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Will chatbots play a significant role for B2B marketingin the future? Chatbots in B2B businesses
(2022)
Digitalization has gained a foothold in our everyday lives. However, it remains to be seen what digital tools B2B companies can benefit from. During the last few years, chatbots have been on the rise and have played a more significant role in B2B marketing. Thus, this research follows a literature review to examine the current state of B2B chatbots. With this, the study will discover the buyer’s preferences for chatbots compared to sales agents and the role of chatbots in different stages of the B2B sales funnel.
Context: Companies that operate in the software-intensive business are confronted with high market dynamics, rapidly evolving technologies as well as fast-changing customer behavior. Traditional product roadmapping practices, such as fixed-time-based charts including detailed planned features, products, or services typically fail in such environments. Until now, the underlying reasons for the failure of product roadmaps in a dynamic and uncertain market environment are not widely analyzed and understood.
Objective: This paper aims to identify current challenges and pitfalls practitioners face when developing and handling product roadmaps in a dynamic and uncertain market environment.
Method: To reach our objective we conducted a grey literature review (GLR).
Results: Overall, we identified 40 relevant papers, from which we could extract 11 challenges of the application of product roadmapping in a dynamic and uncertain market environment. The analysis of the articles showed that the major challenges for practitioners originate from overcoming a feature-driven mindset, not including a lot of details in the product roadmap, and ensuring that the content of the roadmap is not driven by management or expert opinion.
The implementation of human resource (HR) policies often proves troublesome due to the appearance, and stubborn persistence, of gaps in the process. Human resource management (HRM) scholars problematise these gaps and advocate tight implementation to reduce gaps and to ensure the desired impact of policies on organisational performance. Drawing on organisational institutionalism, we contend that gaps in implementing HR policies can actually be productive, as they secure organisational legitimacy, and thus enable organisations to operate viably within several institutional environments. We suggest that different approaches to implementation are needed, some of them premised on accepting sustained implementation gaps. We introduce minimum and moderate implementation approaches, rooted in the notion of decoupling, to complement approaches aimed at tight implementation. Our aim is to support the further development of research based on a richer interpretation of HRM implementation challenges and choices they present for HR managers.
Verification of an active time constant tuning technique for continuous-time delta-sigma modulators
(2022)
In this work we present a technique to compensate the effects of R-C / g m -C time-constant (TC) errors due to process variation in continuous-time delta-sigma modulators. Local TC error compensation factors are shifted around in the modulator loop to positions where they can be implemented efficiently with finely tunable circuit structures, such as current-steering digital-to-analog converters (DAC). We apply our technique to a third-order, single-bit, low-pass continuous-time delta-sigma modulator in cascaded integrator feedback structure, implemented in a 0.35-μm CMOS process. A tuning scheme for the reference currents of the feedback DACs is derived as a function of the individual TC errors and verified by circuit simulations. We confirm the tuning technique experimentally on the fabricated circuit over a TC parameter variation range of ±20%. Stable modulator operation is achieved for all parameter sets. The measured performances satisfy the expectations from our theoretical calculations and circuit-level simulations.
Values Management System
(2022)
The ValuesManagementSystem (VWS) is a management standard to “provide a sustainable safeguard of a firm and its development, in all dimensions (legal, economic, ecological, social)” (VWSZfW, p. 4). It includes a framework for values-driven governance through self-commitment and self-binding mechanisms. Values promote a sense of identity and give organizations guidance in decision-making. This is especially important in decision-making processes where topics are not clearly ruled by laws and regulations.
VMSZfW must be embedded in the specific business strategy, structure, and culture of an organization. The following four steps describe the implementation of the ValuesManagementSystemZfW: (i) Codify core values of an organization, for instance, with a “mission, vision and values statement” or Code of Ethics, (ii) implement guidelines such as Code of Conduct and specific policies and procedures, (iii) systematize these by establishing management systems such as Compliance and CSR management systems, and (iv) finally organize and establish structures to ensure the strategic direction and operational implementation and review of these processes. The top management shows that values management is taken seriously by their self-commitment to the core values of the company.
Unsaturated polyester resins (UPR) and vinyl ester resins (VER) are among the most commercially important thermosetting matrix materials for composites. Although comparatively low cost, their technological performance is suitable for a wide range of applications, such as fiber-reinforced plastics, artificial marble or onyx, polymer concrete, or gel coats. The main areas of UPR consumption include the wind energy, marine, pipe and tank, transportation, and construction industries.
This chapter discusses basic UPR and VER chemistry and technology of manufacturing, and consequent applications. Some important properties and performance characteristics are discussed, such as shrinkage behavior, flame retardance, and property modification by nanoparticles. Also briefly introduced and described are the practical aspects of UPR and VER processing, with special emphasis on the most widely used technological approaches, such as hand and spray layup, resin infusion, resin transfer molding, sheet and bulk molding, pultrusion, winding, and centrifugal casting.
The United Nations (UN) Global Compact is a call to companies to align their strategies and operations with ten universal principles in the areas of human rights, labor, environment, and anti-corruption, and to take actions that advance societal goals (UN Global Compact 2017, p. 3). The UN Global Compacts’ vision is “to mobilize a global movement of sustainable companies and stakeholder to create the world we want” (UN Global Compact 2021a). It is a global network with local presence all around the world.
The Principles for Responsible Investments (PRI) is “the world’s leading proponent of responsible investment” (PRI 2021a). With the development of six Principles for Responsible Investment, the PRI supports its international network of investor signatories in incorporating the environmental, social, and governance (ESG) factors into their investment and ownership decisions. The goal of PRI is to develop a more sustainable global financial system by encouraging “investors to use responsible investment to enhance returns and better manage risks” (PRI 2021a). This independent financial initiative is supported by the United Nations and linked to the United Nations Environmental Program Finance Initiative (UNEP FI 2021) and the United Nations Global Compact (UN Global Compact 2021).
