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Case study: EMP
(2018)
The purpose of this research paper is to investigate the business model of the retailer EMP. The in-depth literature review develops the relevance of merchandising for the rock and heavy metal scene and the relevance of EMP within that market. Literature about existing approaches of multi-channelling has been reviewed. Based on this theoretical framework, a case study of EMP has been drafted. Findings are discussed, focusing on the performance of EMP as a multi-channel and lifestyle retailer and additionally provide valuable managerial implications for fashion retailers. Implications for further research address lifestyle retailers to contribute to the findings or validate them with different examples. The research is clearly limited by the amount of scholar literature concerning EMP in particular. Hence, magazines, journals and information provided by the company serve as reference. Even though EMP provided some information, gathering any information about how EMP manages multi channelling operationally was not possible.
This article aims to point out main changes of the music industry since the advent of the Internet and how the fashion industry can learn from it. Different factors are researched with a birds-eye perspective by conducting a literature review. The results are limited by the availability of sources and the implications are based on a theoretical foundation. For further research the conclusions drawn for the fashion industry have to be proven empirically. After reading the paper, the reader has rather an overview of the changed circumstances and how the music industry reacted than deep knowledge in each field. More specifically, this paper gives an overview of the changed circumstances due to digitalisation and how the music industry reacted within. As both the fashion and music industry have their similarities, they are limited in their comparability, since fashion products cannot be fully digitalized like a music record. The fact that the music industry had to reinvent itself rapidly to adopt new possibilities and chances results from the article. To make use of the sustainability trend and to build communities in order to include them in the creation process are the major suggestions for the fashion industry.
Die Digitalisierung von Arbeitswelt und Führung ist eine der aktuell zentralen Herausforderungen für Organisationen. Ein Resultat der Beschäftigung des AK Unternehmensführung mit diesem Thema war die Erkenntnis, dass eine holistische und integrative Perspektive auf das Thema erforderlich ist. Mit dem in diesem Beitrag vorgeschlagenen konfigurationstheoretischen Ansatz kann es künftig besser gelingen, die Zusammenhänge und Wechselwirkungen verschiedener Dimensionen und Elemente der digitalen Organisation und deren Auswirkungen auf Arbeit und Führung zu verstehen.
Vom 3D-Druck über Tumorzellen bis hin zur Energieversorgung - die erste Ausgabe des Forschungsmagazins re:search gibt einen Überblick über die Forschungsthemen der Hochschule Reutlingen. Ein Schwerpunkt der Ausgabe ist die Energiewende, an der die Mitglieder des Reutlinger Energiezentrums mit Hochdruck forschen. Über die Herausforderungen für Netzbetreiber und die Zukunft der Energiemärkte haben wir mit Klaus Saiger gesprochen, Geschäftsführer der Reutlinger FairNetz GmbH. Professor Alexander Sauer, Leiter des Instituts für Energieeffizienz in der Produktion an der Universität Stuttgart und Professor Stefan Tenbohlen, Leiter des Instituts für Energieübertragung und Hochspannungstechnik, haben mögliche Lösungswege für uns skizziert.
Fashion & music
(2018)
This book will broaden readers’ understanding of the links between the music and fashion industries. It highlights the challenges currently facing the fashion industry in terms of hyper-competition, definition of ever faster trends, changing consumer demands etc. In fact, the fashion industry is heavily influenced by the digital revolution in the music industry, which has changed the face of individual music consumption and social reference, and therefore, also has impacts on fashion consumption and social reference. This understanding is crucial in order to realign any fashion company’s strategies to the demands of modern fashion consumers. In terms of content, the book first discusses the social perspective of fashion and music. This includes an analysis of music as a key influencer of fashion trends, both theoretically and on the basis of a case study on grunge music. Then the role of music in the fashion business is addressed, and covers in-store music and the role of music in fashion communication. Following up, the role of fashion in the music business is analyzed. This includes the trend of co-design of fashion collections, music artists’ role of differentiation by style, and the market for music fashion merchandise articles (both theoretically and drawing on a case study). In closing, potential lessons learned from the music industry are developed for the fashion industry. This includes an analysis of the digital revolution and the advent of the crowdfunding idea (both theoretically and in a case study).
The purpose of this paper is to give an overview about the links between the fashion and music industry. It focuses on the idea that digitalization has broken the rules of the traditional music industry value chain. This touches both the production and the consumption side of music. This change finally also has an intense impact on the fashion industry, as the music industry has been big supplier of fashion trends itself. The absence of this supplier plus the changes within the fashion industry itself by the fast-fashion development are considered as a reason for more competition and therefore price pressure. An in-depth future research about the fashion and music system is therefore required to develop answers for the current situation. This article should be interpreted more as a personal viewpoint of the author to this topic rather than a research paper based on the usual methodological criteria.
Purpose of the present research paper is to examine the current state of research, define dimensions of research and reveal gaps in research on the topic of ‘Fashion and music’. To do so, the methodology of a scientific literature review was applied. The literature review revealed that music and its business mainly serve the fashion industry as influencer on trends, image building marketing tool, support of fashion processes and contributor to the development of innovative fashion products. Both industries provide identify-forming features, unify their mutual target groups in a certain lifestyle and thus enlarge their own target market. This results in increased brand awareness, image and credibility, emotionalized brand experience, differentiation and sophisticated brand identity. The present paper can serve as the basis for further research. It is limited by the time, depth and availability of data collection, the predominance of grey literature and its focus on the modern relationship of fashion and music.
Aim of this paper is to provide an understanding to which extent music and fashion interdepend and interact referring to the music and fashion trend development, focusing the period from 1950 till today. It further helps the reader to gain an insight if the technology provided influences the development and the access of music and fashion in future. The research for this paper required the use of secondary sources including library and online research. The goal was to gather information about the former and current development of music and fashion. These methods were the best alternatives of secondary sources as they provided trusted results thus enhancing the accuracy of the data being collected. But however they were also limited since mainly data for the fashion and music development of the noughties were limited. This is explainable by the key finding that the development of this time is not as distinct as the one of the former times, when a fashion trend came along with a new music genre or hit, which implies that fashion and music correlate to a certain extent, but characterized by a reactivation of the music and fashion trends of previous times without any new inventions.
This paper is purposed to examine the impact of grunge music on fashion and to explain how grunge music is reflected in grunge style. The research methodology applied is a case study on grunge music and grunge style. Key findings suggest that different elements of grunge music had a great impact on the evolution of grunge style: Mentality and philosophy of the movement, musical style and sound as well as lyrical concerns are incorporated by grunge style. Commercial exploitation of grunge partly led to its downfall. Moreover, the original spirit of the movement is not commonly shared by all sub-genres’ respective contemporary styles. Musicians had great impact on the evolution of grunge style and unintentional rose to style icons. The research is limited by the amount of academic literature concerning the connection between grunge music and grunge style. Therefore, journal entries and blogs are used as reference as well.
The purpose of this paper is to identify the role of in-store music in the fashion retail environment and to describe music as an atmospheric building tool in order to influence customer behaviour with emotions created by musical compositions. As offline retailer try to differentiate their stores through shopping experiences, atmospherics like visuals, scent and sound are appropriate tools to reinforce brand image and therefore customers’ willingness to enter, explore and purchase. Music can be a powerful primary element in creating or enhancing sensory experiences of shoppers and serves as a powerful connection to emotions. Focus of the literature review lies on the emotions which are triggered though different musical characteristics and then affect the customer behaviour. The paper offers a concisely presented review and highlights crucial aspects on what role in-store music has on customers’ perception of atmosphere, emotions and behaviour.
Music is omnipresent and an important factor for cultural and social development. Thus, the connection between music and fashion has rarely been contemplated yet. In particular, this research paper is concerned with the connection between music and fashion communication, with special interest to its emotional background in the context of neuromarketing. The research question of how music affects the perception of a fashion brand, when regarded as emotional stimulus in the context of neuromarketing, has been investigated by researching existing literature. Without attempting to explain neurological processes to their core, this paper tries to give an overview of how music generates emotion and how this can be used for branding activities. This led to the result that music causes positive emotional response of the consumer, when used in marketing actions. Through emotional response, the perception, identity, and recall of a brand are strongly influenced.
Co-design and endorsement
(2018)
The purpose of this paper is to determine the success factors regarding celebrities of the music business involved in fashion advertising. That famous people have the power to help brands and products to stand out among others is proven and popular. This paper is concentrating on successful musicians and their endorsements of fashion brands and examines the benefits for both, the brand and the artist. It investigates how consumer perceives brand and artist collaboration and what factors enhance the purchase intention and increase sales. This paper is structured in the following manner: The introduction presents the research question and sets the aim for the paper, followed by the analysis of the existing literature. The paper ends with conclusions, limitations and suggestions for further research.
The purpose of this paper is to find out how musicians are able to differentiate themselves from their competitors by using their style. Casting shows and the evolution of the contestants’ style during and after the show serve as a paradigm for creating differentiation by style. The method of research was diverse but largely drawn from research papers as well as online magazines and newspapers. Within the scope of the research, it was feasible to draw on a varied range of sources to answer the research question. In the course of this research paper, it was possible to define key factors for a musician to create differentiation by style in modern times. By examining the style of casting show contestants, it was explored to which extent they transform from rather normal people to pop stars. In reducing the detailed analysis of casting shows to three shows and contestants, only a broad overview was provided. The paper is of interest to those working for casting shows in order to develop those.
The purpose of this research paper is to find out to which extent rap music merchandise is influencing the fashion world of today. The research design is mainly created through analysing Internet sources. The key findings of this paper describe the way rap merchandise is created and distributed nowadays. Furthermore, is explained how an idea becomes trend and how rap artists influence trend creation, especially through social media channels. The topic around rap merchandising products and strategies is a very new one, thus there is barely any literature to find. Nevertheless, trend leading online music platforms and blogs offer a lot of grey literature about the research topic. In this paper, the analysis of rap merchandise and fashion is focused on clothing items to create a better understanding in which dimension the influence of rap merchandise on the fashion world is given.
