, welche rechtlichen Vorgaben zur Gewährleistung von IT-Sicherheit im Unternehmen bestehen. Schließlich werden auch arbeitsrechtliche Herausforderungen von Industrie 4.0 angesprochen, wie die zunehmende "Entbetrieblichung", das Aufkommen neuer Beschäftigungsformen, die Forderung nach mehr Flexibilisierung der Arbeitswelt sowie Fragen des Mitbestimmungsrechts.
Die Welt dreht sich immer schneller. Etablierte Firmen, die sinnbildlich für innovative Produkte stehen, werden in kurzer Zeit vom Markt gedrängt und durch disruptive Ansätze aus ihrem Geschäft verdrängt. Inkrementelle Ansätze zur Verbesserung der Produktqualität, zur Reduktion von Herstellkosten und der Fokus auf die Produktionsoptimierung nach dem Individualisierungsprinzip (Losgröße 1) sind keine auf die Zukunft ausgerichtete Zielzustände für Automobilhersteller mehr. Neue Wettbewerber, seien es Softwaregiganten oder agile Startups, treten in den Markt ein. Die traditionelle Massenproduktion des Automotivbereichs kann den sich stetig verändernden Kundenanforderungen nicht mehr länger gerecht werden. Dazu bedarf es Geschäftsmodell-Innovationen, wie beispielsweise digitale Preismodelle oder On-Demand Funktionalitäten.
Die Überlebensfähigkeit von Unternehmen am Markt wird vorrangig durch den Input ihrer Lieferanten getrieben, da dem Einkauf bis zu 50% des prognostizierten Innovationspotenzials zugesprochen wird. Dabei gilt vor allem die digitale Transformation als wesentliche Voraussetzung, um die eigene Wettbewerbsfähigkeit langfristig zu sichern. Der vorliegende Beitrag setzt sich daher mit dem Digitalisierungspotenzial strategischer Lieferantenbeziehungen auseinander. Aufbauend auf einem konzeptionellen Modell des Einkaufs 4.0 werden dessen Erfolgstreiber analysiert. Neben der Optimierung von Einkaufsprozessen durch eProcurementlösungen sollte der Fokus auf der Beziehungspflege zu Lieferanten liegen, um das Potenzial von Einkauf 4.0 vollständig ausschöpfen zu können. Denn nur durch den Aufbau strategischer Wertschöpfungspartnerschaften lässt sich das Erfolgspotenzial des Einkaufs langfristig heben.
Gesellschaftliche und industrielle Trends im Zuge der Digitaliserung induzieren Veränderungsprozesse in der Industrie. Eine hohe Flexibilität und schnelle Entscheidungsfindungsprozesse stellen entscheidende Wettbewerbsvorteile für Unternehmen dar, um zukünftig erfolgreich am Markt agieren zu können. Um dies zu ermöglichen, müssen aggregierte Echtzeitdaten und Prognosen unmittelbar sowohl am Ort der Wertschöpfung als auch dezentral zur Verfügung stehen. Die Entscheidungsunterstützung mit Hilfe geeigneter Visualisierungen ist ein maßgeblicher Bestandteil von Shopfloor Management Systemen. Aufgrund der steigenden Anforderungen wurde das konventionelle und analoge Shopfloor Management in den letzten Jahren verstärkt durch digitale Lösungen ersetzt. Ein ganzheitlicher Shopfloor Management Ansatz, der die Trends und die daraus resultierenden Herausforderungen für die Industrie abdeckt, ist aktuell nicht vorhanden. Zukünftige Shopfloor Management Lösungen sollen diese Lücke schließen. Hierfür wurde ein ganzheitliches System entwickelt, welches Produktionsinformationen in Echtzeit unmittelbar am Shopfloor visualisiert, eine integrierte flexible Planung und Steuerung der Produktion beinhaltet sowie die Mitarbeiterbedürfnisse berücksichtigt. Eine flexible und individuelle Schichtplanung durch die Mitarbeiter und eine umfassende automatische Beanspruchungsbeurteilung sind dazu integriert worden. Zudem ermöglicht das System die Prognose und Visualisierung von Produktionsinformationen und unterstützt die Anwender bei der Durchführung strukturierter Shopfloor-Meetings. Dadurch werden Entscheidungen direkt auf den Ort der Wertschöpfung verlagert.
Es wird erwartet, dass die neuen Technologien rund um die Digitalisierung von Gesellschaft und Geschäftswelt zu revolutionären Veränderungen führen werden. Im Zusammenhang mit produzierenden Unternehmen ist hier von einer möglichen vierten Revolution unter dem Stichwort "Industrie 4.0" die Rede. Eine Frage, die damit aber unmittelbar einhergeht, ist, ob sich infolge dieser Revolution auch Organisations- und Produktionsstrukturen von Unternehmen nicht ebenfalls revolutionär ändern müssen.
Dieser Beitrag geht dieser Frage nach, indem er den momentanen Stand der wissenschaftlichen Diskussion zusammenfasst und anschließend bewertet.
An die Produktionslogistik werden komplexe
Anforderungen gestellt, so dass eine systematische Vorgehensweise zu deren Planung erforderlich ist. Aufgrund der Abhängigkeiten in der Supply Chain muss die Produtkionslogistik immer vom Lieferanten beginnend geplant werden. Trotz der Vielfalt an Planungssystematiken bieten diese alle nur sehr wenig Unterstützung bei der Gestaltung der einzelnen Planungsobjekte in der Logistikkette an, sodass die Planung und Lösungsfindung häufig intuitiv erfolgt und sehr stark vom individuellen Erfahrungswissen des Logistikplaners abhängt. Im Folgenden wird eine Planungssystematik, die auf Morphologien basiert, vorgestellt, die eine durchgängige Planung von Produktionslogistiksystemen ermöglicht und den Planer umgfangreich mit Informationen zu Gestaltungsmöglichkeiten und praktischen Umsetzungen unterstützt.
Die Digitalisierung vrändert die Arbeitsweisen in Unternehmen und damit auch bei der Planung von Fabriken. Am Markt verfügbar sind vielfältige Soft- und Hardwaresysteme für die Digitale Fabrik, die die Fabrikplanung unterstützen und teilweise revolutionieren können. Um dieses Potential zu nutzen, muss aber bekannt sein, was diese Systeme können und wie sie sinnvoll genutzt werden können. Bisherige Fabrikplanungssystematiken haben hierzu keine Unterstützung angeboten, da sie nur das generelle Vorgehen der Fabrikplanung beschreiben, ohne den Zusammenhang zu den sich rasch entwickelnden Soft- und Hardwaresystemen herzustellen. Im Folgenden wird die Entwicklung und Umsetzung eines Planungsvorgehens für die Digitale Fabrikplanung dargestellt, das die Potentiale der Soft- und Hardwaresysteme für die Digitale Fabrik aufgreift und in ein passendes Planungsvorgehensmodell integriert.
The level of automation in intralogistics has steadily increased over recent years. For small and medium-sized enterprises (SMEs), however, the associated digital change is a major challenge. Since most SMEs are facing increasing sales volumes (e.g. due to e-commerce and good overall economy) in combination with decreasing lot sizes due to the market demand for individualized products, SMEs have to find innovative solutions to cope with these challenges in production as well as in logistics. Innovative technologies, like 3D printing technologies for the production for small lot sizes and future-oriented intralogistics technologies can serve as enablers in logistics to realize flexible logistic processes for increasing market requiremments. Considering that, this paper examines innovative and future-oriented technologies for intralogistics such as smart containers, driverless forklift systems, data glasses, smart shelves and smart pallets regarding their potential for SMEs. This explorative research paper shows that digital technologies are already suitable and available for SMEs.However, challenges are still seen in areas like the identification and digitalization potential and the financing of these new projects. The primary reason escpecially for SMEs for this is that they have to make investments based on an economically feasible payback period and less based on prestigious reasons like digitalization flagship projecs done by large corporations. In addition, the identification of feasible starting points for digitalization within intralogistic systems embedded in specific factory processes is a major challenge not only for SMEs.
The success of an autonomous robotic system is influenced by several not easily identifiable interdependent factors. This paper is set to lay the foundation of an integrated approach in order to examine all the parameters and understand their contribution to success. After introducing the problem, two autonomous systems for the process of unloading of containers are presented. Then a recently developed method for modelling and interpreting all the parameters, the STIC analysis, are introduced. The preliminary results of applying such a methodology to a first study case is shortly presented. Future research is in the end recommended in order to prove that this methodology is the only way to overcome barriers to the investment in autonomous systems in the logistics sector.