Ultra wideband real-time locating system for tracking people and devices in the operating room
(2022)
Position tracking within the OR could be one possible input for intraoperative situation recognition. Our approach demonstrates a Real-time Locating System (RTLS) using the Ultra Wideband (UWB) technology to determine the position of people or objects. The UWB RTLS was integrated into the research OR at Reutlingen University and the system’s settings were optimized regarding the four factors accuracy, susceptibility to interference, range, and latency. Therefore, different parameters were adapted and the effects on the factors were compared. Goodtracking quality could be achieved under optimal settings. These results indicate that a UWB RTLS is well suited to determine the position of people and devices in our setting. The feasibility of the system needsto be evaluated under real OR conditions.
Turning students into Industry 4.0 entrepreneurs: design and evaluation of a tailored study program
(2022)
Startups in the field of Industry 4.0 could be a huge driver of innovation for many industry sectors such as manufacturing. However, there is a lack of education programs to ensure a sufficient number of well-trained founders and thus a supply of such startups. Therefore, this study presents the design, implementation, and evaluation of a university course tailored to the characteristics of Industry 4.0 entrepreneurship. Educational design-based research was applied with a focus on content and teaching concept. The study program was first implemented in 2021 at a German university of applied sciences with 25 students, of which 22 participated in the evaluation. The evaluation of the study program was conducted with a pretest–posttest-design targeting three areas: (1) knowledge about the application domain, (2) entrepreneurial intention and (3) psychological characteristics. The entrepreneurial intention was measured based on the theory of planned behavior. For measuring psychological characteristics, personality traits associated with entrepreneurship were used. Considering the study context and the limited external validity of the study, the following can be identified in particular: The results show that a university course can improve participants' knowledge of this particular area. In addition, perceived behavioral control of starting an Industry 4.0 startup was enhanced. However, the results showed no significant effects on psychological characteristics.
The food system represents a key industry for Europe and Germany in particular. However, it is also the single most significant contributor to climate and environmental change. A food system transformation is necessary to overcome the system’s major and constantly increasing challenges in the upcoming decades. One possible facilitator for this transformation are radical and disruptive innovations that start-ups develop. There are many challenges for start-ups in general and food start-ups in particular. Various support opportunities and resources are crucial to ensure the success of food start-ups. One aim of this study is to identify how the success of start-ups in the food system can be supported and further strengthened by actors in the innovation ecosystem in Germany. There is still room for improvement and collaboration toward a thriving innovation ecosystem. A successful innovation ecosystem is characterised by a well-organised, collaborative, and supportive environment with a vivid exchange between the members in the ecosystem. The interviewees confirmed this, and although the different actors are already cooperating, there is still room for improvement. The most common recommendation for improving cooperation is learning from other countries and bringing the best to Germany.
Today, companies face increasing market dynamics, rapidly evolving technologies, and rapid changes in customer behavior. Traditional approaches to product development typically fail in such environments and require companies to transform their often feature-driven mindset into a product-led mindset. A promising first step on the way to a product-led company is a better understanding of how product planning can be adapted to the requirements of an increasingly dynamic and uncertain market environment in the sense of product roadmapping. The authors developed the DEEP product roadmap assessment tool to help companies evaluate their current product roadmap practices and identify appropriate actions to transition to a more product-led company. Objective: The goal of this paper is to gain insight into the applicability and usefulness of version 1.1 of the DEEP model. In addition, the benefits, and implications of using the DEEP model in corporate contexts will be explored. Method: We conducted a multiple case study in which participants were observed using the DEEP model. We then interviewed each participant to understand their perceptions of the DEEP model. In addition, we conducted interviews with each company's product management department to learn how the application of the DEEP model influenced their attitudes toward product roadmapping. Results: The study showed that by applying the DEEP model, participants better understood which artifacts and methods were critical to product roadmapping success in a dynamic and uncertain market environment. In addition, the application of the DEEP model helped convince management and other stakeholders of the need to change current product roadmapping practices. The application also proved to be a suitable starting point for the transformation in the participating companies.
Industrial practice is characterized by random events, also referred to as internal and external turbulences, which disturb the target-oriented planning and execution of production and logistics processes. Methods of probabilistic forecasting, in contrast to single value predictions, allow an estimation of the probability of various future outcomes of a random variable in the form of a probability density function instead of predicting the probability of a specific single outcome. Probabilistic forecasting methods, which are embedded into the analytics process to gain insights for the future based on historical data, therefore offer great potential for incorporating uncertainty into planning and control in industrial environments. In order to familiarize students with these potentials, a training module on the application of probabilistic forecasting methods in production and intralogistics was developed in the learning factory 'Werk150' of the ESB Business School (Reutlingen University). The theoretical introduction to the topic of analytics, probabilistic forecasting methods and the transition to the application domain of intralogistics is done based on examples from other disciplines such as weather forecasting and energy consumption forecasting. In addition, data sets of the learning factory are used to familiarize the students with the steps of the analytics process in a practice-oriented manner. After this, the students are given the task of identifying the influencing factors and required information to capture intralogistics turbulences based on defined turbulence scenarios (e.g. failure of a logistical resource) in the learning factory. Within practical production scenario runs, the students apply probabilistic forecasting using and comparing different probabilistic forecasting methods. The graduate training module allows the students to experience the potentials of using probabilistic forecasting methods to improve production and intralogistics processes in context with turbulences and to build up corresponding professional and methodological competencies.
With the progress of technology in modern hospitals, an intelligent perioperative situation recognition will gain more relevance due to its potential to substantially improve surgical workflows by providing situation knowledge in real-time. Such knowledge can be extracted from image data by machine learning techniques but poses a privacy threat to the staff’s and patients’ personal data. De-identification is a possible solution for removing visual sensitive information. In this work, we developed a YOLO v3 based prototype to detect sensitive areas in the image in real-time. These are then deidentified using common image obfuscation techniques. Our approach shows that it is principle suitable for de-identifying sensitive data in OR images and contributes to a privacyrespectful way of processing in the context of situation recognition in the OR.
