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Prior to the introduction of AI-based forecast models in the procurement department of an industrial retail company, we assessed the digital skills of the procurement employees and surveyed their attitudes toward a new digital technology. The aim of the survey was to ascertain important contextual factors which are likely to influence the acceptance and the successful use of the new forecast tool. What we find is that the digital skills of the employees show an intermediate level and that their attitudes toward key aspects of new digital technologies are largely positive. Thus, the conditions for high acceptance and the successful use of the models are good, as evidenced by the high intention of the procurement staff to use the models. In line with previous research, we find that the perceived usefulness of a new technology and the perceived ease of use are significant drivers of the willingness to use the new forecast tool.
Forecasting demand is challenging. Various products exhibit different demand patterns. While demand may be constant and regular for one product, it may be sporadic for another, as well as when demand occurs, it may fluctuate significantly. Forecasting errors are costly and result in obsolete inventory or unsatisfied demand. Methods from statistics, machine learning, and deep learning have been used to predict such demand patterns. Nevertheless, it is not clear for what demand pattern, which algorithm would achieve the best forecast. Therefore, even today a large number of models are used to forecast on a test period. The model with the best result on the test period is used for the actual forecast. This approach is computationally and time intensive and, in most cases, uneconomical. In our paper we show the possibility to use a machine learning classification algorithm, which predicts the best possible model based on the characteristics of a time series. The approach was developed and evaluated on a dataset from a B2B-technical-retailer. The machine learning classification algorithm achieves a mean ROC-AUC of 89%, which emphasizes the skill of the model.
In buchstäblich letzter Minute haben sich die englische Regierung und die Europäische Union auf ein umfangreiches Abkommen geeinigt, um einen ungeregelten Brexit zu verhindern. Nach dem jahrelangen zähen Verhandlungsmarathon fällt der Jubel verhalten aus, dennoch herrscht auf beiden Seiten des Ärmelkanals Erleichterung, weil ein Modus Vivendi gefunden wurde, auf dem sich die künftigen Beziehungen aufbauen und fortführen lassen. Ob sich die englischen Blütenträume, die an den Brexit geknüpft wurden, erfüllen werden, wird die Zukunft erweisen.
Die Strategie und Taktik der englischen Regierungen zum Brexit und bei den Austrittsverhandlungen spiegeln sich in den Erfahrungen wider, die Friedrich List vor genau 175 Jahren bei seinen Bemühungen um eine deutsch-englische Allianz machen musste. Wegen der von England schon damals strikt befolgten Insular und Handelssuprematie musste er sich eingestehen, dass England diese Position hartnäckig verteidigt und deshalb frustriert und ernüchtert seine Pläne aufgeben. Deshalb setzte er seine Hoffnung auf eine "Kontinentalallianz" der europäischen Nationen, wie sie nun nach dem Austritt Großbritanniens aus der Europäischen Union entstanden ist. Vielleicht werden wir uns nun an den Begriff "Kontinentalallianz" gewöhnen müssen und dabei an die Weitsicht von Friedrich List erinnert.
Andererseits gilt auch für die englische Politik das Motto von Lists zweiter Pariser Preisschrift: "Le monde marche - Die Welt bewegt sich", allerdings mit völlig anderen Vorzeichen als vor 175 Jahren: Die Welthandelsachse hat sich von der westlichen auf die östliche Halbkugel verlagert; das britische Weltreich ist Geschichte, die Fließgeschwindigkeit des globalen Wandels hat sich dramatisch beschleunigt und trotz der Lingua Franca erscheint England, vor allem aus asiatischer Sicht, nur noch als kleiner Fleck auf der Weltkarte. Falls die schottische Regierung ihre Absicht durchsetzen und die Unabhängigkeit vom Vereinigten Königreich erreichen sollte, würde sich der Brexit als verhängnisvoller Bumerang erweisen.
Digitalisierung und Mediatisierung prägen die Gesellschaft und auch die Erwachsenenbildung/Weiterbildung. Der Beitrag geht der Frage nach, wie Digitalisierung in Angeboten der Erwachsenenbildung/Weiterbildung gelingt. Damit wird ein Fokus auf den Einsatz digitaler Medien gelegt. Dazu werden die Angebotsentwicklung für Adressatinnen und Adressaten sowie Teilnehmende, medienbezogene Inhalte, Lehr- und Lernarrangements mit digitalen Medien, der Einsatz digitaler Medien und die Zugänglichkeit von Lehr- und Lernmaterialien als relevante Merkmale identifiziert. Insgesamt zeigen die analysierten Interviewdaten, dass der Einsatz digitaler Medien in Angeboten eine Erweiterung der didaktischen Aufgaben darstellt, da Angebote mit digitalen Medien zielgenau auf die Bedarfe und Möglichkeiten von Adressatinnen und Adressaten sowie Teilnehmenden abgestimmt werden müssen.
Forecasting demand is challenging. Various products exhibit different demand patterns. While demand may be constant and regular for one product, it may be sporadic for another, as well as when demand occurs, it may fluctuate significantly. Forecasting errors are costly and result in obsolete inventory or unsatisfied demand. Methods from statistics, machine learning, and deep learning have been used to predict such demand patterns. Nevertheless, it is not clear for what demand pattern, which algorithm would achieve the best forecast. Therefore, even today a large number of models are used to forecast on a test period. The model with the best result on the test period is used for the actual forecast. This approach is computationally and time intensive and, in most cases, uneconomical. In our paper we show the possibility to use a machine learning classification algorithm, which predicts the best possible model based on the characteristics of a time series. The approach was developed and evaluated on a dataset from a B2B-technical-retailer. The machine learning classification algorithm achieves a mean ROC-AUC of 89%, which emphasizes the skill of the model.
Unter den widrigsten wirtschaftlichen und politischen Verhältnissen und Bedingungen wurde die Friedrich-List-Gesellschaft (FLG) 1925 gegründet und bis 1934 fortgeführt. Sie verfolgte vor allem den Zweck, die weit verstreuten, schwer zugänglichen und vielfach unbekannten Schriften, Reden und Briefe von Friedrich List (1789-1846) zusammenzutragen und in Form einer Gesamtausgabe zu publizieren.
Weder diese 10- bzw. 12-bändige Gesamtausgabe, noch die Namen ihrer Herausgeber haben in der Wirtschaftswissenschaft die gebührende Wertschätzung und Aufmerksamkeit erfahren. Die längst überfällige Dankesschuld wird in dem vorliegenden Beitrag nach nahezu 100 Jahren abgetragen. Ohne den engagierten und mutigen Einsatz der Herausgeber, insbesondere von Edgar Salin, wäre die List-Forschung undenkbar und die deutsche Wirtschaftswissenschaft um ein ruhmreiches Kapitel ärmer.
Seit 5 Jahrzehnten steht die Erforschung von Leben, Werk und Wirkungsgeschichte von Friedrich List (1789–1846) im Zentrum der wissenschaftlichen Arbeit von Eugen Wendler. Im Laufe der Zeit sind ca. 30 Monographien und eine größere Anzahl von wissenschaftlichen Aufsätzen und journalistischen Artikeln entstanden. Dabei baute Eugen Wendler auf der unschätzbaren Vorarbeit der Herausgeber der Gesamtausgabe von Lists Werken von 1925 bis 1935 auf.
Der vorliegende Aufsatz vermittelt einen Überblick über die Buchpublikationen von Eugen Wendler zur List-Forschung. Mit seinem eindrucksvollen Oeuvre bekennt er sich zum letzten lebenden Fossil in der Nachfolge der FLG und erweist damit den Herausgebern die gebührende und längst überfällige Wertschätzung und Achtung.
Digitalization increases the pressure for companies to innovate. While current research on digital transformation mostly focuses on technological and management aspects, less attention has been paid to organizational culture and its influence on digital innovations. The purpose of this paper is to identify the characteristics of organizational culture that foster digital innovations. Based on a systematic literature review on three scholarly databases, we initially found 778 articles that were then narrowed down to a total number of 23 relevant articles through a methodical approach. After analyzing these articles, we determine nine characteristics of organizational culture that foster digital innovations: corporate entrepreneurship, digital awareness and necessity of innovations, digital skills and resources, ecosystem orientation, employee participation, agility and organizational structures, error culture and risk-taking, internal knowledge sharing and collaboration, customer and market orientation as well as open-mindedness and willingness to learn.
The early detection of head and neck cancer is a prolonged challenging task. It requires a precise and accurate identification of tissue alterations as well as a distinct discrimination of cancerous from healthy tissue areas. A novel approach for this purpose uses microspectroscopic techniques with special focus on hyperspectral imaging (HSI) methods. Our proof-of-principle study presents the implementation and application of darkfield elastic light scattering spectroscopy (DF ELSS) as a non-destructive, high-resolution, and fast imaging modality to distinguish lingual healthy from altered tissue regions in a mouse model. The main aspect of our study deals with the comparison of two varying HSI detection principles, which are a point-by-point and line scanning imaging, and whether one might be more appropriate in differentiating several tissue types. Statistical models are formed by deploying a principal component analysis (PCA) with the Bayesian discriminant analysis (DA) on the elastic light scattering (ELS) spectra. Overall accuracy, sensitivity, and precision values of 98% are achieved for both models whereas the overall specificity results in 99%. An additional classification of model-unknown ELS spectra is performed. The predictions are verified with histopathological evaluations of identical HE-stained tissue areas to prove the model’s capability of tissue distinction. In the context of our proof-of-principle study, we assess the Pushbroom PCA-DA model to be more suitable for tissue type differentiations and thus tissue classification. In addition to the HE-examination in head and neck cancer diagnosis, the usage of HSI-based statistical models might be conceivable in a daily clinical routine.
Das Buch führt in die Grundlagen der Softwaretechnik ein. Dabei liegt sein Fokus auf der systematischen und modellbasierten Software- und Systementwicklung aber auch auf dem Einsatz agiler Methoden. Die Autoren legen besonderen Wert auf die gleichwertige Behandlung praktischer Aspekte und zugrundeliegender Theorien, was das Buch als Fach- und Lehrbuch gleichermaßen geeignet macht. Die Softwaretechnik wird im Rahmen eines systematischen Frameworks umfassend beschrieben. Ausgewählte und aufeinander abgestimmte Konzepte und Methoden werden durchgängig und integriert dargestellt.
Context:
Test-driven development (TDD) is an agile software development approach that has been widely claimed to improve software quality. However, the extent to which TDD improves quality appears to be largely dependent upon the characteristics of the study in which it is evaluated (e.g., the research method, participant type, programming environment, etc.). The particularities of each study make the aggregation of results untenable.
Objectives:
The goal of this paper is to: increase the accuracy and generalizability of the results achieved in isolated experiments on TDD, provide joint conclusions on the performance of TDD across different industrial and academic settings, and assess the extent to which the characteristics of the experiments affect the quality-related performance of TDD.
Method:
We conduct a family of 12 experiments on TDD in academia and industry. We aggregate their results by means of meta-analysis. We perform exploratory analyses to identify variables impacting the quality-related performance of TDD.
