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Background. The application of lean management is standard in many companies all over the world. It is used to continuously optimise existing production processes and to reduce the complexity of administrative processes. Unfortunately, in higher education, the awareness of lean management as a highly effective methodology is quite low.
Research aims. The research aim is to show how the lean strategy can be applied in university environments. Finally, this paper addresses the question why it is so difficult to implement lean in a university environment and how an institution of higher education can move forward towards becoming a lean university.
Methodology. Based on a literature review, five key lean principles are presented and examples of their implementation are discussed using short case studies from our own institution. We also compare our findings with those in the literature.
Key findings. Lean offers the chance to improve the management of higher education institutions. This requires a commitment on the part of the university top management aiming at convincing all stakeholders that a culture of lean helps the institution to be able to adapt to the rapidly changing environment of higher education.
Thematic issue on human-centred ambient intelligence: cognitive approaches, reasoning and learning
(2017)
This editorial presents advances on human-centred Ambient Intelligence applications which take into account cognitive issues when modelling users (i.e. stress, attention disorders), and learn users’ activities/preferences and adapt to them (i.e. at home, driving a car). These papers also show AmI applications in health and education, which make them even more valuable for the general society.
Ziel eines aktuellen Forschungsprojektes an der Hochschule Reutlingen, das gemeinsam mit dem Ingenieurbüro Ganssloser und der Universität Tübingen durchgeführt wird, ist es, Flexibilitäten in Unternehmen, die im Verbund als virtuelles Kraftwerk am Strommarkt agieren, zu erkennen und nutzbar zu machen. Zu diesem Zweck soll eine Steuerbox für Industrie- und Gewerbebetriebe entwickelt werden, die einerseits mit der zentralen Leitwarte des virtuellen Kraftwerks kommuniziert und andererseits die Anlagen des Unternehmens so steuert, dass die zur Verfügung stehenden Flexibilitäten möglichst optimal genutzt werden. Die Hochschule Reutlingen beschäftigt sich innterhalb des Projekts mit der Erkennung und Beschreibung von Flexibilitäten in Unternehmen.
We were able to identify a set of specific capabilities corporations need to develop in order to enhance brand love. Furthermore, the effects of most dynamic capabilities on brand love have a strong correlation to the degree of customer orientation. Other results are relevant concerning the proposed moderation and mediation hypotheses. Firstly, the impact of customer orientation on brand love is varied under specific market conditions, supporting our central moderation hypothesis (β = .259, p = .001). To be precise, the impact of customer orientation is strongest in markets that have low competitive differentiation in products and services. Other control variables like age, gender, or market form (B2B versus B2C) lead to no significant heterogeneity in the data set. Finally, mediation analyses show no significant “direct effect” of the existing DC constructs on brand love, supporting the mediating role of customer orientation.
Royal Philip's goal was to use innovation to improve the lives of three billion people a year by 2025. To reach that goal, the company was shifting from selling medical products in a transactional manner to providing integrated healthcare solutions based on digital health technology ("HealthTech").
This shift required a dual transformation. On one hand, the company needed to transform how healthcare was conducted. Healthcare professionals would have to change the way they worked and reimbursement schemes needed to change to incentivize payers, providers, and patients in vastly different ways. On the other hand, Philips needed to redesign how it worked internally. The company componentized its business, introduced digital platforms, and co-created solutions with the various stakeholders of the healthcare industry.
In other words: Royal Philips was transforming itself in order to reinvent healthcare in the digital age.
Electronic word-of-mouth (eWoM) communication has received a lot of attention from the academic community. As multiple research papers focus on specific facets of eWoM, there is a need to integrate current research results systematically. Thus, this paper presents a scientific literature analysis in order to determine the current state-of-the-art in the field of eWoM.
Pokémon Go was the first mobile augmented reality (AR) game to reach the top of the download charts of mobile applications. However, little is known about this new generation of mobile online AR games. Existing theories provide limited applicability for user understanding. Against this background, this research provides a comprehensive framework based on uses and gratification theory, technology risk research, and flow theory. The proposed framework aims to explain the drivers of attitudinal and intentional reactions, such as continuance in gaming or willingness to invest money in in-app purchases. A survey among 642 Pokémon Go players provides insights into the psychological drivers of mobile AR games. The results show that hedonic, emotional, and social benefits and social norms drive consumer reactions while physical risks (but not data privacy risks) hinder consumer reactions. However, the importance of these drivers differs depending on the form of user behavior.