The increased availability of data gives rise to the use of machine learning methods for purposes like forecasting or quality control in operations management. Practitioners who want to employ these methods are faced with the task of choosing from a large number of available methods. We give an overview of classification methods and available implementations and present considerations for choosing appropriate methods.
What does the factory of tomorrow have to offer for companies? This question and its aspects are the focus of many actual articles and publications. According to Gartner digital twins, one of 2017 strategic technology trends will play a big role for the future of manufacturing. At the moment digital twins are gaining more importance for the industrial application. If companies want to be competitive in the future they have to implement the digital twin in the factories of today. Therefore this paper provides a basic overview of the concept of the smart factory and its requirements. In addition, digital twins are identified as a necessary concept for the evolution of the factory of today.
While academia and industry see large potential for human-robot collaboration (HRC), only a small number of realized HRC application is currently found in industry. To gather more data about current hindrances to wider implementation of collaborative robots, a study among 15 robot manufactureres and 14 system integrators of collaborative robot technology has been conducted through a predesigned questionnaire procedure. Additionally, five industrial users of human-robot collaboration have been interviewed on the main challenges they experienced during the initial implementation process. The quantitative data has been analyzed using the Wilcoxon-Signed-Rank-Test. Accoring to the study participants, the main challenges within the implementation currently are the identification of HRC-suitable processes, the application of relevant safety norms (such as ISO 10218, ISO/TS 15066) and the application-individual risk assessment.
Mature economies which are driven mainly by small and medium sized enterprises (SMEs) are increasingly becoming dependent on material imports. Global material consumption is ever increasing, mainly driven by population increases. Decoupling of material consumption from economic growth is one of the greatest challenges of the 21st century. Within this paper available methods for the assessment of material efficiency on different economic scales are investigated and those detected that are particulary suitable for the use in SMEs. Recommendations for further improvements of the selected tools and an outlook concerning planned research activities in the field of material efficiency in enterprises, supply chains and circular economy aspects are given.
Die Erfindung betrifft eine Vorrichtung und Verfahren zur Analyse eines Materialstroms S mit einem Einlassbereich E, einem Messbereich M und einen Auslassbereich A sowie mit einer ersten Weiche W1 und einer zweiten Weiche W2 und einem Umlenkbereich U, wobei die beiden Weichen W1, W2 in einem ersten Schaltzustand Z1 einen durchgängigen ersten Materialdurchströmungsraum vom Einlassbereich E über die erste Weiche W1 durch den Messbereich M über die zweite Weiche W2 bis zum Auslassbereich A ausbilden und in einem zweiten Schaltzustand einen durchgängigen zweiten Materialdurchströmungsraum vom Einlassbereich E über die erste Weiche W1 durch den Umkenkbereich U über die zweite Weiche W2 bis zum Auslassbereich A ausbilden.
An apparatus and method for analyzing a flow of material having an inlet region, a measurement range and an outlet region, and having a first diverter and a second diverter, and a deflection area, wherein in a first state of operation, the two diverters form a continuous first material flow space from the inlet region via the first diverter through the measurement range, via the second diverter to the outlet region, and in a second state of operation, form a continuous second material flow space from the inlet region via the first diverter through the deflection area, via the second diverter to the outlet region.
In the last 20 years there have been major advances in autonomous robotics. In IoT (Industry 4.0), mobile robots require more intuitive interaction possibilities with humans in order to expand its field of applications. This paper describes a user-friendly setup, which enables a person to lead the robot in an unknown environment. The environment has to be perceived by means of sensory input. For realizing a cost and resource efficient Follow Me application we use a single monocular camera as low-cost sensor. For efficient scaling of our Simultaneous Localization and Mapping (SLAM) algorithm, we integrate an inertial measurement unit (IMU) sensor. With the camera input we detect and track a person. We propose combining state of the art deep learning with Convolutional Neural Network (CNN) and SLAM algorithms functionality on the same input camera image. Based on the output robot navigation is possible. This work presents the specification, workflow for an efficient development of the Follow Me application. Our application’s delivered point clouds are also used for surface construction. For demonstration, we use our platform SCITOS G5 equipped with the afore mentioned sensors. Preliminary tests show the system works robustly in the wild.
SLAM systems are mainly applied for robot navigation while research on feasibility for motion planning with SLAM for tasks like bin-picking, is scarce. Accurate 3D reconstruction of objects and environments is important for planning motion and computing optimal gripper pose to grasp objects. In this work, we propose the methods to analyze the accuracy of a 3D environment reconstructed using a LSD-SLAM system with a monocular camera mounted onto the gripper of a collaborative robot. We discuss and propose a solution to the pose space conversion problem. Finally, we present several criteria to analyze the 3D reconstruction accuracy. These could be used as guidelines to improve the accuracy of 3D reconstructions with monocular LSD-SLAM and other SLAM based solutions.
We present a new method for detecting gait disorders according to their stadium using cluster methods for sensor data. 21 healthy and 18 Parkinson subjects performed the time up and go test. The time series were segmented into separate steps. For the analysis the horizontal acceleration measured by a mobile sensor system was considered. We used dynamic time warping and hierarchical custering to distinguish the stadiums. A specificity of 92% was achieved.
Auf jeder Stufe der Lebensmittelkette muss von der Herstellung bis zum Inverkehrbringen eine Rückverfolgung der Produkte möglich sein. Erzeuger, Verarbeiter, Transportunternehmen und Händler stehen vor der Herausforderung, Systeme zur Rückverfolgbarkeit effizient in ihre Unternehmensprozesse zu integrieren und gegenseitig zu vernetzen. Für die betriebliche Umsetzung werden die rechtlichen Anforderungen skizziert und die Grundlagen eines Rückverfolgbarkeitssystems vorgestellt.
Research and Development (R&D) is crucial for the growth and future success of research-based pharma companies. To maintain their R&D organisations efficient, pharmaceutical companies started to hedge the potential of open innovation to cut R&D costs and to access external knowledge. These new strategies could be divided into several categories: open source, innovation centres, crowd sourcing and virtual R&D.
Fitting 3D Morphable Face Models (3DMM) to a 2D face image allows the separation of face shape from skin texture, as well as correction for face expression. However, the recovered 3D face representation is not readily amenable to processing by convolutional neural networks (CNN). We propose a conformal mapping from a 3D mesh to a 2D image, which makes these machine learning tools accessible by 3D face data. Experiments with a CNN based face recognition system designed using the proposed representation have been carried out to validate the advocated approach. The results obtained on standard benchmarking data sets show its promise.
In this exploratory research eight suppliers in the automotive industry are interviewed to measure the application of supply chain finance instruments in their supply chain in the Netherlands and the region of South-West Germany. Current adoption levels and reasons for non adoption are discussed. Based on these indicative results, a set of hypotheses is suggested for further research. The theoretical base of this study is a conceptual model of Supply Chain Finance based on literature research and empirical research in the Netherlands.
Early reduction of risks in a startup or an innovation project is highly important. Appropriate means for risk reduction, such as testing business models with different kinds of experiments exist. However, deciding what to test and how to select the right test, is challenging for many startups and innovation projects. This article presents the so-called Business Experiments Navigator (BEN), a toolkit to assist startup and innovation processes. It compliments other tools such as the Business Model Canvas or the Lean Startup process. The main contribution of BEN is to bridge the gap between the riskiest assumptions of a business model and the multitude of available testing techniques by providing assumption templates. The Business Experiments Navigator has been validated in several workshops. Results show that it creates awareness among the workshop participants that a business model is based on assumptions which impose risks and need to be validated. Further, users of BEN were able to identify relevant assumptions and map different kinds of assumptions to appropriate testing techniques. The process applied in the workshops, as well as the assumption templates, helped the participants understand the main concepts and transfer their learnings, to their own business ideas.