Results:
TDD novices achieve a slightly higher code quality with iterative test-last development (i.e., ITL, the reverse approach of TDD) than with TDD. The task being developed largely determines quality. The programming environment, the order in which TDD and ITL are applied, or the learning effects from one development approach to another do not appear to affect quality. The quality-related performance of professionals using TDD drops more than for students. We hypothesize that this may be due to their being more resistant to change and potentially less motivated than students.
Conclusion:
Previous studies seem to provide conflicting results on TDD performance (i.e., positive vs. negative, respectively). We hypothesize that these conflicting results may be due to different study durations, experiment participants being unfamiliar with the TDD process, or case studies comparing the performance achieved by TDD vs. the control approach (e.g., the waterfall model), each applied to develop a different system. Further experiments with TDD experts are needed to validate these hypotheses.
In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of how drugs are discovered, developed and marketed. Critical to this transformation is the adoption of new technologies in the drug development process, catalyzing the transition from serendipity-driven to data-driven medicine. This paradigm shift comes with a need for both translation and precision, leading to a modern Translational Precision Medicine approach to drug discovery and development. Key components of Translational Precision Medicine are multi-omics profiling, digital biomarkers, model-based data integration, artificial intelligence, biomarker-guided trial designs and patient-centric companion diagnostics. In this review, we summarize and critically discuss the potential and challenges of Translational Precision Medicine from a cross-industry perspective.
Intermittent time series forecasting is a challenging task which still needs particular attention of researchers. The more unregularly events occur, the more difficult is it to predict them. With Croston’s approach in 1972 (1.Nr. 3:289–303), intermittence and demand of a time series were investigated the first time separately. He proposes an exponential smoothing in his attempt to generate a forecast which corresponds to the demand per period in average. Although this algorithm produces good results in the field of stock control, it does not capture the typical characteristics of intermittent time series within the final prediction. In this paper, we investigate a time series’ intermittence and demand individually, forecast the upcoming demand value and inter-demand interval length using recent machine learning algorithms, such as long-short-term-memories and light-gradient-boosting machines, and reassemble both information to generate a prediction which preserves the characteristics of an intermittent time series. We compare the results against Croston’s approach, as well as recent forecast procedures where no split is performed.
Context: Agile practices as well as UX methods are nowadays well-known and often adopted to develop complex software and products more efficiently and effectively. However, in the so called VUCA environment, which many companies are confronted with, the sole use of UX research is not sufficient to find the best solutions for customers. The implementation of Design Thinking can support this process. But many companies and their product owners don’t know how much resources they should spend for conducting Design Thinking.
Objective: This paper aims at suggesting a supportive tool, the “Discovery Effort Worthiness (DEW) Index”, for product owners and agile teams to determine a suitable amount of effort that should be spent for Design Thinking activities.
Method: A case study was conducted for the development of the DEW index. Design Thinking was introduced into the regular development cycle of an industry Scrum team. With the support of UX and Design Thinking experts, a formula was developed to determine the appropriate effort for Design Thinking.
Results: The developed “Discovery Effort Worthiness Index” provides an easy-to-use tool for companies and their product owners to determine how much effort they should spend on Design Thinking methods to discover and validate requirements. A company can map the corresponding Design Thinking methods to the results of the DEW Index calculation, and product owners can select the appropriate measures from this mapping. Therefore, they can optimize the effort spent for discovery and validation.
Context: Many companies are facing an increasingly dynamic and uncertain market environment, making traditional product roadmapping practices no longer sufficiently applicable. As a result, many companies need to adapt their product roadmapping practices for continuing to operate successfully in today’s dynamic market environment. However, transforming product roadmapping practices is a difficult process for organizations. Existing literature offers little help on how to accomplish such a process.
Objective: The objective of this paper is to present a product roadmap transformation approach for organizations to help them identify appropriate improvement actions for their roadmapping practices using an analysis of their current practices.
Method: Based on an existing assessment procedure for evaluating product roadmapping practices, the first version of a product roadmap transformation approach was developed in workshops with company experts. The approach was then given to eleven practitioners and their perceptions of the approach were gathered through interviews.
Results: The result of the study is a transformation approach consisting of a process describing what steps are necessary to adapt the currently applied product roadmapping practice to a dynamic and uncertain market environment. It also includes recommendations on how to select areas for improvement and two empirically based mapping tables. The interviews with the practitioners revealed that the product roadmap transformation approach was perceived as comprehensible, useful, and applicable. Nevertheless, we identified potential for improvements, such as a clearer presentation of some processes and the need for more improvement options in the mapping tables. In addition, minor usability issues were identified.
Since the beginning of the energy sector liberalization, the design of energy markets has become a prominent field of research. Markets nowadays facilitate efficient resource allocation in many fields of energy system operation, such as plant dispatch, control reserve provisioning, delimitation of related carbon emissions, grid congestion management, and, more recently, smart grid concepts and local energy trading. Therefore, good market designs play an important role in enabling the energy transition toward a more sustainable energy supply for all. In this chapter, we retrace how market engineering shaped the development of energy markets and how the research focus shifted from national wholesale markets to more decentralized and location-sensitive concepts.
In a networked world, companies depend on fast and smart decisions, especially when it comes to reacting to external change. With the wealth of data available today, smart decisions can increasingly be based on data analysis and be supported by IT systems that leverage AI. A global pandemic brings external change to an unprecedented level of unpredictability and severity of impact. Resilience therefore becomes an essential factor in most decisions when aiming at making and keeping them smart. In this chapter, we study the characteristics of resilient systems and test them with four use cases in a wide-ranging set of application areas. In all use cases, we highlight how AI can be used for data analysis to make smart decisions and contribute to the resilience of systems.
Several studies analyzed existing Web APIs against the constraints of REST to estimate the degree of REST compliance among state-of-the-art APIs. These studies revealed that only a small number of Web APIs are truly RESTful. Moreover, identified mismatches between theoretical REST concepts and practical implementations lead us to believe that practitioners perceive many rules and best practices aligned with these REST concepts differently in terms of their importance and impact on software quality. We therefore conducted a Delphi study in which we confronted eight Web API experts from industry with a catalog of 82 REST API design rules. For each rule, we let them rate its importance and software quality impact. As consensus, our experts rated 28 rules with high, 17 with medium, and 37 with low importance. Moreover, they perceived usability, maintainability, and compatibility as the most impacted quality attributes. The detailed analysis revealed that the experts saw rules for reaching Richardson maturity level 2 as critical, while reaching level 3 was less important. As the acquired consensus data may serve as valuable input for designing a tool-supported approach for the automatic quality evaluation of RESTful APIs, we briefly discuss requirements for such an approach and comment on the applicability of the most important rules.
The Internet of Things (IoT) is coined by many different standards, protocols, and data formats that are often not compatible to each other. Thus, the integration of different heterogeneous (IoT) components into a uniform IoT setup can be a time-consuming manual task. This lacking interoperability between IoT components has been addressed with different approaches in the past. However, only very few of these approaches rely on Machine Learning techniques. In this work, we present a new way towards IoT interoperability based on Deep Reinforcement Learning (DRL). In detail, we demonstrate that DRL algorithms, which use network architectures inspired by Natural Language Processing (NLP), can be applied to learn to control an environment by merely taking raw JSON or XML structures, which reflect the current state of the environment, as input. Applied to IoT setups, where the current state of a component is often reflected by features embedded into JSON or XML structures and exchanged via messages, our NLP DRL approach eliminates the need for feature engineering and manually written code for pre-processing of data, feature extraction, and decision making.
Rotating machinery occupies a predominant place in many industrial applications. However, rotating machines are often encountered with severe vibration problems. The measurement of these machines’ vibrations signal is of particular importance since it plays a crucial role in predictive maintenance. When the vibrations are too high, they often cause fatigue failure. They announce an unexpected stop or break and, consequently, a significant loss of productivity or an attack on the personnel’s safety. Therefore, fault identification at early stages will significantly enhance the machine’s health and significantly reduce maintenance costs. Although considerable efforts have been made to master the field of machine diagnostics, the usual signal processing methods still present several drawbacks. This paper examines the rotating machinery condition monitoring in the time and frequency domains. It also provides a framework for the diagnosis process based on machine learning by analyzing the vibratory signals.
Enterprises and societies currently face crucial challenges, while Industry 4.0 becomes important in the global manufacturing industry all the more. Industry 4.0 offers a range of opportunities for companies to increase the flexibility and efficiency of production processes. The development of new business models can be promoted with digital platforms and architectures for Industry 4.0. Therefore, products from the healthcare sector can increase in value. The adaptive integrated digital architecture framework (AIDAF) for Industry 4.0 is expected to promote and implement the digital platforms and robotics for healthcare and medical communities efficiently. In this paper, we propose that various digital platforms and robotics are designed and evaluated for digital healthcare as for manufacturing industry with Industry 4.0. We argue that the design of an open healthcare platform “Open Healthcare Platform 2030 - OHP2030” for medical product design and robotics can be developed with AIDAF. The vision of AIDAF applications to enable Industry 4.0 in the OHP2030 research initiative is explained and referenced, extended in the context of Society 5.0.
Autonomous navigation is one of the main areas of research in mobile robots and intelligent connected vehicles. In this context, we are interested in presenting a general view on robotics, the progress of research, and advanced methods related to this field to improve autonomous robots’ localization. We seek to evaluate algorithms and techniques that give robots the ability to move safely and autonomously in a complex and dynamic environment. Under these constraints, we focused our work in the paper on a specific problem: to evaluate a simple, fast and light SLAM algorithm that can minimize localization errors. We presented and validated a FastSLAM 2.0 system combining scan matching and loop closure detection. To allow the robot to perceive the environment and detect objects, we have studied one of the best deep learning technique using convolutional neural networks (CNN). We validate our testing using the YOLOv3 algorithm.
The blockchain technology represents a decentralized database that stores information securely in immutable data blocks. Regarding supply chain management, these characteristics offer potentials in increasing supply chain transparency, visibility, automation, and efficiency. In this context, first token-based mapping approaches exist to transfer certain manufacturing processes to the blockchain, such as the creation or assembly of parts as well as their transfer of ownership. However, the decentralized and immutable structure of blockchain technology also creates challenges when applying these token-based approaches to dynamic manufacturing processes. As a first step, this paper investigates existing mapping approaches and exemplifies weaknesses regarding their suitability for products with changeable configurations. Secondly, a concept is proposed to overcome these weaknesses by introducing logically coupled tokens embedded into a flexible smart contract structure. Finally, a concept for a token-based architecture is introduced to map manufacturing processes of products with changeable configurations.
The current advancement of Artificial Intelligence (AI) combined with other digitalization efforts significantly impacts service ecosystems. Artificial intelligence has a substantial impact on new opportunities for the co-creation of value and the development of intelligent service ecosystems. Motivated by experiences and observations from digitalization projects, this paper presents new methodological perspectives and experiences from academia and practice on architecting intelligent service ecosystems and explores the impact of artificial intelligence through real cases supporting an ongoing validation. Digital enterprise architecture models serve as an integral representation of business, information, and technological perspectives of intelligent service-based enterprise systems to support management and development. This paper focuses on architectural models for intelligent service ecosystems, showing the fundamental business mechanism of AI-based value co-creation, the corresponding digital architecture, and management models. The focus of this paper presents the key architectural model perspectives for the development of intelligent service ecosystems.