How to separate the wheat from the chaff: improved variable selection for new customer acquisition
(2017)
Steady customer losses create pressure for firms to acquire new accounts, a task that is both costly and risky. Lacking knowledge about their prospects, firms often use a large array of predictors obtained from list vendors, which in turn rapidly creates massive high-dimensional data problems. Selecting the appropriate variables and their functional relationships with acquisition probabilities is therefore a substantial challenge. This study proposes a Bayesian variable selection approach to optimally select targets for new customer acquisition. Data from an insurance company reveal that this approach outperforms nonselection methods and selection methods based on expert judgment as well as benchmarks based on principal component analysis and bootstrap aggregation of classification trees. Notably, the optimal results show that the Bayesian approach selects panel-based metrics as predictors, detects several nonlinear relationships, selects very large numbers of addresses, and generates profits. In a series of post hoc analyses, the authors consider prospects’ response behaviors and cross selling potential and systematically vary the number of predictors and the estimated profit per response. The results reveal that more predictors and higher response rates do not necessarily lead to higher profits.
Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus
(2017)
Effective restoration of human intervertebral disc degeneration is challenged by numerous limitations of the currently available spinal fusion and arthroplasty treatment strategies. Consequently, use of artificial biomaterial implant is gaining attention as a potential therapeutic strategy. Our study is aimed at investigating and characterizing a novel knitted titanium (Ti6Al4V) implant for the replacement of nucleus pulposus to treat early stages of chronic intervertebral disc degeneration. Specific knitted geometry of the scaffold with a porosity of 67.67 ± 0.824% was used to overcome tissue integration failures. Furthermore, to improve the wear resistance without impairing original mechanical strength, electro-polishing step was employed. Electro-polishing treatment changed a surface roughness from 15.22 ± 3.28 to 4.35 ± 0.87 μm without affecting its wettability which remained at 81.03 ± 8.5°. Subsequently, cellular responses of human mesenchymal stem cells (SCP1 cell line) and human primary chondrocytes were investigated which showed positive responses in terms of adherence and viability. Surface wettability was further enhanced to super hydrophilic nature by oxygen plasma treatment, which eventually caused substantial increase in the proliferation of SCP1 cells and primary chondrocytes. Our study implies that owing to scaffolds physicochemical and biocompatible properties, it could improve the clinical performance of nucleus pulposus replacement.
A wide variety of cell types exhibit substrate topography-based behavior, also known as contact guidance. However, the precise cellular mechanisms underlying this process are still unknown. In this study, we investigated contact guidance by studying the reaction of human endothelial cells (ECs) to well-defined microgroove topographies, both during and after initial cell spreading. As the cytoskeleton plays a major role in cellular adaptation to topographical features, two methods were used to perturb cytoskeletal structures. Inhibition of actomyosin contractility with the chemical inhibitor blebbistatatin demonstrated that initial contact guidance events are independent of traction force generation. However, cell alignment to the grooved substrate was altered at later time points, suggesting an initial ‘passive’ phase of contact guidance, followed by a contractility-dependent ‘active’ phase that relies on mechanosensitive feedback. The actin cytoskeleton was also perturbed in an indirect manner by culturing cells upside down, resulting in decreased levels of contact guidance and suggesting that a possible loss of contact between the actin cytoskeleton and the substrate could lead to cytoskeleton impairment. The process of contact guidance at the microscale was found to be primarily lamellipodia driven, as no bias in filopodia extension was observed on micron-scale grooves.
Intermediate filament reorganization dynamically influences cancer cell alignment and migration
(2017)
The interactions between a cancer cell and its extracellular matrix (ECM) have been the focus of an increasing amount of investigation. The role of the intermediate filament keratin in cancer has also been coming into focus of late, but more research is needed to understand how this piece fits in the puzzle of cytoskeleton-mediated invasion and metastasis. In Panc-1 invasive pancreatic cancer cells, keratin phosphorylation in conjunction with actin inhibition was found to be sufficient to reduce cell area below either treatment alone. We then analyzed intersecting keratin and actin fibers in the cytoskeleton of cyclically stretched cells and found no directional correlation. The role of keratin organization in Panc-1 cellular morphological adaptation and directed migration was then analyzed by culturing cells on cyclically stretched polydimethylsiloxane (PDMS) substrates, nanoscale grates, and rigid pillars. In general, the reorganization of the keratin cytoskeleton allows the cell to become more ‘mobile’- exhibiting faster and more directed migration and orientation in response to external stimuli. By combining keratin network perturbation with a variety of physical ECM signals, we demonstrate the interconnected nature of the architecture inside the cell and the scaffolding outside of it, and highlight the key elements facilitating cancer cell-ECM interactions.