The purpose of this paper is to identify key success factors of Crowdfunding in the Music Business in order to discuss their applicability to the Fashion Industry. The research methodology applied is a literature review examining academic and non-academic references. Key research findings include four main success factors. First explains the innovative and adaptive nature of the music industry caused by historical evolution. Second strong commitment and connection to the fan base is identified as success factor. Third manageable effort for the realisation on a large scale reduces the risk of a failure. And, last success factor describes the successful implementation of campaign specific aspects. The discussion finally shows that three of four success factors can be adapted to the Fashion Business. Due to little scientific research in the field of Crowdfunding in the Music Business, the success factors are worked out independently, based on general literature. Accordingly, quantitative testing and further analysis is recommended.
Case study: Marillion
(2018)
The purpose of this paper is to highlight the use of crowdfunding,
demonstrated by a case study about the rock band Marillion. The research
methodology applied is a literature review examining academic references. On this basis, a case study by exemplary illustrating the rock band Marillion and how they invented crowdfunding has been drafted. Findings suggest that the crowdfunding concept is no new phenomenon, since the rock band Marillion has investigated the business model. Recently, the funding method is applied to the fashion industry; hence it is efficient and engaging to finance projects by that specific business model. A limitation of this paper is that the topic of crowdfunding is new to the fashion business and needs further research and tests until they are practicable to interpret. Results show that there is a high potential for using crowdfunding in fashion by reaching a long-term change in this industry.
Empirical software engineering experts on the use of students and professionals in experiments
(2018)
Using students as participants remains a valid simplification of reality needed in laboratory contexts. It is an effective way to advance software engineering theories and technologies but, like any other aspect of study settings, should be carefully considered during the design, execution, interpretation, and reporting of an experiment. The key is to understand which developer population portion is being represented by the participants in an experiment. Thus, a proposal for describing experimental participants is put forward.
Rational strain engineering requires solid testing of phenotypes including productivity and ideally contributes thereby directly to our understanding of the genotype-phenotype relationship. Actually, the test step of the strain engineering cycle becomes the limiting step, as ever advancing tools for generating genetic diversity exist. Here, we briefly define the challenge one faces in quantifiying phenotypes and summarize existing analytical techniques that partially overcome this challenge. We argue that the evolution of volatile metabolites can be used as proxy for cellular metabolism. In the simplest case, the product of interest is a volatile (e.g., from bulk alcohols to special fragrances) that is directly quantified over time. But also nonvolatile products (e.g., from bulk long-chain fatty acids to natural products) require major flux rerouting that result potentially in altered volatile production. While alternative techniques for volatile determination exist, rather few can be envisaged for medium to high-throughput analysis required for phenotype testing. Here, we contribute a detailed protocol for an ion mobility spectrometry (IMS) analysis that allows volatile metabolite quantification down to the ppb range. The sensivity can be exploited for small-scale fermentation monitoring. The insights shared might contribute to a more frequent use of IMS in biotechnology, while the experimented aspects are of general use for researchers interested in volatile monitoring.
Kleider machen Drummer
(2018)
Nicht nur Songs machen Musiker bekannt, sondern auch ihr Look: David Bowie, Kurt Cobain, Madonna, Elvis Presley haben durch ihre Musik und ihren Kleidungsstil ganze Generationen geprägt. Viele Drummer legen sehr viel Wert auf Technik - doch wenn man in der Musikbranche erfolgreich sein will, sollte man sich auch seiner Wirkungsweis bewusst sein.
A case study with four German fashion retail brands was conducted in order to measure the performance of their Omnichannel services. In detail, their Click & Collect service was analyzed. Click & Collect is one of the first introduced Omnichannel services in fashion retailing. Omnichannel services integrate different sales and communication channels providing a seamless customer journey experience. Offline, online, and mobile app customer experiences should provide a seamless customer experience. Omnichannel performance of the four retailers Decathlon, Hunkemöller, Massimo Dutti and Galeria Kaufhof was measured via mystery shopping. A seamless customer journey experience is not yet a standard in German fashion retailing. The four companies differ in many process details. The biggest market potential and the recommendation for further research emerges in deficits of the offline store Omnichannel customer experience. Here, all four case companies have room to improve. Best overall results regarding the integration of offline, online and mobile shops were found with Hunkemöller, followed by Decathlon, Massimo Dutti, and Galeria Kaufhof.
Radiofrequency ablation is an ablation technique to treat tumors with focused heat. Computer tomography, ultrasound and magnetic resonance imaging (MRI) are imaging modalities which can be used for image-guided procedures. MRI offers several advantages in comparison to the other imaging modalities, such as radiation-free fluoroscopic imaging, temperature mapping, a high-soft-tissue contrast and free selection of imaging planes. This work addresses the application of 3Dcontrollers for controlling interventional, fluoroscopic MR sequences at the scenario of MR guided radiofrequency ablation of hepatic malignancies. During this procedure, the interventionalist can monitor the targeting of the tumor with near-real time fluoroscopic sequences. In general, adjustments of the imaging planes are necessary during tumor targeting, which is performed by an assistant in the control room. Therefore, communication between the interventionalist in the scanner room and the assistant in the control room is essential. However, verbal communication is impaired due to the loud scanning noises. Alternatively, non-verbal communication between the two persons is possible, however limited to a few gestures and susceptible to misunderstandings. This work is analyzing different 3D-controllers to enable control of interventional MR sequences during MR-guided procedures directly by the interventionalist. Leap Motion, Wii Remote, SpaceNavigator, Phantom Omni and Foot Switch were selected. For that a simulation was built in C++ with VTK to feign the real scenario for test purposes. Previous results showed that Leap Motion is not suitable for the application while Wii Remote and Foot Switch are possible input devices. Final evaluation showed a generally time reduction with the use of 3D-controllers. Best results were reached with Wii Remote in 34 seconds. Handholding input devices like Wii Remote have further potential to integrate them in real environment to reduce intervention time.
Marketing ist allgegenwärtig! Es begegnet Ihnen im Supermarkt, in Onlineshops und in sozialen Medien. Doch was steckt konkret hinter dem Marketing und wie gestalten Unternehmen es erfolgreich? Auf diese und weitere Fragen geht das Buch im Detail ein. Zu Beginn vermittelt es Grundlagen zum Konsumentenverhalten, zum Kaufprozess und zur persönlichen Kaufentscheidung. Vor diesem Hintergrund erläutert es Ziele und Maßnahmen der strategischen Marketingplanung. Darauf aufbauend präsentiert es Aspekte einer operativen Marketingplanung und diskutiert die Marken-, Produkt-, Distributions-, Kommunikations- sowie Preispolitik ausführlich. Marketingprofis geben Einblicke in die Praxis. Ein Best Practice-Beispiel macht das Gelernte schnell (be)greifbar.
Nachdem Unternehmen Klarheit über das Kundenverhalten und die damit zusammenhängenden Determinanten haben, gilt es, in einem zweiten Schritt eine Strategie auszuarbeiten, die die bestmögliche Befriedigung der Kundenbedürfnisse in den Mittelpunkt des Handelns setzt. Je besser dieses den Unternehmen gelingt, umso besser lassen sich damit deren eigene Ziele verwirklichen. Dabei gilt es zunächst, einen Marketingplan zu entwickeln.
Das vorliegende Buch ist als eine zusammenfassende Bearbeitung der über viele Jahre gesammelten Erkenntnisse im Bereich der Schussfadenzugkraftmessung entstanden. Für die Schusseintragstechniken mit Greifern, Projektilen und Luftstrahl ist es gelungen, Formeln zur Berechnung der Schussfadenzugkräfte zu erarbeiten, die es auch dem Weberei-Praktiker ermöglichen, die maximalen Schussfadenzugkräfte mit guter Genauigkeit voraus zu berechnen. Ausgehend von diesen Ergebnissen kann über einen Vergleich mit dem Schwachstellenniveau des Schussgarns die Entscheidung über die Einsatzfähigkeit des Schussgarns auf der vorgesehenen Webmaschine oder über die Einsatzfähigkeit der vorgesehenen Webmaschine selbst bei der gewünschten Drehzahl herbeigeführt werden.
Es wird eine Möglichkeit zur Quantifizierung der Schädigung von Geweben bei der Martindale-Flachscheuerung vorgestellt, die eine interessante Möglichkeit darstellt, vergleichende Untersuchungen durchzuführen, auch wenn die Gewebe nicht bis zu einem Fadenbruch gescheuert werden. Die Untersuchungen deuten außerdem eine Skalierbarkeit der Scheuerversuche bei unterschiedlichen Anpressdrücken an. Sollte sich diese Beobachtung in weiteren Untersuchungen bestätigen, würde dies eine grundlegende Vereinfachung der Scheuerprüfung für verschiedene Anwendungen bedeuten.
Im Zuge von REACH wurden gängige hocheffektive halogenierte Flammschutzmittel verboten, da diese unter dem Verdach stehen, kanzerogen, mutagen und teratogen zu sein. Zur Zeit fehlen entsprechende Alternativen. Daher werden am DTNW neue umweltfreundliche und halogenfreie Flammschutzmittel auf der Basis von Phosphor- und Stickstoffverbindungen entwickelt, um einen entsprechenden Flammschutz zu gewährleisten. Neue Möglichkeiten werden im Rahmen dieses Artikels vorgestellt.