The coculture of osteogenic and angiogenic cells and the resulting paracrine signaling via soluble factors are supposed to be crucial for successfully engineering vascularized bone tissue equivalents. In this study, a coculture system combining primary human adiposederived stem cells (hASCs) and primary human dermal microvascular endothelial cells (HDMECs) within two types of hydrogels based on methacryloyl‐modified gelatin (GM) as three‐dimensional scaffolds was examined for its support of tissue specific cell functions. HDMECs, together with hASCs as supporting cells, were encapsulated in soft GM gels and were indirectly cocultured with hASCs encapsulated in stiffer GM hydrogels additionally containing methacrylate‐modified hyaluronic acid and hydroxyapatite particles. After 14 days, the hASC in the stiffer gels (constituting the “bone gels”) expressed matrix proteins like collagen type I and fibronectin, as well as bone‐specific proteins osteopontin and alkaline phosphatase. After 14 days of coculture with HDMEC‐laden hydrogels, the viscoelastic properties of the bone gels were significantly higher compared with the gels in monoculture. Within the soft vascularization gels, the formed capillary‐like networks were significantly longer after 14 days of coculture than the structures in the control gels. In addition, the stability as well as the complexity of the vascular networks was significantly increased by coculture. We discussed and concluded that osteogenic and angiogenic signals from the culture media as well as from cocultured cell types, and tissue‐specific hydrogel composition all contribute to stimulate the interplay between osteogenesis and angiogenesis in vitro and are a basis for engineering vascularized bone.
This paper investigates the evaluation of dense 3D face reconstruction from a single 2D image in the wild. To this end, we organise a competition that provides a new benchmark dataset that contains 2000 2D facial images of 135 subjects as well as their 3D ground truth face scans. In contrast to previous competitions or challenges, the aim of this new benchmark dataset is to evaluate the accuracy of a 3D dense face reconstruction algorithm using real, accurate and high-resolution 3D ground truth face scans. In addition to the dataset, we provide a standard protocol as well as a Python script for the evaluation. Last, we report the results obtained by three state-of-the-art 3D face reconstruction systems on the new benchmark dataset. The competition is organised along with the 2018 13th IEEE Conference on Automatic Face & Gesture Recognition.
Service robots need to be aware of persons in their vicinity in order to interact with them. People tracking enables the robot to perceive persons by fusing the information of several sensors. Most robots rely on laser range scanners and RGB cameras for this task. The thesis focuses on the detection and tracking of heads. This allows the robot to establish eye contact, which makes interactions feel more natural.
Developing a fast and reliable pose invariant head detector is challenging. The head detector that is proposed in this thesis works well on frontal heads, but is not fully pose-invariant. This thesis further explores adaptive tracking to keep track of heads that do not face the robot. Finally, head detector and adaptive tracker are combined within a new people tracking framework and experiments show its effectiveness compared to a state-of the-art system.
An interactive clothing design and a personalized virtual display with user’s own face are presented in this paper to meet the requirement of personalized clothing customization. A customer interactive clothing design approach based on genetic engineering ideas is analyzed by taking suit as an example. Thus, customers could rearrange the clothing style elements, chose available color, fabric and come up with their own personalized suit style. A web 3D customization prototype system of personalized clothing is developed based on the Unity3D and VR technology. The layout of the structure and functions combined with the flow of the system are given. Practical issues such as 3D face scanning, suit style design, fabric selection, and accessory choices are addressed also. Tests to the prototype system indicate that it could show realistic clothing and fabric effect and offer effective visual and customization experience to users.
Completely defined co-culture of adipogenic differentiated ASCs and microvascular endothelial cells
(2018)
Vascularized adipose tissue models are in high demand as alternatives to animal models to elucidate the mechanisms of widespread diseases, screen for new drugs or assess drug safety levels. Animal-derived sera such as fetal bovine serum (FBS), which are commonly used in these models, are associated with ethical concerns, risk of contaminations and inconsistencies of their composition and impact on cells. In this study, we developed a serum-free, defined co culture medium and implemented it in an adipocyte/endothelial cell (EC) co culture model.
Human adipose-derived stem cells were differentiated under defined conditions (diffASCs) and, like human microvascular ECs (mvECs), cultured in a defined co culture medium in mono-, indirect or direct co-culture for 14 days. The defined co-culture medium was superior when compared to mono-culture media and facilitated the functional maintenance and maturation of diffASCs including perilipin A expression, lipid accumulation, and also glycerol and leptin release. The medium also allowed mvEC maintenance, confirmed by the expression of CD31 and von Willebrand factor (vWF), and by acetylated low density lipoprotein (acLDL) uptake. Thereby, mvECs showed strong dependence on EC-specific factors. Additionally, mvECs formed vascular structures in direct co-culture with diffASCs.
The completely defined co-culture system allows for the serum-free culture of adipocyte/EC co-cultures and thereby represents a valuable and ethically acceptable tool for the culture and study of vascularized adipose tissue models.
To date, special interest has been paid to composite scaffolds based on polymers enriched with hydroxyapatite (HA). However, the role of HA containing different trace elements such as silicate in the structure of a polymer scaffold has not yet been fully explored. Here, we report the potential use of silicate-containing hydroxyapatite (SiHA) microparticles and microparticle aggregates in the predominant range from 2.23 to 12.40 μm in combination with polycaprolactone (PCL) as a hybrid scaffold with randomly oriented and well-aligned microfibers for regeneration of bone tissue. Chemical and mechanical properties of the developed 3D scaffolds were investigated with XRD, FTIR, EDX and tensile testing. Furthermore, the internal structure and surface morphology of the scaffolds were analyzed using synchrotron X-ray μCT and SEM. Upon culturing human mesenchymal stem cells (hMSC) on PCL-SiHA scaffolds, we found that both SiHA inclusion and microfiber orientation affected cell adhesion. The best hMSCs viability was revealed at 10 day for the PCL-SiHA scaffolds with well-aligned structure (~82%). It is expected that novel hybrid scaffolds of PCL will improve tissue ingrowth in vivo due to hydrophilic SiHA microparticles in combination with randomly oriented and well-aligned PCL microfibers, which mimic the structure of extracellular matrix of bone tissue.
Background aims: In vitro engineered adipose tissue is in great demand to treat lost or damaged soft tissue or to screen for new drugs, among other applications.However, today most attempts depend on the use of animal-derived sera. To pave the way for the application of adipose tissue-engineered
products in clinical trials or as reliable and robust in vitro test systems, sera should be completely excluded from the production process. In this study, we aimed to develop an in vitro adipose tissue model in the absence of sera and maintain its function long-term.
Methods: Human adipose tissue-derived stem cells were expanded and characterized in a xeno- and serum-free environment. Adipogenic differentiation was induced using a completely defined medium. Developed adipocytes were maintained in a completely defined maturation medium for additional 28 days. In addition to cell-viability and adherence, adipocyte-specific markers such as perilipin A expression of leptin release were evaluated.
Results: The defined differentiation medium enhanced cell adherence and lipid
accumulation at a significant level compared with the corresponding negative control. The defined maturation medium also significantly supported cell adherence and functional adipocyte maturation during the long-term culture period.
Conclusions: The process described here enables functional adipocyte generation and maintenance without the addition fo unknown or unimal-derived constituents, achieving an important milestone in the introduction of adipose tissue engineered products into clinical trials or in vitro screening.
Bone remodeling can be mimicked in vitro by co-culture models. Based on bone cells, such co-cultures help to study synergistic morphological changes and the impact of materials and applied substances. Hence, we examined the formation of osteoclasts on bovine bone materials to prove the bone resorption functionality of the osteoclasts in three different co-culture set-ups using human monocytes (hMCs) and (I) human mesenchymal stem cells (hMSCs), (II) osteogenic differentiated hMSCs (hOBs), and (III) hOBs in addition of soluble monocyte-colony stimulating factor (M CSF) and cytokine receptor activator of NFkB ligand (RANKL).We detected osteoclast-specific actin morphology, as well as the expression of cathepsin K and CD51/61 in single cells in set-up II and in numerous cells in set-up III. Resorption pits on bone material as characteristic proof of functional osteoclasts were not found in set-up I and II, but we detected such resorption pits in set–up III. We conclude in co culture models without M-CSF and RANKL that monocytes can differentiate into osteoclasts that show the characteristic actin structures and protein expression. However, to receive functional bone resorbing osteoclasts in vitro, the addition of M-CSF and RANKL is needed. Moreover, we suggest the use of bone or bone-like materials for future studies evaluating osteoclastogenesis.