AUDI AG has historically focused on producing and selling premium vehicles but has begun to experiment with providing mobility services, built around car sharing. Its response to the so-called sharing economy addressed strategic and transformational challenges. Strategically, the company pursued additional sources of revenue from targeted, premium mobility services, rather than the less segmented services provided by competitors such as BMW and Zipcar. AUDI AG also transformed its organizational structure, processes and architecture to balance autonomy for innovation and integration for competitiveness.
Cell-cell and cell-extracellular matrix (ECM) adhesion regulates fundamental cellular functions and is crucial for cell-material contact. Adhesion is influenced by many factors like affinity and specificity of the receptor-ligand interaction or overall ligand concentration and density. To investigate molecular details of cell ECM and cadherins (cell-cell) interaction in vascular cells functional nanostructured surfaces were used Ligand-functionalized gold nanoparticles (AuNPs) with 6-8 nm diameter, are precisely immobilized on a surface and separated by non-adhesive regions so that individual integrins or cadherins can specifically interact with the ligands on the AuNPs. Using 40 nm and 90 nm distances between the AuNPs and functionalized either with peptide motifs of the extracellular matrix (RGD or REDV) or vascular endothelial cadherins (VEC), the influence of distance and ligand specificity on spreading and adhesion of endothelial cells (ECs) and smooth muscle cells (SMCs) was investigated. We demonstrate that RGD-dependent adhesion of vascular cells is similar to other cell types and that the distance dependence for integrin binding to ECM-peptides is also valid for the REDV motif. VEC-ligands decrease adhesion significantly on the tested ligand distances. These results may be helpful for future improvements in vascular tissue engineering and for development of implant surfaces.
The European Economic and Monetary Union (EMU) has been in turmoil for more than six years. The present governance rules do not seem to solve the problems neither permanently nor effectively. There is no vision about the future of Europe in the 21st century. This article describes a realignment of the economic governance, which does not necessarily lead to a transfer or political union. However, it solves the current and future challenges. In fact, the redesign of present rules is the most likely as well as legally and economically option today. The key ideais the detachment from the compulsive idea of an ever closer union. However, this vision requires boldness towards greater flexibility together with an exit clause or a state insolvency procedure for incompliant member states.
Saving energy and road safety became important in the last decades, hence several driving assistant systems were developed that help to improve the driving behaviour. However, these driving systems cover the area of either energy-efficiency or safety. Furthermore, they do not consider the reaction of the driver to a shown recommendation and the driver stress level. In this paper, the decision process of showing a recommendation to the driver in an energy-efficient and safety relevant driving system is presented. The decision process considers the driver's reaction to a shown recommendation and the driver stress in order to increase the user acceptance and the road safety. The results of the evaluation showed that the driving system was able to show recommendations when needed, while suppressing recommendations when the driver ignored a recommendation repeatedly or when the driver was in stress.
Introducing continuous experimentation in large software-intensive product and service organisations
(2017)
Software development in highly dynamic environments imposes high risks to development organizations. One such risk is that the developed software may be of only little or no value to customers, wasting the invested development efforts.Continuous experiment ation, as an experiment-driven development approach, may reduce such development risks by iteratively testing product and service assumptions that are critical to the success of the software. Although several experiment-driven development approaches are available, there is little guidance available on how to introduce continuous experimentation into an organization. This article presents a multiple-case study that aims at better understanding the process of introducing continuous experimentation into an organization with an already established development process. The results from the study show that companies are open to adopting such an approach and learning throughout the introduction process. Several benefits were obtained, such as reduced development efforts, deeper customer insights, and better support for development decisions. Challenges included complex stakeholder structures, difficulties in defining success criteria, and building experimen- tation skills. Our findings indicate that organizational factors may limit the benefits of experimentation. Moreover, introducing continuous experimentation requires fundamental changes in how companies operate, and a systematic introduction process can increase the chances of a successful start.
To evaluate the quality of sleep, it is important to determine how much time was spent in each sleep stage during the night. The gold standard in this domain is an overnight polysomnography (PSG). But the recording of the necessary electrophysiological signals is extensive and complex and the environment of the sleep laboratory, which is unfamiliar to the patient, might lead to distorted results. In this paper, a sleep stage detection algorithm is proposed that uses only the heart rate signal, derived from electrocardiogram (ECG), as a discriminator. This would make it possible for sleep analysis to be performed at home, saving a lot of effort and money. From the heart rate, using the fast Fourier transformation (FFT), three parameters were calculated in order to distinguish between the different sleep stages. ECG data along with a hypnogram scored by professionals was used from Physionet database, making it easy to compare the results. With an agreement rate of 41.3%, this approach is a good foundation for future research.