Perceptual integration of kinematic components in the recognition of emotional facial expressions
(2018)
According to a long-standing hypothesis in motor control, complex body motion is organized in terms of movement primitives, reducing massively the dimensionality of the underlying control problems. For body movements, this low dimensional organization has been convincingly demonstrated by the learning of low-dimensional representations from kinematic and EMG data. In contrast, the effective dimensionality of dynamic facial expressions is unknown, and dominant analysis approaches have been based on heuristically defined facial ‘‘action units,’’ which reflect contributions of individual face muscles. We determined the effective dimensionality of dynamic facial expressions by learning of a low dimensional model from 11 facial expressions. We found an amazingly low dimensionality with only two movement primitives being sufficient to simulate these dynamic expressions with high accuracy. This low dimensionality is confirmed statistically, by Bayesian model comparison of models with different numbers of primitives, and by a psychophysical experiment that demonstrates that expressions, simulated with only two primitives, are indistinguishable from natural ones.
In addition, we find statistically optimal integration of the emotion information specified by these primitives in visual perception. Taken together, our results indicate that facial expressions might be controlled by a very small number of independent control units, permitting very low dimensional parametrization of the associated facial expression.
Makerspaces sind ein Element einer Open Innovation und bieten die Möglichkeit, den „klassischen Erfinder“ und „Tüftler“ aus seiner Garage, seinem Keller oder seiner Werkstatt herauszuholen. Ziel dabei ist es, ihm ein professionelles und leistungsfähiges Umfeld zur Realisierung seiner Ideen zu bieten, ihn in den Austausch mit Gleichgesinnten zu bringen und eine Verwertungsplattform für die entwickelten Ideen und Prototypen aufzubauen. Diese Optionen sind auch kleinen und mittelständischen Unternehmen zugänglich zu machen, um ihnen darüber die Möglichkeit zu geben, mit ihren zur Verfügung stehenden Mitteln, ähnlich wie Großunternehmen in Sachen Innovation und Kooperation vorzugehen.
Genau hier setzt die vorliegende Studie an und geht der Frage nach den Anforderungen kleiner und mittelständischer Unternehmen an Makerspaces auf den Grund.
In a corporation’s financial life “going public” by means of an IPO is probably the single most important decision. It turns a private company into a public one. Our book will provide an inside view of the IPO process. On the one hand, it draws on the insights of an experienced investment banker, who has gone through numerous IPO transactions. On the other hand, it relates the story of an actual IPO through the eyes of a Chief Executive Officer who has taken two of his companies public. This unique double perspective is our book’s defining feature. We do not discuss initial public offerings in a textbook style fashion. What we would like to bring out is a more comprehensive portrayal of a “once-in-a-lifetime” event for most companies and their management, alike.
Das Ziel dieses Beitrags ist es, einen Überblick zum Thema Kundenbewertung im Sport zu geben. Unter Berücksichtigung der Besonderheiten des Sports aus Marketing-Sicht sowie der wesentlichen Grundlagen des Relationship Marketing im Sport werden der Begriff Kundenwert definiert sowie die Ziele der Kundenbewertung vorgestellt. Vor diesem Hintergrund werden etablierte Methoden der Kundenbewertung aus der Unternehmenspraxis präsentiert. Hierzu gehören die ABC-Analyse, die Kundenerfolgsrechnung, die Customer-Lifetime-Analyse, Scoring-Modelle und Portfolio-Analysen. Diese Verfahren werden insbesondere auf ihre Eignung zur Kundenbewertung im Rahmen des CRM in Sportvereinen analysiert und kritisch gewürdigt.
Der erweiterte Marketing-Mix eröffnet neue Perspektiven für das Sportmarketing. Menschen werden als die wichtigsten Bestandteile einer Sportorganisation betrachtet. Ziel ist es, tragfähige Strategien zu entwickeln, um die Kundenbedürfnisse zu erfüllen. Im Folgenden wird der erweiterte Marketing-Mix des Relationship Marketing im Sport ausführlich vorgestellt.
Ein zukunfts- und innovationsfähiges Personalmanagement stellt sicher, dass der Organisation in qualitativer und quantitativer Hinsicht das erforderliche Personal zur Verfügung steht, um die organisationalen Ziele zu erreichen. Vor dem Hintergrund zunehmend dynamischer Umfelder gelingt dies mit den bislang etablierten Arbeitsweisen, Praktken und Instrumenten des Personalmanagements künftig nicht mehr. Daher muss das Personalmanagement permanent neue Arbeitsweisen, innovative Praktiken und neue Instrumente entwickeln (Exploration). Gleichzeitig hat es jedoch auch die bisherigen "Routineaufgaben" zunehmend effizienter zu erledigen (Exploitation). Diese Herausforderung des beidhändigen Agierens zwischen Exploration und Exploitation verlangt nach dezidierten Innovationsstrukturen, Praktiken und Fähigkeiten im Personalmanagement. Der vorliegende Beitrag plädiert daher für eine organisatorisch aufgehängte "Forschung und Entwicklung" im Personalbereich, die neue Themen innerhalb und außerhalb der Organisation aufgreift, um daraus innovative Personalpraktiken zu generieren.
§ 303 Schuldenkonsolidierung
(2018)
So far, only few authors addressed the serum-free, defined differentiation of adipocytes. And there are hardly any trials available on the defined maintenance of adipocytes. In this study, the development of a defined culture medium for the adipogenic differentiation of primary human adipose-derived stem cells (ASCs) was aimed. Based on the addition of specific factors for the replacement of serum, ASCs were differentiated to viable and characteristic adipocytes for 14 days, which was proven through the accumulation of lipids, the expression of perilipin A and by the release of leptin and glycerol. Furthermore, a defined maintenance medium was developed, which supported the maturation and stability of cells for a long-term period of additional 42 days until day 56.
A series of novel biomedical TPCUs with different percentages of hard segment and a silicone component in the soft segment were synthesized in a multi stage one-pot method. The kinetic profiles of the urethane formation in TPCU-based copolymer systems were monitored by rheological, in line FTIR spectroscopic (React IR) and real-time calorimetric (RC1) methods. This process-analytically monitored multi step synthesis was successfully used to optimize the production of medical-grade TPCU elastomers on preparative scale (in lots of several kg) with controlled molecular structure and mechanical properties. Various surface and bulk analytical methods as well as systematic studies of the mechanic response of the elastomer end-products towards compression and tensile loading were used to estimate the bio-stability of the prepared TPCUs in vitro after 3 months. The tests suggested that high bio-stability of all polyurethane formulations using accelerating in vitro test can be attributed to the synthetic design as well as to the specific techniques used for specimen preparation, namely: (1) the annealing for reducing residual polymer surface stress and preventing IES, (2) stabilization of the morphology by long time storage of the specimens after processing before being immersed in the test liquids, (3) purification by extraction to remove the shot chain oligomers which are the most susceptible to degradation. All mechanical tests were performed on cylindrical and circular disc specimens for modelling the thickness of the meniscus implants under application-relevant stress conditions.
Workshops and tutorials
(2018)
The 19th International Conference on Product-Focused Software Process Improvement (PROFES 2018) hosted two workshops and three tutorials. The workshops and tutorials complemented and enhanced the main conference program, offering a wider knowledge perspective around the conference topics. The topics of the two workshops were Hybrid Development Approaches in Software Systems Development (HELENA) and Managing Quality in Agile & Rapid Software Development Processes (QUaSD). The topics of the tutorials were The human factor in agile transitions – using the personas concept in agile oaching, Process Management 4.0 – Best Practices, and Domain-specific languages for specification, development, and testing of autonomous systems.
Lots of movies are produced every year, too many to watch all of them and in particular, to get an overview about the evolution of typical movie genres and actors playing in them. Moreover, it is a challenging problem to detect correlations among the movies and the actors in those movies, in particular, if we are interested in time-varying data patterns like trends, countertrends, or anomalies and outliers. Those correlations are specifically interesting if they can be inspected on different levels of granularity, e.g., temporal, but also hierarchical in form of country- or continent-based correlations. In this paper we describe the IMDb Explorer, a webbased visualization tool that consists of two major views denoted by the movie cosmos and the career lines. Both views are linked and interactively manipulable while a list of user-defined metrics are explorable. We illustrate the usefulness of the visualization tool by applying it to the entire movie database provided by IMDb.
Zur Entwicklung einer Sofortpreiskalkulation für CNC-Drehteile werden Machine-Learning-Ansätze sowie ein deterministischer Algorithmus untersucht. Der deterministische Algorithmus funktioniert ausschließlich für Drehteile mit geringer Komplexität. Die Machine Learning Modelle hingegen sind zukunftsfähiger, da die ersten Ergebnisse bereits sehr geringe Abweichungswerte zu den festgelegten Referenzpreisen erreichen können. Mit steigendem Datenaufkommen können beide Machine-Learning-Modelle mit geringem Aufwand weiter verbessert werden.
The current paper studies the influence of geometrical parameters of the fused deposition modeling (FDM) - fused filament fabrication (FFF) 3D printing process on printed part strength for open source desktop 3D printers and the most popular material used for that purpose - i.e., polylactic acid (PLA). The study was conducted using a set of different nozzles (0.4, 0.6, and 0.8 mm) and a range of layer heights from the minimum to maximum physical limits of the machine. To assess print strength, a novel assessment method is proposed. A tubular sample is loaded in the weakest direction (across layers) in a three point bending fixture. Mesostructure evaluation through scanning electronic microscopy (SEM) scans of the samples was used to explain the obtained results. We detected a significant influence of geometric process parameters on sample mesostructure, and consequently, on sample strength.