The digitization of factories will be a significant issue for the 2020s. New scenarios are emerging to increase the efficiency of production lines inside the factory, based on a new generation of robots’ collaborative functions. Manufacturers are moving towards data-driven ecosystems by leveraging product lifecycle data from connected goods. Energy-efficient communication schemes, as well as scalable data analytics, will support these various data collection scenarios. With augmented reality, new remote services are emerging that facilitate the efficient sharing of knowledge in the factory. Future communication solutions should generally ensure connectivity between the various production sites spread worldwide and new players in the value chain (e.g., suppliers, logistics) transparent, real-time, and secure. Industry 4.0 brings more intelligence and flexibility to production. Resulting in more lightweight equipment and, thus, offering better ergonomics. 5G will guarantee real-time transmissions with latencies of less than 1 ms. This will provide manufacturers with new possibilities to collect data and trigger actions automatically.
Platforms and their surrounding ecosystems are becoming increasingly important components of many companies' strategies. Artificial Intelligence, in particular, has created new opportunities to create and develop ecosystems around the platform. However, there is not yet a methodology to systematically develop these new opportunities for enterprise development strategy. Therefore, this paper aims to lay a foundation for the conceptualization of Artificial Intelligence-based service ecosystems exploiting a Service-Dominant Logic. The basis for conceptualization is the study of value creation and particularly effective network effects. This research investigates the fundamental idea of extending specific digital concepts considering the influence of Artificial Intelligence on the design of intelligent services, along with their architecture of digital platforms and ecosystems, to enable a smooth evolutionary path and adaptability for human-centric collaborative systems and services. The paper explores an extended digital enterprise conceptual model through a combined, iterative, and permanent task of co-creating value between humans and intelligent systems as part of a new idea of cognitively adapted intelligent services.
This book highlights new trends and challenges in intelligent systems, which play an essential part in the digital transformation of many areas of science and practice. It includes papers offering a deeper understanding of the human-centred perspective on artificial intelligence, of intelligent value co-creation, ethics, value-oriented digital models, transparency, and intelligent digital architectures and engineering to support digital services and intelligent systems, the transformation of structures in digital business and intelligent systems based on human practices, as well as the study of interaction and co-adaptation of humans and systems. All papers were originally presented at the International KES Conference on Human Centred Intelligent Systems 2021 (KES HCIS 2021) held on June 14–16, 2021 in the KES Virtual Conference Centre.
In recent years, artificial intelligence (AI) has increasingly become a relevant technology for many companies. While there are a number of studies that highlight challenges and success factors in the adoption of AI, there is a lack of guidance for firms on how to approach the topic in a holistic and strategic way. The aim of this study is therefore to develop a conceptual framework for corporate AI strategy. To address this aim, a systematic literature review of a wide spectrum of AI-related research is conducted, and the results are analyzed based on an inductive coding approach. An important conclusion is that companies should consider diverse aspects when formulating an AI strategy, ranging from technological questions to corporate culture and human resources. This study contributes to knowledge by proposing a novel, comprehensive framework to foster the understanding of crucial aspects that need to be considered when using the emerging technology of AI in a corporate context.
Context
Microservices as a lightweight and decentralized architectural style with fine-grained services promise several beneficial characteristics for sustainable long-term software evolution. Success stories from early adopters like Netflix, Amazon, or Spotify have demonstrated that it is possible to achieve a high degree of flexibility and evolvability with these systems. However, the described advantageous characteristics offer no concrete guidance and little is known about evolvability assurance processes for microservices in industry as well as challenges in this area. Insights into the current state of practice are a very important prerequisite for relevant research in this field.
Objective
We therefore wanted to explore how practitioners structure the evolvability assurance processes for microservices, what tools, metrics, and patterns they use, and what challenges they perceive for the evolvability of their systems.
Method
We first conducted 17 semi-structured interviews and discussed 14 different microservice-based systems and their assurance processes with software professionals from 10 companies. Afterwards, we performed a systematic grey literature review (GLR) and used the created interview coding system to analyze 295 practitioner online resources.
Results
The combined analysis revealed the importance of finding a sensible balance between decentralization and standardization. Guidelines like architectural principles were seen as valuable to ensure a base consistency for evolvability and specialized test automation was a prevalent theme. Source code quality was the primary target for the usage of tools and metrics for our interview participants, while testing tools and productivity metrics were the focus of our GLR resources. In both studies, practitioners did not mention architectural or service-oriented tools and metrics, even though the most crucial challenges like Service Cutting or Microservices Integration were of an architectural nature.
Conclusions
Practitioners relied on guidelines, standardization, or patterns like Event-Driven Messaging to partially address some reported evolvability challenges. However, specialized techniques, tools, and metrics are needed to support industry with the continuous evaluation of service granularity and dependencies. Future microservices research in the areas of maintenance, evolution, and technical debt should take our findings and the reported industry sentiments into account.
Global, competitive markets which are characterised by mass customisation and rapidly changing customer requirements force major changes in production styles and the configuration of manufacturing systems. As a result, factories may need to be regularly adapted and optimised to meet short-term requirements. One way to optimise the production process is the adaptation of the plant layout to the current or expected order situation. To determine whether a layout change is reasonable, a model of the current layout is needed. It is used to perform simulations and in the case of a layout change it serves as a basis for the reconfiguration process. To aid the selection of possible measurement systems, a requirements analysis was done to identify the important parameters for the creation of a digital shadow of a plant layout. Based on these parameters, a method is proposed for defining limit values and specifying exclusion criteria. The paper thus contributes to the development and application of systems that enable an automatic synchronisation of the real layout with the digital layout.
Programmable nano-bio interfaces driven by tuneable vertically configured nanostructures have recently emerged as a powerful tool for cellular manipulations and interrogations. Such interfaces have strong potential for ground-breaking advances, particularly in cellular nanobiotechnology and mechanobiology. However, the opaque nature of many nanostructured surfaces makes non-destructive, live-cell characterization of cellular behavior on vertically aligned nanostructures challenging to observe. Here, a new nanofabrication route is proposed that enables harvesting of vertically aligned silicon (Si) nanowires and their subsequent transfer onto an optically transparent substrate, with high efficiency and without artefacts. We demonstrate the potential of this route for efficient live-cell phase contrast imaging and subsequent characterization of cells growing on vertically aligned Si nanowires. This approach provides the first opportunity to understand dynamic cellular responses to a cell-nanowire interface, and thus has the potential to inform the design of future nanoscale cellular manipulation technologies.
Organisationale Identität in digitalisierten Arbeitswelten: Grundlagen für gelingende Kooperation
(2021)
Organisationen bilden Identitäten aus und beantworten dabei die Fragen „Wer sind wir? Und wer sind wir nicht?“. Vorstellungen zur organisationalen Identität gehen zunächst von traditionellen Organisationen aus. Durch die Digitalisierung können bisher integrierte Aufgaben stärker modularisiert werden, sodass die Koordination der organisatorischen Gesamtaufgabe stärker sach- und weniger personenorientiert erfolgt. Zudem lassen sich organisationale Aufgaben zunehmend projektorientiert und virtuell abbilden, sodass externe Aufgabenträger leichter integriert werden können. Unsere Vorstellungen zu Organisationsgrenzen und -mitgliedschaften verändern sich dadurch. Dies wirft die Frage auf, inwiefern sich in solchen sach- und projektorientierten, grenzaufgelösten Organisationen eine gemeinsame organisationale Identität ausbildet. Im Beitrag wird argumentiert, dass sich die Wege der Identitätsentwicklung verändern, die Funktionen der organisationalen Identität für gelingende Kooperation aber erhalten bleiben.
Die digitale Arbeitswelt in ihrer Mehrdimensionalität verstehen: Digitalisierungsatlas und -index
(2021)
Die digitale Transformation der Arbeitswelt ist deshalb so herausfordernd, da die Arbeitswelt für sich bereits ein komplexes mehrdimensionales System ist, das sich kaum überblicken lässt. Für Unternehmen ist es deshalb wichtig, die Mehrdimensionalität und Komplexität der digitalen Arbeitswelt zu verstehen, hierfür ein gemeinsames Sprachspiel zu entwickeln und auf dieser Basis eine gemeinsame Einschätzung des Status quo der eigenen Arbeitswelt zu beschreiben. Mithilfe von zwei Instrumenten, dem Digitalisierungsatlas und dem Digitalisierungsindex, kann dies gelingen. In diesem Beitrag werden diese Instrumente im Detail dargestellt und es wird erklärt, wie sie Organisationen dabei helfen, zu beschreiben und zu verstehen, wo sie selbst in der digitalen Transformation der Arbeitswelt stehen.
Wenn Unternehmen den Schritt in die digitale Arbeitswelt gehen wollen, stehen sie vor der Herausforderung, konkrete Vorstellungen, Ziele und Maßnahmen zu entwickeln und umzusetzen. Häufig fehlt es Unternehmen an Wissen, ihre Transformation der Arbeitswelt strategisch zu gestalten und zu planen. Das Projekt DigiTraIn 4.0 setzt hier an und bietet mit dem Digitalisierungskompass ein Instrument, welches Unternehmen dabei unterstützt, eine Vision und spezifische Ziele für die Digitalisierung ihrer eigenen Arbeitswelt zu entwickeln. Im Anschluss daran unterstützt die Transformationsagenda Unternehmen dabei, konkrete Handlungsmaßnahmen zu entwickeln und deren Ablauf zu planen.
Arbeitswelten strategisch entwicklen: mit den DigiTraIn-Instrumenten zur digitalen Transformation
(2021)
Der Weg in die digitale Arbeitswelt ist für viele Unternehmen eine herausfordernde und komplexe Transformation. Um diesen Weg erfolgreich zu beschreiten, benötigen Unternehmen funktionierende Managementinstrumente. Im Projekt DigiTraIn 4.0 wurden vier Instrumente für eine gelingende Transformation in das digitale Arbeiten entwickelt und in der Unternehmenspraxis erprobt. Diese Instrumente werden im vorliegenden Beitrag, ausgehend von der Zielsetzung des Projekts, einführend dargestellt. Zudem wird ein Überblick über die weiteren Beiträge in diesem Buch gegeben, in denen die Instrumente im Detail erläutert werden und spezifische Aspekte des Wandels in die digitale Arbeitswelt im Fokus stehen.
Digitale Arbeitswelt : wie Unternehmen erfolgreich die digitale Transformation gestalten können
(2021)
Der Weg in die digitale Arbeitswelt ist für viele Unternehmen eine herausfordernde und komplexe Veränderung. Um diesen Weg erfolgreich zu beschreiten, benötigen Unternehmen funktionierende Managementinstrumente. Im Projekt "DigiTraIn 4.0: Indiziert. Transformiert. Digitalisiert. Instrumente für den erfolgreichen Wandel ins Arbeiten 4.0" wurden vier Instrumente für eine gelingende Transformation in das digitale Arbeiten entwickelt und in der Unternehmenspraxis erprobt.
In diesem Herausgeberwerk werden die zentralen Projektergebnisse vorgestellt. Die Autorinnen und Autoren führen in die einzelnen Instrumente ein und zeigen anwendungsnah weitere vertiefende Aspekte der digitalen Transformation für die Unternehmenspraxis auf (z. B. Technostress, digitales Mindset, Führung, Homeoffice).