Annotations of subject IDs in images are very important as ground truth for face recognition applications and news retrieval systems. Face naming is becoming a significant research topic in news image indexing applications. By exploiting the uniqueness of name, face naming is transformed to the problem of multiple instance learning (MIL) with exclusive constraint, namely the eMIL problem. First, the positive bags and the negative bags are automatically annotated by a hybrid recurrent convolutional neural network and a distributed affinity propagation cluster. Next, positive instance selection and updating are used to reduce the influence of false-positive bag and to improve the performance. Finally, max exclusive density and iterative Max-ED algorithms are proposed to solve the eMIL problem. The experimental results show that the proposed algorithms achieve a significant improvement over other algorithms.
Nowadays robust, energy-efficient multisensor microsystems often come with heavily restricted power budgets and the characteristic of remaining in certain states for a longer period of time. During this time frame there is no continuous clock signal required which gives the opportunity to suspend the clock until a new transition is requested. In this paper, we present a new topology for on-demand locally clocked finite state machines. The architecture combines a local adaptive clocking approach with synchronous and asynchronous components forming a quasi synchronous system. Using adaptive and local clocking comes with the advantages of reducing the power consumption while saving design effort when no global clock tree is needed. Combining synchronous and asynchronous components is beneficial compared to previous fully asynchronous approaches concerning the design restrictions. The developed topology is verified by the implementation and simulation of a temperature-ADC sensor system realized in a 180 nm process.
This paper introduces a highly scalable heteromodular origami art technique for constructing 3D framework structures using elementary struts and connectors folded from uncut sheets of standard A4 office paper. The presented technique, named ZEBRA, allows the design of meter-scale architectural objects, such as truss bridges and towers, which are capable of bearing substantial mechanical loads. Moving parts, ranging from simple levers to complete multi-bar linkages, can be integrated into static frameworks using a set of kinematic extensions. An overview is given of how the ZEBRA system can be used to teach university students various theoretical and practical aspects of the engineering sciences in an entertaining and hands-on way.
Die Mesago Messe Frankfurt als Veranstalter der Formnext 2018 haben von Prof. Dr.-Ing. Steffen Ritter von der Hochschule Reutlingen eine anschauliche Übersicht erstellen lassen, welche die Vielfalt der unterschiedlichen Verfahren zur additiven Fertigung verständlich erklärt. Die kleine, zweisprachige Broschüre mit dem Titel „AM Field Guide“ bietet auf 12 Seiten strukturierte Vergleichsdarstellungen von insgesamt 19 gängigen 3-D-Druck Technologien für Kunststoffe, Metalle sowie andere Werkstoffe und dazu noch einen Überblick über die Phasen und Prozessschritte in Projekten für Bauteile, die additiv hergestellt werden.
Lithographical hotspot (LH) detection using deep learning (DL) has received much attention in the recent years. It happens mainly due to the facts the DL approach leads to a better accuracy over the traditional, state-of-the-art programming approaches. The purpose of ths study is to compare existing data augmentation (DA) techniques for the integrated circuit (IC) mask data using DL methods. DA is a method which refers to the process of creating new samples similar to the training set, thereby helping to reduce the gap between classes as well as improving the performance of the DL system. Experimental results suggest that the DA methods increase overall DL models performance for the hotspot detection tasks.
A transaction is a demarcated sequence of application operations, for which the following properties are guaranteed by the underlying transaction processing system (TPS): atomicity, consistency, isolation, and durability (ACID). Transactions are therefore a general abstraction, provided by TPS that simplifies application development by relieving transactional applications from the burden of concurrency and failure handling. Apart from the ACID properties, a TPS must guarantee high and robust performance (high transactional throughput and low response times), high reliability (no data loss, ability to recover last consistent state, fault tolerance), and high availability (infrequent outages, short recovery times).
The architectures and workhorse algorithms of a high-performance TPS are built around the properties of the underlying hardware. The introduction of nonvolatile memories (NVM) as novel storage technology opens an entire new problem space, with the need to revise aspects such as the virtual memory hierarchy, storage management and data placement, access paths, and indexing. NVM are also referred to as storage-class memory (SCM).
Active storage
(2018)
In brief, Active Storage refers to an architectural hardware and software paradigm, based on collocation storage and compute units. Ideally, it will allow to execute application-defined data ... within the physical data storage. Thus Active Storage seeks to minimize expensive data movement, improving performance, scalability, and resource efficiency. The effective use of Active Storage mandates new architectures, algorithms, interfaces, and development toolchains.
Blockchains yield to new workloads in database management systems and K/V-stores. Distributed Ledger Technology (DLT) is a technique for managing transactions in ’trustless’ distributed systems. Yet, clients of nodes in blockchain networks are backed by ’trustworthy’ K/V-Stores, like LevelDB or RocksDB in Ethereum, which are based on Log-Structured Merge Trees (LSM Trees). However, LSM-Trees do not fully match the properties of blockchains and enterprise workloads.
In this paper, we claim that Partitioned B-Trees (PBT) fit the properties of this DLT: uniformly distributed hash keys, immutability, consensus, invalid blocks, unspent and off-chain transactions, reorganization and data state / version ordering in a distributed log-structure. PBT can locate records of newly inserted key-value pairs, as well as data of unspent transactions, in separate partitions in main memory. Once several blocks acquire consensus, PBTs evict a whole partition, which becomes immutable, to secondary storage. This behavior minimizes write amplification and enables a beneficial sequential write pattern on modern hardware. Furthermore, DLT implicate some type of log-based versioning. PBTs can serve as MV-store for data storage of logical blocks and indexing in multi-version concurrency control (MVCC) transaction processing.
Modern persistent Key/Value stores are designed to meet the demand for high transactional throughput and high data ingestion rates. Still, they rely on backwards-compatible storage stack and abstractions to ease space management, foster seamless proliferation and system integration. Their dependence on the traditional I/O stack has negative impact on performance, causes unacceptably high write-amplification, and limits the storage longevity.
In the present paper we present NoFTL KV, an approach that results in a lean I/O stack, integrating physical storage management natively in the Key/Value store. NoFTL-KV eliminates backwards compatibility, allowing the Key/Value store to directly consume the characteristics of modern storage technologies. NoFTLKV is implemented under RocksDB. The performance evaluation under LinkBench shows that NoFTL-KV improves transactional throughput by 33%, while response times improve up to 2.3x. Furthermore, NoFTL KV reduces write-amplification 19x and improves storage longevity by imately the same factor.
Background: Internationally, teledermatology has proven to be a viable alternative to conventional physical referrals. Travel cost and referral times are reduced while patient safety is preserved. Especially patients from rural areas benefit from this healthcare innovation. Despite these established facts and positive experiences from EU neighboring countries like the Netherlands or the United Kingdom, Germany has not yet implemented store-and-forward teledermatology in routine care.
Methods: The TeleDerm study will implement and evaluate store-and-forward teledermatology in 50 general practitioner (GP) practices as an alternative to conventional referrals. TeleDerm aims to confirm that the possibility of store-and-forward teledermatology in GP practices is going to lead to a 15% (n = 260) reduction in referrals in the intervention arm. The study uses a cluster-randomized controlled trial design. Randomization is planned for the cluster “county”. The main observational unit is the GP practice. Poisson distribution of referrals is assumed. The evaluation of secondary outcomes like acceptance, enablers and barriers uses a mixed methods design with questionnaires and interviews.
Discussion: Due to the heterogeneity of GP practice organization, patient management software, information technology service providers, GP personal technical affinity and training, we expect several challenges in implementing teledermatology in German GP routine care. Therefore, we plan to recruit 30% more GPs than required by the power calculation. The implementation design and accompanying evaluation is expected to deliver vital insights into the specifics of implementing telemedicine in German routine care.
We present an approach for segmenting individual cells and lamellipodia in epithelial cell clusters using fully convolutional neural networks. The method will set the basis for measuring cell cluster dynamics and expansion to improve the investigation of collective cell migration phenomena. The fully learning-based front-end avoids classical feature engineering, yet the network architecture needs to be designed carefully. Our network predicts how likely each pixel belongs to one of the classes and, thus, is able to segment the image. Besides characterizing segmentation performance, we discuss how the network will be further employed.