Properties data of phenolic resins synthetized for the impregnation of saturating Kraft paper
(2018)
The quality of decorative laminates boards depends on the impregnation process of Kraft papers with a phenolic resin,which constitute the raw materials for the manufacture of the cores of such boards.In the laminates industries,the properties of resins are adapted via their syntheses,usually by mixing phenol and formaldehyde in a batch,where additives,temperature and stirring parameters can be controlled. Therefore, many possibilities of preparation and phenolic resins exist, that leads to different combinations of physico chemical properties. In this article, the properties data of eight phenolic resins synthetized with different parameters of pH and reaction times at 60 °C and 90 °C are presented: the losses of pH after synthesis and the dynamic viscosities measured after synthesis and one the solid content is adjusted to 45%w/w in methanol. Data aquired by Differential Scanning Calorimetry (DSC) of the resins and Inverse Gas Chromatography (IGC) of cured solids are given as well.
This article contains data on the synthesis and mechanical characterization of polysiloxane-based urea-elastomers (PSUs) and is related to the research article entitled “Influence of PDMS molecular weight on transparency and mechanical properties of soft polysiloxane-urea-elastomers for intraocular lens application” (Riehle et al., 2018) [1]. These elastomers were prepared by a two-step polyaddition using the aliphatic diisocyanate 4,4′-Methylenbis(cyclohexylisocyanate) (H12MDI), a siloxane-based chain extender 1,3-Bis(3-aminopropyl)-1,1,3,3-tetramethyldisiloxane (APTMDS) and amino-terminated polydimethylsiloxanes (PDMS) or polydimethyl-methyl-phenyl-siloxane-copolymers (PDMS-Me,Ph), respectively. (More details about the synthesis procedure and the reaction scheme can be found in the related research article (Riehle et al., 2018) [1]).
Amino-terminated polydimethylsiloxanes with varying molecular weights and PDMS-Me,Ph-copolymers were prepared prior by a base-catalyzed ring-chain equilibration of a cyclic siloxane and the endblocker APTMDS. This DiB article contains a procedure for the synthesis of the base catalyst tetramethylammonium-3-aminopropyl-dimethylsilanolate and a generic synthesis procedure for the preparation of a PDMS having a targeted number average molecular weight of 3000 g mol−1. Molecular weights and the amount of methyl-phenyl-siloxane within the polysiloxane-copolymers were determined by 1H NMR and 29Si NMR spectroscopy. The corresponding NMR spectra and data are described in this article.
Additionally, this DiB article contains processed data on in line and off line FTIR-ATR spectroscopy, which was used to follow the reaction progress of the polyaddition by showing the conversion of the diisocyanate. All relevant IR band assignments of a polydimethylsiloxane-urea spectrum are described in this article.
Finally, data on the tensile properties and the mechanical hysteresis-behaviour at 100% elongation of PDMS-based polyurea-elastomers are shown in dependence to the PDMS molecular weight.
Rattern unerwünscht
(2018)
Die Mesago Messe Frankfurt als Veranstalter der Formnext 2018 haben von Prof. Dr.-Ing. Steffen Ritter von der Hochschule Reutlingen eine anschauliche Übersicht erstellen lassen, welche die Vielfalt der unterschiedlichen Verfahren zur additiven Fertigung verständlich erklärt. Die kleine, zweisprachige Broschüre mit dem Titel „AM Field Guide“ bietet auf 12 Seiten strukturierte Vergleichsdarstellungen von insgesamt 19 gängigen 3-D-Druck Technologien für Kunststoffe, Metalle sowie andere Werkstoffe und dazu noch einen Überblick über die Phasen und Prozessschritte in Projekten für Bauteile, die additiv hergestellt werden.
Nowadays robust, energy-efficient multisensor microsystems often come with heavily restricted power budgets and the characteristic of remaining in certain states for a longer period of time. During this time frame there is no continuous clock signal required which gives the opportunity to suspend the clock until a new transition is requested. In this paper, we present a new topology for on-demand locally clocked finite state machines. The architecture combines a local adaptive clocking approach with synchronous and asynchronous components forming a quasi synchronous system. Using adaptive and local clocking comes with the advantages of reducing the power consumption while saving design effort when no global clock tree is needed. Combining synchronous and asynchronous components is beneficial compared to previous fully asynchronous approaches concerning the design restrictions. The developed topology is verified by the implementation and simulation of a temperature-ADC sensor system realized in a 180 nm process.
Functionalised particles are highly requested in materials research, as they can be used as vital components in many advanced applications such as smart materials, functional coatings, drug carrier systems or adsorption materials. In this study, furan-functionalised melamine-formaldehyde (MF) particles were successfully prepared for the first time using an organic sol-gel process. Commercially available 2-Aminomethylfuran (AMF) and 2-Aminomethyl-5-methylfuran (AMMF) were used as modifying agents. In the isolated polymer particles, a melamine (M) to modifying agent ratio of M:AMF mol/mol 2.04:1 and M:AMMF ratio of mol/mol 1.25:1 was used. The obtained particles were isolated in various centrifugation and re-dispersion cycles and analysed using ATR-FT-IR, Raman and solid state 13C NMR spectroscopy, TGA, SEM and DSC measurements. Upon functionalisation the size of the MF particles increased (MF 1.59 µm, 27% CV (coefficient of variation); MF-AMF 2.56 µm, 25% CV; MF-AMMF 2.20 µm, 35% CV). DSC measurements showed that another type of exothermic residual reactivity besides condensation-based curing takes place with the furan-modified particles that is not related to the liberation of volatile compounds. The newly obtained particles are able to undergo Diels-Alder reactions with maleimide groups. The characteristic IR and Raman absorbance bands of the reaction products after the particles were reacted with 4,4′-Diphenylmethanebismaleimide reagent confirm the formation of a Diels-Alder adduct.
Impact of phenolic resin preparation on its properties and its penetration behavior in Kraft paper
(2018)
The core of decorative laminates is generally made of stacked Kraft paper sheets impregnated with a phenolic resin. As the impregnation process in industry is relatively fast, new methods need to be developed to characterize it for different paper-resin systems. Several phenolic resins were synthesized with the same Phenol:Formaldehyde ratio of 1:1.8 and characterized by Fourier Transform Infrared Spectrometry (FTIR) as well as Size-Exclusion Chromatography (SEC). In addition, their viscosities and surface tensions when diluted in methanol to 45% of solid content were measured. The capacity of each resin to penetrate a Kraft paper sheet was characterized using a new method, which measures the conductivities induced by the liquid resin crossing the paper substrate. With this method, crossing times could be measured with a good accuracy. Surprisingly, the results showed that the penetration time of the resin samples is not correlated to the viscosity values, but rather to the surface tension characteristics and the chemical characteristics of paper. Furthermore, some resins had a higher swelling effect on the fibers that delayed the crossing of the liquid through the paper.
Im Vergleich zum digitalen Layoutentwurf weist der analoge Layoutentwurf einen wesentlich geringeren Automatisierungsgrad auf. Dies gilt insbesondere für den Layoutentwurf von Hochfrequenzschaltungen, wo Einflüsse der lokalen Layoutumgebung besonders zu berücksichtigen sind. Bei dieser sog. Kontextabhängigkeit geraten sowohl Optimierungsalgorithmen als auch herkömmliche Generatoransätze schnell an Grenzen. In dieser Arbeit wird eine funktionale Erweiterung des bekannten Generatorprinzips eingesetzt, die es erlaubt, Informationen aus der Layoutumgebung der Instanz in die Layoutgenerierung einzubeziehen. Mit dieser sog. kontextbasierten PCell gelingt die Automatisierung konkreter, bisher nur manuell lösbarer Probleme des Layoutentwurfs von Hochfrequenzschaltungen. Die Arbeit zeigt das Potential kontextbasierter PCells für die weitere Steigerung des Automatisierungsgrades im analogen Layoutentwurf.
Este trabajo se enmarca dentro del vasto contexto de Ciudades Inteligentes, y se centra en el área de la conducción inteligente de vehículos, tanto en zonas urbanas como interurbanas, mediante la recogida de datos en tiempo real, medidos con sensores, por parte de los propios conductores, así como de datos capturados mediante simulación.
El objetivo de este trabajo es doble. Por un lado, el estudio y aplicación de las diferentes técnicas y métodos de detección de valores atípicos en bases de datos multivariantes, además de una comparativa entre ellos mediante las pruebas llevadas a cabo con datos de tráfico real. Y por otro lado, establecer una relación entre las situaciones anómalas de tráfico, como puedan ser atascos o accidentes, con los valores atípicos multivariantes encontrados.
La detección de valores atípicos representa una de las tareas más importantes a la hora de realizar cualquier análisis de datos, sea cual sea el dominio o área de estudio, ya que entre sus funciones primordiales se encuentra el descubrir información útil, que resulta de gran valor, y que por lo general queda oculta por la alta dimensión de los datos.
Con el uso de mecanismos de detección de valores atípicos junto con métodos de clasificación supervisada, se va a poder llevar a cabo el reconocimiento de elementos de la infraestructura vial urbana como pueden ser rotondas, pasos de cebra, cruces o semáforos.
Der spartenübergreifende BDI-Arbeitskreis Internet der Energie hat voraussichtliche Veränderungen durch Künstliche Intelligenz (KI) auf die Bereiche Energie und Klima analysiert und den möglichen Beitrag von KI zur Lösung anstehender Herausforderungen in diesen Bereichen erörtert. KI kann einen wesentlichen Beitrag zum Gelingen der Energiewende in Deutschland leisten. Der Energiesektor ist ein zentraler Bestandteil der deutschen Wirtschaft und daher auch in diesem Kontext äußerst relevant.
This paper presents a dc–dc converter for integration in the power management unit of an ultra-low power microcontroller. The converter is designed to significantly reduce the wake-up energy and startup delay of the supplied core. The use of a minimized output capacitor is the key factor to save the wake-up energy. The converter is buffered with only 56 nF and guarantees a stable output of 1.2 V with a voltage ripple smaller than 30 mV. The controller of the proposed dc–dc converter is based on a predictive peak current control that allows the system to control the energy transfer at extremely low power consumption. The proposed circuit is implemented in 130 nm CMOS technology with an area of only 0.14 mm². It achieves a high conversion efficiency of 92.1% and a small quiescent current of 440 nA. It operates from 1.8 to 3.3 V with a maximum load of 2.65 mA.