Stetiger Wandel macht auch vor dem Vertriebsprozess deutscher KMU nicht Halt. Evolutive Umwelteinflüsse sowie revolutionäres Handeln stehen im Zentrum eines Umbruchs im Vertrieb. Ergebnisse aus einem quantitativen Stimmungsbarometer deutscher KMU ermöglichen das Ableiten unternehmerischer Handlungsempfehlungen für Vertriebsorganisationen.
Sustainability is a development that meets the needs of the present without compromising the ability of future generations to meet their own needs.
Business Model is a plan for the successful operation of a business, identifying sources of revenue, the intended customer base, products, and details of financing.
Circular economy is an approach of how a company creates, captures and delivers value, with a value creation logic designed to improve resource efficiency through contributing to extending the useful life of products and parts (e.g., through long-life design, repair and remanufacturing) and closing material loops.
Lehre und Lernen unterliegt einem stetigen Wandel, wobei Interaktion als ein zentrales Element der Motivationssteigerung im Lernkontext angesehen wird. Der vorliegende Beitrag zeigt verschiedene Ansätze zur Gestaltung von interaktivem und kollaborativem Lehren und Lernen in einem virtuellen Klassenzimmer auf und stellt ein Beispiel für die Umsetzung und den Einsatz eines solchen Systems vor. Die Mehrwerte und Erfolgsfaktoren, die sich beim Einsatz virtueller Klassenzimmer und deren Gestaltung in Form einer interaktiven blended-learning Umgebung ergeben, werden dargestellt und diskutiert. Mit dem System Accelerator wird eine CSILT (Computer Supported Interactive Learning and Teaching)-Umgebung vorgestellt, in der diese Faktoren zum Einsatz kommen.
Das Weltwirtschaftswachstum der vergangenen Jahrzehnte war durch die Dynamik der Digitalisierung und Globalisierung in den Lieferketten geprägt. Die Corona-Pandemie hat die Abhängigkeit und Verletzlichkeit der Lieferketten offengelegt. Trotz einer Vielzahl verbindlicher Standards haben Unternehmen die Digitalisierung und Arbeitsteilung auch für regulatorische Arbitrage genutzt. Einerseits erhöht das die Effizienz der Wirtschaft - was mithin ökologische Ressourcen schont - andererseits werden damit internationale Standards konterkariert. Globalisierung und Digitalisierung sind Segen und Fluch zugleich.
Das Projekt DigiTraIn 4.0 hat ein Beratungskonzept entwickelt und erprobt, das Unternehmen bei der erfolgreichen Digitalisierung ihrer Arbeitswelt unterstützt. Das Beratungskonzept basiert auf vier anwendungsorientierten Instrumenten: Der Digitalisierungsatlas bildet die Digitalisierung der Arbeitswelt in all ihren Dimensionen ab und ermöglicht es, die Notwendigkeit sowie Chancen und Risiken der Veränderungen zu verstehen. Hierauf aufbauend können Unternehmen mit dem Digitalisierungsindex ihren aktuellen Ist-Digitalisierungsgrad der Arbeitswelt individuell bestimmen. Der individuelle Digitalisierungsgrad dient als Ausgangspunkt für den Digitalisierungskompass, der es dem Unternehmen ermöglicht, die Soll-Vorstellung der digitalen Arbeitswelt zu illustrieren und eine unternehmensspezifische Transformationsagenda abzuleiten. Der Beratungsprozess und die Entwicklung der zentralen Instrumente werden in diesem Beitrag dargestellt.
Technologische, sozioökonomische und kulturelle Entwicklungen der letzten Jahrzehnte sowie zuletzt die Covid-19-Pandemie führten zu einer erhöhten Nachfrage nach flexiblen Arbeitsformen wie Homeoffice. In der Forschung wird danach gefragt, welche Faktoren die Umsetzung von flexiblen Arbeitsmodellen in Unternehmen beeinflussen und wie die Faktoren miteinander zusammenhängen. Bisher bietet die Forschung allerdings zu wenige Ansatzpunkte, um relevante Handlungsempfehlungen für eine erfolgreiche Umsetzung von Homeoffice für die Praxis abzuleiten. In dieser Fallstudie können auf organisationaler Ebene technologische, formelle und informelle Rahmenbedingungen, auf interaktionaler Ebene das Team und die Kommunikation sowie auf individueller Ebene Präferenzen, Kompetenzen und personenbezogene Rahmenbedingungen der Beschäftigten als relevante Einflussfaktoren identifiziert werden. Die Themenfelder sind eng miteinander verbunden, wobei sich vor allem stark vernetzte und einflussreiche Faktoren, wie formelle und technologische Rahmenbedingungen sowie Kommunikation, als Ansatzpunkte für die Gestaltung von Homeoffice eignen.
The article analyzes experimentally and theoretically the influence of microscope parameters on the pinhole-assisted Raman depth profiles in uniform and composite refractive media. The main objective is the reliable mapping of deep sample regions. The easiest to interpret results are found with low magnification, low aperture, and small pinholes. Here, the intensities and shapes of the Raman signals are independent of the location of the emitter relative to the sample surface. Theoretically, the results can be well described with a simple analytical equation containing the axial depth resolution of the microscope and the position of the emitter. The lower determinable object size is limited to 2–4 μm. If sub-micrometer resolution is desired, high magnification, mostly combined with high aperture, becomes necessary. The signal intensities and shapes depend now in refractive media on the position relative to the sample surface. This aspect is investigated on a number of uniform and stacked polymer layers, 2–160 μm thick, with the best available transparency. The experimental depth profiles are numerically fitted with excellent accuracy by inserting a Gaussian excitation beam of variable waist and fill fraction through the focusing lens area, and by treating the Raman emission with geometric optics as spontaneous isotropic process through the lens and the variable pinhole, respectively. The intersectional area of these two solid angles yields the leading factor in understanding confocal (pinhole-assisted) Raman depth profiles.
A hybrid deep registration of MR scans to interventional ultrasound for neurosurgical guidance
(2021)
Despite the recent advances in image-guided neurosurgery, reliable and accurate estimation of the brain shift still remains one of the key challenges. In this paper, we propose an automated multimodal deformable registration method using hybrid learning-based and classical approaches to improve neurosurgical procedures. Initially, the moving and fixed images are aligned using classical affine transformation (MINC toolkit), and then the result is provided to the convolutional neural network, which predicts the deformation field using backpropagation. Subsequently, the moving image is transformed using the resultant deformation into a moved image. Our model was evaluated on two publicly available datasets: the retrospective evaluation of cerebral tumors (RESECT) and brain images of tumors for evaluation (BITE). The mean target registration errors have been reduced from 5.35 ± 4.29 to 0.99 ± 0.22 mm in the RESECT and from 4.18 ± 1.91 to 1.68 ± 0.65 mm in the BITE. Experimental results showed that our method improved the state-of-the-art in terms of both accuracy and runtime speed (170 ms on average). Hence, the proposed method provides a fast runtime for 3D MRI to intra-operative US pair in a GPU-based implementation, which shows a promise for its applicability in assisting the neurosurgical procedures compensating for brain shift.
Purpose
Injury or inflammation of the middle ear often results in the persistent tympanic membrane (TM) perforations, leading to conductive hearing loss (HL). However, in some cases the magnitude of HL exceeds that attributable by the TM perforation alone. The aim of the study is to better understand the effects of location and size of TM perforations on the sound transmission properties of the middle ear.
Methods
The middle ear transfer functions (METF) of six human temporal bones (TB) were compared before and after perforating the TM at different locations (anterior or posterior lower quadrant) and to different degrees (1 mm, ¼ of the TM, ½ of the TM, and full ablation). The sound-induced velocity of the stapes footplate was measured using single-point laser-Doppler-vibrometry (LDV). The METF were correlated with a Finite Element (FE) model of the middle ear, in which similar alterations were simulated.
Results
The measured and calculated METF showed frequency and perforation size dependent losses at all perforation locations. Starting at low frequencies, the loss expanded to higher frequencies with increased perforation size. In direct comparison, posterior TM perforations affected the transmission properties to a larger degree than anterior perforations. The asymmetry of the TM causes the malleus-incus complex to rotate and results in larger deflections in the posterior TM quadrants than in the anterior TM quadrants. Simulations in the FE model with a sealed cavity show that small perforations lead to a decrease in TM rigidity and thus to an increase in oscillation amplitude of the TM mainly above 1 kHz.
Conclusion
Size and location of TM perforations have a characteristic influence on the METF. The correlation of the experimental LDV measurements with an FE model contributes to a better understanding of the pathologic mechanisms of middle-ear diseases. If small perforations with significant HL are observed in daily clinical practice, additional middle ear pathologies should be considered. Further investigations on the loss of TM pretension due to perforations may be informative.
Distributed ledger technologies such as the blockchain technology offer an innovative solution to increase visibility and security to reduce supply chain risks. This paper proposes a solution to increase the transparency and auditability of manufactured products in collaborative networks by adopting smart contract-based virtual identities. Compared with existing approaches, this extended smart contract-based solution offers manufacturing networks the possibility of involving privacy, content updating, and portability approaches to smart contracts. As a result, the solution is suitable for the dynamic administration of complex supply chains.
Dieser Beitrag entwickelt ein Managementmodell, das Unternehmen dabei unterstützt, relevante Aktionsfelder zur nachhaltigen Steuerung von Konsumenten entlang der eigenen Customer Journey zu identifizieren. Aufbauend auf dem SHIFT-Modell, als strukturelle Abbildung des nachhaltigen Käuferverhaltens, wird die Customer Journey entlang der owned, paid und earned Touchpoints aufgezogen. Mithilfe des faktisch analytischen Ansatzes, der die Integration neuer Erkenntnisse in die Forschungsstrategie unterstützt, werden Aktionsfelder identifiziert, die als grundlegende Logik Unternehmen dazu anleiten sollen, bei der Ausgestaltung der eigenen nachhaltigen Customer Journey dieses Strukturraster anzunehmen.
The main aim of presented in this manuscript research is to compare the results of objective and subjective measurement of sleep quality for older adults (65+) in the home environment. A total amount of 73 nights was evaluated in this study. Placing under the mattress device was used to obtain objective measurement data, and a common question on perceived sleep quality was asked to collect the subjective sleep quality level. The achieved results confirm the correlation between objective and subjective measurement of sleep quality with the average standard deviation equal to 2 of 10 possible quality points.
Projektmanagement
(2020)
Projektmanagement ist ein Werkzeug um singuläre Aufgaben interdisziplinär und unternehmensübergreifend strukturiert zu bearbeiten, die einmalig und extrem bedeutsam für das Unternehmen sind sowie nicht einfach in der bestehenden Linienorganisation bearbeitet werden können. Unter Projektmanagement versteht man ein Konzept für die Leitung eines komplexen Vorhabens und die Institution, die dieses Vorhaben leitet.
