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Glioblastoma WHO IV belongs to a group of brain tumors that are still incurable. A promising treatment approach applies photodynamic therapy (PDT) with hypericin as a photosensitizer. To generate a comprehensive understanding of the photosensitizer-tumor interactions, the first part of our study is focused on investigating the distribution and penetration behavior of hypericin in glioma cell spheroids by fluorescence microscopy. In the second part, fluorescence lifetime imaging microscopy (FLIM) was used to correlate fluorescence lifetime (FLT) changes of hypericin to environmental effects inside the spheroids. In this context, 3D tumor spheroids are an excellent model system since they consider 3D cell–cell interactions and the extracellular matrix is similar to tumors in vivo. Our analytical approach considers hypericin as probe molecule for FLIM and as photosensitizer for PDT at the same time, making it possible to directly draw conclusions of the state and location of the drug in a biological system. The knowledge of both state and location of hypericin makes a fundamental understanding of the impact of hypericin PDT in brain tumors possible. Following different incubation conditions, the hypericin distribution in peripheral and central cryosections of the spheroids were analyzed. Both fluorescence microscopy and FLIM revealed a hypericin gradient towards the spheroid core for short incubation periods or small concentrations. On the other hand, a homogeneous hypericin distribution is observed for long incubation times and high concentrations. Especially, the observed FLT change is crucial for the PDT efficiency, since the triplet yield, and hence the O2 activation, is directly proportional to the FLT. Based on the FLT increase inside spheroids, an incubation time 30 min is required to achieve most suitable conditions for an effective PDT.
Since half a decade, there has been an increasing interest in Robotic Process Automation (RPA) by business firms. However, academic literature has been lacking attention to RPA, before adopting the topic to a larger extent. The aim of this study is to review and structure the latest state of scholarly research on RPA. This chapter is based on a systematic literature review that is used as a basis to develop a conceptual framework to structure the field. Our study shows that some areas of RPA have been extensively examined by many authors, e.g. potential benefits of RPA. Other categories, such as empirical studies on adoption of RPA or organisational readiness models, have remained research gaps.
Durch die Entwicklungen der vergangenen Jahre hin zu technisch komplexeren Maschinen und Anlagen steigt die Bedeutung der Instandhaltung als wesentlichem Schlüssel zur Sicherung der Verfügbarkeit von Maschinen und Anlagen. Wesentliche Ansatzpunkte zur Verbesserung sind hier die Verfügbarkeit von Informationen, voraussagende Instandhaltungsstrategien und eine verbesserte Informationsbereitstellung. Diese können auf technischer Ebene durch spezialisierte Cyberphysische Systeme realisiert werden. In diesem Beitrag wird ein Überblick über die wesentlichen Bausteine, aus smarten Komponenten, smarten Planungssystemen und smarten Benutzerschnittstellen gegeben, die für eine erfolgreiche Umsetzung notwendig sind.
Das vorliegende Kapitel umreißt die aktuellen empirischen Forschungsfelder der Erwachsenenbildung/Weiterbildung. Diese beschäftigt sich seit ihren Anfängen in den 1960er-Jahren mit Teilnehmenden und mit Lehr- und Lern-Prozessen und wird seither sowohl hinsichtlich ihrer Theoriegrundlegung als auch ihrer Gegenstände weiterentwickelt und ausdifferenziert. Die verschiedenen Theorieperspektiven werden für die empirische Untersuchung ausdifferenzierter Gegenstandsbereiche herangezogen. Zentrale Erkenntnisse der aktuellen empirischen Forschung ermöglichen nicht nur Wissen über die Teilnehmenden, sondern auch über das Lernen Erwachsener, über Programme und Angebote, Institutionen und Organisationen sowie deren Einbettung in staatliche und gesellschaftliche Systeme und bildungspolitische Entscheidungen.
Data analysis is becoming increasingly important to pursue organizational goals, especially in the context of Industry 4.0, where a wide variety of data is available. Here numerous challenges arise, especially when using unstructured data. However, this subject has not been focused by research so far. This research paper addresses this gap, which is interesting for science and practice as well. In a study three major challenges of using unstructured data has been identified: analytical know-how, data issues, variety. Additionally, measures how to improve the analysis of unstructured data in the industry 4.0 context are described. Therefore, the paper provides empirical insights about challenges and potential measures when analyzing unstructured data. The findings are presented in a framework, too. Hence, next steps of the research project and future research points become apparent.
In the current age of innovative business financing opportunities available from fintech apps, social media crowdfunding sites such as Kickstarter, Indiegogo, and RocketHub, et.al., and friends and family private equity investors, start-up firms can strategically source their venture capital funds from many globally disperse organizations and individuals. As the firm in this case learned, the benefit of alternative investing sources comes with a critical hidden risk for corporate governance. After a financial restructuring, a typical Silicon Valley software start-up found itself with close to 300 external individual shareholders, some of whom had not been documented as accredited investors. The regulatory agency could decide that the prior actions of the founders and the decisions of the board had been prejudicial to the interests of the minority investors. The management of this small private company faced an atypical investor relations dilemma, before its initial public offering (IPO).
Purpose
Supporting the surgeon during surgery is one of the main goals of intelligent ORs. The OR-Pad project aims to optimize the information flow within the perioperative area. A shared information space should enable appropriate preparation and provision of relevant information at any time before, during, and after surgery.
Methods
Based on previous work on an interaction concept and system architecture for the sterile OR-Pad system, we designed a user interface for mobile and intraoperative (stationary) use, focusing on the most important functionalities like clear information provision to reduce information overload. The concepts were transferred into a high-fidelity prototype for demonstration purposes. The prototype was evaluated from different perspectives, including a usability study.
