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Engineering of large vascularized adipose tissue constructs is still a challenge for the treatment of extensive high-graded burns or the replacement of tissue after tumor removal. Communication between mature adipocytes and endothelial cells is important for homeostasis and the maintenance of adipose tissue mass but, to date, is mainly neglected in tissue engineering strategies. Thus, new coculture strategies are needed to integrate adipocytes and endothelial cells successfully into a functional construct. This review focuses on the cross-talk of mature adipocytes and endothelial cells and considers their influence on fatty acid metabolism and vascular tone. In addition, the properties and challenges with regard to these two cell types for vascularized tissue engineering are highlighted.
Delivering value to customers in real-time requires companies to utilize real-time deployment of software to expose features to users faster, and to shorten the feedback loop. This allows for faster reaction and helps to ensure that the development is focused on features providing real value. Continuous delivery is a development practice where the software functionality is deployed continuously to customer environment. Although this practice has been established in some domains such as B2C mobile software, the B2B domain imposes specific challenges. This article presents a case study that is conducted in a medium-sized software company operating in the B2B domain. The objective of this study is to analyze the challenges and benefits of continuous delivery in this domain. The results suggest that technical challenges are only one part of the challenges a company encounters in this transition. The company must also address challenges related to the customer and procedures. The core challenges are caused by having multiple customers with diverse environments and unique properties, whose business depends on the software product. Some customers require to perform manual acceptance testing, while some are reluctant towards new versions. By utilizing continuous delivery, it is possible for the case company to shorten the feedback cycles, increase the reliability of new versions, and reduce the amount of resources required for deploying and testing new releases.
Software development as an experiment system : a qualitative survey on the state of the practice
(2015)
An experiment-driven approach to software product and service development is gaining increasing attention as a way to channel limited resources to the efficient creation of customer value. In this approach, software functionalities are developed incrementally and validated in continuous experiments with stakeholders such as customers and users. The experiments provide factual feedback for guiding subsequent development. Although case studies on experimentation in industry exist, the understanding of the state of the practice and the encountered obstacles is incomplete. This paper presents an interview-based qualitative survey exploring the experimentation experiences of ten software development companies. The study found that although the principles of continuous experimentation resonated with industry practitioners, the state of the practice is not yet mature. In particular, experimentation is rarely systematic and continuous. Key challenges relate to changing organizational culture, accelerating development cycle speed, and measuring customer value and product
success.
Modern enterprises reshape and transform continuously by a multitude of management processes with different perspectives. They range from business process management to IT service management and the management of the information systems. Enterprise Architecture (EA) management seeks to provide such a perspective and to align the diverse management perspectives. Therefore, EA management cannot rely on hierarchic - in a tayloristic manner designed - management processes to achieve and promote this alignment. It, conversely, has to apply bottom-up, information-centered coordination mechanisms to ensure that different management processes are aligned with each other and enterprise strategy. Social software provides such a bottom-up mechanism for providing support within EAM-processes. Consequently, challenges of EA management processes are investigated, and contributions of social software presented. A cockpit provides interactive functions and visualization methods to cope with this complexity and enable the practical use of social software in enterprise architecture management processes.
Social and environmental risk management in supply chains : a survey in the clothing industry
(2015)
Almost daily, news indicates that there are environmental and social problems in globally fragmented supply chains. Even though conceptualisations of sustainable supply chain management suggest supplier-related risk management for sustainable products and processes as substantial for companies, research on how risk management for environmental and social issues in supply chains is performed has so far been neglected. This study aims at analysing both why companies in the clothing industry are performing management of social and environmental risks in their supply chain and what kind of action they are taking. Based on the literature on sustainable supply chain management and supply chain risk management as well as 10 expert interviews, a conceptual model for risk management in sustainable supply chains was developed. This model was tested in an empirical study in the clothing industry. The data were analysed by structural equation modelling. Results of the research show high statistical significance for the respective conceptual model. The main driver to perform risk management in environmental and social affairs is pressures and incentives from stakeholders. While companies’ corporate orientation mainly drives social actions, top management drives environmental affairs for differentiating themselves from competitors.
