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The scoring of sleep stages is one of the essential tasks in sleep analysis. Since a manual procedure requires considerable human and financial resources, and incorporates some subjectivity, an automated approach could result in several advantages. There have been many developments in this area, and in order to provide a comprehensive overview, it is essential to review relevant recent works and summarise the characteristics of the approaches, which is the main aim of this article. To achieve it, we examined articles published between 2018 and 2022 that dealt with the automated scoring of sleep stages. In the final selection for in-depth analysis, 125 articles were included after reviewing a total of 515 publications. The results revealed that automatic scoring demonstrates good quality (with Cohen's kappa up to over 0.80 and accuracy up to over 90%) in analysing EEG/EEG + EOG + EMG signals. At the same time, it should be noted that there has been no breakthrough in the quality of results using these signals in recent years. Systems involving other signals that could potentially be acquired more conveniently for the user (e.g. respiratory, cardiac or movement signals) remain more challenging in the implementation with a high level of reliability but have considerable innovation capability. In general, automatic sleep stage scoring has excellent potential to assist medical professionals while providing an objective assessment.
Diese Studie untersucht den kurzfristigen Einfluss der Tagespflege auf die kindliche Entwicklung im Vergleich zur Betreuung in der Kita. Internationale Studien deuten darauf hin, dass der Besuch einer Tagespflege im Vergleich zur Kita eher negative Auswirkungen auf Kinder hat. Mithilfe der Neugeborenen-Kohorte des NEPS können wir evaluieren, ob dies auch im deutschen Kontext gilt. Wir nutzen zwei verschiedene methodische Ansätze, um den Effekt der Tagespflege zu schätzen. Unsere Ergebnisse zeigen, dass die Tagespflege für die Mehrzahl der untersuchten Entwicklungsindikatoren keinen statistisch signifikant schlechteren Einfluss auf die kindliche Entwicklung hat, außer im Bereich der Habituation.
Flame-retardant finishing of cotton fabrics using DOPO functionalized alkoxy- and amido alkoxysilane
(2023)
In the present study, DOPO-based alkoxysilane (DOPO-ETES) and amido alkoxysilane (DOPO-AmdPTES) were synthesized by one-step and without by-products as halogen-free flame retardants. The flame retardants were applied on cotton fabric utilizing sol–gel method and pad-dry-cure finishing process. The flame retardancy, the thermal stability and the combustion ehaviour of treated cotton were evaluated by surface and bottom edge ignition flame test (according to EN ISO 15025), thermogravimetric analysis (TGA) and micro-scale combustion calorimeter (MCC). Unlike CO/DOPO-ETES sample, cotton treated with DOPO-AmdPTES nanosols exhibits self-extinguishing ehaviour with high char residue, an improvement of the LOI value and a significant reduction of the PHRR, HRC and THR compared to pristine cotton. Cotton finished with DOPO-AmdPTES reveals a semi-durability after ten laundering cycles keeping the flame-retardant properties unchanged. According to the results obtained from TGA-FTIR, Py-GC/MS and XPS, the major activity of flame retardant occurs in the condensed phase via catalytic induced char formation as physical barrier along with the activity in the gas phase derived mainly from the dilution effect. The early degradation of CO/DOPO-AmdPTES compared to CO/DOPO-ETES, triggered by the cleavage of the weak bond between P and C=O, as the DFT study indicated, provides the beneficial effect of this flame retardant on the fire resistance of cellulose.
Dieser Beitrag untersucht, wer in Deutschland Bildungsminister:in wird. Zur Klärung dieser Frage entwickelten wir einen Datensatz, der die biografischen Merkmale aller Bildungsminister:innen der deutschen Bundesländer zwischen 1950 und 2020 enthält. Als Beispiel für die Nutzung des Datensatzes untersuchen wir die beiden Merkmale Geschlecht und frühere Berufserfahrung und verknüpfen diese Merkmale mit Indikatoren für die Größe und Entwicklung des Bildungsbudgets und die Dauer der Amtszeit. Wir zeigen, dass zwischen 1950 und 2020 deutlich mehr Männer als Frauen zum/zur Bildungsminister:in ernannt wurden, unabhängig davon, welche Parteien die Bildungsminister:innen stellten. Außerdem verfügt die Mehrheit der Bildungsminister:innen bei Amtsantritt nicht über vorherige Berufserfahrung als Lehrer:in. Die meisten Bildungsminister:innen haben jedoch bereits politische Erfahrung, wenn sie ihr Amt antreten. Unsere Datenbank, die die erste umfassende Erhebung biografischer Merkmale von Bildungsminister:innen in den deutschen Bundesländern enthält, steht allen interessierten Forscher:innen zur Verfügung.
Digitalization and enterprise architecture management: a perspective on benefits and challenges
(2023)
Many companies digitally transform their business models, processes, and services. They have also been using Enterprise Architecture Management approaches for a long time to synchronize corporate strategy and information technology. Such digitalization projects bring different challenges for Enterprise Architecture Management. Without understanding and addressing them, Enterprise Architecture Management projects will fail or not deliver the expected value. Since existing research has not yet addressed these challenges, they were investigated based on a qualitative expert study with leading industry experts from Europe. Furthermore, potential benefits of digitalization projects for Enterprise Architecture Management were researched. Our results provide a theoretical framework consisting of five identified challenges, triggers and a number of benefits. Furthermore, we discuss in what ways digitalization and EAM is a promising topic for future research.
Introduction to the special issue on self‑managing and hardware‑optimized database systems 2022
(2023)
Data management systems have evolved in terms of functionality, performance characteristics, complexity, and variety during the last 40 years. Particularly, the relational database management systems and the big data systems (e.g., Key-Value stores, Document stores, Graph stores and Graph Computation Systems, Spark, MapReduce/Hadoop, or Data Stream Processing Systems) have evolved with novel additions and extensions. However, the systems administration and tasks have become highly complex and expensive, especially given the simultaneous and rapid hardware evolution in processors, memory, storage, or networking. These developments present new open problems and challenges to data management systems as well as new opportunities.
The SMDB (International Workshop on Self-Managing Database Systems) and HardBD&Active (Joint International Workshop on Big Data Management on Emerging Hardware and Data Management on Virtualized Active Systems) workshops organized in conjunction with the IEEE ICDE (International Conference on Data Engineering) offered two distinct platforms for examining the above system-related challenges from different perspectives. The SMDB workshop looks into developing autonomic or self-* features in database and data management systems to tackle complex administrative tasks, while the HardBD&Active workshop focuses on harnessing hardware technologies to enhance efficiency and performance of data processing and management tasks. As a result of these workshops, we are delighted to present the third special issue of DAPD titled “Self-Managing and Hardware-Optimized Database Systems 2022,” which showcases the best contributions from the SMDB 2021/2022 and HardBD&Active 2021/2022 workshops.