Results
The prototype’s central element is a timeline displaying all available case information chronologically, like radiological images, labor findings, or notes. This information space can be adapted for individual purposes (e.g., highlighting a tumor, filtering for own material). With the mobile and intraoperative mode of the system, relevant information can be added, preselected, viewed, and extended during the perioperative process. Overall, the evaluation showed good results and confirmed the vision of the information system.
Conclusion
The high-fidelity prototype of the information system OR-Pad focuses on supporting the surgeon via a timeline making all available case information accessible before, during, and after surgery. The information space can be personalized to enable targeted support. Further development is reasonable to optimize the approach and address missing or insufficient aspects, like the holding arm and sterility concept or new desired features.
Background
Personalized medicine requires the integration and analysis of vast amounts of patient data to realize individualized care. With Surgomics, we aim to facilitate personalized therapy recommendations in surgery by integration of intraoperative surgical data and their analysis with machine learning methods to leverage the potential of this data in analogy to Radiomics and Genomics.
Methods
We defined Surgomics as the entirety of surgomic features that are process characteristics of a surgical procedure automatically derived from multimodal intraoperative data to quantify processes in the operating room. In a multidisciplinary team we discussed potential data sources like endoscopic videos, vital sign monitoring, medical devices and instruments and respective surgomic features. Subsequently, an online questionnaire was sent to experts from surgery and (computer) science at multiple centers for rating the features’ clinical relevance and technical feasibility.
Results
In total, 52 surgomic features were identified and assigned to eight feature categories. Based on the expert survey (n = 66 participants) the feature category with the highest clinical relevance as rated by surgeons was “surgical skill and quality of performance” for morbidity and mortality (9.0 ± 1.3 on a numerical rating scale from 1 to 10) as well as for long-term (oncological) outcome (8.2 ± 1.8). The feature category with the highest feasibility to be automatically extracted as rated by (computer) scientists was “Instrument” (8.5 ± 1.7). Among the surgomic features ranked as most relevant in their respective category were “intraoperative adverse events”, “action performed with instruments”, “vital sign monitoring”, and “difficulty of surgery”.
Conclusion
Surgomics is a promising concept for the analysis of intraoperative data. Surgomics may be used together with preoperative features from clinical data and Radiomics to predict postoperative morbidity, mortality and long-term outcome, as well as to provide tailored feedback for surgeons.
Characterization of low density polyethylene greenhouse films during the composting of rose residues
(2022)
This study presents an evaluation of a potential alternative to plastic degradation in the form of organic composting. It stems from the urgent need of finding solutions to the plastic residues and focuses on the compost-based degradation of greenhouse film covers in an important rose exporter company in Ecuador. Thus, this study analyzes the physical, chemical, and biological changes of rose wastes composting, and also evaluates the stability of new and aged agricultural plastic under these conditions. Interestingly, results of compost characterization show a slow degradation rate of organic matter and total organic carbon, along with a significant increase in pH and rise of bacterial populations. However, the results demonstrate that despite these findings, composting conditions had no significant influence on plastic degradation, and while deterioration of aged plastic samples was reported in some tests, it may be the result of environmental conditions and a prolonged exposure to solar radiation. Importantly, these factors could facilitate the adhesion of microorganisms and promote plastic biodegradation. Hence, it is encouraged for future studies to analyze the ecotoxicity of plastics in the compost, as well as isolate, identify, and evaluate the possible biodegradative potential of these microorganisms as an alternative to plastic waste management.
All around the world, there are numerous academic competitions (e.g., “Academic Olympiads”) and corresponding training courses to foster students’ competences and motivation. But do students’ competences and motivation really benefit from such courses? We developed and evaluated a course that was designed to prepare third and fourth graders to participate in the German Mathematical Olympiad. Its effectiveness was evaluated in a quasi-experimental pre- and posttest design (N = 201 students). Significant positive effects of the training were found for performance in the academic competition (for both third and fourth graders) as well as mathematical competences as measured with a curriculum-oriented test (for fourth graders only). Differential effects across grade levels (with more pronounced positive effects in fourth-grade students) were observed for students’ math self-concept and task-specific interest in mathematics, pointing to possible social comparison effects.
Glioblastomas are the most aggressive fast-growing primary brain cancer which originate in the glial cells of the brain. Accurate identification of the malignant brain tumor and its sub-regions is still one of the most challenging problems in medical image segmentation. The Brain Tumor Segmentation Challenge (BraTS) has been a popular benchmark for automatic brain glioblastomas segmentation algorithms since its initiation. In this year, BraTS 2021 challenge provides the largest multi-parametric (mpMRI) dataset of 2,000 pre-operative patients. In this paper, we propose a new aggregation of two deep learning frameworksnamely, DeepSeg and nnU-Net for automatic glioblastoma recognition in pre-operative mpMRI. Our ensemble method obtains Dice similarity scores of 92.00, 87.33, and 84.10 and Hausdorff Distances of 3.81, 8.91, and 16.02 for the enhancing tumor, tumor core, and whole tumor regions, respectively, on the BraTS 2021 validation set, ranking us among the top ten teams. These experimental findings provide evidence that it can be readily applied clinically and thereby aiding in the brain cancer prognosis, therapy planning, and therapy response monitoring. A docker image for reproducing our segmentation results is available online at (https://hub.docker.com/r/razeineldin/deepseg21).
Database management systems and K/V-Stores operate on updatable datasets – massively exceeding the size of available main memory. Tree-based K/V storage management structures became particularly popular in storage engines. B+ -Trees [1, 4] allow constant search performance, however write-heavy workloads yield in inefficient write patterns to secondary storage devices and poor performance characteristics. LSM-Trees [16, 23] overcome this issue by horizontal partitioning fractions of data – small enough to fully reside in main memory, but require frequent maintenance to sustain search performance.