Zukünftige Montagearbeitsplätze müssen veränderten Herausforderungen, wie z. B. der zunehmenden Anzahl von Mensch Roboter-Kollaborationen, gerecht werden. Die Virtual Reality (VR)-Technik bietet im Rahmen der Arbeitsplatzgestaltung neue Möglichkeiten, diesen veränderten Planungsherausforderungen gerecht zu werden. Die Ausarbeitung stellt eine Methode zur Bewertung des sinnvollen Einsatzes der VR-Technik für einen spezifischen Arbeitsplatz vor. Außerdem wird aufgezeigt, wie die VR-Technik in den Prozess der Arbeitsplatzgestaltung integriert werden kann.
LDMOS transistors in integrated power technologies are often subject to thermo-mechanical stress, which degrades the on-chip metallization and eventually leads to a short. This paper investigates small sense lines embedded in the LDMOS metallization. It will be shown that their resistance depends strongly on the stress cycle number. Thus, they can be used as aging sensors and predict impending failures. Different test structures have been investigated to identify promising layout configurations. Such sensors are key components for resilient systems that adaptively reduce stress to allow aggressive LDMOS scaling without increasing the risk of failure.
Die weiterhin hohen Schulden in einigen Staaten der Europäischen Wirtschafts- und Währungsunion lassen nach wie vor staatliche Insolvenzen befürchten. Um die entstandenen Probleme zu bewältigen, aber auch damit eine solche Situation erst gar nicht eintritt, hält der Autor eine staatliche Insovenzordnung – mit Bail-out durch die anderen Mitgliedstaaten nur in Notfällen – für erforderlich. Er schlägt einen staatlichen Abwicklungsmechanismus für überschuldete Euro-Länder vor, der auf einem Konzept des Sachverständigenrates für Wirtschaft von 2016 beruht.
Electric freight vehicles have the potential to mitigate local urban road freight transport emissions, but their numbers are still insignificant. Logistics companies often consider electric vehicles as too costly compared to vehicles powered by combustion engines. Research within the body of the current literature suggests that increasing the driven mileage can enhance the competitiveness of electric freight vehicles. In this paper we develop a numeric simulation approach to analyze the cost-optimal balance between a high utilization of medium-duty electric vehicles – which often have low operational costs – and the common requirement that their batteries will need expensive replacements. Our work relies on empirical findings of the real-world energy consumption from a large German field test with medium-duty electric vehicles. Our results suggest that increasing the range to the technical maximum by intermediate (quick) charging and multi-shift usage is not the most cost-efficient strategy in every case. A low daily mileage is more cost-efficient at high energy prices or consumptions, relative to diesel prices or consumptions, or if the battery is not safeguarded by a long warranty. In practical applications our model may help companies to choose the most suitable electric vehicle for the application purpose or the optimal trip length from a given set of options. For policymakers, our analysis provides insights on the relevant parameters that may either reduce the cost gap at lower daily mileages, or increase the utilization of medium-duty electric vehicles, in order to abate the negative impact of urban road freight transport on the environment.
Though bioprinting is a forward-looking approach in bone tissue engineering, the development of bioinks which are on the one hand processable with the chosen printing technique, and on the other hand possess the relevant mechanical as well as osteoconductive features remains a challenge. In the present study, polymer solutions based on methacrylated gelatin and methacrylated hyaluronic acid modified with hydroxyapatite (HAp) particles (5 wt%) were prepared. Encapsulation of primary human adipose derived stem cells in the HAp-containing gels and culture for 28 d resulted in a storage moduli significantly increased to 126% ± 9.6% compared to the value on day 1 by the sole influence of the HAp. Additional use of osteogenic media components resulted in an increase of storage module up to 199% ± 27.8%. Similarly, the loss moduli was increased to 370% ± 122.1% under the influence of osteogenic media components and HAp. Those changes in rheological material characteristics indicate a distinct change in elastic and viscous hydrogel properties, and are attributed to extensive matrix production in the hydrogels by the encapsulated cells, what could also be proven by staining of bone matrix components like collagen I, fibronectin, alkaline phosphatase and osteopontin. When using the cell-laden polymer solutions as bioinks to build up relevant geometries, the ink showed excellent printability and the printed grid structure's integrity remained intact over a culture time of 28 d. Again, an intense matrix formation as well as upregulation of osteogenic markers by the encapsulated cells could be shown. In conclusion, we demonstrated that our HAp-containing bioinks and hydrogels on basis of methacrylated gelatin and hyaluronic acid are on the one hand highly suitable for the build up of relevant three-dimensional geometries with microextrusion bioprinting, and on the other hand exhibit a significant positive effect on bone matrix development and remodeling in the hydrogels, as indicated by rheological measurements and staining of bone components. This makes the developed composite hydrogels an excellent material for bone bioprinting approaches.