The euphoria around microservices has decreased over the years, but the trend of modernizing legacy systems to this novel architectural style is unbroken to date. A variety of approaches have been proposed in academia and industry, aiming to structure and automate the often long-lasting and cost-intensive migration journey. However, our research shows that there is still a need for more systematic guidance. While grey literature is dominant for knowledge exchange among practitioners, academia has contributed a significant body of knowledge as well, catching up on its initial neglect. A vast number of studies on the topic yielded novel techniques, often backed by industry evaluations. However, practitioners hardly leverage these resources. In this paper, we report on our efforts to design an architecture-centric methodology for migrating to microservices. As its main contribution, a framework provides guidance for architects during the three phases of a migration. We refer to methods, techniques, and approaches based on a variety of scientific studies that have not been made available in a similarly comprehensible manner before. Through an accompanying tool to be developed, architects will be in a position to systematically plan their migration, make better informed decisions, and use the most appropriate techniques and tools to transition their systems to microservices.
Towards a model for holistic mapping of supply chains by means of tracking and tracing technologies
(2022)
The usage of tracking and tracing technologies not only enables transparency and visibility of supply chains but also offers far-reaching advantages for companies, such as ensuring product quality or reducing supplier risks. Increasing the amount of shared information supports both internal and external planning processes as well as the stability and resilience of globally operating value chains. This paper aims to differentiate and define the functionalities of tracking and tracing technologies that are frequently used interchangeably in literature. Furthermore, this paper incorporates influencing factors impacting a sequencing of the connected world in Industry4.0 supply chain networks. This includes legal influences, the embedment of supply chain-related standards, and new possibilities of emerging technologies. Finally, the results are summarized in a model for the holistic mapping of supply chains by means of tracking and tracing technologies. The resulting technological solutions that can be derived from the model enable companies to address missing elements in order to enable the holistic mapping of supply chain events as well as the transparent representation of a digital shadow throughout the entire supply chain.
Advancements in Internet of Things (IoT), cloud and mobile computing have fostered the digital enrichment—or “digitization”—of physical products, which are gaining increasing relevance in practice. According to recent studies, global IoT spending will exceed USD 1 Trillion by 2021 and there will be over 25 billion IoT connections (KPMG, 2018). Porter and Heppelmann (2014) state that IT is “revolutionizing products [as …] IT is becoming an integral part of the product itself.” Senior business executives like GE’s former CEO Jeff Immelt (2015) are even proposing that “every industrial company in the coming age is also going to become a software and analytics company.” This reflects the increasing relevance of IT components’ (i.e., software, data analytics, cloud computing) integration into previously purely physical products. We call IT-enriched physical products, “digitized” products to differentiate them from purely intangible “digital” products, such as digital music, e-books, and software. Examples of digitized products include the Philips Hue smartphone-controllable lightbulb, Audi Connect internet-connected cars, or Rolls-Royce’s sensor-enabled pay per use jet engines.
Digitized products provide their producers with a wide range of opportunities to offer new functionality and product capabilities (e.g., autonomy) that traditional, physical products do not exhibit (Porter and Heppelmann, 2014). In addition, the digitization of products allows producers to continuously repurpose their offerings, by extending and/or changing the product functionality and, thus, enabling new value creation opportunities. Based on their re-programmability and connectivity, digitized products “remain essentially incomplete […] throughout their lifetime as users continue to add and delete […] and change […] functional capabilities” (Yoo, 2013). For instance, the Philips Hue connected lightbulb enables remote control of basic functions (e.g., switching on and off the light) as well as setting more advanced light scenes for day-to-day tasks (e.g., relax, read) via Amazon’s Alexa artificial intelligence assistant (Signify, 2019), offerings that were not intended use cases when Signify (previously known as Philips Lighting) created Hue in 2012. Thus, digitized products present limitless potentials for new functionality and unforeseen use cases, which provides them with a huge innovation capacity.
Despite the limitless potentials offered by digitized products, there has been a slow uptake of digitized products by businesses so far (Jernigan et al., 2016; Mocker et al., 2019). According to a 2016 MIT Sloan Management Review report (Jernigan et al., 2016) only 24% of the investigated firms were actively using IoT technologies – a key technology for digitized products. In a more recent research study Mocker et al. (2019) found that the median revenue share from digital offerings (i.e., solutions based on IT enriched products) in large companies only accounted for 5% of the total revenue of the investigated companies.
The slow uptake of digitized products might be explained by the challenges that firms face regarding the changing nature of digitized products. Pervasive digital technologies (such as IoT) change the nature of products by adding new functionality that was previously not part of the value proposition of the products/services (e.g., a pair of shoes embedded with sensors and connectivity allows joggers to have access to data regarding their run distance, speed, etc.) (Yoo et al., 2012). The addition of new functionality and use cases of digitized products makes it harder for producers to design and develop relevant products (Hui 2014). As described in the paper ‘Do Your Customers Actually Want a “Smart” Version of Your Product?’, “just because [firms] can make something with IoT technology doesn’t mean people will want it.” (Smith, 2017).
The shift in digitized products’ nature poses new challenges for producers along the entire product development process (Porter and Heppelmann, 2015; Yoo et al., 2012) and create a paradox in product digitization, described by Yoo et al. (2012) as the paradox of pace: while technology accelerates the rate of innovation, companies need to spend more time to digitize their products, extending time to market. The production of these digitized products also becomes more challenging, e.g., as companies need to deal with different clock-speeds of software and hardware development (Porter and Heppelman, 2015). The above-mentioned challenges suggest that producers need to better understand how they can generate value from their digitized products’ generative potentials.
The body of literature on digitized products has been growing in recent years. For instance, Herterich et al. (2016) investigate how digitized product affordances (i.e., potentials) enable industrial service innovation; Nicolescu et al. (2018) explore the emerging meanings of value associated with IoT; and Benbunan-Fich (2019) studies the impact of basic wearable sensors on the quality of the user experience. However, it remains unclear what it takes for firms to generate value with their digitized product potentials. This dissertation investigates this research gap.