New or adapted digital business models have huge impacts on Enterprise Architectures (EA) and require them to become more agile, flexible, and adaptable. All these changes are happening frequently and are currently not well documented. An EA consists of a lot of elements with manifold relationships between them. Thus changing the business model may have multiple impacts on other architectural elements. The EA engineering process deals with the development, change and optimization of architectural elements and their dependencies. Thus an EA provides a holistic view for both business and IT from the perspective of many stakeholders, which are involved in EA decision-making processes. Different stakeholders have specific concerns and are collaborating today in often unclear decision-making processes. In our research we are investigating information from collaborative decision-making processes to support stakeholders in taking current decisions. In addition we provide all information necessary to understand how and why decisions were taken. We are collecting the decision-related information automatically to minimize manual time intensive work as much as possible. The core contribution of our research extends a decisional metamodel, which links basic decisions with architectural elements and extends them with an associated decisional case context. Our aim is to support a new integral method for multi perspective and collaborative decision-making processes. We illustrate this by a practice-relevant decision-making scenario for Enterprise Architecture Engineering.
Leveraging textual information for improving decision making in the business process lifecycle
(2015)
Business process implementations fail, because requirements are elicited incompletely. At the same time, a huge amount of unstructured data is not used for decision-making during the business process lifecycle. Data from questionnaires and interviews is collected but not exploited because the effort doing so is too high. Therefore, this paper shows how to leverage textual information for improving decision making in the business process lifecycle. To do so, text mining is used for analyzing questionnaires and interviews.
For years, agile methods are considered the most promising route toward successful software development, and a considerable number of published studies the (successful) use of agile methods and reports on the benefits companies have from adopting agile methods. Yet, since the world is not black or white, the question for what happened to the traditional models arises. Are traditional models replaced by agile methods? How is the transformation toward Agile managed, and, moreover, where did it start? With this paper we close a gap in literature by studying the general process use over time to investigate how traditional and agile methods are used. Is there coexistence or do agile methods accelerate the traditional processes’ extinction? The findings of our literature study comprise two major results: First, studies and reliable numbers on the general process model use are rare, i.e., we lack quantitative data on the actual process use and, thus, we often lack the ability to ground process-related research in practically relevant issues. Second, despite the assumed dominance of agile methods, our results clearly show that companies enact context-specific hybrid solutions in which traditional and agile development approaches are used in combination.
IOS 2.0 : new aspects on inter-organizational integration through enterprise 2.0 technologies
(2015)
This special theme of „Electronic Markets“ focuses on research concerned with the use of social technologies and "2.0" principles in the interaction between organization (i.e., with "inter-organizational systems (IOS) 2.0"). This theme falls within the larger space of Enterprise 2.0 research, but focuses in particular on inter-organizational use (between enterprises), not intra-organizational use (in a single enterprise). While there is great interest in practice regarding the use of 2.0 technologies to support intra-organizational communication, collaboration and interaction, information systems (IS) research has largely been oblivious to this important use of social technologies.
Stress is recognized as a factor of predominant disease and in the future the costs for treatment will increase. The presented approach tries to detect stress in a very basic and easy to implement way, so that the cost for the device and effort to wear it remain low. The user should benefit from the fact that the system offers an easy interface reporting the status of his body in real time. In parallel, the system provides interfaces to pass the obtained data forward for further processing and (professional) analyses, in case the user agrees. The system is designed to be used in every day’s activities and it is not restricted to laboratory use or environments. The implementation of the enhanced prototype shows that the detection of stress and the reporting can be managed using correlation plots and automatic pattern recognition even on a very light weighted microcontroller platform.
Soft, mechanically compliant robots are developed to safely interact with a “human environment”. The use of textiles and fibrous (composite-) materials for the fabrication of robots opens up new possibilities for “softness/compliance” and safety in human-robot interaction. Besides external motion monitoring systems, textiles allow on-board monitoring and early prediction, or detection, of robot-human contact. The use of soft fibers and textiles for robot skins can increase the acceptance of robots in human surroundings. Novel topology optimization tools, materials, processing technologies and biomimetic engineering allow developing ultra-light-weight, multifunctional, and adaptive structures.