Firstly, we propose Multi-Version Partitioned BTrees (MV-PBT) as sole storage and index management structure in key-sorted storage engines like K/V-Stores. Secondly, we compare MV-PBT against LSM-Trees. The logical horizontal partitioning in MV-PBT allows leveraging recent advances in modern B+ -Tree techniques in a small transparent and memory resident portion of the structure. Structural properties sustain steady read performance, yielding efficient write patterns and reducing write amplification.
We integrated MV-PBT in the WiredTiger [15] KV storage engine. MV-PBT offers an up to 2× increased steady throughput in comparison to LSM-Trees and several orders of magnitude in comparison to B+ -Trees in a YCSB [5] workload.
Purpose
Context awareness in the operating room (OR) is important to realize targeted assistance to support actors during surgery. A situation recognition system (SRS) is used to interpret intraoperative events and derive an intraoperative situation from these. To achieve a modular system architecture, it is desirable to de-couple the SRS from other system components. This leads to the need of an interface between such an SRS and context-aware systems (CAS). This work aims to provide an open standardized interface to enable loose coupling of the SRS with varying CAS to allow vendor-independent device orchestrations.
Methods
A requirements analysis investigated limiting factors that currently prevent the integration of CAS in today's ORs. These elicited requirements enabled the selection of a suitable base architecture. We examined how to specify this architecture with the constraints of an interoperability standard. The resulting middleware was integrated into a prototypic SRS and our system for intraoperative support, the OR-Pad, as exemplary CAS for evaluating whether our solution can enable context-aware assistance during simulated orthopedical interventions.
Results
The emerging Service-oriented Device Connectivity (SDC) standard series was selected to specify and implement a middleware for providing the interpreted contextual information while the SRS and CAS are loosely coupled. The results were verified within a proof of concept study using the OR-Pad demonstration scenario. The fulfillment of the CAS’ requirements to act context-aware, conformity to the SDC standard series, and the effort for integrating the middleware in individual systems were evaluated. The semantically unambiguous encoding of contextual information depends on the further standardization process of the SDC nomenclature. The discussion of the validity of these results proved the applicability and transferability of the middleware.
Conclusion
The specified and implemented SDC-based middleware shows the feasibility of loose coupling an SRS with unknown CAS to realize context-aware assistance in the OR.
Purpose
Artificial intelligence (AI), in particular deep neural networks, has achieved remarkable results for medical image analysis in several applications. Yet the lack of explainability of deep neural models is considered the principal restriction before applying these methods in clinical practice.
Methods
In this study, we propose a NeuroXAI framework for explainable AI of deep learning networks to increase the trust of medical experts. NeuroXAI implements seven state-of-the-art explanation methods providing visualization maps to help make deep learning models transparent.
Results
NeuroXAI has been applied to two applications of the most widely investigated problems in brain imaging analysis, i.e., image classification and segmentation using magnetic resonance (MR) modality. Visual attention maps of multiple XAI methods have been generated and compared for both applications. Another experiment demonstrated that NeuroXAI can provide information flow visualization on internal layers of a segmentation CNN.
Conclusion
Due to its open architecture, ease of implementation, and scalability to new XAI methods, NeuroXAI could be utilized to assist radiologists and medical professionals in the detection and diagnosis of brain tumors in the clinical routine of cancer patients. The code of NeuroXAI is publicly accessible at https://github.com/razeineldin/NeuroXAI.
In our initial DaMoN paper, we set out the goal to revisit the results of “Starring into the Abyss [...] of Concurrency Control with [1000] Cores” (Yu in Proc. VLDB Endow 8: 209-220, 2014). Against their assumption, today we do not see single-socket CPUs with 1000 cores. Instead, multi-socket hardware is prevalent today and in fact offers over 1000 cores. Hence, we evaluated concurrency control (CC) schemes on a real (Intel-based) multi-socket platform. To our surprise, we made interesting findings opposing results of the original analysis that we discussed in our initial DaMoN paper. In this paper, we further broaden our analysis, detailing the effect of hardware and workload characteristics via additional real hardware platforms (IBM Power8 and 9) and the full TPC-C transaction mix. Among others, we identified clear connections between the performance of the CC schemes and hardware characteristics, especially concerning NUMA and CPU cache. Overall, we conclude that no CC scheme can efficiently make use of large multi-socket hardware in a robust manner and suggest several directions on how CC schemes and overall OLTP DBMS should evolve in future.
Das Buch untersucht die Umsetzung der Seidenstraßeninitiative (BRI) in Ostafrika. Die BRI gilt als das zentrale geopolitische und geoökonomische Vorhaben Chinas in der Ära von Präsident Xi Jinping. Durch die Arbeit soll ein Beitrag zur Schließung einiger Forschungslücken geleistet werden, etwa die mangelnde Tiefe von Untersuchungen einzelner BRI-Projekte und die Unterberücksichtigung von Verarbeitungsnarrativen in den teilnehmenden Ländern. Die Leitfrage ist, inwiefern die BRI ein politisches bzw. hegemoniales Projekt des von der KPCh gelenkten Staats-Zivilgesellschafts-Komplexes in Ostafrika ist. Zu deren Beantwortung werden Datenbanken internationaler Organisationen und Policy-Dokumente ausgewertet. Außerdem führt der Verfasser eine qualitative Inhaltsanalyse von Zeitungsartikeln lokaler Medienhäuser in den Ländern Äthiopien, Kenia und Tansania durch, um drei Infrastrukturprojekte zu untersuchen. Die Arbeit verdeutlicht, dass die BRI zur Steigerung der Konnektivität in Ostafrika beiträgt. Gleichzeitig führen die Verdichtung der ökonomischen Beziehungen und die Implementierung der Infrastrukturvorhaben in Ostafrika zu zahlreichen Konsequenzen und konturieren ein hegemoniales Projekt.