In clothing e-commerce, the challenge of optimally recommending clothing that suits a user’s unique characteristics remains a pressing issue. Many platforms simply recommend best-selling or popular clothing, without taking into account important attributes like user’s face color, pupil color, face shape, age, etc. To solve this problem, this paper proposes a personalized clothing recommendation algorithm that incorporates the established 4-Season Color System and user-specific biological characteristics. Firstly, the attributes and colors of clothing are classified by Fnet network, that can learn disjoint label combinations and mitigate the issue of excessive labels. Secondly, on the basis of the 4-Season Color System, the user’s face color model is trained by combined MobileNetV3_DTL, which ensures the model’s generalization and improves the training speed. Thirdly, user’s face shape and age are divided into different categories by an Inception network. Finally, according to the users’ face color, age, face shape and other information, personalized clothing is recommended in a coarse-to-fine manner. Experiments on five datasets demonstrate that the algorithm proposed in this paper achieves state-of-the-art results.
With the rapid development of globalization, the demand for translation between different languages is also increasing. Although pre-training has achieved excellent results in neural machine translation, the existing neural machine translation has almost no high-quality suitable for specific fields. Alignment information, so this paper proposes a pre-training neural machine translation with alignment information via optimal transport. First, this paper narrows the representation gap between different languages by using OTAP to generate domain-specific data for information alignment, and learns richer semantic information. Secondly, this paper proposes a lightweight model DR-Reformer, which uses Reformer as the backbone network, adds Dropout layers and Reduction layers, reduces model parameters without losing accuracy, and improves computational efficiency. Experiments on the Chinese and English datasets of AI Challenger 2018 and WMT-17 show that the proposed algorithm has better performance than existing algorithms.
Assistant platforms
(2023)
Many assistant systems have evolved toward assistant platforms. These platforms combine a range of resources from various actors via a declarative and generative interface. Among the examples are voice-oriented assistant platforms like Alexa and Siri, as well as text-oriented assistant platforms like ChatGPT and Bard. They have emerged as valuable tools for handling tasks without requiring deeper domain expertise and have received large attention with the present advances in generative artificial intelligence. In view of their growing popularity, this Fundamental outlines the key characteristics and capabilities that define assistant platforms. The former comprise a multi-platform architecture, a declarative interface, and a multi-platform ecosystem, while the latter include capabilities for composition, integration, prediction, and generativity. Based on this framework, a research agenda is proposed along the capabilities and affordances for assistant platforms.
Hybride Arbeitsmodelle gelten als Zukunft der Arbeit. Demnach beschäftigt sich die vorliegende Forschungsarbeit mit der Untersuchung hybrider Arbeitsmodelle im Hinblick auf deutsche kleine und mittlere Unternehmen (KMU) im Vergleich zu Großbetrieben. Mithilfe einer multi-methodischen Studie, bestehend aus einer Umfrage und qualitativen Experteninterviews, wird evaluiert, in welchem Maß hybride Arbeitsmodelle in KMU bereits etabliert sind und welche Herausforderungen sie dabei bewältigen müssen. Zusätzlich wird betrachtet, ob soziodemografische Faktoren wie Alter, Geschlecht oder Rolle im Unternehmen einen Einfluss auf hybrides Arbeiten haben.Die Ergebnisse zeigen, dass die Etablierung von hybriden Arbeitsmodellen in KMU im Gegensatz zu Großbetrieben weniger vorangeschritten ist. KMUs stehen vor vielfältigen Herausforderungen, die beispielsweise auf unzureichende Digitalisierung oder traditionellere Strukturen zurückzuführen sind. Insbesondere die Unternehmenskultur sowie die Rolle im Unternehmen und der Einfluss der Führungskraft spielen eine wichtige Rolle.Praktische Relevanz: Der Großteil vorliegender Literatur zum Thema New Work und Hybride Arbeit legt den Fokus auf die Gesamtbetrachtung aller Unternehmensgrößen oder auf Großbetriebe. Aufgrund der spezifischen Merkmale, wie beispielsweise eingeschränkter Ressourcenzugang, können Ergebnisse von Großbetrieben kaum auf KMU übertragen werden. Demnach gibt diese Arbeit eine Orientierung, wie hybride Arbeitsmodelle in KMU sinnvoll und gewinnbringend umgesetzt werden und welche Herausforderungen auftreten.
Fragestellung: Das klinische Standardverfahren und Referenz der Schlafmessung und der Klassifizierung der einzelnen Schlafstadien ist die Polysomnographie (PSG). Alternative Ansätze zu diesem aufwändigen Verfahren könnten einige Vorteile bieten, wenn die Messungen auf eine komfortablere Weise durchgeführt werden. Das Hauptziel dieser Forschung Studie ist es, einen Algorithmus für die automatische Klassifizierung von Schlafstadien zu entwickeln, der ausschließlich Bewegungs- und Atmungssignale verwendet [1].
Patienten und Methoden: Nach der Analyse der aktuellen Forschungsarbeiten haben wir multinomiale logistische Regression als Grundlage für den Ansatz gewählt [2]. Um die Genauigkeit der Auswertung zu erhöhen, wurden vier Features entwickelt, die aus Bewegungs- und Atemsignalen abgeleitet wurden. Für die Auswertung wurden die nächtlichen Aufzeichnungen von 35 Personen verwendet, die von der Charité-Universitätsmedizin Berlin zur Verfügung gestellt wurden. Das Durchschnittsalter der Teilnehmer betrug 38,6 +/– 14,5 Jahre und der BMI lag bei durchschnittlich 24,4 +/– 4,9 kg/m2. Da der Algorithmus mit drei Stadien arbeitet, wurden die Stadien N1, N2 und N3 zum NREM-Stadium zusammengeführt. Der verfügbare Datensatz wurde strikt aufgeteilt: in einen Trainingsdatensatz von etwa 100 h und in einen Testdatensatz mit etwa 160 h nächtlicher Aufzeichnungen. Beide Datensätze wiesen ein ähnliches Verhältnis zwischen Männern und Frauen auf, und der durchschnittliche BMI wies keine signifikante Abweichung auf.
Ergebnisse: Der Algorithmus wurde implementiert und lieferte erfolgreiche Ergebnisse: die Genauigkeit der Erkennung von Wach-/NREM-/REM-Phasen liegt bei 73 %, mit einem Cohen’s Kappa von 0,44 für die analysierten 19.324 Schlafepochen von jeweils 30 s. Die beobachtete gewisse Überschätzung der NREM-Phase lässt sich teilweise durch ihre Prävalenz in einem typischen Schlafmuster erklären. Selbst die Verwendung eines ausbalancierten Trainingsdatensatzes konnte dieses Problem nicht vollständig lösen.