This work is a report on practical experiences with the issue of interoperability in German practice management systems (PMSs) from an ongoing clinical trial on teledermatology, the TeleDerm project. A proprietary and established web-platform for store-and-forward telemedicine is integrated with the IT in the GPs’ offices for automatic exchange of basic patient data. Most of the 19 different PMSs included in the study sample lack support of modern health data exchange standards, therefore the relatively old but widely available German health data exchange interface “Gerätedatentransfer” (GDT) is used. Due to the lack of enforcement and regulation of the GDT standard, several obstacles to interoperability are encountered. As a partial, but reusable working solution to cope with these issues, we present a custom middleware which is used in conjunction with GDT. We describe the design, technical implementation and observed hindrances with the existing infrastructure. A discussion on health care interfacing standards and the current state of interoperability in German PMS software is given.
Impact of phenolic resin preparation on its properties and its penetration behavior in Kraft paper
(2018)
The core of decorative laminates is generally made of stacked Kraft paper sheets impregnated with a phenolic resin. As the impregnation process in industry is relatively fast, new methods need to be developed to characterize it for different paper-resin systems. Several phenolic resins were synthesized with the same Phenol:Formaldehyde ratio of 1:1.8 and characterized by Fourier Transform Infrared Spectrometry (FTIR) as well as Size-Exclusion Chromatography (SEC). In addition, their viscosities and surface tensions when diluted in methanol to 45% of solid content were measured. The capacity of each resin to penetrate a Kraft paper sheet was characterized using a new method, which measures the conductivities induced by the liquid resin crossing the paper substrate. With this method, crossing times could be measured with a good accuracy. Surprisingly, the results showed that the penetration time of the resin samples is not correlated to the viscosity values, but rather to the surface tension characteristics and the chemical characteristics of paper. Furthermore, some resins had a higher swelling effect on the fibers that delayed the crossing of the liquid through the paper.
Functionalised particles are highly requested in materials research, as they can be used as vital components in many advanced applications such as smart materials, functional coatings, drug carrier systems or adsorption materials. In this study, furan-functionalised melamine-formaldehyde (MF) particles were successfully prepared for the first time using an organic sol-gel process. Commercially available 2-Aminomethylfuran (AMF) and 2-Aminomethyl-5-methylfuran (AMMF) were used as modifying agents. In the isolated polymer particles, a melamine (M) to modifying agent ratio of M:AMF mol/mol 2.04:1 and M:AMMF ratio of mol/mol 1.25:1 was used. The obtained particles were isolated in various centrifugation and re-dispersion cycles and analysed using ATR-FT-IR, Raman and solid state 13C NMR spectroscopy, TGA, SEM and DSC measurements. Upon functionalisation the size of the MF particles increased (MF 1.59 µm, 27% CV (coefficient of variation); MF-AMF 2.56 µm, 25% CV; MF-AMMF 2.20 µm, 35% CV). DSC measurements showed that another type of exothermic residual reactivity besides condensation-based curing takes place with the furan-modified particles that is not related to the liberation of volatile compounds. The newly obtained particles are able to undergo Diels-Alder reactions with maleimide groups. The characteristic IR and Raman absorbance bands of the reaction products after the particles were reacted with 4,4′-Diphenylmethanebismaleimide reagent confirm the formation of a Diels-Alder adduct.
Properties data of phenolic resins synthetized for the impregnation of saturating Kraft paper
(2018)
The quality of decorative laminates boards depends on the impregnation process of Kraft papers with a phenolic resin,which constitute the raw materials for the manufacture of the cores of such boards.In the laminates industries,the properties of resins are adapted via their syntheses,usually by mixing phenol and formaldehyde in a batch,where additives,temperature and stirring parameters can be controlled. Therefore, many possibilities of preparation and phenolic resins exist, that leads to different combinations of physico chemical properties. In this article, the properties data of eight phenolic resins synthetized with different parameters of pH and reaction times at 60 °C and 90 °C are presented: the losses of pH after synthesis and the dynamic viscosities measured after synthesis and one the solid content is adjusted to 45%w/w in methanol. Data aquired by Differential Scanning Calorimetry (DSC) of the resins and Inverse Gas Chromatography (IGC) of cured solids are given as well.
The current paper studies the influence of geometrical parameters of the fused deposition modeling (FDM) - fused filament fabrication (FFF) 3D printing process on printed part strength for open source desktop 3D printers and the most popular material used for that purpose - i.e., polylactic acid (PLA). The study was conducted using a set of different nozzles (0.4, 0.6, and 0.8 mm) and a range of layer heights from the minimum to maximum physical limits of the machine. To assess print strength, a novel assessment method is proposed. A tubular sample is loaded in the weakest direction (across layers) in a three point bending fixture. Mesostructure evaluation through scanning electronic microscopy (SEM) scans of the samples was used to explain the obtained results. We detected a significant influence of geometric process parameters on sample mesostructure, and consequently, on sample strength.
Lots of movies are produced every year, too many to watch all of them and in particular, to get an overview about the evolution of typical movie genres and actors playing in them. Moreover, it is a challenging problem to detect correlations among the movies and the actors in those movies, in particular, if we are interested in time-varying data patterns like trends, countertrends, or anomalies and outliers. Those correlations are specifically interesting if they can be inspected on different levels of granularity, e.g., temporal, but also hierarchical in form of country- or continent-based correlations. In this paper we describe the IMDb Explorer, a webbased visualization tool that consists of two major views denoted by the movie cosmos and the career lines. Both views are linked and interactively manipulable while a list of user-defined metrics are explorable. We illustrate the usefulness of the visualization tool by applying it to the entire movie database provided by IMDb.
Workshops and tutorials
(2018)
The 19th International Conference on Product-Focused Software Process Improvement (PROFES 2018) hosted two workshops and three tutorials. The workshops and tutorials complemented and enhanced the main conference program, offering a wider knowledge perspective around the conference topics. The topics of the two workshops were Hybrid Development Approaches in Software Systems Development (HELENA) and Managing Quality in Agile & Rapid Software Development Processes (QUaSD). The topics of the tutorials were The human factor in agile transitions – using the personas concept in agile oaching, Process Management 4.0 – Best Practices, and Domain-specific languages for specification, development, and testing of autonomous systems.
Being able to monitor the heart activity of patients during their daily life in a reliable, comfortable and affordable way is one main goal of the personalized medicine. Current wearable solutions lack either on the wearing comfort, the quality and type of the data provided or the price of the device. This paper shows the development of a Textile Sensor Platform (TSP) in the form of an electrocardiogram (ECG)-measuring T-shirt that is able to transmit the ECG signal to a smartphone. The development process includes the selection of the materials, the design of the textile electrodes taking into consideration their electrical characteristics and ergonomy, the integration of the electrodes on the garment and their connection with the embedded electronic part. The TSP is able to transmit a real-time streaming of the ECG-signal to an Android smartphone through Bluetooth Low Energy (BLE). Initial results show a good electrical quality in the textile electrodes and promising results in the capture and transmission of the ECG signal. This is still a working- progress and it is the result of an interdisciplinary master project between the School of Informatics and the School of Textiles & Design of the Reutlingen University.
A series of novel biomedical TPCUs with different percentages of hard segment and a silicone component in the soft segment were synthesized in a multi stage one-pot method. The kinetic profiles of the urethane formation in TPCU-based copolymer systems were monitored by rheological, in line FTIR spectroscopic (React IR) and real-time calorimetric (RC1) methods. This process-analytically monitored multi step synthesis was successfully used to optimize the production of medical-grade TPCU elastomers on preparative scale (in lots of several kg) with controlled molecular structure and mechanical properties. Various surface and bulk analytical methods as well as systematic studies of the mechanic response of the elastomer end-products towards compression and tensile loading were used to estimate the bio-stability of the prepared TPCUs in vitro after 3 months. The tests suggested that high bio-stability of all polyurethane formulations using accelerating in vitro test can be attributed to the synthetic design as well as to the specific techniques used for specimen preparation, namely: (1) the annealing for reducing residual polymer surface stress and preventing IES, (2) stabilization of the morphology by long time storage of the specimens after processing before being immersed in the test liquids, (3) purification by extraction to remove the shot chain oligomers which are the most susceptible to degradation. All mechanical tests were performed on cylindrical and circular disc specimens for modelling the thickness of the meniscus implants under application-relevant stress conditions.