To generate greater value faster from digital innovation, many companies are increasing how much they learn from their own innovation efforts. However, in many companies, these changes are limited to one stakeholder group: innovation teams. Two other stakeholder groups, senior executives and experts from corporate functions, also need to learn from digital innovation initiatives. We have defined three learning imperatives that address a company’s needs to learn continually about building (1) a successful innovation, (2) a portfolio of initiatives that realizes strategic objectives faster, and (3) shared resources that propel multiple initiatives. All three imperatives involve collecting data regularly from digital innovation initiatives. In this research briefing we outline the three learning imperatives and provide examples of how companies are pursuing them to achieve strategic objectives more effectively and efficiently.
The time has come : application of artificial intelligence in small- and medium-sized enterprises
(2022)
Artificial intelligence (AI) is not yet widely used in small- and medium-sized industrial enterprises (SME). The reasons for this are manifold and range from not understanding use cases, not enough trained employees, to too little data. This article presents a successful design-oriented case study at a medium-sized company, where the described reasons are present. In this study, future demand forecasts are generated based on historical demand data for products at a material number level using a gradient boosting machine (GBM). An improvement of 15% on the status quo (i.e. based on the root mean squared error) could be achieved with rather simple techniques. Hence, the motivation, the method, and the first results are presented. Concluding challenges, from which practical users should derive learning experiences and impulses for their own projects, are addressed.
Purpose
This field study aims to investigate the interactive relationships of millennial employee’s gender, supervisor’s gender and country culture on the conflict-management strategies (CMS) in ten countries (USA, China, Turkey, Germany, Bangladesh, Portugal, Pakistan, Italy, Thailand and Hong Kong).
Design/methodology/approach
This exploratory study extends past research by examining the interactive effects of gender × supervisor’s gender × country on the CMS within a single generation of workers, millennials. The Rahim Organizational Conflict Inventory–II, Form A was used to assess the use of the five CMS (integrating, obliging, dominating, avoiding and compromising). Data analysis found CMS used in the workplace are associated with the interaction of worker and supervisor genders and the national context of their work.
Findings
Data analysis (N = 2,801) was performed using the multivariate analysis of covariance with work experience as a covariate. The analysis provided support for the three-way interaction. This interaction suggests how one uses the CMS depends on self-gender, supervisor’s gender and the country where the parties live. Also, the covariate – work experience – was significantly associated with CMS.
Research limitations/implications
One of the limitations of this study is that the authors collected data from a collegiate sample of employed management students in ten countries. There are significant implications for leading global teams and training programs for mid-level millennials.
Practical implications
There are various conflict situations where one conflict strategy may be more appropriate than others. Organizations may have to change their policies for recruiting employees who are more effective in conflict management.
Social implications
Conflict management is not only important for managers but it is also important for all human beings. Individuals handle conflict every day and it would be really good if they could handle it effectively and improve their gains.
Originality/value
To the best of the authors’ knowledge, no study has tested a three-way interaction of variables on CMS. This study has a wealth of information on CMS for global managers.
Compared to the automotive sector, where automation is the rule, in many other less standardized sectors automation is still the exception. This could soon hurt the productivity of industrialized countries, where the unemployment is low and the population is aging. Phenomena like the recent downfall in productivity, due to lockdowns and social distancing for prevention of health hazards during the COVID19 pandemic, only add to the problem. For these reasons, the relevance, motivation and intention for more automation in less standardized sectors has probably never been higher. However, available statistics say that providers and users of technologies struggle to bring more automation into action in automation-unfriendly sectors. In this paper, we present a decision support method for investment in automation that tackles the problem: the STIC analysis. The method takes a holistic and quantitative approach tying together technological, context-related and economic input parameters and synthetizing them in a final economic indicator. Thanks to the modelling of such parameters, it is possible to gain sensibility on the technological and/or process adjustments that would have the highest impact on the efficiency of the automation, thereby delivering value for both technology users and technology providers.
Public transport maps are typically designed in a way to support route finding tasks for passengers, while they also provide an overview about stations, metro lines, and city-specific attractions. Most of those maps are designed as a static representation, maybe placed in a metro station or printed in a travel guide. In this paper, we describe a dynamic, interactive public transport map visualization enhanced by additional views for the dynamic passenger data on different levels of temporal granularity. Moreover, we also allow extra statistical information in form of density plots, calendar-based visualizations, and line graphs. All this information is linked to the contextual metro map to give a viewer insights into the relations between time points and typical routes taken by the passengers. We also integrated a graph-based view on user-selected routes, a way to interactively compare those routes, an attribute- and property-driven automatic computation of specific routes for one map as well as for all available maps in our repertoire, and finally, also the most important sights in each city are included as extra information to include in a user-selected route. We illustrate the usefulness of our interactive visualization and map navigation system by applying it to the railway system of Hamburg in Germany while also taking into account the extra passenger data. As another indication for the usefulness of the interactively enhanced metro maps we conducted a controlled user experiment with 20 participants.
Gender pay gaps are commonly studied in populations with already completed educational careers. We focus on an earlier stage by investigating the gender pay gap among university students working alongside their studies. With data from five cohorts of a large-scale student survey from Germany, we use regression and wage decomposition techniques to describe gender pay gaps and potential explanations. We find that female students earn about 6% less on average than male students, which reduces to 4.1% when accounting for a rich set of explanatory variables. The largest explanatory factor is the type of jobs male and female students pursue.
In our initial DaMoN paper, we set out the goal to revisit the results of “Starring into the Abyss [...] of Concurrency Control with [1000] Cores” (Yu in Proc. VLDB Endow 8: 209-220, 2014). Against their assumption, today we do not see single-socket CPUs with 1000 cores. Instead, multi-socket hardware is prevalent today and in fact offers over 1000 cores. Hence, we evaluated concurrency control (CC) schemes on a real (Intel-based) multi-socket platform. To our surprise, we made interesting findings opposing results of the original analysis that we discussed in our initial DaMoN paper. In this paper, we further broaden our analysis, detailing the effect of hardware and workload characteristics via additional real hardware platforms (IBM Power8 and 9) and the full TPC-C transaction mix. Among others, we identified clear connections between the performance of the CC schemes and hardware characteristics, especially concerning NUMA and CPU cache. Overall, we conclude that no CC scheme can efficiently make use of large multi-socket hardware in a robust manner and suggest several directions on how CC schemes and overall OLTP DBMS should evolve in future.