This paper presents a wide-Vin step-down parallel-resonant converter (PRC), comprising an integrated 5-bit capacitor array and a 300-nH resonant coil, placed in parallel to a conventional buck converter. Soft-switching resonant converters are beneficial for high-Vin multi-MHz converters to reduce dominant switching losses, enabling higher switching frequencies. The output filter inductor is optimized based on an empirical study of available inductors. The study shows that faster switching significantly reduces not only the inductor value but also volume, price, and even the inductor losses. In addition, unlike conventional resonant concepts, soft-switching control as part of the proposed PRC eliminates input voltage-dependent losses over a wide operating range, resulting in 76.3% peak efficiency. At Vin = 48 V, a loss reduction of 35% is achieved compared with the conventional buck converter. Adjusting an integrated capacitor array, and selecting the number of oscillation periods, keeps the switching frequency within a narrow range. This ensures high efficiency across a wide range of Vin = 12–48 V, 100–500-mA load, and 5-V output at up to 25-MHz switching frequency. Thanks to the low output current ripple, the output capacitor can be as small
as 50 nF.
This paper presents a fully integrated gate driver in a 180-nm bipolar CMOS DMOS (BCD) technology with 1.5-A max. gate current, suitable for normally OFF gallium nitride (GaN) power switches, including gate-injection transistors (GIT). Full-bridge driver architecture provides a bipolar and three-level gate drive voltage for a robust and efficient GaN switching. The concept of high voltage energy storing (HVES), which comprises an on-chip resonant LC tank, enables a very area-efficient buffer capacitor integration and superior gatedriving speed. It reduces the component count and the influence of parasitic gate-loop inductance. Theory and calculations confirm the benefits of HVES compared to other capacitor implementation methods. The proposed gate driver delivers a gate charge of up to 11.6 nC, sufficient to drive most types of currently available GaN power transistors. Consequently, HVES enables to utilize the fast switching capabilities of GaN for advanced and compact power electronics.
Boost converters suffer from a bandwidth limitation caused by the right-half plane zero (RHPZ), which occurs in the control-to-output transfer function. In contrast, there are many applications that require superior dynamic behavior. Further, size and cost of boost converter systems can be minimized by reduced voltage deviations and fast transient responses in case of large signal load transients. The key idea of the proposed ΔV/Δt-intervention control concept is to adapt the controller output to its new steady state value immediately after a load transient by prediction from known parameters. The concept is implemented in a digital control circuit, consisting of an ASIC in a 110 nm-technology and a Xilinx Spartan-6 field programmable gate array (FPGA). In a boost converter with 3.5V input voltage, 6.3V output voltage, 1.2A load, and 500 kHz switching frequency, the output voltage deviations are 2.8x smaller, scaling down the output capacitor value by the same factor. The recovery times are 2.4x shorter in case of large signal load transients with the proposed concept. The control is widely applicable, as it supports constant switching frequencies and allows for duty cycle and inductor current limitations. It also shows various advantages compared to conventional control and to selected adaptive control concepts.
Due to their superior fast-switching performance, GaN transistors show enormous potential to enable compact power electronics in applications like renewable energy, electrical cars and home appliances by shrinking down the size of passives. However, fast switching poses challenges for the gate driver. Since GaN transistors have a low threshold voltage Vt of ~1V, an unintended driver turn-on can occur in case of a unipolar gate control as shown for a typical half-bridge in Fig. 24.2.1 (top left). This is due to coupling via the gate-drain capacitance (Miller coupling), when the low-side driver turns on, causing a peak current into the gate. This is usually tackled by applying a negative gate voltage to enhance the safety margin towards Vt, resulting in a bipolar gate-driving scheme. In many power-electronics applications GaN transistors operate in reverse conduction, carrying the inductor current during the dead time t, when the high-side and low-side switch are off (as illustrated at a high-side switch in Fig. 24.2.1, bottom left). As there is no real body diode as in silicon devices, the GaN transistor turns on in reverse operation with a voltage drop VF across the drain-source terminals (quasi-body diode behavior). As a negative gate voltage adds to VF, 63% higher reverse-conduction losses were measured for a typical GaN switch in bipolar gate-drive operation. This drawback is addressed by a three-level gate voltage (positive, 0V, negative), which at the same time provides robustness against unintended turn-on similar to the bipolar gate driver, proven in [1] for a discrete driver.
A wide-bandwidth galvanically isolated current sensing circuit with an integrated Rogowski coil in 180nm CMOS is presented. Exploiting the high-frequency properties of an optimized on-chip Rogowski coil, currents can be measured up to a bandwidth of 75 MHz. The analog sensor front-end comprises a two-stage integrator, which allows a chopper frequency below signal bandwidth, resulting in 2.2 mVrms output noise. An additional integrated Hall sensor extends the measurement range towards DC.
The level shifter and the floating gate supply for high-side transistors are a major challenge in high-voltage DCDC converters. This paper presents a high speed and power-efficient level shifter for voltages of up to 50V, suitable for both PMOS and NMOS power FETs. A switching node falling edge detection allows both, a sensitive and safe signal detection. This enables a robust operation during steep dv / dt transitions and a power consumption as low as 4.1 pJ per switching cycle, which is a reduction of more than 40% compared to prior art. An active clamping circuit prevents common mode displacement currents into the high-side supply. The level shifter is implemented in a 180nm BiCMOS technology. Measurements confirm a 50V 120MHz high-speed operation of the level shifter with a rising / falling propagation delay of 1.45 ns / 1.3 ns, respectively. The dv / dt robustness has been confirmed by measurements for transitions up to 6V/ ns.
This paper presents a digitally controlled boost converter IC for high output voltage and fast transient applications. Thus, it is well applicable in automotive and industrial environments. The 3V-to-6V input voltage, 6.3V output voltage, 1A boost converter IC is fabricated in a 180nm BCD technology. Digital control enables cost savings, advanced control concepts, and it is less parameter sensitive compared to common analog control. A 90 ns latency, 6-bit delay line ADC operates with a window concept, meeting high resolution requirements, e.g. in car battery applications. An output voltage live tracking is included for extending the ADC conversion window. A charge pump DAC provides high resolution, monotonicity, and short 128 ns conversion time. Further, a standard digital PI controller is enhanced by a simple but effective ΔV/Δt-intervention control. It results in 2.8x reduced output voltage deviations in case of load steps, scaling down the output capacitor value by the same factor.
Polyelectrolyte multilayer (PEM) are thin polymeric films produced by alternating adsorption of positively and negatively charged polyelectrolytes (PE) on a substrate. These films are considered drug delivery agents as well as coating material for implants, due to their antibiofouling and biologically benign properties. For these reasons the film mechanical properties as well as response to mechanical stress are important measurement parameters. Especially intriguing is the correlation of the mechanical properties of PEM on macroscopic level with the structure of PEM on molecular level, which is addressed here for the first time. This study investigates PEM from PDADMA/PSS produced by spraying technique with neutron and X-ray reflectometry. Reflectometry technique provides precise information on thickness and density (i.e., electron density or scattering length density, respectively), and, this way, allows to conclude on changes in film composition. Thus, neutron and X-ray reflectometry technique is suitable to investigate the overall and the internal transformations, which PEM films might undergo upon exposure to mechanical load. During uniaxial elongation two regimes of PEM deformation can be observed: An elastic regime at small elongations (below ca. 0.2%), which is characterized by a reversible change of film thickness, and a plastic regime with a permanent change above this limit. Both regimes have in common, that the mechanical load induces an increase of the film thickness, which is accompanied by an uptake of water from the surrounding atmosphere. The strain causes a molecular rearrangement within the PEM-structure of stratified layers, which, even in elastic regime, is permanent, although the thickness change remains reversible.
Polyelectrolyte multi-layer (PEM) coatings are prepared by alternative deposition of single polyelectrolyte monolayers on charged surfaces using the Layer-by-Layer (LbL) dip coating procedure. These are nanometre scaled coatings which allow fulfilling of different technical or biological requirements. The build-up process is based on selfassembly and self organization of polycations and polyanions on different substrates including complex geometrical structures and even closed volumes, forming homogeneous layer without defects. Depending on the proper selection of the applied polyelectrolytes, coatings with different stabilities can be prepared. Some of the coatings are stable and cannot be removed from the surface. Others are degradable and can be used as systems for controlled local drug delivery. Here we summarise the results of our experience in preparation of PEM coatings with different functionalities. PEM coatings can be used as controllable delivery system for siRNA polyplexes. They can be used to control the adhesion of different cell types on the surfaces and support e.g. the endothelialisation process on cardio-vascular medical devices as e.g. stents or reduce the immunological response of the tissue after implantation. We summarise results from physical characterisation of the coatings (e.g. film thickness, roughness, electrical charge and hydrophilicity) combined with in-vitro biological studies on adhesion of HUVEC cells.
Sole value – the sneaker resale market :
an explorative analysis of the sneaker resale market
(2018)
The purpose of this explorative research paper is to examine the sneaker resale market and its typical processes in order to give a comprehensive overview over the secondary market for limited edition sneakers. Hypotheses are presented that will be analysed with the empirical research methods of expert interviews and sales data analysis. Amongst other findings, this paper shows that there is a complementary relationship between sneaker brands and the resale market; that product limitation is essential for value increases; that collaborations are necessary for sneaker brands to be relevant on the resale market and that the market is very fragmented. All combined circumstances described in this paper explain the sneaker resale market and its processes. Additionally, some outlooks on the future will be given with the help of expert interviewees and current developments on the market will be discussed.