So far, only few authors addressed the serum-free, defined differentiation of adipocytes. And there are hardly any trials available on the defined maintenance of adipocytes. In this study, the development of a defined culture medium for the adipogenic differentiation of primary human adipose-derived stem cells (ASCs) was aimed. Based on the addition of specific factors for the replacement of serum, ASCs were differentiated to viable and characteristic adipocytes for 14 days, which was proven through the accumulation of lipids, the expression of perilipin A and by the release of leptin and glycerol. Furthermore, a defined maintenance medium was developed, which supported the maturation and stability of cells for a long-term period of additional 42 days until day 56.
This paper addresses what we call the investment question: under what plausible circumstances, if any, can variable renewable energy (VRE, and solar photovoltaic (PV) in particular) be a good investment? Although VRE has been growing rapidly world-wide, it is generally subsidized. Under what cost and market conditions can solar PV flourish without subsidy? We employ solar insolation and market price data from the U.S. and from Germany to gain insight into the investment question. We find that unsubsidized solar PV is or may soon be a justifiable investment, but that market arrangements may play a crucial role in determining success. We end by sketching a proposal that amounts to a reformed capacity market that would afford participation of solar PV.
Zur Entwicklung einer Sofortpreiskalkulation für CNC-Drehteile werden Machine-Learning-Ansätze sowie ein deterministischer Algorithmus untersucht. Der deterministische Algorithmus funktioniert ausschließlich für Drehteile mit geringer Komplexität. Die Machine Learning Modelle hingegen sind zukunftsfähiger, da die ersten Ergebnisse bereits sehr geringe Abweichungswerte zu den festgelegten Referenzpreisen erreichen können. Mit steigendem Datenaufkommen können beide Machine-Learning-Modelle mit geringem Aufwand weiter verbessert werden.
Die Segmentierung und das Tracking von minimal-invasiven robotergeführten Instrumenten ist ein wesentlicher Bestandteil für verschiedene computer assistierte Eingriffe. Allerdings treten in der minimal-invasiven Chirurgie, die das Anwendungsfeld für den hier beschriebenen Ansatz darstellt, häufig Schwierigkeiten durch Reflexionen, Schatten oder visuelle Verdeckungen durch Rauch und Organe auf und erschweren die Segmentierung und das Tracking der Instrumente.
Dieser Beitrag stellt einen Deep Learning Ansatz für ein markerloses Tracking von minimal-invasiven Instrumenten vor und wird sowohl auf simulierten als auch realen Daten getestet. Es wird ein simulierter als auch realer Datensatz mit Ground Truth Kennzeichnung für die binäre Segmentierung von Instrument und Hintergrund erstellt. Für den simulierten Datensatz werden Bilder aus einem simulierten Instrument und realem Hintergrund zusammengesetzt. Im Falle des realen Datensatzes spricht man von der Zusammensetzung der Bilder aus einem realen Instrument und Hintergrund. Insgesamt wird auf den simulierten Daten eine Pixelgenauigkeit von 94.70 Prozent und auf den realen Daten eine Pixelgenauigkeit von 87.30 Prozent erreicht.
Die minimal-invasive Chirurgie (MIC) entwickelt sich durch den Einsatz von medizinischen Robotern wie dem da Vinci System von Intuitive Surgical stetig weiter. Hierdurch kann eine bessere oder gleichwertige Operation bei deutlich geringerer körperlicher Belastung des Operateurs erreicht werden. Dabei entstehen jedoch neue Problemstellungen wie beispielsweise Kollision zwischen Roboterarmen und die benötigte Zeit zum Einrichten einer geeigneten Roboterkonfiguration. Daher ist eine effiziente Vorbereitung und Planung der Interventionen erforderlich. Diese Arbeit präsentiert einen Ansatz für eine verbesserte Planung mit Augmented Reality (AR) und einer Robotik Simulationssoftware (RS). Die Robotik Simulation dient zur Berechnung einer Roboterkonfiguration unter Vorgabe der Port-Positionen. Augmented Reality wird verwendet, um die berechneten Pose in der realen Umgebung zu visualisieren und somit leichter in den Operationssaal zu übertragen.
The focus of the developed maturity model was set on processes. The concept of the widespread CMM and its practices has been transferred to the perioperative domain and the concept of the new maturity model. Additional optimization goals and technological as well as networking-specific aspects enable a process- and object-focused view of the maturity model in order to ensure broad coverage of different subareas. The evaluation showed that the model is applicable to the perioperative field. Adjustments and extensions of the maturity model are future steps to improve the rating and classification of the new maturity model.
A shift in attitudes to purchasing departments can be perceived. No longer is the chief goal solely to reduce costs; the procurement function is assuming strategic relevance in the business model, leveraging the supplier as a foundation for innovation. The knowledge accumulated by suppliers is accessed over the journey of long-term partnerships to streamline business practice. Businesses are finding themselves in increasingly competitive environments, and thus need to address inefficiencies in supplier management. “Procurement 4.0” is a concept used in discussing digitalisation in business processes, referring to the process of supplier relationship management and optimisation. This model and its application to supplier relationship management will be the focus of this article. Realising the efficiencies to be obtained in buyer-supplier relationships through “Procurement 4.0” will be explored, primarily through an emphasis on digitalisation of the relationship between the procurement department and supplier.
Surface topographies are often discussed as an important parameter influencing basic cell behavior. Whereas most in vitro studies deal with microstructures with sharp edges, smooth, curved microscale topographies might be more relevant concerning in-vivo situations. Addressing the lack of highly defined surfaces with varying curvature, we present a topography chip system with 3D curved features of varying spacing, curvature radii as well as varying overall dimensions of curved surfaces. The CurvChip is produced by low-cost photolithography with thermal reflow, subsequent (repetitive) PDMS molding and hot embossing. The platform facilitates the systematic in-vitro investigation of the impact of substrate curvature on cell types like epithelial, endothelial, smooth muscle cells, or stem cells. Such investigations will not only help to further understand the mechanism of curvature sensation but may also contribute to optimize cell-material interactions in the field of regenerative medicine.
In Neurofibromatosis 1 (NF1) germ line loss of function mutations result in reduction of cellular neurofibromin content (NF1+/−, NF1 haploinsufficiency). The Ras-GAP neurofibromin is a very large cytoplasmic protein (2818 AA, 319 kDa) involved in the RAS-MAPK pathway. Aside from regulation of proliferation, it is involved in mechanosensoric of cells. We investigated neurofibromin replacement in cultured human fibroblasts showing reduced amount of neurofibromin. Full length neurofibromin was produced recombinantly in insect cells and purified. Protein transduction into cultured fibroblasts was performed employing cell penetrating peptides along with photochemical internalization. This combination of transduction strategies ensures the intracellular uptake and the translocation to the cytoplasm of neurofibromin. The transduced neurofibromin is functional, indicated by functional rescue of reduced mechanosensoric blindness and reduced RasGAP activity in cultured fibroblasts of NF1 patients or normal fibroblasts treated by NF1 siRNA. Our study shows that recombinant neurofibromin is able to revert cellular effects of NF1 haploinsuffiency in vitro, indicating a use of protein transduction into cells as a potential treatment strategy for the monogenic disease NF1.
Rattern unerwünscht
(2018)
Die Additive Fertigung bietet großes Potenzial zur Erschließung neuer, flexibler und innovativer Fertigungsprozesse mit kurzen Durchlaufzeiten. Erhöhte Komplexität und die Integration von Funktionen in Bauteile wird gefördert. Zur Steigerung der Konkurrenzfähigkeit und weiteren Ausweitung des Einsatzgebietes sind automatisierte Fertigungsschritte nach dem Bauprozess erforderlich. Werkzeugmaschinen spielen auch in der Prozesskette der Additiven Fertigung eine zentrale Rolle bei der Erzeugung von genauen Funktionsflächen. Dabei ist evtl. eine andere Auslegung aufgrund reduzierter Zerspanvolumen und geringeren Flächen möglich.