Since project managers still face problems in managing interorganizational R&D projects, it is a promising approach to manage these projects project-culturally-aware. However, an important prerequisite for a project-culture-aware management is that the involved individual organizations pursue a collaborative strategy. Therefore, our article provides a conceptual approach including a new tool, the Collaborative Iron Triangle, which supports both project sponsors and managers in different phases of the collaboration process to pursue a collaborative strategy in interorganizational R&D projects.
Cell migration plays an essential role in wound healing and inflammatory processes inside the human body. Peripheral blood neutrophils, a type of polymorphonuclear leukocyte (PMN), are the first cells to be activated during inflammation and subsequently migrate toward an injured tissue or infection site. This response is dependent on both biochemical signaling and the extracellular environment, one aspect of which includes increased temperature in the tissues surrounding the inflammation site. In our study, we analyzed temperature-dependent neutrophil migration using differentiated HL-60 cells. The migration speed of differentiated HL-60 cells was found to correlate positively with temperature from 30 to 42 °C, with higher temperatures inducing a concomitant increase in cell detachment. The migration persistence time of differentiated HL-60 cells was higher at lower temperatures (30–33 °C), while the migration persistence length stayed constant throughout the temperature range. Coupled with the increased speed observed at high temperatures, this suggests that neutrophils are primed to migrate more effectively at the elevated temperatures characteristic of inflammation. Temperature gradients exist on both cell and tissue scales. Taking this into consideration, we also investigated the ability of differentiated HL-60 cells to sense and react to the presence of temperature gradients, a process known as thermotaxis. Using a two-dimensional temperature gradient chamber with a range of 27–43 °C, we observed a migration bias parallel to the gradient, resulting in both positive and negative thermotaxis. To better mimic the extracellular matrix (ECM) environment in vivo, a three-dimensional collagen temperature gradient chamber was constructed, allowing observation of biased neutrophil-like differentiated HL-60 migration toward the heat source.
Background
Although teledermatology has been proven internationally to be an effective and safe addition to the care of patients in primary care, there are few pilot projects implementing teledermatology in routine outpatient care in Germany. The aim of this cluster randomized controlled trial was to evaluate whether referrals to dermatologists are reduced by implementing a store-and-forward teleconsultation system in general practitioner practices.
Methods
Eight counties were cluster randomized to the intervention and control conditions. During the 1-year intervention period between July 2018 and June 2019, 46 general practitioner practices in the 4 intervention counties implemented a store-and-forward teledermatology system with Patient Data Management System interoperability. It allowed practice teams to initiate teleconsultations for patients with dermatologic complaints. In the four control counties, treatment as usual was performed. As primary outcome, number of referrals was calculated from routine health care data. Poisson regression was used to compare referral rates between the intervention practices and 342 control practices.
Results
The primary analysis revealed no significant difference in referral rates (relative risk = 1.02; 95% confidence interval = 0.911–1.141; p = .74). Secondary analyses accounting for sociodemographic and practice characteristics but omitting county pairing resulted in significant differences of referral rates between intervention practices and control practices. Matched county pair, general practitioner age, patient age, and patient sex distribution in the practices were significantly related to referral rates.
Conclusions
While a store-and-forward teleconsultation system was successfully implemented in the German primary health care setting, the intervention's effect was superimposed by regional factors. Such regional factors should be considered in future teledermatology research.
This article explores the question of how sustainability and labour law are interrelated. The modern world of work is characterised by the growing social and environmental responsibility of companies. Especially in the post-COVID era, sustainability also plays an increasingly important role in the corporate context, which is also noticeable in the so-called ‘war for talent’. Achieving personal career goals is no longer enough for employees today. Corporate values and in particular the so-called ESG criteria (Environment, Social, Governance) are thus also becoming increasingly important in the employment relationship and in corporate reporting requirements. In terms of social sustainability, labour law instruments can, for example, promote the creation of a discrimination-free working environment, the introduction of flexible working time models or the protection of whistleblowers. From an ecological perspective, labour regulations are also suitable for implementing ‘green mobility’ and other measures to reduce companies’ ecological footprints. Working from home, which experienced a huge boom during the COVID-19 pandemic, is also sustainable, especially from an ecological point of view. Appropriate consideration of these sustainable work tools in future corporate social responsibility (CSR) strategies not only creates a competitive advantage but can also be beneficial in recruitment.
Background
Personalized medicine requires the integration and analysis of vast amounts of patient data to realize individualized care. With Surgomics, we aim to facilitate personalized therapy recommendations in surgery by integration of intraoperative surgical data and their analysis with machine learning methods to leverage the potential of this data in analogy to Radiomics and Genomics.
Methods
We defined Surgomics as the entirety of surgomic features that are process characteristics of a surgical procedure automatically derived from multimodal intraoperative data to quantify processes in the operating room. In a multidisciplinary team we discussed potential data sources like endoscopic videos, vital sign monitoring, medical devices and instruments and respective surgomic features. Subsequently, an online questionnaire was sent to experts from surgery and (computer) science at multiple centers for rating the features’ clinical relevance and technical feasibility.
Results
In total, 52 surgomic features were identified and assigned to eight feature categories. Based on the expert survey (n = 66 participants) the feature category with the highest clinical relevance as rated by surgeons was “surgical skill and quality of performance” for morbidity and mortality (9.0 ± 1.3 on a numerical rating scale from 1 to 10) as well as for long-term (oncological) outcome (8.2 ± 1.8). The feature category with the highest feasibility to be automatically extracted as rated by (computer) scientists was “Instrument” (8.5 ± 1.7). Among the surgomic features ranked as most relevant in their respective category were “intraoperative adverse events”, “action performed with instruments”, “vital sign monitoring”, and “difficulty of surgery”.