This paper studies whether a monetary union can be managed solely by a rule based approach. The Five Presidents’ Report of the European Union rejects this idea. It suggests a centralisation of powers. We analyse the philosophy of policy rules from the vantage point of the German economic school of thought. There is evidence that a monetary union consisting of sovereign states is well organised by rules, together with the principle of subsidiarity. The root cause of the euro crisis is rather the weak enforcement of rules, compounded by structural problems. Therefore, we suggest a genuine rule-based paradigm for a stable future of the Economic and Monetary Union.
The purpose of this paper is to study the impact of transparency on the political budget cycle (PBC) over time and across countries. So far, the literature on electoral cycles finds evidence that cycles depend on the stage of an economy. However, the author shows – for the first time – a reliance of the budget cycle on transparency. The author uses a new data set consisting of 99 developing and 34 Organization for Economic Cooperation and Development countries. First, the author develops a model and demonstrates that transparency mitigates the political cycles. Second, the author confirms the proposition through the econometric assessment. The author uses time series data from 1970 to 2014 and discovers smaller cycles in countries with higher transparency, especially G8 countries.
In retail environments, consumers commonly evaluate products while standing on some type of flooring and concurrently being exposed to music; however, no study has examined the interaction of these two atmospheric cues. To bridge this gap, this research examines whether retailers can benefit from creating multisensory atmospheric congruent rather than incongruent retail environments of flooring and music. The results of an experiment in a real retail store reveal positive effects of multisensory congruent retail environments (e.g., soft music combined with soft flooring) on product evaluations. This study provides a new process explanation with consumers’ purchase-related self-confidence mediating these effects. Specifically, consumers in congruent rather than incongruent retail environments experience more purchase-related self confidence, which in turn leads to more favorable product evaluations. Furthermore, this study shows that consumers with a low rather than a high preference for haptic information are influenced more by multisensory atmospheric congruence when evaluating a product haptically.
Structural and functional thermosetting composite materials are exposed to different kinds of stress which can damage the polymer matrix, thus impairing the intended properties. Therefore, self-healing materials have attracted the attention of many research groups over the last decades in order to provide satisfactory material properties and outstanding product durability. The present article provides a critical overview of promising self-healing strategies for crosslinked thermoset polymers. It is organized in two parts: an overview about the different approaches to self-healing is given in the first part, whereas the second part focuses on the specific chemistries of the main strategies to achieve self-healing through crosslinking. It is attempted to provide a comprehensive discussion of different approaches which are described in the scientific literature. By comparison of the advantages and disadvantages, the authors wish to provide helpful insights on the assessment of the potential to transfer the extensive present knowledge about self-healing materials and methods to surface varnishing thermoset coatings.
This article provides a general overview of the most promising candidates of bio based materials and deals with the most important issues when it comes to their incorporation into PF resins. Due to their abundance on Earth, much knowledge of lignin-based materials has already been gained and uses of lignin in PF resins have been studied for many decades. Other natural polyphenols that are less frequently considered for impregnation are covered as well, as they do also possess some potential for PF substitution.
High quality decorative laminate panels typically consist of two major types of components: the surface layers comprising décor and overlay papers that are impregnated with melamine-based resins, and the core which is made of stacks of kraft papers impregnated with phenolic (PF) resin. The PF-impregnated layers impart superior hydrolytic stability, mechanical strength and fire-resistance to the composite. The manufacturing involves the complex interplay between resin, paper and impregnation/drying processes. Changes in the input variables cause significant alterations in the process characteristics and adaptations of the used materials and specific process conditions may, in turn, be required. This review summarizes the main variables influencing both processability and technological properties of phenolic resin impregnated papers and laminates produced therefrom. It is aimed at presenting the main influences from the involved components (resin and paper), how these may be controlled during the respective process steps (resin preparation and paper production), how they influence the impregnation and lamination conditions, how they affect specific aspects of paper and laminate performance, and how they interact with each other
(synergies).
Context: Development of software intensive products and services increasingly occurs by continuously deploying product or service increments, such as new features and enhancements, to customers. Product and service developers must continuously find out what customers want by direct customer feedback and usage behaviour observation. Objective: This paper examines the preconditions for setting up an experimentation system for continuous customer experiments. It describes the RIGHT model for Continuous Experimentation (Rapid Iterative value creation Gained through High-frequency Testing), illustrating the building blocks required for such a system. Method: An initial model for continuous experimentation is analytically derived from prior work. The model is matched against empirical case study findings from two startup companies and further developed. Results: Building blocks for a continuous experimentation system and infrastructure are presented. Conclusions: A suitable experimentation system requires at least the ability to release minimum viable products or features with suitable instrumentation, design and manage experiment plans, link experiment results with a product roadmap, and manage a flexible business strategy. The main challenges are proper, rapid design of experiments, advanced instrumentation of software to collect, analyse, and store relevant data, and the integration of experiment results in both the product development cycle and the software development process.