Von den Covid-19-Restriktionen wurden im Automobilsektor die Zulieferer wesentlich stärker getroffen als die Fahrzeughersteller. Vor allem die Entwicklung des Working Capitals im ersten Pandemie-Jahr erwies sich als kritisch. Der Beitrag gibt einen Überblick über mögliche Lösungen für eine allseits vorteilhaftere, stabile Supply-Chain-Finanzierung in künftigen Krisen.
Values Management System
(2022)
The ValuesManagementSystem (VWS) is a management standard to “provide a sustainable safeguard of a firm and its development, in all dimensions (legal, economic, ecological, social)” (VWSZfW, p. 4). It includes a framework for values-driven governance through self-commitment and self-binding mechanisms. Values promote a sense of identity and give organizations guidance in decision-making. This is especially important in decision-making processes where topics are not clearly ruled by laws and regulations.
VMSZfW must be embedded in the specific business strategy, structure, and culture of an organization. The following four steps describe the implementation of the ValuesManagementSystemZfW: (i) Codify core values of an organization, for instance, with a “mission, vision and values statement” or Code of Ethics, (ii) implement guidelines such as Code of Conduct and specific policies and procedures, (iii) systematize these by establishing management systems such as Compliance and CSR management systems, and (iv) finally organize and establish structures to ensure the strategic direction and operational implementation and review of these processes. The top management shows that values management is taken seriously by their self-commitment to the core values of the company.
The Principles for Responsible Investments (PRI) is “the world’s leading proponent of responsible investment” (PRI 2021a). With the development of six Principles for Responsible Investment, the PRI supports its international network of investor signatories in incorporating the environmental, social, and governance (ESG) factors into their investment and ownership decisions. The goal of PRI is to develop a more sustainable global financial system by encouraging “investors to use responsible investment to enhance returns and better manage risks” (PRI 2021a). This independent financial initiative is supported by the United Nations and linked to the United Nations Environmental Program Finance Initiative (UNEP FI 2021) and the United Nations Global Compact (UN Global Compact 2021).
The United Nations (UN) Global Compact is a call to companies to align their strategies and operations with ten universal principles in the areas of human rights, labor, environment, and anti-corruption, and to take actions that advance societal goals (UN Global Compact 2017, p. 3). The UN Global Compacts’ vision is “to mobilize a global movement of sustainable companies and stakeholder to create the world we want” (UN Global Compact 2021a). It is a global network with local presence all around the world.
Recognition of sleep and wake states is one of the relevant parts of sleep analysis. Performing this measurement in a contactless way increases comfort for the users. We present an approach evaluating only movement and respiratory signals to achieve recognition, which can be measured non-obtrusively. The algorithm is based on multinomial logistic regression and analyses features extracted out of mentioned above signals. These features were identified and developed after performing fundamental research on characteristics of vital signals during sleep. The achieved accuracy of 87% with the Cohen’s kappa of 0.40 demonstrates the appropriateness of a chosen method and encourages continuing research on this topic.
One of the key challenges for automatic assistance is the support of actors in the operating room depending on the status of the procedure. Therefore, context information collected in the operating room is used to gain knowledge about the current situation. In literature, solutions already exist for specific use cases, but it is doubtful to what extent these approaches can be transferred to other conditions. We conducted a comprehensive literature research on existing situation recognition systems for the intraoperative area, covering 274 articles and 95 cross-references published between 2010 and 2019. We contrasted and compared 58 identified approaches based on defined aspects such as used sensor data or application area. In addition, we discussed applicability and transferability. Most of the papers focus on video data for recognizing situations within laparoscopic and cataract surgeries. Not all of the approaches can be used online for real-time recognition. Using different methods, good results with recognition accuracies above 90% could be achieved. Overall, transferability is less addressed. The applicability of approaches to other circumstances seems to be possible to a limited extent. Future research should place a stronger focus on adaptability. The literature review shows differences within existing approaches for situation recognition and outlines research trends. Applicability and transferability to other conditions are less addressed in current work.
The Dow Jones Sustainability Indexes (DJSI) track the performance of companies that lead in corporate sustainability in their respective sectors or in the geographies they operate. The Sustainable Asset Management (SAM) Indexes GmbH publishes and markets the indexes, the so-called Dow Jones Sustainability Indexes in collaboration with SAM. All indexes of the DJSI family are assessed according to SAM’s Corporate Sustainability AssessmentTM methodology.
Public transport maps are typically designed in a way to support route finding tasks for passengers, while they also provide an overview about stations, metro lines, and city-specific attractions. Most of those maps are designed as a static representation, maybe placed in a metro station or printed in a travel guide. In this paper, we describe a dynamic, interactive public transport map visualization enhanced by additional views for the dynamic passenger data on different levels of temporal granularity. Moreover, we also allow extra statistical information in form of density plots, calendar-based visualizations, and line graphs. All this information is linked to the contextual metro map to give a viewer insights into the relations between time points and typical routes taken by the passengers. We also integrated a graph-based view on user-selected routes, a way to interactively compare those routes, an attribute- and property-driven automatic computation of specific routes for one map as well as for all available maps in our repertoire, and finally, also the most important sights in each city are included as extra information to include in a user-selected route. We illustrate the usefulness of our interactive visualization and map navigation system by applying it to the railway system of Hamburg in Germany while also taking into account the extra passenger data. As another indication for the usefulness of the interactively enhanced metro maps we conducted a controlled user experiment with 20 participants.
Am 1. November 2010 wurde der Leitfaden zur gesellschaftlichen Verantwortung von Organisationen – „Guidance on Social Responsibility“ (ISO 26000:2010) – veröffentlicht. Dieses Normendokument wurde innerhalb von sechs Jahren in einem auch für die ‚International Organization for Standardization’(ISO) einzigartigen, weltweiten Normierungsprozess mit mehr als 400 Experten aus 99 Ländern erarbeitet.