Public enterprises find themselves in increasingly competitive markets, a situation that makes having an entrepreneurial orientation (EO) an urgent need, given that EO is an indispensable driver of performance. Research describes politicians delaying the strategic change of public enterprises when serving as board members, but empirical evidence of the impact of board behavior on EO in public enterprises is lacking. We draw on stakeholder-agency theory (SAT) and resource dependence theory (RDT) and use structural equation modeling (SEM) to investigate survey data collected from 110 German energy suppliers that are majority government owned. Results indicate that board strategy control and board networking do not seem to predict EO on first sight. Closer analysis reveals a board networking–EO relationship depending on ownership structure. Remarkably, we find that it is not the usually suspected local municipal owner who hinders EO in our sample organizations but minority shareholders engaging in board networking activities. The results shed light on the intersection of governance and entrepreneurship with special reference to the fine-grained conceptualization of RDT.
Effektives Risiko-Management sollte neben quantifizierbaren, bekannten Risiken auch Ereignisse berücksichtigen, die entweder in ähnlicher Art bereits eingetreten oder grundsätzlich vorstellbar sind. Für eine Identifikation dieser "Grauen Schwäne" müssen institutionell-organisatorische Voraussetzungen geschaffen und analytisch-konzeptionelle Instrumente bereitgestellt werden.
The cloud evolved into an attractive execution environment for parallel applications, which make use of compute resources to speed up the computation of large problems in science and industry. Whereas Infrastructure as a Service (IaaS) offerings have been commonly employed, more recently, serverless computing emerged as a novel cloud computing paradigm with the goal of freeing developers from resource management issues. However, as of today, serverless computing platforms are mainly used to process computations triggered by events or user requests that can be executed independently of each other and benefit from on-demand and elastic compute resources as well as per-function billing. In this work, we discuss how to employ serverless computing platforms to operate parallel applications. We specifically focus on the class of parallel task farming applications and introduce a novel approach to free developers from both parallelism and resource management issues. Our approach includes a proactive elasticity controller that adapts the physical parallelism per application run according to user-defined goals. Specifically, we show how to consider a user-defined execution time limit after which the result of the computation needs to be present while minimizing the associated monetary costs. To evaluate our concepts, we present a prototypical elastic parallel system architecture for self-tuning serverless task farming and implement two applications based on our framework. Moreover, we report on performance measurements for both applications as well as the prediction accuracy of the proposed proactive elasticity control mechanism and discuss our key findings.
Unternehmen wenden insbesondere bei IT-nahen Projekten seit einigen Jahren auch im Controlling verstärkt ein agiles Vorgehen an. Erfahrungen zeigen jedoch, dass dies nicht bei allen Projekten in jedem Unternehmen funktioniert. Hybride Ansätze, die agile mit klassischen Projekt-Management-Methoden verbinden, bieten eine Lösung.
Hypermedia as the Engine of Application State (HATEOAS) is one of the core constraints of REST. It refers to the concept of embedding hyperlinks into the response of a queried or manipulated resource to show a client possible follow-up actions and transitions to related resources. Thus, this concept aims to provide a client with a navigational support when interacting with a Web-based application. Although HATEOAS should be implemented by any Web-based API claiming to be RESTful, API providers tend to offer service descriptions in place of embedding hyperlinks into responses. Instead of relying on a navigational support, a client developer has to read the service description and has to identify resources and their URIs that are relevant for the interaction with the API. In this paper, we introduce an approach that aims to identify transitions between resources of a Web-based API by systematically analyzing the service description only. We devise an algorithm that automatically derives a URI Model from the service description and then analyzes the payload schemas to identify feasible values for the substitution of path parameters in URI Templates. We implement this approach as a proxy application, which injects hyperlinks representing transitions into the response payload of a queried or manipulated resource. The result is a HATEOAS-like navigational support through an API. Our first prototype operates on service descriptions in the OpenAPI format. We evaluate our approach using ten real-world APIs from different domains. Furthermore, we discuss the results as well as the observations captured in these tests.
Annotations of character IDs in news images are critical as ground truth for news retrieval and recommendation system. Universality and accuracy optimization of deep neural network models constitutes the key technology to improve the precision and computing efficiency of automatic news character identification, which is attracting increased attention globally. This paper explores the optimized deep neural network model for automatic focus personage identification in multi-lingual news. First, the face model of the focus personage is trained by using the corresponding face images from German news as positive samples. Next, the scheme of Recurrent Convolutional Neural Network (RCNN) + Bi-directional Long-Short Term Memory (Bi-LSTM) + Conditional Random Field (CRF) is utilized to label the focus name, and the RCNN-RCNN encoder–decoder is applied to translate names of people into multiple languages. Third, face features are described by combining the advantages of Local Gabor Binary Pattern Histogram Sequence (LGBPHS) and RCNN, and iterative quantization (ITQ) is used to binarize codes. Finally, a name semantic network is built for different domains. Experiments are performed on a dataset which comprises approximately 100,000 news images. The experimental results demonstrate that the proposed method achieves a significant improvement over other algorithms.
We discuss the fabrication technologies for IC chips in this chapter. We will focus on the main process steps and especially on those aspects that are of particular importance for understanding how they affect, and in some cases drive, the layout of ICs. All our analyses in this chapter will be for silicon as the base material; the principles and understanding gained can be applied to other substrates as well. Following a brief introduction to the fundamentals of IC fabrication (Sect. 2.1) and the base material used in it, namely silicon (Sect. 2.2), we discuss the photolithography process deployed for all structuring work in Sect. 2.3. We will then present in Sect. 2.4 some theoretical opening remarks on typical phenomena encountered in IC fabrication. Knowledge of these phenomena is very useful for understanding the process steps we cover in Sects. 2.5–2.8. We examine a simple exemplar process in Sect. 2.9 and observe how a field-effect transistor (FET) – the most important device in modern integrated circuits—is created. To drive the key points home, we provide a review of each topic at the end of every section from the point of view of layout design by discussing relevant physical design aspects.
Das ZD.BB - Digitaler Hub für kleine und mittelständische Unternehmen in der Region Stuttgart
(2020)
Die Digitale Transformation ist eines der meistdiskutierten Themen in der heutigen Geschäftswelt. Viele Unternehmen, vor allem kleine und mittelständische Unternehmen (KMU), tun sich schwer die Chancen und Risiken der Digitalisierung einzuschätzen. Mit all den Möglichkeiten und Chancen, welche die Digitalisierung birgt, droht Unternehmen, die sich vor den Entwicklungen verschließen, der Verlust ihrer Markt- und Wettbewerbsposition. Mit dem im Februar 2019 eröffneten Digital Hub ZD.BB (Zentrum Digitalisierung) besteht in der Region Stuttgart eine neue, zentrale Anlaufstelle für Fragen rund um das Thema Digitalisierung. Am ZD.BB erhalten kleine und mittelständische Unternehmen (KMU) sowie Startups für ihre digitalen Transformationsprozesse eine kompetente Beratung und Betreuung. Sie geht von der Sensibilisierung über die Analyse bis zur Lösungsentwicklung für digitale Prozesse. Mithilfe einer digitalen Qualifizierungsoffensive und mittelstandsgerechten Methoden zur Geschäftsmodellentwicklung werden Unternehmen im ZD.BB umfassend bei ihren Digitalisierungsvorhaben unterstützt. Dazu werden in Innovationslaboren, in Coworking Spaces und bei Events unterschiedliche Kompetenzen, Disziplinen, Ideen, Technologien und Kreativität vernetzt und auf diese Weise digitale Innovationen hervorgebracht.
Additive Manufacturing is increasingly used in the industrial sector as a result of continuous development. In the Production Planning and Control (PPC) system, AM enables an agile response in the area of detailed and process planning, especially for a large number of plants. For this purpose, a concept for a PPC system for AM is presented, which takes into account the requirements for integration into the operational enterprise software system. The technical applicability will be demonstrated by individual implemented sections. The presented solution approach promises a more efficient utilization of the plants and a more elastic use.
Personalmanagement
(2020)
Auch wenn der Wert in keiner Bilanz auftaucht: das Humankapital entscheidet über den Unternehmenserfolg. Während Kapital im Überfluss vorhanden ist, ist das Personal zunehmend der Engpassfaktor. Wurde bis in die 1980er-Jahre der Mensch als Produktionsfaktor und die Personalabteilung als seine Verwaltungsinstanz gesehen, so ist die Personalarbeit heute ein integratives Element des Managementprozesses und die Personalabteilung aktiver Teil des Managementteams (Scholz 2014c). Damit verbunden ist der begriffliche Wandel von Personalwirtschaft bzw. Personalverwaltung hin zum Personalmanagement bzw. Human Ressource Management (HRM). Die Begriffe signalisieren eine stärker strategisch ausgerichtete Auseinandersetzung mit allen Fragen, die den Einsatz von Personal und die Verknüpfung der Personal- mit der Unternehmensstrategie zum Gegenstand haben.
Wichtige Aufgaben der Personalarbeit sind Personalplanung, Personalbeschaffung, Personalentwicklung, Personaleinsatz, Personalkostenmanagement, Personalführung. Diese werden in der Regel von unterschiedlichen Stellen wahrgenommen – neben der Personalabteilung spielen dabei auch die direkte Führungskraft sowie die Unternehmensleitung eine wichtige Rolle.
Context: Nowadays, companies are challenged by increasing market dynamics, rapid changes and disruptive participants entering the market. To survive in such an environment, companies must be able to quickly discover product ideas that meet the needs of both customers and the company and deliver these products to customers. Dual-track agile is a new type of agile development that combines product discovery and delivery activities in parallel, iterative, and cyclical ways. At present, many companies have difficulties in finding and establishing suitable approaches for implementing dual-track agile in their business context.
Objective: In order to gain a better understanding of how product discovery and product delivery can interact with each other and how this interaction can be implemented in practice, this paper aims to identify suitable approaches to dual-track agile.
Method: We conducted a grey literature review (GLR) according to the guidelines to Garousi et al.
Results: Several approaches that support the integration of product discovery with product delivery were identified. This paper presents a selection of these approaches, i.e., the Discovery-Delivery Cycle model, Now-Next-Later Product Roadmaps, Lean Sprints, Product Kata, and Dual-Track Scrum. The approaches differ in their granularity but are similar in their underlying rationales. All approaches aim to ensure that only validated ideas turn into products and thus promise to lead to products that are better received by their users.
Context: A product roadmap is an important tool in product development. It sets the strategic direction in which the product is to be developed to achieve the company’s vision. However, for product roadmaps to be successful, it is essential that all stakeholders agree with the company’s vision and objectives and are aligned and committed to a common product plan.
Objective: In order to gain a better understanding of product roadmap alignment, this paper aims at identifying measures, activities and techniques in order to align the different stakeholders around the product roadmap.
Method: We conducted a grey literature review according the guidelines to Garousi et al.
Results: Several approaches to gain alignment were identified such as defining and communicating clear objectives based on the product vision, conducting cross-functional workshops, shuttle diplomacy, and mission briefing. In addition, our review identified the “Behavioural Change Stairway Model” that suggests five steps to gain alignment by building empathy and a trustful relationship.