Software engineering education is under constant pressure to provide students with industry-relevant knowledge and skills. Educators must address issues beyond exercises and theories that can be directly rehearsed in small settings. Industry training has similar requirements of relevance as companies seek to keep their workforce up to date with technological advances. Real-life software development often deals with large, software-intensive systems and is influenced by the complex effects of teamwork and distributed software development, which are hard to demonstrate in an educational environment. A way to experience such effects and to increase the relevance of software engineering education is to apply empirical studies in teaching. In this paper, we show how different types of empirical studies can be used for educational purposes in software engineering. We give examples illustrating how to utilize empirical studies, discuss challenges, and derive an initial guideline that supports teachers to include empirical studies in software engineering courses. Furthermore, we give examples that show how empirical studies contribute to high-quality learning outcomes, to student motivation, and to the awareness of the advantages of applying software engineering principles. Having awareness, experience, and understanding of the actions required, students are more likely to apply such principles under real-life constraints in their working life.
In vitro composed vascularized adipose tissue is and will continue to be in great demand e.g. for the treatment of extensive high-graded burns or the replacement of tissue after tumor removal. Up to date, the lack of adequate culture conditions, mainly a culture medium, decelerates further achievements. In our study, we evaluated the influence of epidermal growth factor (EGF) and hydrocortisone (HC), often supplemented in endothelial cell (EC) specific media, on the co-culture of adipogenic differentiated adipose derived stem cells (ASCs) and microvascular endothelial cells (mvECs). In ASCs, EGF and HC are thought to inhibit adipogenic differentiation and have lipolytic activities. Our results showed that in indirect co-culture for 14 days, adipogenic differentiated ASCs further incorporated lipids and partly gained an univacuolar morphology when kept in media with low levels of EGF and HC. In media with high EGF and HC levels, cells did not incorporate further lipids, on the contrary, cells without lipid droplets appeared. Glycerol release, to measure lipolysis, also increased with elevated amounts of EGF and HC in the culture medium. Adipogenic differentiated ASCs were able to release leptin in all setups. MvECs were functional and expressed the cell specific markers, CD31 and von Willebrand factor (vWF), independent of the EGF and HC content as long as further EC specific factors were present. Taken together, our study demonstrates that adipogenic differentiated ASCs can be successfully co-cultured with mvECs in a culture medium containing low or no amounts of EGF and HC, as long as further endothelial cell and adipocyte specific factors are available.
Decreasing batch sizes in production in line with Industrie 4.0 will lead to tremendous changes of the control of logistic processes in future production systems. Intelligent bins are crucial enablers to establish decentrally controlled material flow systems in value chain networks as well as at the intralogistics level. These intelligent bins have to be integrated into an overall decentralized monitoring and control approach and have to interact with humans and other entities just like other cyber-physical systems (CPS) within the cyber-physical production system (CPPS). To realize a decentralized material supply following the overall aim of a decentralized control of all production and logistics processes, an intelligent bin system is currently developed at the ESB Logistics Learning Factory. This intelligent bin system will be integrated into the self developed, cloud-based and event-oriented SES system (so-called “Self Execution System”) which goes beyond the common functionalities and capabilities of traditional manufacturing execution systems (MES).
To ensure a holistic integration of the intelligent bin for different material types into the SES framework, the required hard- and software components for the decentrally controlled bin system will be split into a common and an adaptable component. The common component represents the localization and network layer which is common for every bin, whereas the flexible component will be customizable to different requirements, like to the specific characteristics of the parts.
Close and safe interaction of humans and robots in joint production environments is technically feasible, however should not be implemented as an end in itself but to deliver improvement in any of a production system’s target dimensions. Firstly, this paper shows that an essential challenge for system integrators during the design of HRC applications is to identify a suitable distribution of available tasks between a robotic and a human resource. Secondly, it proposes an approach to determine task allocation by considering the actual capabilities of both human and robot in order to improve work quality. It matches those capabilities with given requirements of a certain task in order to identify the maximum congruence as the basis for the allocation decision. The approach is based on a study and subsequent generic description of human and robotic capabilities as well as a heuristic procedure that facilities the decision making process.