Soft thermoplastic polysiloxane-urea-elastomers (PSUs) were prepared for the application as a biomaterial to replace the human natural lens after cataract surgery. PSUs were synthesized from amino-terminated polydimethylsiloxanes (PDMS), 4,4′-Methylenebis(cyclohexylisocyanate) (H12MDI) and 1,3–Bis(3-aminopropyl)-1,1,3,3–tetramethyldisiloxane (APTMDS) by a two-step polyaddition route. Such a material has to be highly transparent and must exhibit a low Young’s Modulus and excellent dimensional stability. Polydimethylsiloxanes in the range of 3000–33,000 g·mol−1 were therefore prepared by ring-chain-equilibration of octamethylcyclotetrasiloxane (D4) and APTMDS in order to study the influence of the soft segment molecular weight on the mechanical properties and the transparency of the PSU-elastomers. 2,4,6,8-Tetramethyl-2,4,6,8-tetraphenylcyclotetrasiloxane (D4Me,Ph) was co-polymerized with D4 in order to adjust the refractive index of the polydimethyl-methyl-phenyl-siloxane-copolymers to a value equivalent to a young human natural lens. Very elastic PSUs with Elongation at Break values higher than 700% were prepared. PSU-elastomers, synthesized from PDMS of molecular weights up to 18,000 g·mol−1, showed transmittance values of over 90% within the visible spectrum range. The soft segment refractive index was increased through the incorporation of 14 mol % of methyl-phenyl-siloxane from 1.4011 to 1.4346 (37 °C). Young’s Moduli of PSU-elastomers were around 1 MPa and lower at PDMS molecular weights up to 15,000 g·mol−1. 10-cycle hysteresis measurements were applied to evaluate the mechanical stability of the PSUs at repeated stress. Hysteresis values at 100% strain decreased from 32 to 2% (10th cycle) with increasing PDMS molecular weight. Furthermore, hysteresis at 5% strain was only detected in PSU-elastomers with low PDMS molecular weights. Finally, preliminary results of in vitro cytotoxicity tests on a PSU-elastomer showed no toxic effects on HaCaT-cells.
This article contains data on the synthesis and mechanical characterization of polysiloxane-based urea-elastomers (PSUs) and is related to the research article entitled “Influence of PDMS molecular weight on transparency and mechanical properties of soft polysiloxane-urea-elastomers for intraocular lens application” (Riehle et al., 2018) [1]. These elastomers were prepared by a two-step polyaddition using the aliphatic diisocyanate 4,4′-Methylenbis(cyclohexylisocyanate) (H12MDI), a siloxane-based chain extender 1,3-Bis(3-aminopropyl)-1,1,3,3-tetramethyldisiloxane (APTMDS) and amino-terminated polydimethylsiloxanes (PDMS) or polydimethyl-methyl-phenyl-siloxane-copolymers (PDMS-Me,Ph), respectively. (More details about the synthesis procedure and the reaction scheme can be found in the related research article (Riehle et al., 2018) [1]).
Amino-terminated polydimethylsiloxanes with varying molecular weights and PDMS-Me,Ph-copolymers were prepared prior by a base-catalyzed ring-chain equilibration of a cyclic siloxane and the endblocker APTMDS. This DiB article contains a procedure for the synthesis of the base catalyst tetramethylammonium-3-aminopropyl-dimethylsilanolate and a generic synthesis procedure for the preparation of a PDMS having a targeted number average molecular weight of 3000 g mol−1. Molecular weights and the amount of methyl-phenyl-siloxane within the polysiloxane-copolymers were determined by 1H NMR and 29Si NMR spectroscopy. The corresponding NMR spectra and data are described in this article.
Additionally, this DiB article contains processed data on in line and off line FTIR-ATR spectroscopy, which was used to follow the reaction progress of the polyaddition by showing the conversion of the diisocyanate. All relevant IR band assignments of a polydimethylsiloxane-urea spectrum are described in this article.
Finally, data on the tensile properties and the mechanical hysteresis-behaviour at 100% elongation of PDMS-based polyurea-elastomers are shown in dependence to the PDMS molecular weight.
Small Island Developing States (SIDS) face tension between economic growth and environmental impact. Tourism fuels growth, but the resulting solid waste and other pollutants threaten the SIDS’ natural beauty, quality of life for residents, attractiveness to tourists, and economic success. We assess the tension between tourism-driven economic growth and environmental degradation from a limits-to-growth perspective, developing a generic system dynamics model of the problem using 38 years of data from the Maldives to estimate parameters and Monte-Carlo methods to assess the sensitivity of results to uncertainty. We contrast development paths for the next three decades under three sets of policies focusing on promoting growth, managing tourism demand–supply balance, and improving waste management. Findings are counterintuitive; policies focused on better waste management alone are self defeating, because they increase tourism, growth and waste generation, undermining attractiveness and growth later. Policies that limit tourism demand improve economic and environmental health.
Future intralogistics systems need to adapt flexibly to changing material flow requirements in line with future versatile factory environments, producing personalized products under the performance and cost conditions of today's mass production. Small batch sized down to a batch size of "1" lead to a high complexity in the design and economical manufacturing of these customized products. Intralogistics systems are integrated into higher-level areas (segment level) as well as into upsteam and downstream performance units (system-wide areas). This includes the logistic activities relevant for the system (organized according to storage, picking, transport) such as transportation or storage tasks of tools, semi-finished products, components, assemblies and containers, and waste. Today's centralized material flow control systems, which work based on predefined processes, are not capable and more specifically not suitable to deal with the arising complexity of changeable intralogistics systems. Autononomous, decentralized material flow control systems distribute the required decision-making and control processes on intelligent logistic entities. A major step for the development of an autonomous control method for hybrid intralogistics systems (manual, semi-automated and automated) is the development of a generic archetype for intralogistics systems regarding the system boundaries, elements and relations resulting in a descriptive model taking into account amongst others the time of demand, availability of resources, economic efficiency and technical performance parameters. The ESB Logistics Learning Factory at ESB Business School (Reutlingen University) serves for this as a close-to-reality development and validation environment.
In recent years, the numer of hybrid work systems using human robot collaboration (HRC) increased in industrial production environments - enhancing productivity while reducing work-related burden. Despite growing availability of HRC-suitable manipulation and safety technology, tools and techniques facilitating the design, planning and implementation process are still lacking. System engineers who strive to implement technically feasible, ergonomically meaningful and economically beneficial HRC application need to make design and technology decisions in various subject areas, whereas the design alternatives per morphological analysis is applied to establish a description model that can serve as both a supporting design guideline for future HRC application of value-adding, industrial quality as well as a tool to characterize and compare existing applications. It focuses on HRC within assembly processes, and illustrates the complexity of HRC applications in a comprehensible manner through its multi-dimensional structure. The morphology has been validated through its application on various existing industrial HRC applications, research demonstrators and interviews of experts from academia.
Polyelectrolyte multi-layer (PEM) coatings are prepared by alternative deposition of single polyelectrolyte monolayers on charged surfaces using the Layer-by-Layer (LbL) dip coating procedure. These are nanometre scaled coatings which allow fulfilling of different technical or biological requirements. The build-up process is based on selfassembly and self organization of polycations and polyanions on different substrates including complex geometrical structures and even closed volumes, forming homogeneous layer without defects. Depending on the proper selection of the applied polyelectrolytes, coatings with different stabilities can be prepared. Some of the coatings are stable and cannot be removed from the surface. Others are degradable and can be used as systems for controlled local drug delivery. Here we summarise the results of our experience in preparation of PEM coatings with different functionalities. PEM coatings can be used as controllable delivery system for siRNA polyplexes. They can be used to control the adhesion of different cell types on the surfaces and support e.g. the endothelialisation process on cardio-vascular medical devices as e.g. stents or reduce the immunological response of the tissue after implantation. We summarise results from physical characterisation of the coatings (e.g. film thickness, roughness, electrical charge and hydrophilicity) combined with in-vitro biological studies on adhesion of HUVEC cells.
Polyelectrolyte multilayer (PEM) are thin polymeric films produced by alternating adsorption of positively and negatively charged polyelectrolytes (PE) on a substrate. These films are considered drug delivery agents as well as coating material for implants, due to their antibiofouling and biologically benign properties. For these reasons the film mechanical properties as well as response to mechanical stress are important measurement parameters. Especially intriguing is the correlation of the mechanical properties of PEM on macroscopic level with the structure of PEM on molecular level, which is addressed here for the first time. This study investigates PEM from PDADMA/PSS produced by spraying technique with neutron and X-ray reflectometry. Reflectometry technique provides precise information on thickness and density (i.e., electron density or scattering length density, respectively), and, this way, allows to conclude on changes in film composition. Thus, neutron and X-ray reflectometry technique is suitable to investigate the overall and the internal transformations, which PEM films might undergo upon exposure to mechanical load. During uniaxial elongation two regimes of PEM deformation can be observed: An elastic regime at small elongations (below ca. 0.2%), which is characterized by a reversible change of film thickness, and a plastic regime with a permanent change above this limit. Both regimes have in common, that the mechanical load induces an increase of the film thickness, which is accompanied by an uptake of water from the surrounding atmosphere. The strain causes a molecular rearrangement within the PEM-structure of stratified layers, which, even in elastic regime, is permanent, although the thickness change remains reversible.