Drei Stufen geben Sicherheit
(2018)
GaN-Transistoren bieten ein enormes Potenzial für kompakte Leistungselektronik, indem sie die Größe von passiven Bauelementen verringern. Allerdings bringt das schnelle Schalten Herausforderungen für den Gate-Treiber mit sich. Ein vollständig integrierter Treiber mit drei Spannungsstufen hilft, diese zu lösen.
Customer relationship management (CRM) is one of the most frequently adopted management tools and has received much attention in the literature. From a company-wide perspective, CRM is viewed as a complex process requiring interventions in different company areas. Previous research has already highlighted the pitfalls and failures related to a partial and incomplete view of CRM. This study advances research on CRM by investigating the impact of the relative implementation time according to which interventions are implemented in different areas (customer management, CRM technology, organizational alignment, and CRM strategy) on CRM performance. The results of the empirical study reveal that compared to other critical CRM activities, a later implementation of organizational alignment activities has a negative impact on performance. Further, our results show that CRM implementations do not equally address the areas of customer acquisition, growth, and loyalty, since this clearly depends on company objectives and also on geographical differences.
In recent years, the numer of hybrid work systems using human robot collaboration (HRC) increased in industrial production environments - enhancing productivity while reducing work-related burden. Despite growing availability of HRC-suitable manipulation and safety technology, tools and techniques facilitating the design, planning and implementation process are still lacking. System engineers who strive to implement technically feasible, ergonomically meaningful and economically beneficial HRC application need to make design and technology decisions in various subject areas, whereas the design alternatives per morphological analysis is applied to establish a description model that can serve as both a supporting design guideline for future HRC application of value-adding, industrial quality as well as a tool to characterize and compare existing applications. It focuses on HRC within assembly processes, and illustrates the complexity of HRC applications in a comprehensible manner through its multi-dimensional structure. The morphology has been validated through its application on various existing industrial HRC applications, research demonstrators and interviews of experts from academia.
Digital transformation has changed corporate reality and, with that, firms’ IT environments and IT governance (ITG). As such, the perspective of ITG has shifted from the design of a relatively stable, closed and controllable system of a self-sufficient enterprise to a relatively fluid, open, agile and transformational system of networked co adaptive entities. Related to this paradigm shift in ITG, this paper aims to clarify how the concept of an effective ITG framework has changed in terms of the demand for agility in organizations. Thus, this study conducted 33 qualitative interviews with executives and senior managers from the banking industry in Germany, Switzerland and Austria. Analysis of the interviews focused on the formation of categories and the assignment of individual text parts (codings) to these categories to allow for a quantitative evaluation of the codings per category. Regarding traditional and agile ITG dimensions, 22 traditional and 25 agile dimensions were identified. Moreover, agile strategies within the agile ITG construct and ten ITG patterns were identified from the interview data. The data show relevant perspectives on the implementation of traditional and new ITG dimensions and highlight ambidextrous aspects in ITG frameworks.
In Neurofibromatosis 1 (NF1) germ line loss of function mutations result in reduction of cellular neurofibromin content (NF1+/−, NF1 haploinsufficiency). The Ras-GAP neurofibromin is a very large cytoplasmic protein (2818 AA, 319 kDa) involved in the RAS-MAPK pathway. Aside from regulation of proliferation, it is involved in mechanosensoric of cells. We investigated neurofibromin replacement in cultured human fibroblasts showing reduced amount of neurofibromin. Full length neurofibromin was produced recombinantly in insect cells and purified. Protein transduction into cultured fibroblasts was performed employing cell penetrating peptides along with photochemical internalization. This combination of transduction strategies ensures the intracellular uptake and the translocation to the cytoplasm of neurofibromin. The transduced neurofibromin is functional, indicated by functional rescue of reduced mechanosensoric blindness and reduced RasGAP activity in cultured fibroblasts of NF1 patients or normal fibroblasts treated by NF1 siRNA. Our study shows that recombinant neurofibromin is able to revert cellular effects of NF1 haploinsuffiency in vitro, indicating a use of protein transduction into cells as a potential treatment strategy for the monogenic disease NF1.
Surface topographies are often discussed as an important parameter influencing basic cell behavior. Whereas most in vitro studies deal with microstructures with sharp edges, smooth, curved microscale topographies might be more relevant concerning in-vivo situations. Addressing the lack of highly defined surfaces with varying curvature, we present a topography chip system with 3D curved features of varying spacing, curvature radii as well as varying overall dimensions of curved surfaces. The CurvChip is produced by low-cost photolithography with thermal reflow, subsequent (repetitive) PDMS molding and hot embossing. The platform facilitates the systematic in-vitro investigation of the impact of substrate curvature on cell types like epithelial, endothelial, smooth muscle cells, or stem cells. Such investigations will not only help to further understand the mechanism of curvature sensation but may also contribute to optimize cell-material interactions in the field of regenerative medicine.
Die für Deutschland verfügbaren Studien zur Digitalen Transformation in klein- und mittelständischen Unternehmen (KMU) sind sich weitgehend einig. KMU tun sich mit dem Thema Digitalisierung schwer. Der vorliegende Beitrag diskutiert, weshalb KMU an der Digitalen Transformation scheitern und was dagegen getan werden kann.
Digital transformation has changed corporate reality and, with that, firms’ IT environments and IT governance (ITG). As such, the perspective of ITG has shifted from the design of a relatively stable, closed and controllable System of a self-sufficient Enterprise to a relatively fluid, open, agile and transformational system of networked co-adaptive entities. Related to this paradigm shift in ITG, this paper aims to clarify how the concept of an effective ITG framework has changed in terms of the demand for agility in organizations. Thus, this study conducted 33 qualitative interviews with executives and senior managers from the banking industry in Germany, Switzerland and Austria. Analysis of the interviews focused on the formation of categories and the assignment of individual text parts (codings)
to these categories to allow for a quantitative evaluation of the codings per category. Regarding traditional and agile ITG dimensions, 22 traditional and 25 agile dimensions in terms of structures, processes and relational mechanisms were identified. Moreover, agile strategies within the agile ITG construct and ten ITG patterns were identified from the interview data. The data show relevant perspectives on the implementation of traditional and new ITG dimensions and highlight ambidextrous aspects in ITG in the German-speaking banking industry.
Future intralogistics systems need to adapt flexibly to changing material flow requirements in line with future versatile factory environments, producing personalized products under the performance and cost conditions of today's mass production. Small batch sized down to a batch size of "1" lead to a high complexity in the design and economical manufacturing of these customized products. Intralogistics systems are integrated into higher-level areas (segment level) as well as into upsteam and downstream performance units (system-wide areas). This includes the logistic activities relevant for the system (organized according to storage, picking, transport) such as transportation or storage tasks of tools, semi-finished products, components, assemblies and containers, and waste. Today's centralized material flow control systems, which work based on predefined processes, are not capable and more specifically not suitable to deal with the arising complexity of changeable intralogistics systems. Autononomous, decentralized material flow control systems distribute the required decision-making and control processes on intelligent logistic entities. A major step for the development of an autonomous control method for hybrid intralogistics systems (manual, semi-automated and automated) is the development of a generic archetype for intralogistics systems regarding the system boundaries, elements and relations resulting in a descriptive model taking into account amongst others the time of demand, availability of resources, economic efficiency and technical performance parameters. The ESB Logistics Learning Factory at ESB Business School (Reutlingen University) serves for this as a close-to-reality development and validation environment.
Small Island Developing States (SIDS) face tension between economic growth and environmental impact. Tourism fuels growth, but the resulting solid waste and other pollutants threaten the SIDS’ natural beauty, quality of life for residents, attractiveness to tourists, and economic success. We assess the tension between tourism-driven economic growth and environmental degradation from a limits-to-growth perspective, developing a generic system dynamics model of the problem using 38 years of data from the Maldives to estimate parameters and Monte-Carlo methods to assess the sensitivity of results to uncertainty. We contrast development paths for the next three decades under three sets of policies focusing on promoting growth, managing tourism demand–supply balance, and improving waste management. Findings are counterintuitive; policies focused on better waste management alone are self defeating, because they increase tourism, growth and waste generation, undermining attractiveness and growth later. Policies that limit tourism demand improve economic and environmental health.
Active storage
(2018)
In brief, Active Storage refers to an architectural hardware and software paradigm, based on collocation storage and compute units. Ideally, it will allow to execute application-defined data ... within the physical data storage. Thus Active Storage seeks to minimize expensive data movement, improving performance, scalability, and resource efficiency. The effective use of Active Storage mandates new architectures, algorithms, interfaces, and development toolchains.
A transaction is a demarcated sequence of application operations, for which the following properties are guaranteed by the underlying transaction processing system (TPS): atomicity, consistency, isolation, and durability (ACID). Transactions are therefore a general abstraction, provided by TPS that simplifies application development by relieving transactional applications from the burden of concurrency and failure handling. Apart from the ACID properties, a TPS must guarantee high and robust performance (high transactional throughput and low response times), high reliability (no data loss, ability to recover last consistent state, fault tolerance), and high availability (infrequent outages, short recovery times).
The architectures and workhorse algorithms of a high-performance TPS are built around the properties of the underlying hardware. The introduction of nonvolatile memories (NVM) as novel storage technology opens an entire new problem space, with the need to revise aspects such as the virtual memory hierarchy, storage management and data placement, access paths, and indexing. NVM are also referred to as storage-class memory (SCM).