A fast way to test business ideas and to explore customer problems and needs is to talk to them. Customer interviews help to understand what solutions customers will pay for before investing valuable resources to develop solutions. Customer interviews are a good way to gain qualitative insights. However, conducting interviews can be a difficult procedure and requires specific skills. The current ways of teaching interview skills have significant deficiencies. They especially lack guidance and opportunities to practice. Objective: The goal of this work is to develop and validate a workshop format to teach interview skills for conducting good customer interviews in a practical manner. Method: The research method is based on design science research which serves as a framework. A game-based workshop format was designed to teach interview skills. The approach consists of a half-day, hands-on workshop and is based on an analysis of necessary interview skills. The approach has been validated in several workshops and improved based on learnings from those workshops. Results: Results of the validation show that participants could significantly improve their interview skills while enjoying the game-based exercises. The game-based learning approach supports learning and practicing customer interview skills with playful and interactive elements that encourage greater motivation among participants to conduct interviews.
Background
The actual task of electrocardiographic examinations is to increase the reliability of diagnosing the condition of the heart. Within the framework of this task, an important direction is the solution of the inverse problem of electrocardiography, based on the processing of electrocardiographic signals of multichannel cardio leads at known electrode coordinates in these leads (Titomir et al. Noninvasiv electrocardiotopography, 2003), (Macfarlane et al. Comprehensive Electrocardiology, 2nd ed. (Chapter 9), 2011).
Results
In order to obtain more detailed information about the electrical activity of the heart, we carry out a reconstruction of the distribution of equivalent electrical sources on the heart surface. In this area, we hold reconstruction of the equivalent sources during the cardiac cycle at relatively low hardware cost. ECG maps of electrical potentials on the surface of the torso (TSPM) and electrical sources on the surface of the heart (HSSM) were studied for different times of the cardiac cycle. We carried out a visual and quantitative comparison of these maps in the presence of pathological regions of different localization. For this purpose we used the model of the heart electrical activity, based on cellular automata.
Conclusions
The model of cellular automata allows us to consider the processes of heart excitation in the presence of pathological regions of various sizes and localization. It is shown, that changes in the distribution of electrical sources on the surface of the epicardium in the presence of pathological areas with disturbances in the conduction of heart excitation are much more noticeable than changes in ECG maps on the torso surface.
The recovery of our body and brain from fatigue directly depends on the quality of sleep, which can be determined from the results of a sleep study. The classification of sleep stages is the first step of this study and includes the measurement of vital data and their further processing. The non-invasive sleep analysis system is based on a hardware sensor network of 24 pressure sensors providing sleep phase detection. The pressure sensors are connected to an energy-efficient microcontroller via a system-wide bus. A significant difference between this system and other approaches is the innovative way in which the sensors are placed under the mattress. This feature facilitates the continuous use of the system without any noticeable influence on the sleeping person. The system was tested by conducting experiments that recorded the sleep of various healthy young people. Results indicate the potential to capture respiratory rate and body movement.
Today, many companies are adapting their strategy, business models, products, services as well as business processes and information systems in order to expand their digitalization level through intelligent systems and services. The paper raises an important question: What are cognitive co-creation mechanisms for extending digital services and architectures to readjust the usage value of smart services? Typically, extensions of digital services and products and their architectures are manual design tasks that are complex and require specialized, rare experts. The current publication explores the basic idea of extending specific digital artifacts, such as intelligent service architectures, through mechanisms of cognitive co-creation to enable a rapid evolutionary path and better integration of humans and intelligent systems. We explore the development of intelligent service architectures through a combined, iterative, and permanent task of co-creation between humans and intelligent systems as part of a new concept of cognitively adapted smart services. In this paper, we present components of a new platform for the joint co-creation of cognitive services for an ecosystem of intelligent services that enables the adaptation of digital services and architectures.
Intelligent systems and services are the strategic targets of many current digitalization efforts and part of massive digital transformations based on digital technologies with artificial intelligence. Digital platform architectures and ecosystems provide an essential base for intelligent digital systems. The paper raises an important question: Which development paths are induced by current innovations in the field of artificial intelligence and digitalization for enterprise architectures? Digitalization disrupts existing enterprises, technologies, and economies and promotes the architecture of cognitive and open intelligent environments. This has a strong impact on new opportunities for value creation and the development of intelligent digital systems and services. Digital technologies such as artificial intelligence, the Internet of Things, service computing, cloud computing, blockchains, big data with analysis, mobile systems, and social business network systems are essential drivers of digitalization. We investigate the development of intelligent digital systems supported by a suitable digital enterprise architecture. We present methodological advances and an evolutionary path for architectures with an integral service and value perspective to enable intelligent systems and services that effectively combine digital strategies and digital architectures with artificial intelligence.
While many maintainability metrics have been explicitly designed for service-based systems, tool-supported approaches to automatically collect these metrics are lacking. Especially in the context of microservices, decentralization and technological heterogeneity may pose challenges for static analysis. We therefore propose the modular and extensible RAMA approach (RESTful API Metric Analyzer) to calculate such metrics from machine-readable interface descriptions of RESTful services. We also provide prototypical tool support, the RAMA CLI, which currently parses the formats OpenAPI, RAML, and WADL and calculates 10 structural service-based metrics proposed in scientific literature. To make RAMA measurement results more actionable, we additionally designed a repeatable benchmark for quartile-based threshold ranges (green, yellow, orange, red). In an exemplary run, we derived thresholds for all RAMA CLI metrics from the interface descriptions of 1,737 publicly available RESTful APIs. Researchers and practitioners can use RAMA to evaluate the maintainability of RESTful services or to support the empirical evaluation of new service interface metrics.
Cloud resources can be dynamically provisioned according to application-specific requirements and are payed on a per-use basis. This gives rise to a new concept for parallel processing: Elastic parallel computations. However, it is still an open research question to which extent parallel applications can benefit from elastic scaling, which requires resource adaptation at runtime and corresponding coordination mechanisms. In this work, we analyze how to address these system-level challenges in the context of developing and operating elastic parallel tree search applications. Based on our findings, we discuss the design and implementation of TASKWORK, a cloud-aware runtime system specifically designed for elastic parallel tree search, which enables the implementation of elastic applications by means of higher-level development frameworks. We show how to implement an elastic parallel branch-and-bound application based on an exemplary development framework and report on our experimental evaluation that also considers several benchmarks for parallel tree search.
The advent of chatbots in customer service solutions received increasing attention by research and practice throughout the last years. However, the relevant dimensions and features for service quality and service performance for chatbots remain quite unclear. Therefore, this research develops and tests a conceptual model for customer service quality and customer service performance in the context of chatbots. Additionally, the impact of the developed service dimensions on different customer relationship metrics is measured across different service channels (hotline versus chatbots). Findings of six independent studies indicate a strong main effect of the conceptualized service dimensions on customer satisfaction, service costs, intention to service reusage, word-of-mouth, and customer loyalty. However, different service dimensions are relevant for chatbots compared to a traditional service hotline.
This book describes the current state of the art in integrated ring resonators, covering more than two decades in the development of this exciting device. It discusses in depth one of the most fascinating and versatile integrated optical filters, providing readers with a panoramic view spanning from design and simulation to implementation in various material systems. Written by authors with extensive experience in both academia and industry, this second edition offers a much-needed, major update as interest in integrated ring resonators undergoes a global revival. The new edition includes a comprehensive technological update, and a timely discussion of recent advances in new application areas, such as optofluidics and microfluidics, telecom operations and biosensors. This aptly named compendium is the ideal guide for researchers and engineers looking to review the field as a whole while exploring several of its possible and exciting future trajectories.
Context: Currently, most companies apply approaches for product roadmapping that are based on the assumption that the future is highly predicable. However, nowadays companies are facing the challenge of increasing market dynamics, rapidly evolving technologies, and shifting user expectations. Together with the adaption of lean and agile practices it makes it increasingly difficult to plan and predict upfront which products, services or features will satisfy the needs of the customers. Therefore, they are struggling with their ability to provide product roadmaps that fit into dynamic and uncertain market environments and that can be used together with lean and agile software development practices.
Objective: To gain a better understanding of modern product roadmapping processes, this paper aims to identify suitable processes for the creation and evolution of product roadmaps in dynamic and uncertain market environments.
Method: We performed a Grey Literature Review (GLR) according to the guidelines from Garousi et al.
Results: 32 approaches to product roadmapping were identified. Typical characteristics of these processes are the strong connection between the product roadmap and the product vision, an emphasis on stakeholder alignment, the definition of business and customer goals as part of the roadmapping process, a high degree of flexibility with respect to reaching these goals, and the inclusion of validation activities in the roadmapping process. An overall goal of nearly all approaches is to avoid waste by early reducing development and business risks. From the list of the 32 approaches found, four representative roadmapping processes are described in detail.
This book discusses important topics for engineering and managing software startups, such as how technical and business aspects are related, which complications may arise and how they can be dealt with. It also addresses the use of scientific, engineering, and managerial approaches to successfully develop software products in startup companies.
The book covers a wide range of software startup phenomena, and includes the knowledge, skills, and capabilities required for startup product development; team capacity and team roles; technical debt; minimal viable products; startup metrics; common pitfalls and patterns observed; as well as lessons learned from startups in Finland, Norway, Brazil, Russia and USA. All results are based on empirical findings, and the claims are backed by evidence and concrete observations, measurements and experiments from qualitative and quantitative research, as is common in empirical software engineering.
The book helps entrepreneurs and practitioners to become aware of various phenomena, challenges, and practices that occur in real-world startups, and provides insights based on sound research methodologies presented in a simple and easy-to-read manner. It also allows students in business and engineering programs to learn about the important engineering concepts and technical building blocks of a software startup. It is also suitable for researchers at different levels in areas such as software and systems engineering, or information systems who are studying advanced topics related to software business.
Die Annexion der Krim, die Kriegsführung in Syrien, das finanzielle Engagement in Zypern, das Tauziehen um die Ukraine und Weißrussland oder die Namensgebung Sputnik 5 für den Impfstoff gegen die Corona Epidemie sind eindeutige Belege für das aktuelle russische Machtstreben – und seine Expansionspolitik. Deshalb ist es nicht uninteressant zu fragen, welches Meinungsbild Friedrich List (1789–1846) von Russland hatte, zumal es heute noch so aktuell, wie vor 180 bis 190 Jahren erscheint und in seinen Schriften dargelegt ist. Dieses Meinungsbild wird in diesem Aufsatz erstmals untersucht und umfassend dargestellt.
In digital transformierten Arbeitswelten organisieren die Mitarbeitenden ihre Arbeitszeit, ihren Arbeitsort und die Art und Weise, wie sie Aufgaben erledigen, in größerem Umfang selbst. Unternehmen, die im Zuge des Transformationsprozesses den Grad der Selbstorganisation erhöhen möchten, stehen vor einer komplexen Herausforderung. Selbstorganisation betrifft zahlreiche Elemente der Organisation wie Arbeitsaufgaben und Rollen, Führung, Regeln und Kompetenzen. Auf Basis eines empirisch entwickelten Bezugsrahmens, dem Digitalisierungsatlas, können die verschiedenen Elemente integrativ betrachtet und die Wechselwirkungen zwischen den Dimensionen in den Blick genommen werden. Wird Selbstorganisation ausgehend von der Autonomie der Beschäftigten, Arbeitsaufgaben und die eigene Rolle in der Organisation selbst zu beeinflussen, in den Blick genommen, sind insbesondere die Wechselwirkungen zwischen den organisationalen Dimensionen sowie Führung relevant. Die Spannungen zwischen diesen Dimensionen werden näher fokussiert. Insgesamt zeigt der Beitrag auf, dass Selbstorganisation nicht als ein unabhängiges Phänomen verstanden werden kann, sondern stets in Wechselwirkung mit anderen Dimensionen steht.