Schlussfolgerungen: Die erreichten Ergebnisse haben die Tauglichkeit des Ansatzes prinzipiell bestätigt. Dieser hat den Vorteil, dass nur Bewegungs- und Atemsignale verwendet werden, die mit weniger Aufwand und komfortabler für Benutzer aufgezeichnet werden können als z. B. Herz- oder EEG-Signale. Daher stellt das neue System eine deutliche Verbesserung im Vergleich zu bestehenden Ansätzen dar. Die Zusammenführung der beschriebenen algorithmischen Software mit dem in [1] beschriebenen Hardwaresystem zur Messung von Atem- und Körperbewegungssignalen zu einem autonomen, berührungslosen System zur kontinuierlichen Schlafüberwachung ist eine mögliche Richtung zukünftiger Arbeiten.
Purpose
For the modeling, execution, and control of complex, non-standardized intraoperative processes, a modeling language is needed that reflects the variability of interventions. As the established Business Process Model and Notation (BPMN) reaches its limits in terms of flexibility, the Case Management Model and Notation (CMMN) was considered as it addresses weakly structured processes.
Methods
To analyze the suitability of the modeling languages, BPMN and CMMN models of a Robot-Assisted Minimally Invasive Esophagectomy and Cochlea Implantation were derived and integrated into a situation recognition workflow. Test cases were used to contrast the differences and compare the advantages and disadvantages of the models concerning modeling, execution, and control. Furthermore, the impact on transferability was investigated.
Results
Compared to BPMN, CMMN allows flexibility for modeling intraoperative processes while remaining understandable. Although more effort and process knowledge are needed for execution and control within a situation recognition system, CMMN enables better transferability of the models and therefore the system. Concluding, CMMN should be chosen as a supplement to BPMN for flexible process parts that can only be covered insufficiently by BPMN, or otherwise as a replacement for the entire process.
Conclusion
CMMN offers the flexibility for variable, weakly structured process parts, and is thus suitable for surgical interventions. A combination of both notations could allow optimal use of their advantages and support the transferability of the situation recognition system.
Context
Web APIs are one of the most used ways to expose application functionality on the Web, and their understandability is important for efficiently using the provided resources. While many API design rules exist, empirical evidence for the effectiveness of most rules is lacking.
Objective
We therefore wanted to study 1) the impact of RESTful API design rules on understandability, 2) if rule violations are also perceived as more difficult to understand, and 3) if demographic attributes like REST-related experience have an influence on this.
Method
We conducted a controlled Web-based experiment with 105 participants, from both industry and academia and with different levels of experience. Based on a hybrid between a crossover and a between-subjects design, we studied 12 design rules using API snippets in two complementary versions: one that adhered to a rule and one that was a violation of this rule. Participants answered comprehension questions and rated the perceived difficulty.
Results
For 11 of the 12 rules, we found that violation performed significantly worse than rule for the comprehension tasks. Regarding the subjective ratings, we found significant differences for 9 of the 12 rules, meaning that most violations were subjectively rated as more difficult to understand. Demographics played no role in the comprehension performance for violation.
Conclusions
Our results provide first empirical evidence for the importance of following design rules to improve the understandability of Web APIs, which is important for researchers, practitioners, and educators.
Geopolitische Risiken sind nicht erst seit Ausbruch des Ukraine-Kriegs für den Erfolg und die Überlebensfähigkeit von Unternehmen von großer Relevanz. Nur durch den Aufbau von Methodenkompetenz, diese besonderen Risiken zu identifizieren, schaffen Unternehmen die notwendigen Voraussetzungen für ein erfolgreiches Management von geopolitischen Ereignissen.
In den letzten Jahren hat der Trend zur Digitalisierung und Konnektivität die Kundenerwartungen an den B2B-Kundenservice verändert. Vorliegender Artikel arbeitet mit zwei klaren Studienzielen und untersucht zum einen die Rolle von IoT (Internet of Things) und Cybersicherheit als Erfolgsfaktoren für den Business-to-Business (B2B) Kundenservice und zum anderen wie eine sichere Integration zu einem Wettbewerbsvorteil auf dem deutschen Markt beitragen kann. Durch einen qualitativen Ansatz mithilfe von 20 Befragungen wurde untersucht, dass IoT und Cybersicherheit als Erfolgsfaktoren für den deutschen B2B-Kundenservice angesehen werden können. Als Ergebnis liefert diese Studie fünf Kernaussagen (Hypothesen) aus qualitativen Interviews. Neben der Diskussion allgemeiner Erfolgsfaktoren und deren Einfluss, wurde die Rolle von IoT bei der Optimierung des B2B Kundendienstes diskutiert. Zudem werden potenzielle Sicherheitsrisken in Zusammenhang mit den Dienstleistungsmodellen, notwendige Anforderungen an Cybersicherheit sowie Datenerfassung erörtert. Abschließend wurde ein Modell entwickelt, das interne und externe Aspekte aufzeigt, die dazu beitragen, dass IoT und Cybersicherheit als Erfolgsfaktoren in der Aktivitätskette des Kunden in der Pre-Sales‑, Sales- und After-Sales-Phase erlebt werden.
Dieser praxis-nahe und industrie-übergreifende Artikel liefert somit Einblicke basierend auf qualitativen Erkenntnissen für weitere Forschung in der Theorie und befähigt Organisationen das Thema ganzeinheitlich zu betrachten.
Public transport maps are typically designed in a way to support route finding tasks for passengers, while they also provide an overview about stations, metro lines, and city-specific attractions. Most of those maps are designed as a static representation, maybe placed in a metro station or printed in a travel guide. In this paper, we describe a dynamic, interactive public transport map visualization enhanced by additional views for the dynamic passenger data on different levels of temporal granularity. Moreover, we also allow extra statistical information in form of density plots, calendar-based visualizations, and line graphs. All this information is linked to the contextual metro map to give a viewer insights into the relations between time points and typical routes taken by the passengers. We also integrated a graph-based view on user-selected routes, a way to interactively compare those routes, an attribute- and property-driven automatic computation of specific routes for one map as well as for all available maps in our repertoire, and finally, also the most important sights in each city are included as extra information to include in a user-selected route. We illustrate the usefulness of our interactive visualization and map navigation system by applying it to the railway system of Hamburg in Germany while also taking into account the extra passenger data. As another indication for the usefulness of the interactively enhanced metro maps we conducted a controlled user experiment with 20 participants.