Conclusion
Surgomics is a promising concept for the analysis of intraoperative data. Surgomics may be used together with preoperative features from clinical data and Radiomics to predict postoperative morbidity, mortality and long-term outcome, as well as to provide tailored feedback for surgeons.
Up to now biorefinery concepts can hardly compete with the conventional production of fossil-based chemicals. On one hand, conventional chemical production has been optimised over many decades in terms of energy, yield and costs. Biorefineries, on the other hand, do not have the benefit of long-term experience and therefore have a huge potential for optimisation. This study deals with the economic evaluation of a newly developed biorefinery concept based on superheated steam (SHS) torrefaction of biomass residues with recovery of valuable platform chemicals. Two variants of the biorefinery were economically investigated. One variant supplies various platform chemicals and torrefied biomass. The second variant supplies thermal energy for external consumers in addition to platform chemicals. The results show that both variants can be operated profitably if the focus of the platform chemicals produced is on high quality and thus on the higher-priced segment. The economic analysis gives clear indications of the most important financial influencing parameters. The economic impact of integration into existing industrial structures is positive. With the analysis, a viable business model can be developed. Based on the results of the present study, an open-innovation platform is recommended for the further development and commercialisation of the novel biorefinery.
Within the last decade, research on torrefaction has gained increasing attention due to its ability to improve the physical properties and chemical composition of biomass residues for further energetic utilisation. While most of the research works focused on improving the energy density of the solid fraction to offer an ecological alternative to coal for energy applications, little attention was paid to the valorisation of the condensable gases as platform chemicals and its ecological relevance when compared to conventional production processes. Therefore, the present study focuses on the ecological evaluation of an innovative biorefinery concept that includes superheated steam drying and the torrefaction of biomass residues at ambient pressure, the recovery of volatiles and the valorisation/separation of several valuable platform chemicals. For a reference case and an alternative system design scenario, the ecological footprint was assessed, considering the use of different biomass residues. The results show that the newly developed process can compete with established bio-based and conventional production processes for furfural, 5-HMF and acetic acid in terms of the assessed environmental performance indicators. The requirements for further research on the synthesis of other promising platform chemicals and the necessary economic evaluation of the process were elaborated.
Database management systems and K/V-Stores operate on updatable datasets – massively exceeding the size of available main memory. Tree-based K/V storage management structures became particularly popular in storage engines. B+ -Trees [1, 4] allow constant search performance, however write-heavy workloads yield in inefficient write patterns to secondary storage devices and poor performance characteristics. LSM-Trees [16, 23] overcome this issue by horizontal partitioning fractions of data – small enough to fully reside in main memory, but require frequent maintenance to sustain search performance.
Firstly, we propose Multi-Version Partitioned BTrees (MV-PBT) as sole storage and index management structure in key-sorted storage engines like K/V-Stores. Secondly, we compare MV-PBT against LSM-Trees. The logical horizontal partitioning in MV-PBT allows leveraging recent advances in modern B+ -Tree techniques in a small transparent and memory resident portion of the structure. Structural properties sustain steady read performance, yielding efficient write patterns and reducing write amplification.
We integrated MV-PBT in the WiredTiger [15] KV storage engine. MV-PBT offers an up to 2× increased steady throughput in comparison to LSM-Trees and several orders of magnitude in comparison to B+ -Trees in a YCSB [5] workload.
One of the key challenges for automatic assistance is the support of actors in the operating room depending on the status of the procedure. Therefore, context information collected in the operating room is used to gain knowledge about the current situation. In literature, solutions already exist for specific use cases, but it is doubtful to what extent these approaches can be transferred to other conditions. We conducted a comprehensive literature research on existing situation recognition systems for the intraoperative area, covering 274 articles and 95 cross-references published between 2010 and 2019. We contrasted and compared 58 identified approaches based on defined aspects such as used sensor data or application area. In addition, we discussed applicability and transferability. Most of the papers focus on video data for recognizing situations within laparoscopic and cataract surgeries. Not all of the approaches can be used online for real-time recognition. Using different methods, good results with recognition accuracies above 90% could be achieved. Overall, transferability is less addressed. The applicability of approaches to other circumstances seems to be possible to a limited extent. Future research should place a stronger focus on adaptability. The literature review shows differences within existing approaches for situation recognition and outlines research trends. Applicability and transferability to other conditions are less addressed in current work.
Social commerce
(2022)
The concept of “social commerce” refers to a synthesis of e-commerce and social media. Despite the rapid growth in users of and revenues from social commerce, so far little in-depth research has been conducted in Germany on this topic. The goal here, therefore, is to conduct schematic research of the literature and an online survey of German consumers to analyze the potential opportunities for companies.
The respiratory rate is a vital sign indicating breathing illness. It is necessary to analyze the mechanical oscillations of the patient's body arising from chest movements. An inappropriate holder on which the sensor is mounted, or an inappropriate sensor position is some of the external factors which should be minimized during signal registration. This paper considers using a non-invasive device placed under the bed mattress and evaluates the respiratory rate. The aim of the work is the development of an accelerometer sensor holder for this system. The normal and deep breathing signals were analyzed, corresponding to the relaxed state and when taking deep breaths. The evaluation criterion for the holder's model is its influence on the patient's respiratory signal amplitude for each state. As a result, we offer a non-invasive system of respiratory rate detection, including the mechanical component providing the most accurate values of mentioned respiratory rate.
Modifying the natural characteristics of PLA 3D-printed models is of interest in various research areas in which 3D-printing is applied. Thus, in this study, we describe the simple impregnation of FDM 3D-printed PLA samples with well-defined silver nanoparticles and an iron metal salt. Quasi-spherical and dodecahedra silver particles were strongly attached at the channels of 3D-printed milli-fluidic reactors to demonstrate their attachment and interaction with the flow, as an example. Furthermore, Fenton-like reactions were successfully developed by an iron catalyst impregnated in 3D-printed stirrer caps to induce the degradation of a dye and showed excellent reproducibility.