Prior to the introduction of AI-based forecast models in the procurement department of an industrial retail company, we assessed the digital skills of the procurement employees and surveyed their attitudes toward a new digital technology. The aim of the survey was to ascertain important contextual factors which are likely to influence the acceptance and the successful use of the new forecast tool. What we find is that the digital skills of the employees show an intermediate level and that their attitudes toward key aspects of new digital technologies are largely positive. Thus, the conditions for high acceptance and the successful use of the models are good, as evidenced by the high intention of the procurement staff to use the models. In line with previous research, we find that the perceived usefulness of a new technology and the perceived ease of use are significant drivers of the willingness to use the new forecast tool.
Forecasting demand is challenging. Various products exhibit different demand patterns. While demand may be constant and regular for one product, it may be sporadic for another, as well as when demand occurs, it may fluctuate significantly. Forecasting errors are costly and result in obsolete inventory or unsatisfied demand. Methods from statistics, machine learning, and deep learning have been used to predict such demand patterns. Nevertheless, it is not clear for what demand pattern, which algorithm would achieve the best forecast. Therefore, even today a large number of models are used to forecast on a test period. The model with the best result on the test period is used for the actual forecast. This approach is computationally and time intensive and, in most cases, uneconomical. In our paper we show the possibility to use a machine learning classification algorithm, which predicts the best possible model based on the characteristics of a time series. The approach was developed and evaluated on a dataset from a B2B-technical-retailer. The machine learning classification algorithm achieves a mean ROC-AUC of 89%, which emphasizes the skill of the model.
In buchstäblich letzter Minute haben sich die englische Regierung und die Europäische Union auf ein umfangreiches Abkommen geeinigt, um einen ungeregelten Brexit zu verhindern. Nach dem jahrelangen zähen Verhandlungsmarathon fällt der Jubel verhalten aus, dennoch herrscht auf beiden Seiten des Ärmelkanals Erleichterung, weil ein Modus Vivendi gefunden wurde, auf dem sich die künftigen Beziehungen aufbauen und fortführen lassen. Ob sich die englischen Blütenträume, die an den Brexit geknüpft wurden, erfüllen werden, wird die Zukunft erweisen.
Die Strategie und Taktik der englischen Regierungen zum Brexit und bei den Austrittsverhandlungen spiegeln sich in den Erfahrungen wider, die Friedrich List vor genau 175 Jahren bei seinen Bemühungen um eine deutsch-englische Allianz machen musste. Wegen der von England schon damals strikt befolgten Insular und Handelssuprematie musste er sich eingestehen, dass England diese Position hartnäckig verteidigt und deshalb frustriert und ernüchtert seine Pläne aufgeben. Deshalb setzte er seine Hoffnung auf eine "Kontinentalallianz" der europäischen Nationen, wie sie nun nach dem Austritt Großbritanniens aus der Europäischen Union entstanden ist. Vielleicht werden wir uns nun an den Begriff "Kontinentalallianz" gewöhnen müssen und dabei an die Weitsicht von Friedrich List erinnert.
Andererseits gilt auch für die englische Politik das Motto von Lists zweiter Pariser Preisschrift: "Le monde marche - Die Welt bewegt sich", allerdings mit völlig anderen Vorzeichen als vor 175 Jahren: Die Welthandelsachse hat sich von der westlichen auf die östliche Halbkugel verlagert; das britische Weltreich ist Geschichte, die Fließgeschwindigkeit des globalen Wandels hat sich dramatisch beschleunigt und trotz der Lingua Franca erscheint England, vor allem aus asiatischer Sicht, nur noch als kleiner Fleck auf der Weltkarte. Falls die schottische Regierung ihre Absicht durchsetzen und die Unabhängigkeit vom Vereinigten Königreich erreichen sollte, würde sich der Brexit als verhängnisvoller Bumerang erweisen.
Digitalisierung und Mediatisierung prägen die Gesellschaft und auch die Erwachsenenbildung/Weiterbildung. Der Beitrag geht der Frage nach, wie Digitalisierung in Angeboten der Erwachsenenbildung/Weiterbildung gelingt. Damit wird ein Fokus auf den Einsatz digitaler Medien gelegt. Dazu werden die Angebotsentwicklung für Adressatinnen und Adressaten sowie Teilnehmende, medienbezogene Inhalte, Lehr- und Lernarrangements mit digitalen Medien, der Einsatz digitaler Medien und die Zugänglichkeit von Lehr- und Lernmaterialien als relevante Merkmale identifiziert. Insgesamt zeigen die analysierten Interviewdaten, dass der Einsatz digitaler Medien in Angeboten eine Erweiterung der didaktischen Aufgaben darstellt, da Angebote mit digitalen Medien zielgenau auf die Bedarfe und Möglichkeiten von Adressatinnen und Adressaten sowie Teilnehmenden abgestimmt werden müssen.
Forecasting demand is challenging. Various products exhibit different demand patterns. While demand may be constant and regular for one product, it may be sporadic for another, as well as when demand occurs, it may fluctuate significantly. Forecasting errors are costly and result in obsolete inventory or unsatisfied demand. Methods from statistics, machine learning, and deep learning have been used to predict such demand patterns. Nevertheless, it is not clear for what demand pattern, which algorithm would achieve the best forecast. Therefore, even today a large number of models are used to forecast on a test period. The model with the best result on the test period is used for the actual forecast. This approach is computationally and time intensive and, in most cases, uneconomical. In our paper we show the possibility to use a machine learning classification algorithm, which predicts the best possible model based on the characteristics of a time series. The approach was developed and evaluated on a dataset from a B2B-technical-retailer. The machine learning classification algorithm achieves a mean ROC-AUC of 89%, which emphasizes the skill of the model.