One of the key challenges for automatic assistance is the support of actors in the operating room depending on the status of the procedure. Therefore, context information collected in the operating room is used to gain knowledge about the current situation. In literature, solutions already exist for specific use cases, but it is doubtful to what extent these approaches can be transferred to other conditions. We conducted a comprehensive literature research on existing situation recognition systems for the intraoperative area, covering 274 articles and 95 cross-references published between 2010 and 2019. We contrasted and compared 58 identified approaches based on defined aspects such as used sensor data or application area. In addition, we discussed applicability and transferability. Most of the papers focus on video data for recognizing situations within laparoscopic and cataract surgeries. Not all of the approaches can be used online for real-time recognition. Using different methods, good results with recognition accuracies above 90% could be achieved. Overall, transferability is less addressed. The applicability of approaches to other circumstances seems to be possible to a limited extent. Future research should place a stronger focus on adaptability. The literature review shows differences within existing approaches for situation recognition and outlines research trends. Applicability and transferability to other conditions are less addressed in current work.
Von den Covid-19-Restriktionen wurden im Automobilsektor die Zulieferer wesentlich stärker getroffen als die Fahrzeughersteller. Vor allem die Entwicklung des Working Capitals im ersten Pandemie-Jahr erwies sich als kritisch. Der Beitrag gibt einen Überblick über mögliche Lösungen für eine allseits vorteilhaftere, stabile Supply-Chain-Finanzierung in künftigen Krisen.
In our initial DaMoN paper, we set out the goal to revisit the results of “Starring into the Abyss [...] of Concurrency Control with [1000] Cores” (Yu in Proc. VLDB Endow 8: 209-220, 2014). Against their assumption, today we do not see single-socket CPUs with 1000 cores. Instead, multi-socket hardware is prevalent today and in fact offers over 1000 cores. Hence, we evaluated concurrency control (CC) schemes on a real (Intel-based) multi-socket platform. To our surprise, we made interesting findings opposing results of the original analysis that we discussed in our initial DaMoN paper. In this paper, we further broaden our analysis, detailing the effect of hardware and workload characteristics via additional real hardware platforms (IBM Power8 and 9) and the full TPC-C transaction mix. Among others, we identified clear connections between the performance of the CC schemes and hardware characteristics, especially concerning NUMA and CPU cache. Overall, we conclude that no CC scheme can efficiently make use of large multi-socket hardware in a robust manner and suggest several directions on how CC schemes and overall OLTP DBMS should evolve in future.
Purpose
Artificial intelligence (AI), in particular deep neural networks, has achieved remarkable results for medical image analysis in several applications. Yet the lack of explainability of deep neural models is considered the principal restriction before applying these methods in clinical practice.
Methods
In this study, we propose a NeuroXAI framework for explainable AI of deep learning networks to increase the trust of medical experts. NeuroXAI implements seven state-of-the-art explanation methods providing visualization maps to help make deep learning models transparent.
Results
NeuroXAI has been applied to two applications of the most widely investigated problems in brain imaging analysis, i.e., image classification and segmentation using magnetic resonance (MR) modality. Visual attention maps of multiple XAI methods have been generated and compared for both applications. Another experiment demonstrated that NeuroXAI can provide information flow visualization on internal layers of a segmentation CNN.
Conclusion
Due to its open architecture, ease of implementation, and scalability to new XAI methods, NeuroXAI could be utilized to assist radiologists and medical professionals in the detection and diagnosis of brain tumors in the clinical routine of cancer patients. The code of NeuroXAI is publicly accessible at https://github.com/razeineldin/NeuroXAI.
Purpose
Context awareness in the operating room (OR) is important to realize targeted assistance to support actors during surgery. A situation recognition system (SRS) is used to interpret intraoperative events and derive an intraoperative situation from these. To achieve a modular system architecture, it is desirable to de-couple the SRS from other system components. This leads to the need of an interface between such an SRS and context-aware systems (CAS). This work aims to provide an open standardized interface to enable loose coupling of the SRS with varying CAS to allow vendor-independent device orchestrations.
Methods
A requirements analysis investigated limiting factors that currently prevent the integration of CAS in today's ORs. These elicited requirements enabled the selection of a suitable base architecture. We examined how to specify this architecture with the constraints of an interoperability standard. The resulting middleware was integrated into a prototypic SRS and our system for intraoperative support, the OR-Pad, as exemplary CAS for evaluating whether our solution can enable context-aware assistance during simulated orthopedical interventions.
Results
The emerging Service-oriented Device Connectivity (SDC) standard series was selected to specify and implement a middleware for providing the interpreted contextual information while the SRS and CAS are loosely coupled. The results were verified within a proof of concept study using the OR-Pad demonstration scenario. The fulfillment of the CAS’ requirements to act context-aware, conformity to the SDC standard series, and the effort for integrating the middleware in individual systems were evaluated. The semantically unambiguous encoding of contextual information depends on the further standardization process of the SDC nomenclature. The discussion of the validity of these results proved the applicability and transferability of the middleware.
Conclusion
The specified and implemented SDC-based middleware shows the feasibility of loose coupling an SRS with unknown CAS to realize context-aware assistance in the OR.
All around the world, there are numerous academic competitions (e.g., “Academic Olympiads”) and corresponding training courses to foster students’ competences and motivation. But do students’ competences and motivation really benefit from such courses? We developed and evaluated a course that was designed to prepare third and fourth graders to participate in the German Mathematical Olympiad. Its effectiveness was evaluated in a quasi-experimental pre- and posttest design (N = 201 students). Significant positive effects of the training were found for performance in the academic competition (for both third and fourth graders) as well as mathematical competences as measured with a curriculum-oriented test (for fourth graders only). Differential effects across grade levels (with more pronounced positive effects in fourth-grade students) were observed for students’ math self-concept and task-specific interest in mathematics, pointing to possible social comparison effects.
Characterization of low density polyethylene greenhouse films during the composting of rose residues
(2022)
This study presents an evaluation of a potential alternative to plastic degradation in the form of organic composting. It stems from the urgent need of finding solutions to the plastic residues and focuses on the compost-based degradation of greenhouse film covers in an important rose exporter company in Ecuador. Thus, this study analyzes the physical, chemical, and biological changes of rose wastes composting, and also evaluates the stability of new and aged agricultural plastic under these conditions. Interestingly, results of compost characterization show a slow degradation rate of organic matter and total organic carbon, along with a significant increase in pH and rise of bacterial populations. However, the results demonstrate that despite these findings, composting conditions had no significant influence on plastic degradation, and while deterioration of aged plastic samples was reported in some tests, it may be the result of environmental conditions and a prolonged exposure to solar radiation. Importantly, these factors could facilitate the adhesion of microorganisms and promote plastic biodegradation. Hence, it is encouraged for future studies to analyze the ecotoxicity of plastics in the compost, as well as isolate, identify, and evaluate the possible biodegradative potential of these microorganisms as an alternative to plastic waste management.