Silicones
(2022)
Silicones are found in a variety of applications with requirements that range from long life at elevated temperatures to fluidity at low temperatures. This chapter first considers silicone elastomers and their application in room temperature vulcanizing (RTV) and heat curing systems (HTV). Also, new technologies for UV curing are introduced. Coverage of RTVs includes both one-component and two-component systems and the different cure chemistries of each and is followed by a separate discussion of silicone laminates. Due to the high importance of silicone fluids, they are also discussed. Fluids include polishes, release agents, surfactants, and dielectric fluids.
Modern production systems are characterized by the increasingly use of CPS and IoT networks. However, processing the available information for adaptation and reconfiguration often occurs in relatively large time cycles. It thus does not take advantage of the optimization potential available in the short term. In this paper, a concept is presented that, considering the process information of the individual heterogeneous system elements, detects optimization potentials and performs or proposes adaptation or reconfiguration. The concept is evaluated utilizing a case study in a learning factory. The resulting system thus enables better exploitation of the potentials of the CPPS.
A premise guaranteeing the successful interdisciplinary teamwork in product design is a mutual understanding of both professional and academic communities of the different design expertise and the role they play in the process. It appears that the open compound word industrial design is open to interpretation in European education. This ambiguity had a negative impact on the labour policies of some European countries, which have labelled some professions with incorrect names. Therefore, this terminological inconsistency urges for clarification within the design community. This work analyses the term industrial design, it presents historical developments in European industrial design education, in particular in Germany and in the Netherlands, and discusses how the education to the industrial design profession was positioned towards product development. This paper suggests that the causes for the observed lack of clarity about the meaning of the term industrial design are of an etymological and disciplinary kind. In order to act as a bridge between the professional and academic communities, universities should create the premises for interdisciplinary collaboration between designers and engineers through standardized communication, ultimately contributing for a sustainable future in both design and engineering education.
Purpose
Context awareness in the operating room (OR) is important to realize targeted assistance to support actors during surgery. A situation recognition system (SRS) is used to interpret intraoperative events and derive an intraoperative situation from these. To achieve a modular system architecture, it is desirable to de-couple the SRS from other system components. This leads to the need of an interface between such an SRS and context-aware systems (CAS). This work aims to provide an open standardized interface to enable loose coupling of the SRS with varying CAS to allow vendor-independent device orchestrations.
Methods
A requirements analysis investigated limiting factors that currently prevent the integration of CAS in today's ORs. These elicited requirements enabled the selection of a suitable base architecture. We examined how to specify this architecture with the constraints of an interoperability standard. The resulting middleware was integrated into a prototypic SRS and our system for intraoperative support, the OR-Pad, as exemplary CAS for evaluating whether our solution can enable context-aware assistance during simulated orthopedical interventions.
Results
The emerging Service-oriented Device Connectivity (SDC) standard series was selected to specify and implement a middleware for providing the interpreted contextual information while the SRS and CAS are loosely coupled. The results were verified within a proof of concept study using the OR-Pad demonstration scenario. The fulfillment of the CAS’ requirements to act context-aware, conformity to the SDC standard series, and the effort for integrating the middleware in individual systems were evaluated. The semantically unambiguous encoding of contextual information depends on the further standardization process of the SDC nomenclature. The discussion of the validity of these results proved the applicability and transferability of the middleware.
Conclusion
The specified and implemented SDC-based middleware shows the feasibility of loose coupling an SRS with unknown CAS to realize context-aware assistance in the OR.
This article illustrates a method for sensorless control of a switched reluctance motor. The detection of the time instants for switching between the working phases is determined based on the evaluation of the switching frequency of the hysteresis current controllers for appropriately selected sensing phases. This enables a simple and cost efficient implementation. The method is compared with a pulse injection method in terms of efficiency and resolution.
For collision and obstacle avoidance as well as trajectory planning, robots usually generate and use a simple 2D costmap without any semantic information about the detected obstacles. Thus a robot’s path planning will simply adhere to an arbitrarily large safety margin around obstacles. A more optimal approach is to adjust this safety margin according to the class of an obstacle. For class prediction, an image processing convolutional neural network can be trained. One of the problems in the development and training of any neural network is the creation of a training dataset. The first part of this work describes methods and free open source software, allowing a fast generation of annotated datasets. Our pipeline can be applied to various objects and environment settings and is extremely easy to use to anyone for synthesising training data from 3D source data. We create a fully synthetic industrial environment dataset with 10 k physically-based rendered images and annotations. Our da taset and sources are publicly available at https://github.com/LJMP/synthetic-industrial-dataset. Subsequently, we train a convolutional neural network with our dataset for costmap safety class prediction. We analyse different class combinations and show that learning the safety classes end-to-end directly with a small dataset, instead of using a class lookup table, improves the quantity and precision of the predictions.
Self-healing thermosets
(2022)
This chapter discusses the basic extrinsic, intrinsic, and combined extrinsic/intrinsic strategies for equipping thermosetting polymers with self-healing properties. The main focus will be on the presentation of a holistic optimization of thermosetting materials, that is, on a simultaneous optimization of both self-healing and other, specialized material properties. Due to their very rigid, highly cross-linked three-dimensional structure, thermosetting polymers require special chemical strategies to achieve self-healing properties. The main chemical strategies available for this will be briefly outlined. The examples given illustrate interesting and/or typical procedures and serve as an inspiration to find solutions for your own applications. They summarize important recent development in research and technology aiming toward multifunctional truly smart self-healing thermosetting materials. An important aspect in this topic area is also how precisely the self-healing effects are analytically checked, quantified, and evaluated. A range of measuring methods is available for this purpose. In this chapter, the most important analytical tools for testing self-healing properties are briefly introduced and highlighted with some illustrative examples.