Technologies for mapping the “digital twin“ have been under development for approximately 20 years. Nowadays increasingly intelligent, individualized products encourages companies to respond innovatively to customer requirements and to handle the rising product variations quickly.
An integrated engineering network, spanning across the entire value chain, is operated to intelligently connect various company divisions, and to generate a business ecosystem for products, services and communities. The conditions for the digital twin are thereby determined in which the digital world can be fed into the real, and the real world back into the digital to deal such intelligent products with rising variations.
The term digital twin can be described as a digital copy of a real factory, machine, worker etc., that is created and can be independently expanded, automatically updated as well as being globally available in real time. Every real product and production site is permanently accompanied by a digital twin. First prototypes of such digital twins already exist in the ESB Logistics Learning Factory on a cloud- and app based software that builds on a dynamic, multidimensional data and information model. A standardized language of the robot control systems via software agents and positioning systems has to be integrated. The aspect of the continuity of the real factory in the digital factory as an economical means of ensuring continuous actuality of digital models looks as the basis of changeability.
For the indoor localization sensor combinations that in addition to the hardware already contain the software required for the sensor data fusion should be used. Processing systems, scenario-live-simulations and digital shop floor management results in a mandatory procedural combination. Essential to the digital twin is the ability to consistently provide all subsystems with the latest state of all required information, methods and algorithms.
Despite the significant potential offered by the powder coating process for finishing wood-based materials, until now it has been used almost exclusively for coating Medium Density Fiber Board (MDF). A research project aims to develop processes and substrate materials that will allow lightweight boards to be powder coated.
Obwohl Vorteile wertorientierter Preissetzung seit Jahren bekannt sind, gewinnt sie nur langsam an Boden. Die erste Studie des Preisverhaltens nach Geschäftstypen zeigt: 35 Jahre Preisforschung und -beratung konnten die Dominanz der Kostenorientierung erstmals schwächen. Der Autor wagt einen Erklärungsversuch und ermutigt zu mehr Marktorientierung.
Zusammen mit Partnern aus Industrie und Politik untersuchen die ESB Business School der Hochschule Reutlingen, die Hochschule Offenburg und die Fachhochschule Nordwestschweiz (FHNW) in einem Interreg-Projekt die Möglichkeiten, klima- und gesundheitsschädliche Emissionen im Grenzverkehr am Hochrhein zu reduzieren. Elektromobilität und Fahrgemeinschaften werden dazu im Rahmen eines Pilotprojekts gefördert und die Wirkung analysiert. Erste Ergebnisse zeigen, dass heutige Elektroautos für das grenzüberschreitende Pendeln unter bestimmten Voraussetzungen geeignet sind.
Um einen Funksensor zum Messen der Windgeschwindigkeit per Energy Harvesting mit Energie zu versorgen, bietet es sich an, das Messsignal selbst zur Energiegewinnung zu nutzen. Mit optimierter Funkübertragung und Energiemanagement lässt sich ein autarker Windstärke-Funksensor realisieren, der ab 2 m/s Windgeschwindigkeiten messen und die Messwerte per Funk übertragen kann.
Der Zusammenschluss von Unternehmen in Lieferantennetzwerken auf Basis digitaler Plattformen bietet eine Möglichkeit, der Forderung nach Flexibilität in der Industrie 4.0 nachzukommen. Anhand der Charakterisierung eines realen Lieferantennetzwerkes werden use cases für die Lieferantenanbindung hergeleitet. Diese dienen als Diskussionsgrundlage von Potenzialen und Herausforderungen der Anbindung, wobei sich die Frage nach der optimalen Integrationstiefe stellt. Hierzu wurde ein anwenderorientiertes Entscheidungsmodell abgeleitet.
Learning factories present a promising environment for education, training and research, especially in manufacturing related areas which are a main driver for wealth creation in any nation. While numerous learning factories have been built in industry and academia in the last decades, a comprehensive scientific overview of the topic is still missing. This paper intends to close this gap establishing the state of the art of learning factories. The motivations, historic background, and the didactic foundations of learning factories are outlined. Definitions of the term learning factory and the corresponding morphological model are provided. An overview of existing learning factory approaches in industry and academia is provided, showing the broad range of different applications and varying contents. The state of the art of learning factories curricula design and their use to enhance learning and research as well as potentials and limitations are presented. Conclusions and an outlook on further research priorities are offered.