Elasticity is considered to be the most beneficial characteristic of cloud environments, which distinguishes the cloud from clusters and grids. Whereas elasticity has become mainstream for web-based, interactive applications, it is still a major research challenge how to leverage elasticity for applications from the high-performance computing (HPC) domain, which heavily rely on efficient parallel processing techniques. In this work, we specifically address the challenges of elasticity for parallel tree search applications. Well-known meta-algorithms based on this parallel processing technique include branch-and-bound and backtracking search. We show that their characteristics render static resource provisioning inappropriate and the capability of elastic scaling desirable. Moreover, we discuss how to construct an elasticity controller that reasons about the scaling behavior of a parallel system at runtime and dynamically adapts the number of processing units according to user-defined cost and efficiency thresholds. We evaluate a prototypical elasticity controller based on our findings by employing several benchmarks for parallel tree search and discuss the applicability of the proposed approach. Our experimental results show that, by means of elastic scaling, the performance can be controlled according to user-defined thresholds, which cannot be achieved with static resource provisioning.
This book presents an empirical investigation of the efforts that multinational pharmaceutical companies take in order to find a business model that allows for a profitable access to the Bottom of the Pyramid (BoP) markets. The Bottom of the Pyramid in Africa is frequently mentioned as an attractive market due to its sheer size. Yet most companies struggle to access it because of the low price level, difficult physical market access and challenges when it comes to payment.
More specifically, the book investigates the following business model-related questions: Do pharmaceutical companies provide products that meet the needs of the BoP? What characterizes the value generation of the company? What revenue model leads to a profitable business, and what role does a network of partners play in the business model?
Findings reveal that there is no ‘one-size-fits-all’ answer to these questions. Providing continuous availability, affordability at a good quality of goods and services, creating health awareness, as well as localizing business to achieve a level of inclusivenessare essential prerequisites for success. In the last chapter this book provides a business model prototype that accounts for these key success factors for business at the Bottom of the Pyramid and points to further research topics.
Die rasante Entwicklung der Sensortechnik im Endverbraucherbereich lässt einen klinischen Nutzen der verfügbaren dezentral erhobenen Daten aus dem Patientenalltag zur Überwachung des individuellen Gesundheitszustands vermuten. Zur Überprüfung dieser Vermutung ist die Bereitstellung einer entsprechenden Plattform in den klinischen Alltag erforderlich. Hierzu wird die bwHealthApp entwickelt, mit der sowohl die aktuelle Bandbreite als auch die Evolution der Sensortechnik auf die klinische Anwendung abbildbar ist. Mit dem flexiblen Entwurf lässt sich der klinische Nutzen für die personalisierte Medizin evaluieren. Außerdem bietet die bwHealthApp einen an Machbarkeit orientierten Diskussionsbeitrag zu offenen rechtlichen, regulatorischen und ethischen Fragestellungen der Digitalisierung in der Medizin in Deutschland.
The livestock sector is growing steadily and is responsible for around 18% of global greenhouse‐gas‐emissions, which is more than the global transport sec-tor (Steinfeld et al. 2006). This paper examines the potential of social marketing to reduce meat consumption. The aim is to understand consumers’ motivation in diet choices and to learn what opportunities social marketing can provide to counteract negative environmental and health trends. The authors believe that research to answer this question should start in metropolitan areas, be-cause measures should be especially effective there. Based on the Theory of Planned Behaviour (TPB, Ajzen 1991) and the Technology‐Acceptance‐Model by Huijts et al. (2012), an online‐study with participants from the metropolitan region (n = 708) was conducted in which central socio‐psychological constructs for a meat consumption reduction were examined. It was shown that attitude, personal norm and habit have a critical influence on the intention to reduce meat consumption. A segmentation of consumers based on these factors led to three consumer clusters: vegetarians/flexitarians, potential flexitarians and convinced meat eaters. Potential flexitarians are an especially relevant target group for the development of social‐marketing‐measures to reduce meat consumption. In co‐creation‐workshops with potential flexitarians from the metropolitan region, barriers and benefits of reducing meat consumption were identified. The factors of environmental protection, animal welfare and desire for variety turn out to be the most relevant motivational factors. Based on these factors, consumers proposed a variety of social marketing measures, such as applications and labels to inform about the environmental impact of meat products.
Wie kann die Digitalisierung in der Bauzulieferbranche erfolgreich gemeistert werden? Die Fülle und Komplexität der Fragen dazu lassen sich auf zwei zentrale Kernfragen reduzieren: Was sind die richtigen Inhalte und wesentlichen Werttreiber der Digitalisierung? Und wie muss zukünftig mit der steigenden Informationsflut, der rasant wachsenden Komplexität und der abnehmenden Planbarkeit umgegangen werden?
In diesem Beitrag wird ein Framework vorgestellt, das Bauzulieferern hilft, ihr digitales Zielbild mit seinen Werttreibern systematisch aus dem Kundennutzen abzuleiten. Das Framework berücksichtigt die Besonderheiten der Bauzulieferindustrie, kann aber mit leichten Anpassungen auch auf andere Branchen angewendet werden. Aufbauend auf dem Zielbild können Unternehmen definieren, welche technischen, personellen und organisatorischen Veränderungen für dessen Umsetzung erforderlich sind. Um flexibel mit den dynamischen Veränderungen in ihrem Ökosystem und kulturellen Herausforderungen umgehen zu können, werden zudem fünf Einflussgrößen identifiziert, die Unternehmen bei der Entwicklung der dafür benötigten Evolutionskompetenz berücksichtigen müssen.
Im Gegensatz etwa zur klassischen Werbung handelt es sich beim Event-Marketing um ein dynamisches Kommunikationsinstrument, das laufend Trends und Neuerungen mit sich bringt. Die vielfältigen Einsatzmöglichkeiten und Potenziale des Event-Marketing ermöglichen es, entsprechend dem momentanen Zeitgeist relevante Zielgruppen zu erreichen, markenrelevante Wirklichkeiten und Erlebniswelten zu generieren, Emotionen und Sympathiewerte zu erzeugen und auf diese Weise eine Bindung zwischen Marke bzw. Unternehmen und Rezipienten herzustellen.
Im Frühjahr 1817 unternahm der damalige Professor Friedrich List an der Universität Tübingen eine Reise nach Frankfurt a. M., wo zu dieser Zeit die berühmte Ostermesse stattfand. Dort traf er mit den Anführern der Kaufleute zusammen, die darüber klagten, dass die zaghafte wirtschaftliche Entwicklung unter den vielen Zollschranken und den Billigimporten aus England stark zu leiden habe. Deshalb forderten sie die Abschaffung der Binnenzölle und die Bildung einer Wirtschaftsunion. Im Auftrag der Kaufleute verfasste List seine berühmt gewordene Petition an die Bundesversammlung, die lose Interessenvertretung des Deutschen Bundes in Frankfurt. Als die Petition mit großem Beifall aufgenommen wurde, gründete List im Hochgefühl seines Erfolges spontan den "Allgemeinen Deutschen Handels- und Gewerbsverein" – die erste Interessenvertretung deutscher Kaufleute. Er legte damit den Grundstein für den politischen Prozess zur Gründung des Zollvereins von 1834, der wiederum die Vorstufe zur Gründung des Deutschen Reiches von 1871 bildete. Lists damalige Forderungen sind zurzeit wieder hoch aktuell.
Exogenous factors of influence on exhaled breath analysis by ion-mobility spectrometry (MCC/IMS)
(2019)
The interpretation of exhaled breath analysis needs to address to the influence of exogenous factors, especially to a transfer of confounding analytes by the test persons. A test person who was exposed to a disinfectant had exhaled breath analysis by MCC/IMS (Bioscout®) after different time intervals. Additionally, a new sampling method with inhalation of synthetic air before breath analysis was tested. After exposure to the disinfectant, 3-Pentanone monomer, 3-Pentanone dimer, Hexanal, 3-Pentanone trimer, 2-Propanamine, 1-Propanol, Benzene, Nonanal showed significantly higher intensities, in exhaled breath and air of the examination room, compared to the corresponding baseline measurements. Only one ingredient of the disinfectant (1-Propanol) was identical to the 8 analytes. Prolonging the time intervals between exposure and breath analysis showed a decrease of their intensities. However, the half-time of the decrease was different. The inhalation of synthetic air - more than consequently airing the examination room with fresh air - reduced the exogenous and also relevant endogenous analytes, leading to a reduction and even changing polarity of the alveolar gradient. The interpretation of exhaled breath needs further knowledge about the former residence of the proband and the likelihood and relevance of the inhalation of local, site-specific and confounding exogenous analytes by him. Their inhalation facilitates a transfer to the examination room and a detection of high concentrations in room air and exhaled breath, but also the exhalation of new analytes. This may lead to a misinterpretation of these analytes as endogenous resp. disease-specific ones.
Standardisation of breath sampling is important for application of breath analysis in clinical settings. By studying the effect of room airing on indoor and breath analytes and by generating time series of room air with different sampling intervals we sought to get further insights into room air metabolism, to detect the relevance of exogenous VOCs and to make conclusions about their consideration for the interpretation of exhaled breath. Room air and exhaled breath of a healthy subject were analysed before and after room airing. Furthermore a time series of room air with doors and windows closed was taken over 84 h by an automatic sampling every 180 min. A second times series studied room air analytes over 70 h with samples taken every 16.5 min. For breath and room air measurements an IMS coupled to a multi-capillary column (IMS/MCC) [Bio-Scout® - B&S Analytik GmbH, Dortmund, Germany] was used. The peaks were characterized using the Software Visual Now (B&S Analytik, Dortmund Germany) and identified using the software package MIMA (version 1.1, provided by the Max Planck Institute for Informatics, Saarbrücken, Germany) and the database 20160426_SubstanzDbNIST_122 (B & S Analytik GmbH, Dortmund, Germany). In the morning 4 analytes (Decamethylcylopentasiloxane [541-02-6]; Pentan-2-one [107-87-9] – Dimer; Hexan-1-al [66-25-1]; Pentan-2-one [107-87-9]) – Monomer showed high intensities in the room air and exhaled breath. They were significantly but not equally reduced by room airing. The time series about 84 h showed a time dependent decrease of analytes (limonen-monomer and -dimer; Decamethylcylopentasiloxane, Butan-1-ol, Butan-1-ol) as well as increase (Pentan-2-one [107-87-9] – Dimer). Shorter sampling intervals exhibited circadian variations of analyte concentrations for many analytes. Breath sampling in the morning needs room airing before starting. Then the variation of the intensity of indoor analytes can be kept small. The time series of indoor analytes show, that their intensities have a different behaviour, with time dependent declines, constant increases and circadian variations, dependent on room airing. This has implications on the breath sampling procedure and the intrepretation of exhaled breath.