Background
Personalized medicine requires the integration and analysis of vast amounts of patient data to realize individualized care. With Surgomics, we aim to facilitate personalized therapy recommendations in surgery by integration of intraoperative surgical data and their analysis with machine learning methods to leverage the potential of this data in analogy to Radiomics and Genomics.
Methods
We defined Surgomics as the entirety of surgomic features that are process characteristics of a surgical procedure automatically derived from multimodal intraoperative data to quantify processes in the operating room. In a multidisciplinary team we discussed potential data sources like endoscopic videos, vital sign monitoring, medical devices and instruments and respective surgomic features. Subsequently, an online questionnaire was sent to experts from surgery and (computer) science at multiple centers for rating the features’ clinical relevance and technical feasibility.
Results
In total, 52 surgomic features were identified and assigned to eight feature categories. Based on the expert survey (n = 66 participants) the feature category with the highest clinical relevance as rated by surgeons was “surgical skill and quality of performance” for morbidity and mortality (9.0 ± 1.3 on a numerical rating scale from 1 to 10) as well as for long-term (oncological) outcome (8.2 ± 1.8). The feature category with the highest feasibility to be automatically extracted as rated by (computer) scientists was “Instrument” (8.5 ± 1.7). Among the surgomic features ranked as most relevant in their respective category were “intraoperative adverse events”, “action performed with instruments”, “vital sign monitoring”, and “difficulty of surgery”.
Conclusion
Surgomics is a promising concept for the analysis of intraoperative data. Surgomics may be used together with preoperative features from clinical data and Radiomics to predict postoperative morbidity, mortality and long-term outcome, as well as to provide tailored feedback for surgeons.
Glioblastoma WHO IV belongs to a group of brain tumors that are still incurable. A promising treatment approach applies photodynamic therapy (PDT) with hypericin as a photosensitizer. To generate a comprehensive understanding of the photosensitizer-tumor interactions, the first part of our study is focused on investigating the distribution and penetration behavior of hypericin in glioma cell spheroids by fluorescence microscopy. In the second part, fluorescence lifetime imaging microscopy (FLIM) was used to correlate fluorescence lifetime (FLT) changes of hypericin to environmental effects inside the spheroids. In this context, 3D tumor spheroids are an excellent model system since they consider 3D cell–cell interactions and the extracellular matrix is similar to tumors in vivo. Our analytical approach considers hypericin as probe molecule for FLIM and as photosensitizer for PDT at the same time, making it possible to directly draw conclusions of the state and location of the drug in a biological system. The knowledge of both state and location of hypericin makes a fundamental understanding of the impact of hypericin PDT in brain tumors possible. Following different incubation conditions, the hypericin distribution in peripheral and central cryosections of the spheroids were analyzed. Both fluorescence microscopy and FLIM revealed a hypericin gradient towards the spheroid core for short incubation periods or small concentrations. On the other hand, a homogeneous hypericin distribution is observed for long incubation times and high concentrations. Especially, the observed FLT change is crucial for the PDT efficiency, since the triplet yield, and hence the O2 activation, is directly proportional to the FLT. Based on the FLT increase inside spheroids, an incubation time 30 min is required to achieve most suitable conditions for an effective PDT.
Purpose
Supporting the surgeon during surgery is one of the main goals of intelligent ORs. The OR-Pad project aims to optimize the information flow within the perioperative area. A shared information space should enable appropriate preparation and provision of relevant information at any time before, during, and after surgery.
Methods
Based on previous work on an interaction concept and system architecture for the sterile OR-Pad system, we designed a user interface for mobile and intraoperative (stationary) use, focusing on the most important functionalities like clear information provision to reduce information overload. The concepts were transferred into a high-fidelity prototype for demonstration purposes. The prototype was evaluated from different perspectives, including a usability study.
Results
The prototype’s central element is a timeline displaying all available case information chronologically, like radiological images, labor findings, or notes. This information space can be adapted for individual purposes (e.g., highlighting a tumor, filtering for own material). With the mobile and intraoperative mode of the system, relevant information can be added, preselected, viewed, and extended during the perioperative process. Overall, the evaluation showed good results and confirmed the vision of the information system.
Conclusion
The high-fidelity prototype of the information system OR-Pad focuses on supporting the surgeon via a timeline making all available case information accessible before, during, and after surgery. The information space can be personalized to enable targeted support. Further development is reasonable to optimize the approach and address missing or insufficient aspects, like the holding arm and sterility concept or new desired features.
Gender pay gaps are commonly studied in populations with already completed educational careers. We focus on an earlier stage by investigating the gender pay gap among university students working alongside their studies. With data from five cohorts of a large-scale student survey from Germany, we use regression and wage decomposition techniques to describe gender pay gaps and potential explanations. We find that female students earn about 6% less on average than male students, which reduces to 4.1% when accounting for a rich set of explanatory variables. The largest explanatory factor is the type of jobs male and female students pursue.
Turning students into Industry 4.0 entrepreneurs: design and evaluation of a tailored study program
(2022)
Startups in the field of Industry 4.0 could be a huge driver of innovation for many industry sectors such as manufacturing. However, there is a lack of education programs to ensure a sufficient number of well-trained founders and thus a supply of such startups. Therefore, this study presents the design, implementation, and evaluation of a university course tailored to the characteristics of Industry 4.0 entrepreneurship. Educational design-based research was applied with a focus on content and teaching concept. The study program was first implemented in 2021 at a German university of applied sciences with 25 students, of which 22 participated in the evaluation. The evaluation of the study program was conducted with a pretest–posttest-design targeting three areas: (1) knowledge about the application domain, (2) entrepreneurial intention and (3) psychological characteristics. The entrepreneurial intention was measured based on the theory of planned behavior. For measuring psychological characteristics, personality traits associated with entrepreneurship were used. Considering the study context and the limited external validity of the study, the following can be identified in particular: The results show that a university course can improve participants' knowledge of this particular area. In addition, perceived behavioral control of starting an Industry 4.0 startup was enhanced. However, the results showed no significant effects on psychological characteristics.