Rattern nicht erwünscht
(2018)
Die Additive Fertigung bietet großes Potenzial zur Erschließung neuer, flexibler und innovativer Fertigungsprozesse mit kurzen Durchlaufzeiten. Erhöhte Komplexität und die Integration von Funktionen in Bauteile wird gefördert. Zur Steigerung der Konkurrenzfähigkeit und weiteren Ausweitung des Einsatzgebietes sind automatisierte Fertigungsschritte nach dem Bauprozess erforderlich. Werkzeugmaschinen spielen auch in der Prozesskette der Additiven Fertigung eine zentrale Rolle bei der Erzeugung von genauen Funktionsflächen. Dabei ist evtl. eine andere Auslegung aufgrund reduzierter Zerspanvolumen und geringeren Flächen möglich.
Soft thermoplastic polysiloxane-urea-elastomers (PSUs) were prepared for the application as a biomaterial to replace the human natural lens after cataract surgery. PSUs were synthesized from amino-terminated polydimethylsiloxanes (PDMS), 4,4′-Methylenebis(cyclohexylisocyanate) (H12MDI) and 1,3–Bis(3-aminopropyl)-1,1,3,3–tetramethyldisiloxane (APTMDS) by a two-step polyaddition route. Such a material has to be highly transparent and must exhibit a low Young’s Modulus and excellent dimensional stability. Polydimethylsiloxanes in the range of 3000–33,000 g·mol−1 were therefore prepared by ring-chain-equilibration of octamethylcyclotetrasiloxane (D4) and APTMDS in order to study the influence of the soft segment molecular weight on the mechanical properties and the transparency of the PSU-elastomers. 2,4,6,8-Tetramethyl-2,4,6,8-tetraphenylcyclotetrasiloxane (D4Me,Ph) was co-polymerized with D4 in order to adjust the refractive index of the polydimethyl-methyl-phenyl-siloxane-copolymers to a value equivalent to a young human natural lens. Very elastic PSUs with Elongation at Break values higher than 700% were prepared. PSU-elastomers, synthesized from PDMS of molecular weights up to 18,000 g·mol−1, showed transmittance values of over 90% within the visible spectrum range. The soft segment refractive index was increased through the incorporation of 14 mol % of methyl-phenyl-siloxane from 1.4011 to 1.4346 (37 °C). Young’s Moduli of PSU-elastomers were around 1 MPa and lower at PDMS molecular weights up to 15,000 g·mol−1. 10-cycle hysteresis measurements were applied to evaluate the mechanical stability of the PSUs at repeated stress. Hysteresis values at 100% strain decreased from 32 to 2% (10th cycle) with increasing PDMS molecular weight. Furthermore, hysteresis at 5% strain was only detected in PSU-elastomers with low PDMS molecular weights. Finally, preliminary results of in vitro cytotoxicity tests on a PSU-elastomer showed no toxic effects on HaCaT-cells.
A shift in attitudes to purchasing departments can be perceived. No longer is the chief goal solely to reduce costs; the procurement function is assuming strategic relevance in the business model, leveraging the supplier as a foundation for innovation. The knowledge accumulated by suppliers is accessed over the journey of long-term partnerships to streamline business practice. Businesses are finding themselves in increasingly competitive environments, and thus need to address inefficiencies in supplier management. “Procurement 4.0” is a concept used in discussing digitalisation in business processes, referring to the process of supplier relationship management and optimisation. This model and its application to supplier relationship management will be the focus of this article. Realising the efficiencies to be obtained in buyer-supplier relationships through “Procurement 4.0” will be explored, primarily through an emphasis on digitalisation of the relationship between the procurement department and supplier.
The focus of the developed maturity model was set on processes. The concept of the widespread CMM and its practices has been transferred to the perioperative domain and the concept of the new maturity model. Additional optimization goals and technological as well as networking-specific aspects enable a process- and object-focused view of the maturity model in order to ensure broad coverage of different subareas. The evaluation showed that the model is applicable to the perioperative field. Adjustments and extensions of the maturity model are future steps to improve the rating and classification of the new maturity model.
Die minimal-invasive Chirurgie (MIC) entwickelt sich durch den Einsatz von medizinischen Robotern wie dem da Vinci System von Intuitive Surgical stetig weiter. Hierdurch kann eine bessere oder gleichwertige Operation bei deutlich geringerer körperlicher Belastung des Operateurs erreicht werden. Dabei entstehen jedoch neue Problemstellungen wie beispielsweise Kollision zwischen Roboterarmen und die benötigte Zeit zum Einrichten einer geeigneten Roboterkonfiguration. Daher ist eine effiziente Vorbereitung und Planung der Interventionen erforderlich. Diese Arbeit präsentiert einen Ansatz für eine verbesserte Planung mit Augmented Reality (AR) und einer Robotik Simulationssoftware (RS). Die Robotik Simulation dient zur Berechnung einer Roboterkonfiguration unter Vorgabe der Port-Positionen. Augmented Reality wird verwendet, um die berechneten Pose in der realen Umgebung zu visualisieren und somit leichter in den Operationssaal zu übertragen.
Die Segmentierung und das Tracking von minimal-invasiven robotergeführten Instrumenten ist ein wesentlicher Bestandteil für verschiedene computer assistierte Eingriffe. Allerdings treten in der minimal-invasiven Chirurgie, die das Anwendungsfeld für den hier beschriebenen Ansatz darstellt, häufig Schwierigkeiten durch Reflexionen, Schatten oder visuelle Verdeckungen durch Rauch und Organe auf und erschweren die Segmentierung und das Tracking der Instrumente.
Dieser Beitrag stellt einen Deep Learning Ansatz für ein markerloses Tracking von minimal-invasiven Instrumenten vor und wird sowohl auf simulierten als auch realen Daten getestet. Es wird ein simulierter als auch realer Datensatz mit Ground Truth Kennzeichnung für die binäre Segmentierung von Instrument und Hintergrund erstellt. Für den simulierten Datensatz werden Bilder aus einem simulierten Instrument und realem Hintergrund zusammengesetzt. Im Falle des realen Datensatzes spricht man von der Zusammensetzung der Bilder aus einem realen Instrument und Hintergrund. Insgesamt wird auf den simulierten Daten eine Pixelgenauigkeit von 94.70 Prozent und auf den realen Daten eine Pixelgenauigkeit von 87.30 Prozent erreicht.
This paper addresses what we call the investment question: under what plausible circumstances, if any, can variable renewable energy (VRE, and solar photovoltaic (PV) in particular) be a good investment? Although VRE has been growing rapidly world-wide, it is generally subsidized. Under what cost and market conditions can solar PV flourish without subsidy? We employ solar insolation and market price data from the U.S. and from Germany to gain insight into the investment question. We find that unsubsidized solar PV is or may soon be a justifiable investment, but that market arrangements may play a crucial role in determining success. We end by sketching a proposal that amounts to a reformed capacity market that would afford participation of solar PV.
Being able to monitor the heart activity of patients during their daily life in a reliable, comfortable and affordable way is one main goal of the personalized medicine. Current wearable solutions lack either on the wearing comfort, the quality and type of the data provided or the price of the device. This paper shows the development of a Textile Sensor Platform (TSP) in the form of an electrocardiogram (ECG)-measuring T-shirt that is able to transmit the ECG signal to a smartphone. The development process includes the selection of the materials, the design of the textile electrodes taking into consideration their electrical characteristics and ergonomy, the integration of the electrodes on the garment and their connection with the embedded electronic part. The TSP is able to transmit a real-time streaming of the ECG-signal to an Android smartphone through Bluetooth Low Energy (BLE). Initial results show a good electrical quality in the textile electrodes and promising results in the capture and transmission of the ECG signal. This is still a working- progress and it is the result of an interdisciplinary master project between the School of Informatics and the School of Textiles & Design of the Reutlingen University.
This work is a report on practical experiences with the issue of interoperability in German practice management systems (PMSs) from an ongoing clinical trial on teledermatology, the TeleDerm project. A proprietary and established web-platform for store-and-forward telemedicine is integrated with the IT in the GPs’ offices for automatic exchange of basic patient data. Most of the 19 different PMSs included in the study sample lack support of modern health data exchange standards, therefore the relatively old but widely available German health data exchange interface “Gerätedatentransfer” (GDT) is used. Due to the lack of enforcement and regulation of the GDT standard, several obstacles to interoperability are encountered. As a partial, but reusable working solution to cope with these issues, we present a custom middleware which is used in conjunction with GDT. We describe the design, technical implementation and observed hindrances with the existing infrastructure. A discussion on health care interfacing standards and the current state of interoperability in German PMS software is given.
We present an approach for segmenting individual cells and lamellipodia in epithelial cell clusters using fully convolutional neural networks. The method will set the basis for measuring cell cluster dynamics and expansion to improve the investigation of collective cell migration phenomena. The fully learning-based front-end avoids classical feature engineering, yet the network architecture needs to be designed carefully. Our network predicts how likely each pixel belongs to one of the classes and, thus, is able to segment the image. Besides characterizing segmentation performance, we discuss how the network will be further employed.
Background: Internationally, teledermatology has proven to be a viable alternative to conventional physical referrals. Travel cost and referral times are reduced while patient safety is preserved. Especially patients from rural areas benefit from this healthcare innovation. Despite these established facts and positive experiences from EU neighboring countries like the Netherlands or the United Kingdom, Germany has not yet implemented store-and-forward teledermatology in routine care.
Methods: The TeleDerm study will implement and evaluate store-and-forward teledermatology in 50 general practitioner (GP) practices as an alternative to conventional referrals. TeleDerm aims to confirm that the possibility of store-and-forward teledermatology in GP practices is going to lead to a 15% (n = 260) reduction in referrals in the intervention arm. The study uses a cluster-randomized controlled trial design. Randomization is planned for the cluster “county”. The main observational unit is the GP practice. Poisson distribution of referrals is assumed. The evaluation of secondary outcomes like acceptance, enablers and barriers uses a mixed methods design with questionnaires and interviews.