The wet chemical deposition of solution processed transparent conducting oxides (TCO) provides an alternative low cost and economical deposition technique to realize large-areas of conducting films. Since the price for the most common TCO Indium Tin Oxide rises enormously, Aluminum Zinc Oxide (AZO) as alternative TCO reaches more and more interest. The optoelectronical properties of nanoparticle coatings strongly depend beneath the porosity of the coating on the shape and size of the used particles. By using bigger or rod-shaped particles it is possible to minimize the amount of grain boundaries resulting in an improvement of the electrical properties, whereas particles bigger than 100 nm should not be used if highly transparent coatings are necessary as these big particles scatter the visible light and lower the transmittance of the coatings. In this work we present a simple method to synthesize AZO particles with different shape and size, but comparable electronical properties. We use a simple, well reproducible polyol method for synthesis and influence the shape and size of the particles by adding different amounts of water to the precursor solution. We can show that the addition of aluminum as dopant strongly hinders the crystal growth but the addition of water counteracts this, so that both, spherical and rod-shaped particles can be obtained.
Das Knie ist das am häufigsten von Verletzungen betroffene Gelenk beim Skifahren. Durch die Messung bestimmter Einflussfaktoren, wie Kniewinkel und Muskelaktivität, kann eine Aussage über die Wahrscheinlichkeit einer drohenden Verletzung getroffen werden. Diese Daten können als Basis genutzt werden, um eine entsprechende Reaktion des Bindungssystems des Skis hervorzurufen. Durch die automatische Auslösung der Skibindung bei der Überschreitung der Grenzwerte wird das Knie entlastet, um möglichen Verletzungen vorzubeugen. Im Rahmen eines Forschungsprojekts der TU München wurde von einem Team der TU München und der Hochschule Reutlingen eine Skiunterhose entwickelt, mit der in Echtzeit der Kniewinkel erfasst und drahtlos an eine Auswerteeinheit gesendet werden kann.
Der flächendeckende Einsatz digitaler Zähler wird eine bislang ungekannte Menge an Kundendaten mit sich bringen. Wie können die deutschen Energieversorger hieraus ein besseres Kundenverständnis entwickeln? Die systematische Datenauslese unter Zuhilfenahme modellgestützter Zukunftsprognosen - sog. Predictive Analytics - scheint hier ein vielversprechendes Instrument zu sein. Aufbauend auf einer mit Unterstützung des Verbandes kommunaler Unternehmen durchgeführten Untersuchung lassen sich vier Handlungsempfehlungen ableiten, wie man die Digitalisierung im Vertrieb nutzen kann. Demnach sind die Festlegung von klaren Zielen und Strategien, die systematische Erschließung von Datenquellen, der Aufbau von Inhouse-Kompetenz sowie ein "Joint effort" von Marketing, Vertrieb und IT zu forcieren.
Die Bereitstellung von Wärme ist für ungefähr die Hälfte des Endenergieverbruchs in Deutschland verantwortlich und, angesichts eines Anteils erneuerbarer Energien an der Wärmebereitstellung von heute 14%, auch für einen bedeutenden Anteil der Treibhausgasemissionen. Die Bundesregierung strebt an, bis 2050 die Wärmeversorgung klimaneutral zu gestalten, sodass drei Ziele den zukünftigen Wärmemarkt und seine Innovationserfordernisse prägen: Reduktion des Wärmebedarfs, Steigerung des Anteils erneuerbarer Energien, Ausbau der Nah- und Fernwärmenetze. Für attraktive Geschäftsmodelle nicht minder wichtig sind jedoch die Kundenbedürfnisse, die sich auch aufgrund technologischer Entwicklungen stetig wandeln. Dementsprechend eröffnen sich neue Optionen für Geschäftsmodelle im Wärmesektor, z.B. erneuerbare Wärme mit Flatrate oder partizipative Wärme mit Energiesparanreizen.
Mit der Energiewende hat die Bundesregierung den Umbau der Energieversorgung begonnen. Da das Gelingen der Energiewende für die Zukunfts- und Wettbewerbsfähigkeit des Wirtschaftsstandorts Deutschland essenziell ist, wurden seitens des Bundesverbandes der deutschen Industrie (BDI) bereits 2013 Impulse für eine smarte Energiewende veröffentlicht, in denen fünf Prinzipien abgeleitet werden, die einen Rahmen für den Diskurs über die zu ergreifenden Maßnahmen setzen. Erneuerbare Energien werden in dem kommenden Jahren die dominierende Stromquelle darstellen. Daraus entstehen neue Herausforderungen. Zu deren Bewältigung hat das Bundeswirtschaftsministerium (BMWi) kürzlich eine 10-Punkte-Agenda (ZPA) für die zentralen Vorhaben der Energiewende vorgelegt. Zu diskutieren ist, inwieweit sie im Einklang mit den fünf Prinzipien des BDI steht und an welchen Stellen Anpassungen notwendig werden, damit der Umbau des Energiesystems erfolgreich gelingen kann.