Companies are becoming aware of the potential risks arising from sustainability aspects in supply chains. These risks can affect ecological, economic or social aspects. One important element in managing those risks is improved transparency in supply chains by means of digital transformation. Innovative technologies like blockchain technology can be used to enforce transparency. In this paper, we present a smart contract-based Supply Chain Control Solution to reduce risks. Technological capabilities of the solution will be compared to a similar technology approach and evaluated regarding their benefits and challenges within the framework of supply chain models. As a result, the proposed solution is suitable for the dynamic administration of complex supply chains.
Due to digitalization, constant technological progress and ever shorter product life cycles, enterprises are currently facing major challenges. In order to succeed in the market, business models have to be adapted more often and more quickly to changing market conditions than they used to be. Fast adaptability, also called agility, is a decisive competitive factor in today’s world. Because of the ever-growing IT part of products and the fact that they are manufactured using IT, changing the business model has a major impact on the enterprise architecture (EA). However, developing EAs is a very complex task, because many stakeholders with conflicting interests are involved in the decision-making process. Therefore, a lot of collaboration is required. To support organizations in developing their EA, this article introduces a novel integrative method that systematically integrates stakeholder interests into decision-making activities. By using the method, collaboration between stakeholders involved is improved by identifying points of contact between them. Furthermore, standardized activities make decision-making more transparent and comparable without limiting creativity.
Enterprises are currently transforming their strategy, processes, and their information systems to extend their degree of digitalization. The potential of the Internet and related digital technologies, like Internet of Things, services computing, cloud computing, artificial intelligence, big data with analytics, mobile systems, collaboration networks, and cyber physical systems both drives and enables new business designs. Digitalization deeply disrupts existing businesses, technologies and economies and fosters the architecture of digital environments with many rather small and distributed structures. This has a strong impact for new value producing opportunities and architecting digital services and products guiding their design through exploiting a Service-Dominant Logic. The main result of the book chapter extends methods for integral digital strategies with value-oriented models for digital products and services which are defined in the framework of a multi-perspective digital enterprise architecture reference model.
This chapter presents an introduction to the emerging trends for architecting the digital transformation having a strong focus on digital products, intelligent services, and related systems together with methods, models and architectures. The primary aim of this book is to highlight some of the most recent research results in the field. We are providing a focused set of brief descriptions of the chapters included in the book.
The digital transformation is today’s dominant business transformation having a strong influence on how digital services and products are designed in a service-dominant way. A popular underlying theory of value creation and economic exchange that is known as the service-dominant (S-D) logic can be connected to many successful digital business models. However, S-D logic by itself is abstract. Companies cannot directly use it as an instrument for business model innovation and design in an easy way. To address this a comprehensive ideation method based on S-D logic is proposed, called service-dominant design (SDD). SDD is aimed at supporting firms in the transition to a service- and value-oriented perspective. The method provides a simplified way to structure the ideation process based on four model components. Each component consists of practical implications, auxiliary questions and visualization techniques that were derived from a literature review, a use case evaluation of digital mobility and a focus group discussion. SDD represents a first step of having a toolset that can support established companies in the process of service- and value-orientation as part of their digital transformation efforts.
This research-oriented book presents key contributions on architecting the digital transformation. It includes the following main sections covering 20 chapters: · Digital Transformation · Digital Business · Digital Architecture · Decision Support · Digital Applications Focusing on digital architectures for smart digital products and services, it is a valuable resource for researchers, doctoral students, postgraduates, graduates, undergraduates, academics and practitioners interested in digital transformation.
Companies compete more and more as integrated supply chains rather than as individual firms. The success of the entire supply chain determines the economic well-being of the individual company. With management attention shifting to supply chains, the role of management accounting naturally must extend to the cross-company layer as well. This book demonstrates how management accounting can make a significant contribution to supply chain success.It targets students who are already familiar with the fundamentals of accounting and now want to extend their expertise in the field of cross company (or network) management accounting. Practitioners will draw valuable insights from the text as well.
Investigation of tympanic membrane influences on middle-ear impedance measurements and simulations
(2020)
This study simulates acoustic impedance measurements in the human ear canal and investigates error influences due to improperly accounted evanescence in the probe’s near field, cross-section area changes, curvature of the ear canal, and pressure inhomogeneities across the tympanic membrane, which arise mainly at frequencies above 10 kHz. Evanescence results from strongly damped modes of higher order, which can only be found in the near field of the sound source and are excited due to sharp cross-sectional changes as they occur at the transition from the probe loudspeaker to the ear canal. This means that different impedances are measured depending on the probe design. The influence of evanescence cannot be eliminated completely from measurements, however, it can be reduced by a probe design with larger distance between speaker and microphone. A completely different approach to account for the influence of evanescence is to evaluate impedance measurements with the help of a finite element model, which takes the precise arrangement of microphone and speaker in the measurement into account. The latter is shown in this study exemplary on impedance measurements at a tube terminated with a steel plate. Furthermore, the influences of shape changes of the tympanic membrane and ear canal curvature on impedance are investigated.
Purpose: Gliomas are the most common and aggressive type of brain tumors due to their infiltrative nature and rapid progression. The process of distinguishing tumor boundaries from healthy cells is still a challenging task in the clinical routine. Fluid attenuated inversion recovery (FLAIR) MRI modality can provide the physician with information about tumor infiltration. Therefore, this paper proposes a new generic deep learning architecture, namely DeepSeg, for fully automated detection and segmentation of the brain lesion using FLAIR MRI data.
Methods: The developed DeepSeg is a modular decoupling framework. It consists of two connected core parts based on an encoding and decoding relationship. The encoder part is a convolutional neural network (CNN) responsible for spatial information extraction. The resulting semantic map is inserted into the decoder part to get the full-resolution probability map. Based on modified U-Net architecture, different CNN models such as residual neural network (ResNet), dense convolutional network (DenseNet), and NASNet have been utilized in this study.
Results: The proposed deep learning architectures have been successfully tested and evaluated on-line based on MRI datasets of brain tumor segmentation (BraTS 2019) challenge, including s336 cases as training data and 125 cases for validation data. The dice and Hausdorff distance scores of obtained segmentation results are about 0.81 to 0.84 and 9.8 to 19.7 correspondingly.
Conclusion: This study showed successful feasibility and comparative performance of applying different deep learning models in a new DeepSeg framework for automated brain tumor segmentation in FLAIR MR images. The proposed DeepSeg is open source and freely available at https://github.com/razeineldin/DeepSeg/.
This study describes a non-contact measuring and system identification procedure for evaluating inhomogeneous stiffness and damping characteristics of the annular ligament in the physiological amplitude and frequency range without the application of large static external forces that can cause unnatural displacements of the stapes. To verify the procedure, measurements were first conducted on a steel beam. Then, measurements on an individual human cadaveric temporal bone sample were performed. The estimated results support the inhomogeneous stiffness and damping distribution of the annular ligament and are in a good agreement with the multiphoton microscopy results which show that the posterior-inferior corner of the stapes footplate is the stiffest region of the annular ligament.
Internet of Things (IoT) provides a strong platform for computer users to connect objects, devices, and people to the Internet for exchanging or sharing of information with each other. IoT is growing rapidly and is expected to adapt to disciplines such as manufacturing, agriculture, healthcare, and robotics. Furthermore, the new concept of IoT is proposed and shown, especially for robotics areas as Internet of Robotics Things (IoRT). IoRT is a mixed structure of diverse technologies such as cloud computing, artificial intelligence, and machine learning. However, to promote and realize IoRT, digitization and digital transformation should be proceeded and implemented in the robotics enterprise. In this paper, we propose and architecture framework for IoRT-based digital platforms an verify it using a planned case in a global robotics enterprise. The associated challenges and future research directions in this field are also presented.
Das Phänomen des Populismus wird in den verschiedensten wissenschaftlichen Disziplinen seit Jahrzehnten erörtert. Dss vorherrschende Narrativ ist aber ökonomischer Natur. Die (Finanz-)Globalisierung und der technologische Fortschritt entfremden die Menschen und bewirken Verunsicherung. Zudem erkennen die Bürger mehr die Herausforderungen als die Chancen in diesem Transformationsprozess.
The critical process parameters cell density and viability during mammalian cell cultivation are assessed by UV/VIS spectroscopy in combination with multivariate data analytical methods. This direct optical detection technique uses a commercial optical probe to acquire spectra in a label-free way without signal enhancement. For the cultivation, an inverse cultivation protocol is applied, which simulates the exponential growth phase by exponentially replacing cells and metabolites of a growing Chinese hamster ovary cell batch with fresh medium. For the simulation of the death phase, a batch of growing cells is progressively replaced by a batch with completely starved cells. Thus, the most important parts of an industrial batch cultivation are easily imitated. The cell viability was determined by the well-established method partial least squares regression (PLS). To further improve process knowledge, the viability has been determined from the spectra based on a multivariate curve resolution (MCR) model. With this approach, the progress of the cultivations can be continuously monitored solely based on an UV/VIS sensor. Thus, the monitoring of critical process parameters is possible inline within a mammalian cell cultivation process, especially the viable cell density. In addition, the beginning of cell death can be detected by this method which allows us to determine the cell viability with acceptable error. The combination of inline UV/VIS spectroscopy with multivariate curve resolution generates additional process knowledge complementary to PLS and is considered a suitable process analytical tool for monitoring industrial cultivation processes.
Automatic classification of rotating machinery defects using Machine Learning (ML) algorithms
(2020)
Electric machines and motors have been the subject of enormous development. New concepts in design and control allow expanding their applications in different fields. The vast amount of data have been collected almost in any domain of interest. They can be static; that is to say, they represent real-world processes at a fixed point of time. Vibration analysis and vibration monitoring, including how to detect and monitor anomalies in vibration data are widely used techniques for predictive maintenance in high-speed rotating machines. However, accurately identifying the presence of a bearing fault can be challenging in practice, especially when the failure is still at its incipient stage, and the signal-to-noise ratio of the monitored signal is small. The main objective of this work is to design a system that will analyze the vibration signals of a rotating machine, based on recorded data from sensors, in the time/frequency domain. As a consequence of such substantial interest, there has been a dramatic increase of interest in applying Machine Learning (ML) algorithms to this task. An ML system will be used to classify and detect abnormal behavior and recognize the different levels of machine operation modes. The proposed solution can be deployed as predictive maintenance for Industry 4.0.
Power line communications (PLC) reuse the existing power-grid infrastructure for the transmission of data signals. As power line the communication technology does not require a dedicated network setup, it can be used to connect a multitude of sensors and Internet of Things (IoT) devices. Those IoT devices could be deployed in homes, streets, or industrial environments for sensing and to control related applications. The key challenge faced by future IoT-oriented narrowband PLC networks is to provide a high quality of service (QoS). In fact, the power line channel has been traditionally considered too hostile. Combined with the fact that spectrum is a scarce resource and interference from other users, this requirement calls for means to increase spectral efficiency radically and to improve link reliability. However, the research activities carried out in the last decade have shown that it is a suitable technology for a large number of applications. Motivated by the relevant impact of PLC on IoT, this paper proposed a cooperative spectrum allocation in IoT-oriented narrowband PLC networks using an iterative water-filling algorithm.