Unter den widrigsten wirtschaftlichen und politischen Verhältnissen und Bedingungen wurde die Friedrich-List-Gesellschaft (FLG) 1925 gegründet und bis 1934 fortgeführt. Sie verfolgte vor allem den Zweck, die weit verstreuten, schwer zugänglichen und vielfach unbekannten Schriften, Reden und Briefe von Friedrich List (1789-1846) zusammenzutragen und in Form einer Gesamtausgabe zu publizieren.
Weder diese 10- bzw. 12-bändige Gesamtausgabe, noch die Namen ihrer Herausgeber haben in der Wirtschaftswissenschaft die gebührende Wertschätzung und Aufmerksamkeit erfahren. Die längst überfällige Dankesschuld wird in dem vorliegenden Beitrag nach nahezu 100 Jahren abgetragen. Ohne den engagierten und mutigen Einsatz der Herausgeber, insbesondere von Edgar Salin, wäre die List-Forschung undenkbar und die deutsche Wirtschaftswissenschaft um ein ruhmreiches Kapitel ärmer.
Seit 5 Jahrzehnten steht die Erforschung von Leben, Werk und Wirkungsgeschichte von Friedrich List (1789–1846) im Zentrum der wissenschaftlichen Arbeit von Eugen Wendler. Im Laufe der Zeit sind ca. 30 Monographien und eine größere Anzahl von wissenschaftlichen Aufsätzen und journalistischen Artikeln entstanden. Dabei baute Eugen Wendler auf der unschätzbaren Vorarbeit der Herausgeber der Gesamtausgabe von Lists Werken von 1925 bis 1935 auf.
Der vorliegende Aufsatz vermittelt einen Überblick über die Buchpublikationen von Eugen Wendler zur List-Forschung. Mit seinem eindrucksvollen Oeuvre bekennt er sich zum letzten lebenden Fossil in der Nachfolge der FLG und erweist damit den Herausgebern die gebührende und längst überfällige Wertschätzung und Achtung.
Digitalization increases the pressure for companies to innovate. While current research on digital transformation mostly focuses on technological and management aspects, less attention has been paid to organizational culture and its influence on digital innovations. The purpose of this paper is to identify the characteristics of organizational culture that foster digital innovations. Based on a systematic literature review on three scholarly databases, we initially found 778 articles that were then narrowed down to a total number of 23 relevant articles through a methodical approach. After analyzing these articles, we determine nine characteristics of organizational culture that foster digital innovations: corporate entrepreneurship, digital awareness and necessity of innovations, digital skills and resources, ecosystem orientation, employee participation, agility and organizational structures, error culture and risk-taking, internal knowledge sharing and collaboration, customer and market orientation as well as open-mindedness and willingness to learn.
The early detection of head and neck cancer is a prolonged challenging task. It requires a precise and accurate identification of tissue alterations as well as a distinct discrimination of cancerous from healthy tissue areas. A novel approach for this purpose uses microspectroscopic techniques with special focus on hyperspectral imaging (HSI) methods. Our proof-of-principle study presents the implementation and application of darkfield elastic light scattering spectroscopy (DF ELSS) as a non-destructive, high-resolution, and fast imaging modality to distinguish lingual healthy from altered tissue regions in a mouse model. The main aspect of our study deals with the comparison of two varying HSI detection principles, which are a point-by-point and line scanning imaging, and whether one might be more appropriate in differentiating several tissue types. Statistical models are formed by deploying a principal component analysis (PCA) with the Bayesian discriminant analysis (DA) on the elastic light scattering (ELS) spectra. Overall accuracy, sensitivity, and precision values of 98% are achieved for both models whereas the overall specificity results in 99%. An additional classification of model-unknown ELS spectra is performed. The predictions are verified with histopathological evaluations of identical HE-stained tissue areas to prove the model’s capability of tissue distinction. In the context of our proof-of-principle study, we assess the Pushbroom PCA-DA model to be more suitable for tissue type differentiations and thus tissue classification. In addition to the HE-examination in head and neck cancer diagnosis, the usage of HSI-based statistical models might be conceivable in a daily clinical routine.
Context:
Test-driven development (TDD) is an agile software development approach that has been widely claimed to improve software quality. However, the extent to which TDD improves quality appears to be largely dependent upon the characteristics of the study in which it is evaluated (e.g., the research method, participant type, programming environment, etc.). The particularities of each study make the aggregation of results untenable.
Objectives:
The goal of this paper is to: increase the accuracy and generalizability of the results achieved in isolated experiments on TDD, provide joint conclusions on the performance of TDD across different industrial and academic settings, and assess the extent to which the characteristics of the experiments affect the quality-related performance of TDD.
Method:
We conduct a family of 12 experiments on TDD in academia and industry. We aggregate their results by means of meta-analysis. We perform exploratory analyses to identify variables impacting the quality-related performance of TDD.
Results:
TDD novices achieve a slightly higher code quality with iterative test-last development (i.e., ITL, the reverse approach of TDD) than with TDD. The task being developed largely determines quality. The programming environment, the order in which TDD and ITL are applied, or the learning effects from one development approach to another do not appear to affect quality. The quality-related performance of professionals using TDD drops more than for students. We hypothesize that this may be due to their being more resistant to change and potentially less motivated than students.
Conclusion:
Previous studies seem to provide conflicting results on TDD performance (i.e., positive vs. negative, respectively). We hypothesize that these conflicting results may be due to different study durations, experiment participants being unfamiliar with the TDD process, or case studies comparing the performance achieved by TDD vs. the control approach (e.g., the waterfall model), each applied to develop a different system. Further experiments with TDD experts are needed to validate these hypotheses.