The analysis of exhaled metabolites has become a promising field of research in recent decades. Several volatile organic compounds reflecting metabolic disturbance and nutrition status have even been reported. These are particularly important for long-term measurements, as needed in medical research for detection of disease progression and therapeutic efficacy. In this context, it has become urgent to investigate the effect of fasting and glucose treatment for breath analysis. In the present study, we used amodel of ventilated rats that fasted for 12 h prior to the experiment. Ten rats per group were randomly assigned for continuous intravenous infusion without glucose or an infusion including 25 mg glucose per 100 g per hour during an observation period of 12 h. Exhaled gas was analysed using multicapillary column ion-mobility spectrometry. Analytes were identified by the BS-MCC/IMS database (version 1209; B & S Analytik, Dortmund, Germany). Glucose infusion led to a significant increase in blood glucose levels (p<0.05 at 4 h and thereafter) and cardiac output (p<0.05 at 4 h and thereafter). During the observation period, 39 peaks were found collectively. There were significant differences between groups in the concentration of ten volatile organic compounds: p<0.001 at 4 h and thereafter for isoprene, cyclohexanone, acetone, p-cymol, 2-hexanone, phenylacetylene, and one unknown compound, and p<0.001 at 8 h and thereafter for 1-pentanol, 1-propanol, and 2-heptanol. Our results indicate that for long-term measurement, fasting and the withholding of glucose could contribute to changes of volatile metabolites in exhaled air.
The proposed approach applies current unsupervised clustering approaches in a different dynamic manner. Instead of taking all the data as input and finding clusters among them, the given approach clusters Holter ECG data (longterm electrocardiography data from a holter monitor) on a given interval which enables a dynamic clustering approach (DCA). Therefore advanced clustering techniques based on the well known Dynamic TimeWarping algorithm are used. Having clusters e.g. on a daily basis, clusters can be compared by defining cluster shape properties. Doing this gives a measure for variation in unsupervised cluster shapes and may reveal unknown changes in healthiness. Embedding this approach into wearable devices offers advantages over the current techniques. On the one hand users get feedback if their ECG data characteristic changes unforeseeable over time which makes early detection possible. On the other hand cluster properties like biggest or smallest cluster may help a doctor in making diagnoses or observing several patients. Further, on found clusters known processing techniques like stress detection or arrhythmia classification may be applied.
New business concepts such as Enterprise 2.0 foster the use of social software in enterprises. Especially social production significantly increases the amount of data in the context of business processes. Unfortunately, these data are still an unearthed treasure in many enterprises. Due to advances in data processing such as Big Data, the exploitation of context data becomes feasible. To provide a foundation for the methodical exploitation of context data, this paper introduces a classification, based on two classes, intrinsic and extrinsic data.
An ongoing challenge in our days is to lower the impact on the quality of life caused by dysfunctionality through individual support. With the background of an aging society and continuous increases in costs for care, a holistic solution is needed. This solution must integrate individual needs and preferences, locally available possibilities, regional conditions, professional and informal caregivers and provide the flexibility to implement future requirements. The proposed model is a result of a common initiative to overcome the major obstacles and to center a solution on individual needs caused by dysfunctionality.
Today fiber reinforced plastics (FRP) are well established in manifold technical applications, because they provide advantages such as low weight, high stiffness, high strength and chemical resistance. The broad range of production methods starts from cost effective mass production up to the manufacturing of ultra-lightweight composite parts.
Biological materials are also usually composite materials: Higher plants or bones of higher animals are hierarchically organized and are composed of only a few materials such as lignin, cellulose, apatite and collagen. The large variety and the mechanical properties of natural tissues results primarily from an optimized fiber lay-up to adapt to the mechanical requirements of the respective “installation circumstances”.
Advanced lightweight technical solutions need strong materials and structurally optimized structures. In many industries, the structural optimization by an appropriate fiber lay-up has become an important method to save more weight. Corresponding software tools help to optimize topology/shape (e.g. Mattheck: CAO/SKO, Co. Altair: Optistruct), mainly using finite element analyzing technology.
The combination of strong lightweight materials, optimized topology and sophisticated fiber lay-up is also present in many bio-mineralized planktonic shells — for instance diatoms and radiolaria—but also in glass sponges.
Following it is shown, how the high weight-related mechanical properties of plankton are biomimetically transferred into ultra-lightweight technical structures.
Excellence in IT is a key enabler for the digital transformation of enterprises. To realize the vision of digital enterprises it is necessary to cope with changing business requirements and to align business and IT. In order to evaluate the contribution of enterprise architecture management to these goals, our paper explores the impact of various factors to the perceived benefit of EAM in enterprises. Based on literature, we build an empirical research model. It is tested with empirical data of European EAM experts using a structural equation modelling approach. It is shown that changing business requirements, IT business alignment, the complexity of information technology infrastructure as well as enterprise architecture knowledge of information technology employees are crucial impact factors to the perceived benefit of EAM in enterprises.