Public enterprises find themselves in increasingly competitive markets, a situation that makes having an entrepreneurial orientation (EO) an urgent need, given that EO is an indispensable driver of performance. Research describes politicians delaying the strategic change of public enterprises when serving as board members, but empirical evidence of the impact of board behavior on EO in public enterprises is lacking. We draw on stakeholder-agency theory (SAT) and resource dependence theory (RDT) and use structural equation modeling (SEM) to investigate survey data collected from 110 German energy suppliers that are majority government owned. Results indicate that board strategy control and board networking do not seem to predict EO on first sight. Closer analysis reveals a board networking–EO relationship depending on ownership structure. Remarkably, we find that it is not the usually suspected local municipal owner who hinders EO in our sample organizations but minority shareholders engaging in board networking activities. The results shed light on the intersection of governance and entrepreneurship with special reference to the fine-grained conceptualization of RDT.
Das Weltwirtschaftswachstum der vergangenen Jahrzehnte war durch die Dynamik der Digitalisierung und Globalisierung in den Lieferketten geprägt. Die Corona-Pandemie hat die Abhängigkeit und Verletzlichkeit der Lieferketten offengelegt. Trotz einer Vielzahl verbindlicher Standards haben Unternehmen die Digitalisierung und Arbeitsteilung auch für regulatorische Arbitrage genutzt. Einerseits erhöht das die Effizienz der Wirtschaft - was mithin ökologische Ressourcen schont - andererseits werden damit internationale Standards konterkariert. Globalisierung und Digitalisierung sind Segen und Fluch zugleich.
The article analyzes experimentally and theoretically the influence of microscope parameters on the pinhole-assisted Raman depth profiles in uniform and composite refractive media. The main objective is the reliable mapping of deep sample regions. The easiest to interpret results are found with low magnification, low aperture, and small pinholes. Here, the intensities and shapes of the Raman signals are independent of the location of the emitter relative to the sample surface. Theoretically, the results can be well described with a simple analytical equation containing the axial depth resolution of the microscope and the position of the emitter. The lower determinable object size is limited to 2–4 μm. If sub-micrometer resolution is desired, high magnification, mostly combined with high aperture, becomes necessary. The signal intensities and shapes depend now in refractive media on the position relative to the sample surface. This aspect is investigated on a number of uniform and stacked polymer layers, 2–160 μm thick, with the best available transparency. The experimental depth profiles are numerically fitted with excellent accuracy by inserting a Gaussian excitation beam of variable waist and fill fraction through the focusing lens area, and by treating the Raman emission with geometric optics as spontaneous isotropic process through the lens and the variable pinhole, respectively. The intersectional area of these two solid angles yields the leading factor in understanding confocal (pinhole-assisted) Raman depth profiles.
Purpose
Injury or inflammation of the middle ear often results in the persistent tympanic membrane (TM) perforations, leading to conductive hearing loss (HL). However, in some cases the magnitude of HL exceeds that attributable by the TM perforation alone. The aim of the study is to better understand the effects of location and size of TM perforations on the sound transmission properties of the middle ear.
Methods
The middle ear transfer functions (METF) of six human temporal bones (TB) were compared before and after perforating the TM at different locations (anterior or posterior lower quadrant) and to different degrees (1 mm, ¼ of the TM, ½ of the TM, and full ablation). The sound-induced velocity of the stapes footplate was measured using single-point laser-Doppler-vibrometry (LDV). The METF were correlated with a Finite Element (FE) model of the middle ear, in which similar alterations were simulated.
Results
The measured and calculated METF showed frequency and perforation size dependent losses at all perforation locations. Starting at low frequencies, the loss expanded to higher frequencies with increased perforation size. In direct comparison, posterior TM perforations affected the transmission properties to a larger degree than anterior perforations. The asymmetry of the TM causes the malleus-incus complex to rotate and results in larger deflections in the posterior TM quadrants than in the anterior TM quadrants. Simulations in the FE model with a sealed cavity show that small perforations lead to a decrease in TM rigidity and thus to an increase in oscillation amplitude of the TM mainly above 1 kHz.
Conclusion
Size and location of TM perforations have a characteristic influence on the METF. The correlation of the experimental LDV measurements with an FE model contributes to a better understanding of the pathologic mechanisms of middle-ear diseases. If small perforations with significant HL are observed in daily clinical practice, additional middle ear pathologies should be considered. Further investigations on the loss of TM pretension due to perforations may be informative.
Die Annexion der Krim, die Kriegsführung in Syrien, das finanzielle Engagement in Zypern, das Tauziehen um die Ukraine und Weißrussland oder die Namensgebung Sputnik 5 für den Impfstoff gegen die Corona Epidemie sind eindeutige Belege für das aktuelle russische Machtstreben – und seine Expansionspolitik. Deshalb ist es nicht uninteressant zu fragen, welches Meinungsbild Friedrich List (1789–1846) von Russland hatte, zumal es heute noch so aktuell, wie vor 180 bis 190 Jahren erscheint und in seinen Schriften dargelegt ist. Dieses Meinungsbild wird in diesem Aufsatz erstmals untersucht und umfassend dargestellt.
Context
Microservices as a lightweight and decentralized architectural style with fine-grained services promise several beneficial characteristics for sustainable long-term software evolution. Success stories from early adopters like Netflix, Amazon, or Spotify have demonstrated that it is possible to achieve a high degree of flexibility and evolvability with these systems. However, the described advantageous characteristics offer no concrete guidance and little is known about evolvability assurance processes for microservices in industry as well as challenges in this area. Insights into the current state of practice are a very important prerequisite for relevant research in this field.
Objective
We therefore wanted to explore how practitioners structure the evolvability assurance processes for microservices, what tools, metrics, and patterns they use, and what challenges they perceive for the evolvability of their systems.
Method
We first conducted 17 semi-structured interviews and discussed 14 different microservice-based systems and their assurance processes with software professionals from 10 companies. Afterwards, we performed a systematic grey literature review (GLR) and used the created interview coding system to analyze 295 practitioner online resources.
Results
The combined analysis revealed the importance of finding a sensible balance between decentralization and standardization. Guidelines like architectural principles were seen as valuable to ensure a base consistency for evolvability and specialized test automation was a prevalent theme. Source code quality was the primary target for the usage of tools and metrics for our interview participants, while testing tools and productivity metrics were the focus of our GLR resources. In both studies, practitioners did not mention architectural or service-oriented tools and metrics, even though the most crucial challenges like Service Cutting or Microservices Integration were of an architectural nature.
Conclusions
Practitioners relied on guidelines, standardization, or patterns like Event-Driven Messaging to partially address some reported evolvability challenges. However, specialized techniques, tools, and metrics are needed to support industry with the continuous evaluation of service granularity and dependencies. Future microservices research in the areas of maintenance, evolution, and technical debt should take our findings and the reported industry sentiments into account.