This paper presents a digitally controlled boost converter IC for high output voltage and fast transient applications. Thus, it is well applicable in automotive and industrial environments. The 3V-to-6V input voltage, 6.3V output voltage, 1A boost converter IC is fabricated in a 180nm BCD technology. Digital control enables cost savings, advanced control concepts, and it is less parameter sensitive compared to common analog control. A 90 ns latency, 6-bit delay line ADC operates with a window concept, meeting high resolution requirements, e.g. in car battery applications. An output voltage live tracking is included for extending the ADC conversion window. A charge pump DAC provides high resolution, monotonicity, and short 128 ns conversion time. Further, a standard digital PI controller is enhanced by a simple but effective ΔV/Δt-intervention control. It results in 2.8x reduced output voltage deviations in case of load steps, scaling down the output capacitor value by the same factor.
Boost converters suffer from a bandwidth limitation caused by the right-half plane zero (RHPZ), which occurs in the control-to-output transfer function. In contrast, there are many applications that require superior dynamic behavior. Further, size and cost of boost converter systems can be minimized by reduced voltage deviations and fast transient responses in case of large signal load transients. The key idea of the proposed ΔV/Δt-intervention control concept is to adapt the controller output to its new steady state value immediately after a load transient by prediction from known parameters. The concept is implemented in a digital control circuit, consisting of an ASIC in a 110 nm-technology and a Xilinx Spartan-6 field programmable gate array (FPGA). In a boost converter with 3.5V input voltage, 6.3V output voltage, 1.2A load, and 500 kHz switching frequency, the output voltage deviations are 2.8x smaller, scaling down the output capacitor value by the same factor. The recovery times are 2.4x shorter in case of large signal load transients with the proposed concept. The control is widely applicable, as it supports constant switching frequencies and allows for duty cycle and inductor current limitations. It also shows various advantages compared to conventional control and to selected adaptive control concepts.
This paper presents a wide-Vin step-down parallel-resonant converter (PRC), comprising an integrated 5-bit capacitor array and a 300-nH resonant coil, placed in parallel to a conventional buck converter. Soft-switching resonant converters are beneficial for high-Vin multi-MHz converters to reduce dominant switching losses, enabling higher switching frequencies. The output filter inductor is optimized based on an empirical study of available inductors. The study shows that faster switching significantly reduces not only the inductor value but also volume, price, and even the inductor losses. In addition, unlike conventional resonant concepts, soft-switching control as part of the proposed PRC eliminates input voltage-dependent losses over a wide operating range, resulting in 76.3% peak efficiency. At Vin = 48 V, a loss reduction of 35% is achieved compared with the conventional buck converter. Adjusting an integrated capacitor array, and selecting the number of oscillation periods, keeps the switching frequency within a narrow range. This ensures high efficiency across a wide range of Vin = 12–48 V, 100–500-mA load, and 5-V output at up to 25-MHz switching frequency. Thanks to the low output current ripple, the output capacitor can be as small
as 50 nF.
This paper presents a dc–dc converter for integration in the power management unit of an ultra-low power microcontroller. The converter is designed to significantly reduce the wake-up energy and startup delay of the supplied core. The use of a minimized output capacitor is the key factor to save the wake-up energy. The converter is buffered with only 56 nF and guarantees a stable output of 1.2 V with a voltage ripple smaller than 30 mV. The controller of the proposed dc–dc converter is based on a predictive peak current control that allows the system to control the energy transfer at extremely low power consumption. The proposed circuit is implemented in 130 nm CMOS technology with an area of only 0.14 mm². It achieves a high conversion efficiency of 92.1% and a small quiescent current of 440 nA. It operates from 1.8 to 3.3 V with a maximum load of 2.65 mA.
Der spartenübergreifende BDI-Arbeitskreis Internet der Energie hat voraussichtliche Veränderungen durch Künstliche Intelligenz (KI) auf die Bereiche Energie und Klima analysiert und den möglichen Beitrag von KI zur Lösung anstehender Herausforderungen in diesen Bereichen erörtert. KI kann einen wesentlichen Beitrag zum Gelingen der Energiewende in Deutschland leisten. Der Energiesektor ist ein zentraler Bestandteil der deutschen Wirtschaft und daher auch in diesem Kontext äußerst relevant.
Rattern nicht erwünscht
(2018)
Este trabajo se enmarca dentro del vasto contexto de Ciudades Inteligentes, y se centra en el área de la conducción inteligente de vehículos, tanto en zonas urbanas como interurbanas, mediante la recogida de datos en tiempo real, medidos con sensores, por parte de los propios conductores, así como de datos capturados mediante simulación.
El objetivo de este trabajo es doble. Por un lado, el estudio y aplicación de las diferentes técnicas y métodos de detección de valores atípicos en bases de datos multivariantes, además de una comparativa entre ellos mediante las pruebas llevadas a cabo con datos de tráfico real. Y por otro lado, establecer una relación entre las situaciones anómalas de tráfico, como puedan ser atascos o accidentes, con los valores atípicos multivariantes encontrados.
La detección de valores atípicos representa una de las tareas más importantes a la hora de realizar cualquier análisis de datos, sea cual sea el dominio o área de estudio, ya que entre sus funciones primordiales se encuentra el descubrir información útil, que resulta de gran valor, y que por lo general queda oculta por la alta dimensión de los datos.
Con el uso de mecanismos de detección de valores atípicos junto con métodos de clasificación supervisada, se va a poder llevar a cabo el reconocimiento de elementos de la infraestructura vial urbana como pueden ser rotondas, pasos de cebra, cruces o semáforos.
Im Vergleich zum digitalen Layoutentwurf weist der analoge Layoutentwurf einen wesentlich geringeren Automatisierungsgrad auf. Dies gilt insbesondere für den Layoutentwurf von Hochfrequenzschaltungen, wo Einflüsse der lokalen Layoutumgebung besonders zu berücksichtigen sind. Bei dieser sog. Kontextabhängigkeit geraten sowohl Optimierungsalgorithmen als auch herkömmliche Generatoransätze schnell an Grenzen. In dieser Arbeit wird eine funktionale Erweiterung des bekannten Generatorprinzips eingesetzt, die es erlaubt, Informationen aus der Layoutumgebung der Instanz in die Layoutgenerierung einzubeziehen. Mit dieser sog. kontextbasierten PCell gelingt die Automatisierung konkreter, bisher nur manuell lösbarer Probleme des Layoutentwurfs von Hochfrequenzschaltungen. Die Arbeit zeigt das Potential kontextbasierter PCells für die weitere Steigerung des Automatisierungsgrades im analogen Layoutentwurf.
Digitization is the use of digital technologies for creating innovative digital business models and transforming existing business models, processes and systems. Digitization creates profound changes in the economy and society. Information is often captured and processed without human intervention using digital means. Digitization impacts nearly all products and services as well as the customer and the value-creation perspective.
A procedural approach to automate the manual design process in analog integrated circuit design
(2018)
This paper presents a novel approach to automating the design of analog integrated circuits: (1) the Expert Design Plan (EDP), a procedural generator, and (2) the EDP Language, a high-level description language for writing an EDP. An EDP is a parameterizable, executable script, which reproduces a designer’s course of action when designing a circuit. Thus, an EDP formalizes the design expert’s knowledge-based strategy and makes it reusable. Since it is essential that an EDP represents a circuit designers’ way of thinking and working as close as possible, the designers themselves should be enabled to create the EDP. Therefore, our approach provides a input method through a domain-specific language called EDP Language (EDPL). Using this language is intuitive and requires no special training. In an exemplary implementation of our approach, a common-source amplifier is automatically sized using a set of only 10 instructions. Even in the first usage our EDP approach has appeared to be more efficient than the manual sizing process.