In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of how drugs are discovered, developed and marketed. Critical to this transformation is the adoption of new technologies in the drug development process, catalyzing the transition from serendipity-driven to data-driven medicine. This paradigm shift comes with a need for both translation and precision, leading to a modern Translational Precision Medicine approach to drug discovery and development. Key components of Translational Precision Medicine are multi-omics profiling, digital biomarkers, model-based data integration, artificial intelligence, biomarker-guided trial designs and patient-centric companion diagnostics. In this review, we summarize and critically discuss the potential and challenges of Translational Precision Medicine from a cross-industry perspective.
Context: Agile practices as well as UX methods are nowadays well-known and often adopted to develop complex software and products more efficiently and effectively. However, in the so called VUCA environment, which many companies are confronted with, the sole use of UX research is not sufficient to find the best solutions for customers. The implementation of Design Thinking can support this process. But many companies and their product owners don’t know how much resources they should spend for conducting Design Thinking.
Objective: This paper aims at suggesting a supportive tool, the “Discovery Effort Worthiness (DEW) Index”, for product owners and agile teams to determine a suitable amount of effort that should be spent for Design Thinking activities.
Method: A case study was conducted for the development of the DEW index. Design Thinking was introduced into the regular development cycle of an industry Scrum team. With the support of UX and Design Thinking experts, a formula was developed to determine the appropriate effort for Design Thinking.
Results: The developed “Discovery Effort Worthiness Index” provides an easy-to-use tool for companies and their product owners to determine how much effort they should spend on Design Thinking methods to discover and validate requirements. A company can map the corresponding Design Thinking methods to the results of the DEW Index calculation, and product owners can select the appropriate measures from this mapping. Therefore, they can optimize the effort spent for discovery and validation.
Context: Many companies are facing an increasingly dynamic and uncertain market environment, making traditional product roadmapping practices no longer sufficiently applicable. As a result, many companies need to adapt their product roadmapping practices for continuing to operate successfully in today’s dynamic market environment. However, transforming product roadmapping practices is a difficult process for organizations. Existing literature offers little help on how to accomplish such a process.
Objective: The objective of this paper is to present a product roadmap transformation approach for organizations to help them identify appropriate improvement actions for their roadmapping practices using an analysis of their current practices.
Method: Based on an existing assessment procedure for evaluating product roadmapping practices, the first version of a product roadmap transformation approach was developed in workshops with company experts. The approach was then given to eleven practitioners and their perceptions of the approach were gathered through interviews.
Results: The result of the study is a transformation approach consisting of a process describing what steps are necessary to adapt the currently applied product roadmapping practice to a dynamic and uncertain market environment. It also includes recommendations on how to select areas for improvement and two empirically based mapping tables. The interviews with the practitioners revealed that the product roadmap transformation approach was perceived as comprehensible, useful, and applicable. Nevertheless, we identified potential for improvements, such as a clearer presentation of some processes and the need for more improvement options in the mapping tables. In addition, minor usability issues were identified.
Since the beginning of the energy sector liberalization, the design of energy markets has become a prominent field of research. Markets nowadays facilitate efficient resource allocation in many fields of energy system operation, such as plant dispatch, control reserve provisioning, delimitation of related carbon emissions, grid congestion management, and, more recently, smart grid concepts and local energy trading. Therefore, good market designs play an important role in enabling the energy transition toward a more sustainable energy supply for all. In this chapter, we retrace how market engineering shaped the development of energy markets and how the research focus shifted from national wholesale markets to more decentralized and location-sensitive concepts.
In a networked world, companies depend on fast and smart decisions, especially when it comes to reacting to external change. With the wealth of data available today, smart decisions can increasingly be based on data analysis and be supported by IT systems that leverage AI. A global pandemic brings external change to an unprecedented level of unpredictability and severity of impact. Resilience therefore becomes an essential factor in most decisions when aiming at making and keeping them smart. In this chapter, we study the characteristics of resilient systems and test them with four use cases in a wide-ranging set of application areas. In all use cases, we highlight how AI can be used for data analysis to make smart decisions and contribute to the resilience of systems.
Several studies analyzed existing Web APIs against the constraints of REST to estimate the degree of REST compliance among state-of-the-art APIs. These studies revealed that only a small number of Web APIs are truly RESTful. Moreover, identified mismatches between theoretical REST concepts and practical implementations lead us to believe that practitioners perceive many rules and best practices aligned with these REST concepts differently in terms of their importance and impact on software quality. We therefore conducted a Delphi study in which we confronted eight Web API experts from industry with a catalog of 82 REST API design rules. For each rule, we let them rate its importance and software quality impact. As consensus, our experts rated 28 rules with high, 17 with medium, and 37 with low importance. Moreover, they perceived usability, maintainability, and compatibility as the most impacted quality attributes. The detailed analysis revealed that the experts saw rules for reaching Richardson maturity level 2 as critical, while reaching level 3 was less important. As the acquired consensus data may serve as valuable input for designing a tool-supported approach for the automatic quality evaluation of RESTful APIs, we briefly discuss requirements for such an approach and comment on the applicability of the most important rules.
The Internet of Things (IoT) is coined by many different standards, protocols, and data formats that are often not compatible to each other. Thus, the integration of different heterogeneous (IoT) components into a uniform IoT setup can be a time-consuming manual task. This lacking interoperability between IoT components has been addressed with different approaches in the past. However, only very few of these approaches rely on Machine Learning techniques. In this work, we present a new way towards IoT interoperability based on Deep Reinforcement Learning (DRL). In detail, we demonstrate that DRL algorithms, which use network architectures inspired by Natural Language Processing (NLP), can be applied to learn to control an environment by merely taking raw JSON or XML structures, which reflect the current state of the environment, as input. Applied to IoT setups, where the current state of a component is often reflected by features embedded into JSON or XML structures and exchanged via messages, our NLP DRL approach eliminates the need for feature engineering and manually written code for pre-processing of data, feature extraction, and decision making.