Programmable nano-bio interfaces driven by tuneable vertically configured nanostructures have recently emerged as a powerful tool for cellular manipulations and interrogations. Such interfaces have strong potential for ground-breaking advances, particularly in cellular nanobiotechnology and mechanobiology. However, the opaque nature of many nanostructured surfaces makes non-destructive, live-cell characterization of cellular behavior on vertically aligned nanostructures challenging to observe. Here, a new nanofabrication route is proposed that enables harvesting of vertically aligned silicon (Si) nanowires and their subsequent transfer onto an optically transparent substrate, with high efficiency and without artefacts. We demonstrate the potential of this route for efficient live-cell phase contrast imaging and subsequent characterization of cells growing on vertically aligned Si nanowires. This approach provides the first opportunity to understand dynamic cellular responses to a cell-nanowire interface, and thus has the potential to inform the design of future nanoscale cellular manipulation technologies.
Unternehmen wenden insbesondere bei IT-nahen Projekten seit einigen Jahren auch im Controlling verstärkt ein agiles Vorgehen an. Erfahrungen zeigen jedoch, dass dies nicht bei allen Projekten in jedem Unternehmen funktioniert. Hybride Ansätze, die agile mit klassischen Projekt-Management-Methoden verbinden, bieten eine Lösung.
The cloud evolved into an attractive execution environment for parallel applications, which make use of compute resources to speed up the computation of large problems in science and industry. Whereas Infrastructure as a Service (IaaS) offerings have been commonly employed, more recently, serverless computing emerged as a novel cloud computing paradigm with the goal of freeing developers from resource management issues. However, as of today, serverless computing platforms are mainly used to process computations triggered by events or user requests that can be executed independently of each other and benefit from on-demand and elastic compute resources as well as per-function billing. In this work, we discuss how to employ serverless computing platforms to operate parallel applications. We specifically focus on the class of parallel task farming applications and introduce a novel approach to free developers from both parallelism and resource management issues. Our approach includes a proactive elasticity controller that adapts the physical parallelism per application run according to user-defined goals. Specifically, we show how to consider a user-defined execution time limit after which the result of the computation needs to be present while minimizing the associated monetary costs. To evaluate our concepts, we present a prototypical elastic parallel system architecture for self-tuning serverless task farming and implement two applications based on our framework. Moreover, we report on performance measurements for both applications as well as the prediction accuracy of the proposed proactive elasticity control mechanism and discuss our key findings.
Annotations of character IDs in news images are critical as ground truth for news retrieval and recommendation system. Universality and accuracy optimization of deep neural network models constitutes the key technology to improve the precision and computing efficiency of automatic news character identification, which is attracting increased attention globally. This paper explores the optimized deep neural network model for automatic focus personage identification in multi-lingual news. First, the face model of the focus personage is trained by using the corresponding face images from German news as positive samples. Next, the scheme of Recurrent Convolutional Neural Network (RCNN) + Bi-directional Long-Short Term Memory (Bi-LSTM) + Conditional Random Field (CRF) is utilized to label the focus name, and the RCNN-RCNN encoder–decoder is applied to translate names of people into multiple languages. Third, face features are described by combining the advantages of Local Gabor Binary Pattern Histogram Sequence (LGBPHS) and RCNN, and iterative quantization (ITQ) is used to binarize codes. Finally, a name semantic network is built for different domains. Experiments are performed on a dataset which comprises approximately 100,000 news images. The experimental results demonstrate that the proposed method achieves a significant improvement over other algorithms.
Effektives Risiko-Management sollte neben quantifizierbaren, bekannten Risiken auch Ereignisse berücksichtigen, die entweder in ähnlicher Art bereits eingetreten oder grundsätzlich vorstellbar sind. Für eine Identifikation dieser "Grauen Schwäne" müssen institutionell-organisatorische Voraussetzungen geschaffen und analytisch-konzeptionelle Instrumente bereitgestellt werden.
Context:
Test-driven development (TDD) is an agile software development approach that has been widely claimed to improve software quality. However, the extent to which TDD improves quality appears to be largely dependent upon the characteristics of the study in which it is evaluated (e.g., the research method, participant type, programming environment, etc.). The particularities of each study make the aggregation of results untenable.
Objectives:
The goal of this paper is to: increase the accuracy and generalizability of the results achieved in isolated experiments on TDD, provide joint conclusions on the performance of TDD across different industrial and academic settings, and assess the extent to which the characteristics of the experiments affect the quality-related performance of TDD.
Method:
We conduct a family of 12 experiments on TDD in academia and industry. We aggregate their results by means of meta-analysis. We perform exploratory analyses to identify variables impacting the quality-related performance of TDD.
Results:
TDD novices achieve a slightly higher code quality with iterative test-last development (i.e., ITL, the reverse approach of TDD) than with TDD. The task being developed largely determines quality. The programming environment, the order in which TDD and ITL are applied, or the learning effects from one development approach to another do not appear to affect quality. The quality-related performance of professionals using TDD drops more than for students. We hypothesize that this may be due to their being more resistant to change and potentially less motivated than students.
Conclusion:
Previous studies seem to provide conflicting results on TDD performance (i.e., positive vs. negative, respectively). We hypothesize that these conflicting results may be due to different study durations, experiment participants being unfamiliar with the TDD process, or case studies comparing the performance achieved by TDD vs. the control approach (e.g., the waterfall model), each applied to develop a different system. Further experiments with TDD experts are needed to validate these hypotheses.
Seit 5 Jahrzehnten steht die Erforschung von Leben, Werk und Wirkungsgeschichte von Friedrich List (1789–1846) im Zentrum der wissenschaftlichen Arbeit von Eugen Wendler. Im Laufe der Zeit sind ca. 30 Monographien und eine größere Anzahl von wissenschaftlichen Aufsätzen und journalistischen Artikeln entstanden. Dabei baute Eugen Wendler auf der unschätzbaren Vorarbeit der Herausgeber der Gesamtausgabe von Lists Werken von 1925 bis 1935 auf.
Der vorliegende Aufsatz vermittelt einen Überblick über die Buchpublikationen von Eugen Wendler zur List-Forschung. Mit seinem eindrucksvollen Oeuvre bekennt er sich zum letzten lebenden Fossil in der Nachfolge der FLG und erweist damit den Herausgebern die gebührende und längst überfällige Wertschätzung und Achtung.
Unter den widrigsten wirtschaftlichen und politischen Verhältnissen und Bedingungen wurde die Friedrich-List-Gesellschaft (FLG) 1925 gegründet und bis 1934 fortgeführt. Sie verfolgte vor allem den Zweck, die weit verstreuten, schwer zugänglichen und vielfach unbekannten Schriften, Reden und Briefe von Friedrich List (1789-1846) zusammenzutragen und in Form einer Gesamtausgabe zu publizieren.