Discussion: Due to the heterogeneity of GP practice organization, patient management software, information technology service providers, GP personal technical affinity and training, we expect several challenges in implementing teledermatology in German GP routine care. Therefore, we plan to recruit 30% more GPs than required by the power calculation. The implementation design and accompanying evaluation is expected to deliver vital insights into the specifics of implementing telemedicine in German routine care.
Modern persistent Key/Value stores are designed to meet the demand for high transactional throughput and high data ingestion rates. Still, they rely on backwards-compatible storage stack and abstractions to ease space management, foster seamless proliferation and system integration. Their dependence on the traditional I/O stack has negative impact on performance, causes unacceptably high write-amplification, and limits the storage longevity.
In the present paper we present NoFTL KV, an approach that results in a lean I/O stack, integrating physical storage management natively in the Key/Value store. NoFTL-KV eliminates backwards compatibility, allowing the Key/Value store to directly consume the characteristics of modern storage technologies. NoFTLKV is implemented under RocksDB. The performance evaluation under LinkBench shows that NoFTL-KV improves transactional throughput by 33%, while response times improve up to 2.3x. Furthermore, NoFTL KV reduces write-amplification 19x and improves storage longevity by imately the same factor.
Blockchains yield to new workloads in database management systems and K/V-stores. Distributed Ledger Technology (DLT) is a technique for managing transactions in ’trustless’ distributed systems. Yet, clients of nodes in blockchain networks are backed by ’trustworthy’ K/V-Stores, like LevelDB or RocksDB in Ethereum, which are based on Log-Structured Merge Trees (LSM Trees). However, LSM-Trees do not fully match the properties of blockchains and enterprise workloads.
In this paper, we claim that Partitioned B-Trees (PBT) fit the properties of this DLT: uniformly distributed hash keys, immutability, consensus, invalid blocks, unspent and off-chain transactions, reorganization and data state / version ordering in a distributed log-structure. PBT can locate records of newly inserted key-value pairs, as well as data of unspent transactions, in separate partitions in main memory. Once several blocks acquire consensus, PBTs evict a whole partition, which becomes immutable, to secondary storage. This behavior minimizes write amplification and enables a beneficial sequential write pattern on modern hardware. Furthermore, DLT implicate some type of log-based versioning. PBTs can serve as MV-store for data storage of logical blocks and indexing in multi-version concurrency control (MVCC) transaction processing.
Turbidity sensing is very common in the control of drinking water. Furthermore, turbidity measurements are applied in the chemical (e.g., process monitoring), pharmaceutical (e.g., drug discovery), and food industries (e.g., the filtration of wine and beer). The most common measurement technique is nephelometric turbidimetry. A nephelometer is a device for measuring the amount of scattered light of suspended particles in a liquid by using a light source and a light detector orientated in 90°to each other. Commercially available nephelometers cost usually—depending on the measurable range, reliability, and precision —thousands of euros. In contrast, our new developed GRIN-lens-based nephelometer, called GRINephy, combines low costs with excellent reproducibility and precision, even at very low turbidity levels, which is achieved by its ability to rotate the sample. Thereby, many cuvette positions can be measured, which results in a more precise average value for the turbidity calculated by an algorithm, which also eliminates errors caused by scratches and contaminations on the cuvettes. With our compact and cheap Arduino-based sensor, we are able to measure in the range of 0.1–1000 NTU and confirm the ISO 7027-1:2016 for low turbidity values.
Consistent supply chain management across all levels of value creation is a common approach in the industrial sector. The implementation in agricultural processes requires rethinking in the supply chain concept. The reasons are the heuristic characterized processes, the stochastic environmental conditions, the mobility of the production facilities and the low division of work.
In this paper we deal with how concepts of innovative supply chain management of Industrie 4.0 could not only deliver a way to overcome said problems but also provide the foundation for the development of new forms of work and business models for Farming 4.0.
A fully passive RFID temperature sensor SoC with an accuracy of ±0.4°C (3σ) from 0°C to 125°C
(2018)
This paper presents a fully passive 13.56 MHz RFID temperature sensor system-on-chip. Its power management unit (PMU) operates over a large temperature range using a zero temperature coefficient (TC) bias source. On-chip temperature sensing is accomplished with low voltage, low power CMOS circuitry and time-domain signal processing. Two operating modes have been defined to study supply noise sensitivity: command mode and listening mode, which represent sensor operation during RFID command transfer and listening, respectively. Besides a standard readout command, a customized serial readout command is utilized to distinguish the data from both modes. In command mode, the sensor suffers from interference from the RFID command packet and outputs interference as well, while the sensor outputs no interference in listening mode. Measurements show that sensor resolution in listening mode is improved by a factor of approximately 16 compared to command mode. The chip was fabricated in a standard 0.35 µm CMOS technology and chip-on-board mounted to a tuned RFID transponder coil on an aluminium core FRA4 PCB substrate. Real-time wireless temperature sensing has been demonstrated with a commercial HF RFID reader. With a two-point calibration, the SoC achiesves a 3σ sensing accuracy of ±0.4°C from 0° C to 125° C.
Coupling electricity and heat sector is one of the most necessary actions for the successful energy transition. Efficient electrification for space heating and domestic hot water generation is needed for buildings, which are not connected to any district heating network, as distributed heating demand momentarily is largely met by fossil fuels. Hence, hybrid energy systems will play a pivotal role for the energy transition in buildings. Heat pumps running on PV-electricity is one of the most widely discussed combination for this purpose. In this paper, a heuristic optimization method for the optimal operation of a heat pump driven by the objective for maximum onsite PV electricity utilization is presented. In this context, the thermal flexibility of the building and a thermal energy storage (TES) for generation of domestic hot water (DHW) are activated in order to shift the operation of the heat pump to times of PV-generation. Yearly simulations for a system consisting of heat pump, PV modules, building with floor heating installation and TES for DHW generation are carried out. Variation parameters for the simulation include room temperature amplitude (0.5, 1, 1.5 and 2 K) based on mean room temperature (21 °C), PV-capacity (4, 6, 8 and 10 kW) and type of heat pump (ground source and air source type). The yearly energy balances show that buildings offer significant thermal storage capacity avoiding an additional, large TES for space heating fulfillment and improving the share of onsite PV electricity utilization. With introduction of a battery, which has been analyzed as well for different sizes (1.9, 4.8, 7.7 and 10.6 kWh), the share of onsite PVelectricity utilization can even be improved. However, thermal flexibility supplemented by the varying room temperature amplitude for a bigger battery does not improve the share of onsite PV-electricity utilization. Nevertheless, even with a battery not more than 50% of the electrical load including operation of the heat pump can be covered by PV-electricity for the specific system under investigation. This is noteworthy on the one hand, since it indicates that a hybrid heating system consisting of heat pump and PV cannot solely cover the heat demand of residential buildings. One the other hand, this emphasizes the necessity to include further renewable sources like wind power, in order to draw the complete picture. This, however, is beyond the scope of this paper, which mainly focuses on introduction and verification of the novel control method with regard to a practical building.
Micro grids often consist of energy generators, storages and consumers with controllers which are not prepared for their integration into communication networks for energy systems. In this paper it will be presented, how standards from the field of energy automation can be applied in such controllers. The data for communication interfaces can be structured according to the IEC 61850- or the VHPREADY standard. It is investigated which requirements must be supported to implement such data models within the controllers. For the transmission of the data we propose the OPC UA protocol, which supports extensive security measures and which is today available for nearly all modern types of controllers and computers.
Historically, research and development (R&D) in the pharmaceutical sector has predominantly been an in-house activity. To enable investments for game changing late-stage assets and to enable better and less costly go/no-go decisions, most companies have employed a fail early paradigm through the implementation of clinical proof-of-concept organizations. To fuel their pipelines, some pioneers started to complement their internal R&D efforts through collaborations as early as the 1990s. In recent years, multiple extrinsic and intrinsic factors induced an opening for external sources of innovation and resulted in new models for open innovation, such as open sourcing, crowdsourcing, public–private partnerships, innovations centres, and the virtualization of R&D. Three factors seem to determine the breadth and depth regarding how companies approach external innovation: (1) the company’s legacy, (2) the company’s willingness and ability to take risks and (3) the company’s need to control IP and competitors. In addition, these factors often constitute the major hurdles to effectively leveraging external opportunities and assets. Conscious and differential choices of the R&D and business models for different companies and different divisions in the same company seem to best allow a company to fully exploit the potential of both internal and external innovations.
This paper investigates if food ^ retailing mobile applications from Germany, Austria, USA and the United Kingdom are meant to stay a marginal topic in grocery shopping, or if they have the potential to significantly shape the future of grocery retailing by serving as competitive advantages that can fulfil customer requirements and satisfaction. It has filtered out success factors in form of functions of grocery apps and it has extracted key competencies that can be used to create customer value. The Kano model can help selecting the right app functions. But, there are other prerequisites, like customers’ general attitude towards technology and their acceptance towards any kind of apps, that play an important role looking at the big picture of apps in grocery retailing. However, this paper has contributed one vital part of giving more importance to apps in grocery retailing in form of app functions that clearly deliver customer value. In short, apps that fit customers’ needs and that provide usability and convenience clearly have the potential to shape the future of grocery retailing - if key barriers towards app use are eliminated and if incentives are given that overcome scepticism.
This book investigates and highlights the most critical challenges the pharmaceutical industry faces in an increasingly competitive environment of inflationary R&D investments and tightening cost control pressures. The authors present three sources of pharmaceutical innovation: new management methods in the drug development pipeline; new technologies as enablers for cutting-edge R&D; and new forms of cooperation and internationalization, such as open innovation in the early phases of R&D. New models and methods are illustrated with cases from Europe, the US, and Asia. This third fully revised edition was expanded to reflect the latest updates in open and collaborative innovation, the greater strategic importance of venture capital and early stage investments, and the new range of emerging technologies now being put to use in pharmaceutical innovation.