Artificial intelligence is a field of research that is seen as a means of realization regarding digitalization and industry 4.0. It is considered as the critical technology needed to drive the future evolution of manufacturing systems. At the same time, autonomous guided vehicles (AGV) developed as an essential part due to the flexibility they contribute to the whole manufacturing process within manufacturing systems. However, there are still open challenges in the intelligent control of these vehicles on the factory floor. Especially when considering dynamic environments where resources should be controlled in such a way, that they can be adjusted to turbulences efficiently. Therefore, this paper aimed to develop a conceptual framework for addressing a catalog of criteria that considers several machine learning algorithms to find the optimal algorithm for the intelligent control of AGVs. By applying the developed framework, an algorithm is automatically selected that is most suitable for the current operation of the AGV in order to enable efficient control within the factory environment. In future work, this decision-making framework can be transferred to even more scenarios with multiple AGV systems, including internal communication along with AGV fleets. With this study, the automatic selection of the optimal machine learning algorithm for the AGV improves the performance in such a way, that computational power is distributed within a hybrid system linking the AGV and cloud storage in an efficient manner.
Motivation: Aim of this project is the automatic classification of total hip endoprosthesis (THEP) components in 2D Xray images. Revision surgeries of total hip arthroplasty (THA) are common procedures in orthopedics and trauma surgery. Currently, around 400.000 procedures per year are performed in the United States (US) alone. To achieve the best possible result, preoperative planning is crucial. Especially if parts of the current THEP system are to be retained.
Methods: First, a ground truth based on 76 X-ray images was created: We used an image processing pipeline consisting of a segmentation step performed by a convolutional neural network and a classification step performed by a support vector machine (SVM). In total, 11 classes (5 pans and 6 shafts) shall be classified.
Results: The ground truth generated was of good quality even though the initial segmentation was performed by technicians. The best segmentation results were achieved using a U-net architecture. For classification, SVM architectures performed much better than additional neural networks.
Conclusions: The overall image processing pipeline performed well, but the ground truth needs to be extended to include a broader variability of implant types and more examples per training class.
This research briefing describes the organizational capability of scaling at scale, which we define as enabling multiple digital innovation initiatives to realize bottom-line value from their innovation by leveraging shared resources. We illustrate this concept with a case study from global multi-energy company Repsol, which implemented scaling at scale to cultivate a portfolio of more than 450 initiatives and helped over seventy percent of initiatives to reach the scale-up stage. As a result, over five years Repsol realized €800 million of bottom-line value from digital innovations.
The world population is growing and alternative ways of satisfying the increasing demand for meat are being explored, such as using animal cells for the fabrication of cultured meat. Edible biomaterials are required as supporting structures. Hence, we chose agarose, gellan and a xanthan-locust bean gum blend (XLB) as support materials with pea and soy protein additives and analyzed them regarding material properties and biocompatibility. We successfully built stable hydrogels containing up to 1% pea or soy protein. Higher amounts of protein resulted in poor handling properties and unstable gels. The gelation temperature range for agarose and gellan blends is between 23–30 °C, but for XLB blends it is above 55 °C. A change in viscosity and a decrease in the swelling behavior was observed in the polysaccharide-protein gels compared to the pure polysaccharide gels. None of the leachates of the investigated materials had cytotoxic effects on the myoblast cell line C2C12. All polysaccharide-protein blends evaluated turned out as potential candidates for cultured meat. For cell-laden gels, the gellan blends were the most suitable in terms of processing and uniform distribution of cells, followed by agarose blends, whereas no stable cell-laden gels could be formed with XLB blends.
Recently, blockchain-based tokens have earned an important role in fields such as the art market or online gaming. First approaches exist, which adopt the potentials of blockchain tokens in supply chain management to increase transparency, visibility, automation, and disintermediation of supply chains. In context, the tokenization of assets in supply chains refers to the practice of creating virtual representations of physical assets on the blockchain. Solutions in supply chain management based on the tokenization of assets vary in terms of application objectives, token types, asset characteristics, as well as the complexities of supply chain events to be mapped on the blockchain. Currently, however, no review exists that summarizes the characteristics of blockchain-based tokens and their scope of applications. This paper provides a clear terminological distinction of existing blockchain token types and therefore distinguishes between fungible tokens, non-fungible tokens, smart non-fungible tokens, and dynamic smart non-fungible tokens. Subsequently, the token types are classified regarding their traceability, modifiability, and authorization to evaluate suitability for mapping assets in supply chains. Given the potential of blockchain in supply chain management, the results of the review serve as a foundation for a practical guide supporting the selection process of suitable token types for industrial applications.
The proper selection of a demand forecasting method is directly linked to the success of supply chain management (SCM). However, today’s manufacturing companies are confronted with uncertain and dynamic markets. Consequently, classical statistical methods are not always appropriate for accurate and reliable forecasting. Algorithms of Artificial intelligence (AI) are currently used to improve statistical methods. Existing literature only gives a very general overview of the AI methods used in combination with demand forecasting. This paper provides an analysis of the AI methods published in the last five years (2017-2021). Furthermore, a classification is presented by clustering the AI methods in order to define the trend of the methods applied. Finally, a classification of the different AI methods according to the dimensionality of data, volume of data, and time horizon of the forecast is presented. The goal is to support the selection of the appropriate AI method to optimize demand forecasting.
Purpose
Returnable transport packaging (RTP) solutions have found increasing attention in the recent past. It is not clear, however, under what conditions an RTP system improves a company's financial performance. This paper investigates the operational factors that influence the financial attractiveness of an RTP solution in a manufacturing environment and discusses how these factors are related to each other.
Design/methodology/approach
The paper presents the results of five empirical RTP use cases and compares the case study findings with the results found in literature in order to develop a taxonomy of RTP cost effects. Drawing on the concept of value-based management (VBM), the operational drivers of these RTP cost effects are systematized and categorized in a value driver model that relates RTP cost effects to overall economic value added (EVA).
Findings
Based on the use case findings, additional cost factors are identified that have not been previously discussed in literature. The amended taxonomy of influence factors is further operationalized in a value driver model.
Originality/value
The present paper is the first one providing a taxonomy of RTP cost effects and putting these effects in a conceptual framework that can be used for decision-making and performance benchmarking.