Weder diese 10- bzw. 12-bändige Gesamtausgabe, noch die Namen ihrer Herausgeber haben in der Wirtschaftswissenschaft die gebührende Wertschätzung und Aufmerksamkeit erfahren. Die längst überfällige Dankesschuld wird in dem vorliegenden Beitrag nach nahezu 100 Jahren abgetragen. Ohne den engagierten und mutigen Einsatz der Herausgeber, insbesondere von Edgar Salin, wäre die List-Forschung undenkbar und die deutsche Wirtschaftswissenschaft um ein ruhmreiches Kapitel ärmer.
In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of how drugs are discovered, developed and marketed. Critical to this transformation is the adoption of new technologies in the drug development process, catalyzing the transition from serendipity-driven to data-driven medicine. This paradigm shift comes with a need for both translation and precision, leading to a modern Translational Precision Medicine approach to drug discovery and development. Key components of Translational Precision Medicine are multi-omics profiling, digital biomarkers, model-based data integration, artificial intelligence, biomarker-guided trial designs and patient-centric companion diagnostics. In this review, we summarize and critically discuss the potential and challenges of Translational Precision Medicine from a cross-industry perspective.
Digitalisierung und Mediatisierung prägen die Gesellschaft und auch die Erwachsenenbildung/Weiterbildung. Der Beitrag geht der Frage nach, wie Digitalisierung in Angeboten der Erwachsenenbildung/Weiterbildung gelingt. Damit wird ein Fokus auf den Einsatz digitaler Medien gelegt. Dazu werden die Angebotsentwicklung für Adressatinnen und Adressaten sowie Teilnehmende, medienbezogene Inhalte, Lehr- und Lernarrangements mit digitalen Medien, der Einsatz digitaler Medien und die Zugänglichkeit von Lehr- und Lernmaterialien als relevante Merkmale identifiziert. Insgesamt zeigen die analysierten Interviewdaten, dass der Einsatz digitaler Medien in Angeboten eine Erweiterung der didaktischen Aufgaben darstellt, da Angebote mit digitalen Medien zielgenau auf die Bedarfe und Möglichkeiten von Adressatinnen und Adressaten sowie Teilnehmenden abgestimmt werden müssen.
In buchstäblich letzter Minute haben sich die englische Regierung und die Europäische Union auf ein umfangreiches Abkommen geeinigt, um einen ungeregelten Brexit zu verhindern. Nach dem jahrelangen zähen Verhandlungsmarathon fällt der Jubel verhalten aus, dennoch herrscht auf beiden Seiten des Ärmelkanals Erleichterung, weil ein Modus Vivendi gefunden wurde, auf dem sich die künftigen Beziehungen aufbauen und fortführen lassen. Ob sich die englischen Blütenträume, die an den Brexit geknüpft wurden, erfüllen werden, wird die Zukunft erweisen.
Die Strategie und Taktik der englischen Regierungen zum Brexit und bei den Austrittsverhandlungen spiegeln sich in den Erfahrungen wider, die Friedrich List vor genau 175 Jahren bei seinen Bemühungen um eine deutsch-englische Allianz machen musste. Wegen der von England schon damals strikt befolgten Insular und Handelssuprematie musste er sich eingestehen, dass England diese Position hartnäckig verteidigt und deshalb frustriert und ernüchtert seine Pläne aufgeben. Deshalb setzte er seine Hoffnung auf eine "Kontinentalallianz" der europäischen Nationen, wie sie nun nach dem Austritt Großbritanniens aus der Europäischen Union entstanden ist. Vielleicht werden wir uns nun an den Begriff "Kontinentalallianz" gewöhnen müssen und dabei an die Weitsicht von Friedrich List erinnert.
Andererseits gilt auch für die englische Politik das Motto von Lists zweiter Pariser Preisschrift: "Le monde marche - Die Welt bewegt sich", allerdings mit völlig anderen Vorzeichen als vor 175 Jahren: Die Welthandelsachse hat sich von der westlichen auf die östliche Halbkugel verlagert; das britische Weltreich ist Geschichte, die Fließgeschwindigkeit des globalen Wandels hat sich dramatisch beschleunigt und trotz der Lingua Franca erscheint England, vor allem aus asiatischer Sicht, nur noch als kleiner Fleck auf der Weltkarte. Falls die schottische Regierung ihre Absicht durchsetzen und die Unabhängigkeit vom Vereinigten Königreich erreichen sollte, würde sich der Brexit als verhängnisvoller Bumerang erweisen.
The early detection of head and neck cancer is a prolonged challenging task. It requires a precise and accurate identification of tissue alterations as well as a distinct discrimination of cancerous from healthy tissue areas. A novel approach for this purpose uses microspectroscopic techniques with special focus on hyperspectral imaging (HSI) methods. Our proof-of-principle study presents the implementation and application of darkfield elastic light scattering spectroscopy (DF ELSS) as a non-destructive, high-resolution, and fast imaging modality to distinguish lingual healthy from altered tissue regions in a mouse model. The main aspect of our study deals with the comparison of two varying HSI detection principles, which are a point-by-point and line scanning imaging, and whether one might be more appropriate in differentiating several tissue types. Statistical models are formed by deploying a principal component analysis (PCA) with the Bayesian discriminant analysis (DA) on the elastic light scattering (ELS) spectra. Overall accuracy, sensitivity, and precision values of 98% are achieved for both models whereas the overall specificity results in 99%. An additional classification of model-unknown ELS spectra is performed. The predictions are verified with histopathological evaluations of identical HE-stained tissue areas to prove the model’s capability of tissue distinction. In the context of our proof-of-principle study, we assess the Pushbroom PCA-DA model to be more suitable for tissue type differentiations and thus tissue classification. In addition to the HE-examination in head and neck cancer diagnosis, the usage of HSI-based statistical models might be conceivable in a daily clinical routine.
Monday is unique for its reputation as a “bad” day—one that is characterized by pessimism and reluctance as noted by Rystrom and Benson (Financ Anal J 45(5):75–78, 1989). But the extent to which this applies to stock markets is still in dispute. While early evidence points to a Monday effect leading to negative returns, recent studies tend to suggest its disappearance or reversal.As a replication study, this paper searches for new evidence of this effect in the German stock market.We use data on the German blue-chip index DAX between 2000 and 2017 to test for the presence of a Monday effect by applying regression and controlling with GARCH analysis. The observation period provides a detailed insight into different market phases in one of the most liquid and information efficient international stock markets. Our results contribute no evidence to the persistent existence of a Monday effect on the German stock market. Our analysis is robust against the background of different market sentiments before, during and after the financial crisis.