The blockchain technology represents a decentralized database that stores information securely in immutable data blocks. Regarding supply chain management, these characteristics offer potentials in increasing supply chain transparency, visibility, automation, and efficiency. In this context, first token-based mapping approaches exist to transfer certain manufacturing processes to the blockchain, such as the creation or assembly of parts as well as their transfer of ownership. However, the decentralized and immutable structure of blockchain technology also creates challenges when applying these token-based approaches to dynamic manufacturing processes. As a first step, this paper investigates existing mapping approaches and exemplifies weaknesses regarding their suitability for products with changeable configurations. Secondly, a concept is proposed to overcome these weaknesses by introducing logically coupled tokens embedded into a flexible smart contract structure. Finally, a concept for a token-based architecture is introduced to map manufacturing processes of products with changeable configurations.
The current advancement of Artificial Intelligence (AI) combined with other digitalization efforts significantly impacts service ecosystems. Artificial intelligence has a substantial impact on new opportunities for the co-creation of value and the development of intelligent service ecosystems. Motivated by experiences and observations from digitalization projects, this paper presents new methodological perspectives and experiences from academia and practice on architecting intelligent service ecosystems and explores the impact of artificial intelligence through real cases supporting an ongoing validation. Digital enterprise architecture models serve as an integral representation of business, information, and technological perspectives of intelligent service-based enterprise systems to support management and development. This paper focuses on architectural models for intelligent service ecosystems, showing the fundamental business mechanism of AI-based value co-creation, the corresponding digital architecture, and management models. The focus of this paper presents the key architectural model perspectives for the development of intelligent service ecosystems.
The digitization of factories will be a significant issue for the 2020s. New scenarios are emerging to increase the efficiency of production lines inside the factory, based on a new generation of robots’ collaborative functions. Manufacturers are moving towards data-driven ecosystems by leveraging product lifecycle data from connected goods. Energy-efficient communication schemes, as well as scalable data analytics, will support these various data collection scenarios. With augmented reality, new remote services are emerging that facilitate the efficient sharing of knowledge in the factory. Future communication solutions should generally ensure connectivity between the various production sites spread worldwide and new players in the value chain (e.g., suppliers, logistics) transparent, real-time, and secure. Industry 4.0 brings more intelligence and flexibility to production. Resulting in more lightweight equipment and, thus, offering better ergonomics. 5G will guarantee real-time transmissions with latencies of less than 1 ms. This will provide manufacturers with new possibilities to collect data and trigger actions automatically.
Platforms and their surrounding ecosystems are becoming increasingly important components of many companies' strategies. Artificial Intelligence, in particular, has created new opportunities to create and develop ecosystems around the platform. However, there is not yet a methodology to systematically develop these new opportunities for enterprise development strategy. Therefore, this paper aims to lay a foundation for the conceptualization of Artificial Intelligence-based service ecosystems exploiting a Service-Dominant Logic. The basis for conceptualization is the study of value creation and particularly effective network effects. This research investigates the fundamental idea of extending specific digital concepts considering the influence of Artificial Intelligence on the design of intelligent services, along with their architecture of digital platforms and ecosystems, to enable a smooth evolutionary path and adaptability for human-centric collaborative systems and services. The paper explores an extended digital enterprise conceptual model through a combined, iterative, and permanent task of co-creating value between humans and intelligent systems as part of a new idea of cognitively adapted intelligent services.
In recent years, artificial intelligence (AI) has increasingly become a relevant technology for many companies. While there are a number of studies that highlight challenges and success factors in the adoption of AI, there is a lack of guidance for firms on how to approach the topic in a holistic and strategic way. The aim of this study is therefore to develop a conceptual framework for corporate AI strategy. To address this aim, a systematic literature review of a wide spectrum of AI-related research is conducted, and the results are analyzed based on an inductive coding approach. An important conclusion is that companies should consider diverse aspects when formulating an AI strategy, ranging from technological questions to corporate culture and human resources. This study contributes to knowledge by proposing a novel, comprehensive framework to foster the understanding of crucial aspects that need to be considered when using the emerging technology of AI in a corporate context.
Context
Microservices as a lightweight and decentralized architectural style with fine-grained services promise several beneficial characteristics for sustainable long-term software evolution. Success stories from early adopters like Netflix, Amazon, or Spotify have demonstrated that it is possible to achieve a high degree of flexibility and evolvability with these systems. However, the described advantageous characteristics offer no concrete guidance and little is known about evolvability assurance processes for microservices in industry as well as challenges in this area. Insights into the current state of practice are a very important prerequisite for relevant research in this field.
Objective
We therefore wanted to explore how practitioners structure the evolvability assurance processes for microservices, what tools, metrics, and patterns they use, and what challenges they perceive for the evolvability of their systems.
Method
We first conducted 17 semi-structured interviews and discussed 14 different microservice-based systems and their assurance processes with software professionals from 10 companies. Afterwards, we performed a systematic grey literature review (GLR) and used the created interview coding system to analyze 295 practitioner online resources.
Results
The combined analysis revealed the importance of finding a sensible balance between decentralization and standardization. Guidelines like architectural principles were seen as valuable to ensure a base consistency for evolvability and specialized test automation was a prevalent theme. Source code quality was the primary target for the usage of tools and metrics for our interview participants, while testing tools and productivity metrics were the focus of our GLR resources. In both studies, practitioners did not mention architectural or service-oriented tools and metrics, even though the most crucial challenges like Service Cutting or Microservices Integration were of an architectural nature.
Conclusions
Practitioners relied on guidelines, standardization, or patterns like Event-Driven Messaging to partially address some reported evolvability challenges. However, specialized techniques, tools, and metrics are needed to support industry with the continuous evaluation of service granularity and dependencies. Future microservices research in the areas of maintenance, evolution, and technical debt should take our findings and the reported industry sentiments into account.